DK3102576T3 - Dihydropyrrolopyridininhibitorer af ror-gamma - Google Patents

Dihydropyrrolopyridininhibitorer af ror-gamma Download PDF

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Publication number
DK3102576T3
DK3102576T3 DK15705744.9T DK15705744T DK3102576T3 DK 3102576 T3 DK3102576 T3 DK 3102576T3 DK 15705744 T DK15705744 T DK 15705744T DK 3102576 T3 DK3102576 T3 DK 3102576T3
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Prior art keywords
ror
gamma
dihydropyrrolopyridine
inhibitors
dihydropyrrolopyridine inhibitors
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DK15705744.9T
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English (en)
Inventor
David A Claremon
Lawrence Wayne Dillard
Chengguo Dong
Yi Fan
Lanqi Jia
Zhijie Liu
Stephen D Lotesta
Andrew Marcus
Suresh B Singh
Colin M Tice
Jing Yuan
Yajun Zheng
Linghang Zhuang
Wei Zhao
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Vitae Pharmaceuticals Llc
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Application filed by Vitae Pharmaceuticals Llc filed Critical Vitae Pharmaceuticals Llc
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Publication of DK3102576T3 publication Critical patent/DK3102576T3/da

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    • C—CHEMISTRY; METALLURGY
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
DK15705744.9T 2014-02-03 2015-01-30 Dihydropyrrolopyridininhibitorer af ror-gamma DK3102576T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461935162P 2014-02-03 2014-02-03
US201461970637P 2014-03-26 2014-03-26
PCT/US2015/013699 WO2015116904A1 (en) 2014-02-03 2015-01-30 Dihydropyrrolopyridine inhibitors of ror-gamma

Publications (1)

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DK3102576T3 true DK3102576T3 (da) 2019-07-22

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DK15705744.9T DK3102576T3 (da) 2014-02-03 2015-01-30 Dihydropyrrolopyridininhibitorer af ror-gamma

Country Status (26)

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US (6) US9266886B2 (da)
EP (2) EP3102576B8 (da)
JP (1) JP6466461B2 (da)
KR (1) KR102408261B1 (da)
CN (1) CN105940002B (da)
AU (1) AU2015210833B2 (da)
CA (1) CA2938311C (da)
CL (1) CL2016001947A1 (da)
DK (1) DK3102576T3 (da)
EA (1) EA031804B1 (da)
EC (1) ECSP16071151A (da)
ES (1) ES2735099T3 (da)
HU (1) HUE045511T2 (da)
IL (1) IL246902B (da)
LT (1) LT3102576T (da)
MX (1) MX371017B (da)
PE (1) PE20161372A1 (da)
PH (1) PH12016501457A1 (da)
PL (1) PL3102576T3 (da)
PT (1) PT3102576T (da)
RS (1) RS59007B1 (da)
SG (1) SG11201606080SA (da)
SI (1) SI3102576T1 (da)
TW (1) TWI658041B (da)
UA (1) UA121309C2 (da)
WO (1) WO2015116904A1 (da)

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US11311512B2 (en) 2014-08-12 2022-04-26 Monash University Lymph directing prodrugs
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US9845308B2 (en) 2014-11-05 2017-12-19 Vitae Pharmaceuticals, Inc. Isoindoline inhibitors of ROR-gamma
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CN107614062A (zh) 2015-03-12 2018-01-19 加利福尼亚大学董事会 用RORγ抑制剂治疗癌症的方法
EP3845526A1 (en) * 2015-05-15 2021-07-07 Aurigene Discovery Technologies Limited Method for the preparation of tetrahydroquinolinone compounds having ror-gamma modulating activity
JP6549735B2 (ja) 2015-06-09 2019-07-24 アッヴィ・インコーポレイテッド 核内受容体調節剤
WO2017010399A1 (ja) * 2015-07-10 2017-01-19 塩野義製薬株式会社 ＲＯＲγｔ阻害作用を有する化合物およびそれらを含有する医薬組成物
ES2856931T3 (es) 2015-08-05 2021-09-28 Vitae Pharmaceuticals Llc Moduladores de ROR-gamma
AU2016318229A1 (en) 2015-09-08 2018-03-29 Monash University Lymph directing prodrugs
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EA034514B1 (ru) 2015-12-15 2020-02-14 Астразенека Аб Изоиндольные соединения
TW202220968A (zh) * 2016-01-29 2022-06-01 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
CN106632313B (zh) * 2016-03-04 2021-04-09 上海贤鼎生物科技有限公司 一种抗癌药帕博昔布重要中间体及合成工艺
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AR109042A1 (es) 2016-07-14 2018-10-24 Cadila Healthcare Ltd COMPUESTOS MODULARES DE RORg
EP3481809A1 (en) 2016-07-14 2019-05-15 Cadila Healthcare Limited Cyclopropyl derivatives as ror-gamma modulators
WO2018042342A1 (en) * 2016-08-30 2018-03-08 Glenmark Pharmaceuticals S.A. 1,2,3-benzotriazole derivatives as ror gamma t modulators
TWI705958B (zh) 2016-12-05 2020-10-01 荷蘭商領導醫藥控股責任有限公司 ＲＯＲγ調節子
JP2020502238A (ja) 2016-12-23 2020-01-23 バイスクルアールディー・リミテッド 新規連結構造を有するペプチド誘導体
JP2020059651A (ja) * 2016-12-26 2020-04-16 科研製薬株式会社 ピラゾール誘導体及びそれを含有する医薬
WO2018191146A1 (en) 2017-04-10 2018-10-18 Navitor Pharmaceuticals, Inc. Heteroaryl rheb inhibitors and uses thereof
US10857196B2 (en) 2017-04-27 2020-12-08 Bicycletx Limited Bicyclic peptide ligands and uses thereof
CN109963845B (zh) * 2017-05-23 2021-09-03 江苏恒瑞医药股份有限公司 螺环甲酰胺类衍生物、其制备方法及其在医药上的应用
CN110730780A (zh) 2017-06-14 2020-01-24 阿斯利康(瑞典)有限公司 用作ROR-γ调节剂的2，3-二氢异吲哚-1-甲酰胺
JP2020142989A (ja) * 2017-06-21 2020-09-10 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 イミダゾール誘導体及びそれを含有する医薬
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WO2019024809A1 (zh) 2017-08-01 2019-02-07 正大天晴药业集团股份有限公司 作为RORγ抑制剂的双环化合物
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