AR063311A1 - Compuestos organicos - Google Patents
Compuestos organicosInfo
- Publication number
- AR063311A1 AR063311A1 ARP070104573A ARP070104573A AR063311A1 AR 063311 A1 AR063311 A1 AR 063311A1 AR P070104573 A ARP070104573 A AR P070104573A AR P070104573 A ARP070104573 A AR P070104573A AR 063311 A1 AR063311 A1 AR 063311A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- unsubstituted
- lower alkyl
- hydrogen
- formula
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D263/57—Aryl or substituted aryl radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Abstract
La presente proporciona compuestos de la siguiente estructura: A-L1-B-C-D que son utiles para el tratamiento o la prevencion de las condiciones o los trastornos asociados con la actividad de DGAT1 en animales, en particular en seres humanos. Reivindicacion 1: Un compuesto que tiene la siguiente estructura: A-L1-B-C-D y sales farmacéuticamente aceptables y pro-fármacos del mismo, en donde: A se selecciona a partir de un alquilo sustituido o insustituido, alcoxilo sustituido o insustituido, cicloalquilo sustituido o insustituido, arilo sustituido o insustituido, y un heterociclilo sustituido o insustituido, en donde A está enlazado con L1 por medio de un miembro de carbono del anillo, cuando A es un anillo, L1 se selecciona a partir del grupo que consiste en: un grupo amina de la formula -(CH2)n-(CR4R4')p-(CH2)m-N(R3)-, un grupo tiocarbamoílo de la formula -(CH2)n-(CR4R4')p(CH2)m-N(R3)-C(S), un grupo amida de la formula -C(O)-N(R3)-(CH2)n-(CR4R4')p-(CH2)m-, un grupo amidina de la formula -C(NH)-N(R3)-(CH2)n-(CR4R4')p(CH2)m-, un grupo amida de la formula -(CH2)n-(CR4R4')p-(CH2)m-C(O)-N(R3)-, un grupo sulfonamida de la formula -(CH2)n-(CR4R4')p-(CH2)mS(O2)-N(R3)-, un grupo carbamato de la formula -(CH2)n- (CR4R4')p-(CH2)m-(O)-C(O)-N(R3)-, o un grupo urea de la formula -(CH2)n--(CR4R4')p-(CH2)m-N(R3)-C (O)-N(R3A)-, en donde: R3 y R3A son, independientemente uno del otro, hidrogeno o alquilo inferior, m, n, y p son, independientemente unos de otros, un entero de 0 a 2, R4 y R4' son, independientemente uno del otro, hidrogeno, halogeno, hidroxilo, alcoxilo inferior, alcoxilo inferior-carbonilo, carboxilo, o alquilo inferior, o R4 y R4' se unen juntos para formar un residuo espiro de la formula (2) en donde: X es NR3', O, S, o CR3-R4-, r y s son, independientemente uno del otro, cero o un entero de 1 a 3, R3' es hidrogeno o alquilo inferior, R3ö es hidrogeno, halogeno, hidroxilo, alcoxilo, o alquilo inferior, R4ö es hidrogeno o alquilo inferior, B es un grupo heteroarilo divalente sustituido o insustituido seleccionado a partir de uno de los siguientes grupos de formulas (3) en donde X1 y X2' se seleccionan independientemente a partir de O, NH, NR9 o S, en donde R9 se selecciona a partir de alquilo inferior, alquilo inferior-amino, alcoxilo inferior-alquilo, hidroxi-alquilo inferior, X1', X2, X3, y X4 se seleccionan independientemente a partir de N o CH, C es como en formula (4) en donde R1 se selecciona a partir de H, ciano, alquilo inferior-sulfonil-amino, alcanoil-amino, halogeno, alquilo inferior, trifluoro-metilo, alcoxilo inferior, alquilo inferior-amino, dialquilo inferior-amino, y NO2, R'1, R2, y R'2 se seleccionan independientemente a partir de hidrogeno, halogeno, trifluoro-metilo, ariloxilo, alquilo inferior, alcoxilo inferior, alquilo inferior-amino, dialquilo inferior-amino, y NO2, o C también puede ser un grupo arilo o heteroarilo bicíclico sustituido o insustituido, D se selecciona a partir de hidrogeno, halogeno, hidroxilo, ciano, alcanoil-amino, carboxilo, carbamoílo, -O-L2-E, -S-L2-E', -C(O)-O-L2-E, -L2-Eö, y -NR6-L2-E', L2 es -(CH2)n'-(CR5R5')p'-(CH2)m'-, E es: alquilo, acilo, alcoxi-carbonilo, ácido fosfonico, fosfonato, cicloalcoxi- carbonilo, ariloxi-carbonilo, heterocicliloxi-carbonilo, carboxilo, carbamoílo, sulfonilo, -SO2-OH, sulfamoílo, sulfonil carbamoilo, sulfoniloxilo, sulfonamido, -C(O)-O-R-PRO, arilo sustituido o