PE20180481A1 - Anticuerpos de union a tau - Google Patents
Anticuerpos de union a tauInfo
- Publication number
- PE20180481A1 PE20180481A1 PE2017002750A PE2017002750A PE20180481A1 PE 20180481 A1 PE20180481 A1 PE 20180481A1 PE 2017002750 A PE2017002750 A PE 2017002750A PE 2017002750 A PE2017002750 A PE 2017002750A PE 20180481 A1 PE20180481 A1 PE 20180481A1
- Authority
- PE
- Peru
- Prior art keywords
- seq
- tau
- binding antibody
- variable region
- heavy chain
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Animal Behavior & Ethology (AREA)
- Psychiatry (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
Referido a un anticuerpo aislado de union a Tau o fragmento de union del mismo caracterizado porque comprende una region variable de cadena ligera que comprende una CDR1 seleccionada a partir de SEQ ID No.: 1, una CDR2 seleccionada a partir de SEQ ID No.: 2 y una CDR3 seleccionada a partir de SEQ ID No.: 3; y una region variable de cadena pesada que comprende una CDR1 seleccionada a partir de SEQ ID No.: 4, una CDR2 seleccionada a partir de SEQ ID No.: 5, y/o una CDR3 seleccionada a partir de SEQ ID No.: 6. Tambien se refiere a una molecula aislada de acido nucleico, que codifica para la cadena ligera y/o pesada de un anticuerpo de union a Tau; un vector de clonacion o expresion, una celula hospedadora, y un metodo para producir un anticuerpo de union a Tau; en donde se utilizan en el tratamiento de una tauopatia, como en la enfermedad de Alzheimer o en la paralisis supranuclear progresiva.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15175522 | 2015-07-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20180481A1 true PE20180481A1 (es) | 2018-03-07 |
Family
ID=53524640
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2017002750A PE20180481A1 (es) | 2015-07-06 | 2016-07-05 | Anticuerpos de union a tau |
Country Status (28)
Country | Link |
---|---|
US (4) | US10287343B2 (es) |
EP (1) | EP3319983A1 (es) |
JP (3) | JP6630426B2 (es) |
KR (1) | KR20180025962A (es) |
CN (1) | CN107849104B (es) |
AR (1) | AR105267A1 (es) |
AU (1) | AU2016289755C1 (es) |
BR (1) | BR112017028102A2 (es) |
CA (1) | CA2991451A1 (es) |
CL (1) | CL2018000043A1 (es) |
CO (1) | CO2017012971A2 (es) |
EA (1) | EA037092B1 (es) |
EC (1) | ECSP18000887A (es) |
HK (1) | HK1246804A1 (es) |
IL (1) | IL256685B (es) |
MA (2) | MA42377A (es) |
MX (1) | MX2017015817A (es) |
MY (1) | MY193677A (es) |
NZ (1) | NZ738058A (es) |
PE (1) | PE20180481A1 (es) |
PH (1) | PH12017502207A1 (es) |
SG (1) | SG10202010735PA (es) |
TN (1) | TN2017000539A1 (es) |
TW (1) | TWI745295B (es) |
UA (1) | UA124616C2 (es) |
UY (1) | UY36773A (es) |
WO (1) | WO2017005734A1 (es) |
ZA (1) | ZA201800027B (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20180317A1 (es) | 2015-06-05 | 2018-02-09 | Genentech Inc | Anticuerpos anti-tau y metodos de uso |
CA2991264C (en) | 2015-07-06 | 2023-10-10 | Ucb Biopharma Sprl | Tau-binding antibodies |
WO2017005734A1 (en) | 2015-07-06 | 2017-01-12 | Ucb Biopharma Sprl | Tau-binding antibodies |
CN117820467A (zh) | 2016-12-07 | 2024-04-05 | 基因泰克公司 | 抗tau抗体和使用方法 |
KR102587130B1 (ko) | 2016-12-07 | 2023-10-11 | 제넨테크, 인크. | 항-타우 항체 및 이의 이용 방법 |
MA47499A (fr) | 2017-02-17 | 2019-12-25 | Denali Therapeutics Inc | Anticorps anti-tau et leurs procédés d'utilisation |
JOP20180014A1 (ar) | 2017-02-27 | 2019-01-30 | Teijin Pharma Ltd | جسم مضاد متوافق مع البشر لعلاج أو الوقاية من الاضطرابات الإدراكية، وعملية لإنتاجه، وعامل لعلاج أو الوقاية من الاضطرابات الإدراكية باستخدامه |
US10829547B2 (en) | 2017-10-16 | 2020-11-10 | Eisai R&D Management Co., Ltd. | Anti-tau antibodies and uses thereof |
US20220017611A1 (en) * | 2018-12-13 | 2022-01-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | New anti tau svqivykpv epitope single domain antibody |
MX2022001817A (es) * | 2019-08-13 | 2022-03-11 | Washington University St Louis | Metodos para detectar isoformas de la region de union a microtubulos (mtbr) tau y uso de las mismas. |
WO2021163031A1 (en) | 2020-02-12 | 2021-08-19 | Eli Lilly And Company | Crystallization of antibodies or antigen-binding fragments |
TW202216759A (zh) | 2020-06-25 | 2022-05-01 | 美商默沙東藥廠 | 靶向絲胺酸413經磷酸化之tau之高親和力抗體 |
WO2023092004A1 (en) | 2021-11-17 | 2023-05-25 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of tau-related disorders |
WO2024107745A1 (en) * | 2022-11-14 | 2024-05-23 | Washington University | Methods to detect csf mtbr-tau and uses thereof |
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KR102048382B1 (ko) | 2011-11-11 | 2019-11-25 | 유씨비 바이오파마 에스피알엘 | 알부민 결합 항체 및 이의 결합 단편 |
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CA2991264C (en) | 2015-07-06 | 2023-10-10 | Ucb Biopharma Sprl | Tau-binding antibodies |
WO2017005734A1 (en) | 2015-07-06 | 2017-01-12 | Ucb Biopharma Sprl | Tau-binding antibodies |
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2016
- 2016-07-05 WO PCT/EP2016/065813 patent/WO2017005734A1/en active Application Filing
- 2016-07-05 CN CN201680039795.4A patent/CN107849104B/zh active Active
- 2016-07-05 CA CA2991451A patent/CA2991451A1/en active Pending
- 2016-07-05 AU AU2016289755A patent/AU2016289755C1/en active Active
- 2016-07-05 NZ NZ738058A patent/NZ738058A/en unknown
- 2016-07-05 PE PE2017002750A patent/PE20180481A1/es unknown
- 2016-07-05 KR KR1020187003689A patent/KR20180025962A/ko not_active Application Discontinuation
- 2016-07-05 EP EP16734676.6A patent/EP3319983A1/en active Pending
- 2016-07-05 JP JP2018500423A patent/JP6630426B2/ja active Active
- 2016-07-05 MA MA042377A patent/MA42377A/fr unknown
- 2016-07-05 SG SG10202010735PA patent/SG10202010735PA/en unknown
- 2016-07-05 BR BR112017028102A patent/BR112017028102A2/pt active Search and Examination
- 2016-07-05 MA MA41670A patent/MA41670A1/fr unknown
- 2016-07-05 EA EA201890172A patent/EA037092B1/ru not_active IP Right Cessation
- 2016-07-05 US US15/742,087 patent/US10287343B2/en active Active
- 2016-07-05 MY MYPI2018700043A patent/MY193677A/en unknown
- 2016-07-05 MX MX2017015817A patent/MX2017015817A/es unknown
- 2016-07-05 UA UAA201711739A patent/UA124616C2/uk unknown
- 2016-07-05 TN TNP/2017/000539A patent/TN2017000539A1/en unknown
- 2016-07-06 UY UY0001036773A patent/UY36773A/es not_active Application Discontinuation
- 2016-07-06 TW TW105121455A patent/TWI745295B/zh active
- 2016-07-06 AR ARP160102045A patent/AR105267A1/es unknown
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2017
- 2017-12-04 PH PH12017502207A patent/PH12017502207A1/en unknown
- 2017-12-18 CO CONC2017/0012971A patent/CO2017012971A2/es unknown
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2018
- 2018-01-01 IL IL256685A patent/IL256685B/en unknown
- 2018-01-03 ZA ZA2018/00027A patent/ZA201800027B/en unknown
- 2018-01-05 CL CL2018000043A patent/CL2018000043A1/es unknown
- 2018-01-05 EC ECIEPI2018887A patent/ECSP18000887A/es unknown
- 2018-05-10 HK HK18106080.8A patent/HK1246804A1/zh unknown
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2019
- 2019-05-13 US US16/409,945 patent/US10889640B2/en active Active
- 2019-12-06 JP JP2019220807A patent/JP7100008B2/ja active Active
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2020
- 2020-12-29 US US17/136,189 patent/US11732034B2/en active Active
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2022
- 2022-06-30 JP JP2022105415A patent/JP7413448B2/ja active Active
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2023
- 2023-06-30 US US18/344,945 patent/US20230416350A1/en active Pending
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