insustituido, heterociclilo sustituido o insustituido, o heteroarilo sustituido o insustituido, y, cuando n' + m' + p' es igual a cero, E no es sulfoniloxilo o sulfonamido, E' es: alquilo, arilo, alcoxi-carbonilo, cicloalcoxi-carbonilo, ariloxi carbonilo heterocicliloxi-carbonilo, carboxilo, carbamoílo, sulfonil carbamoilo, sulfonilo, -SO2-OH, sulfamoílo, sulfonamido, ácido fosfonico, fosfonato, sulfoniloxilo, -C(O)-O-R-PRO, arilo sustituido o insustituido, heterociclilo sustituido o insustituido, o heteroarilo sustituido o insustituido, y, cuando n' + m' + p' es igual a cero, E' no es sulfamoílo, sulfonamido, ácido fosfonico, fosfonato, o sulfoniloxilo, Eö es: alquilo, acilo, alcoxi-carbonilo, ácido fosfonico, fosfonato, cicloalcoxi-carbonilo, ariloxi-carbonilo, heterocicliloxi-carbonilo, carboxilo, carbamoílo, sulfonilo, sulfamoílo, sulfoniloxilo, sulfonamido, -SO2-OH, sulfonil-carbamoilo, -C(O)-O-R-PRO, arilo sustituido o insustituido, heterociclilo sustituido o insustituido, o heteroarilo sustituido o insustituido, m', n', y p' son, independientemente unos de otros, un entero de 0 a 4, m' + n' + p' es entre 0 y 12, de preferencia 0, 1, 2, 3, o 4, R5 y R5' son, independientemente uno del otro, hidrogeno, halogeno, hidroxilo, alcoxilo inferior, o alquilo inferior, o R5 y R5' se unen juntos para formar un residuo espiro de la formula (5) en donde X' es NRx, O, S, o CRx'Rxö, r' y s' son, independientemente uno del otro, cero o un entero de 1 a 3, Rx es hidrogeno o alquilo inferior, Rx' es hidrogeno, halogeno, hidroxilo, alcoxilo, o alquilo inferior, Rxö es hidrogeno o alquilo interior; o un estereoisomero, enantiomero, o tautomero del mismo, una sal farmacéuticamente aceptable del mismo, o un pro-fármaco del mismo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US82998006P | 2006-10-18 | 2006-10-18 | |
US95234107P | 2007-07-27 | 2007-07-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR063311A1 true AR063311A1 (es) | 2009-01-21 |
Family
ID=39276877
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070104573A AR063311A1 (es) | 2006-10-18 | 2007-10-16 | Compuestos organicos |
Country Status (15)
Country | Link |
---|---|
US (1) | US8222248B2 (es) |
EP (1) | EP2074089B1 (es) |
JP (1) | JP5298022B2 (es) |
KR (1) | KR20090071642A (es) |
AR (1) | AR063311A1 (es) |
AU (1) | AU2007311087B2 (es) |
BR (1) | BRPI0718478A2 (es) |
CA (1) | CA2666880A1 (es) |
CL (1) | CL2007002974A1 (es) |
ES (1) | ES2440253T3 (es) |
MX (1) | MX2009004047A (es) |
PE (1) | PE20080888A1 (es) |
RU (1) | RU2009118489A (es) |
TW (1) | TW200829563A (es) |
WO (1) | WO2008048991A2 (es) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2005315430B2 (en) | 2004-12-14 | 2010-05-27 | Astrazeneca Ab | Oxadiazole derivatives as DGAT inhibitors |
WO2007071966A1 (en) | 2005-12-22 | 2007-06-28 | Astrazeneca Ab | Pyrimido- [4, 5-b] -oxazines for use as dgat inhibitors |
KR20090010092A (ko) | 2006-05-30 | 2009-01-28 | 아스트라제네카 아베 | Dgat1 억제제로서의 1,3,4-옥사디아졸 유도체 |
AU2007266796B2 (en) | 2006-05-30 | 2011-02-10 | Astrazeneca Ab | Substituted 5-phenylamino-1,3,4-oxadiazol-2-ylcarbonylamino-4-phenoxy-cyclohexane carboxylic acid as inhibitors of acetyl coenzyme A diacylglycerol acyltransferase |
AU2008339570B2 (en) | 2007-12-20 | 2012-04-12 | Astrazeneca Ab | Carbamoyl compounds as DGAT1 inhibitors 190 |
WO2009112445A1 (en) * | 2008-03-10 | 2009-09-17 | Novartis Ag | Method of increasing cellular phosphatidyl choline by dgat1 inhibition |
US20110301192A1 (en) * | 2008-10-01 | 2011-12-08 | The Regents Of The University Of California | Inhibitors of Cyclin Kinase Inhibitor p21 |
GB0821913D0 (en) | 2008-12-02 | 2009-01-07 | Price & Co | Antibacterial compounds |
AR075858A1 (es) * | 2009-03-18 | 2011-05-04 | Schering Corp | Compuestos biciclicos como inhibidores de diacilglicerol aciltransferasa |
KR20120037939A (ko) | 2009-06-19 | 2012-04-20 | 아스트라제네카 아베 | Dgat1의 억제제로서 피라진 카르복사미드 |
SG177740A1 (en) * | 2009-07-23 | 2012-02-28 | Univ Vanderbilt | Substituted benzoimidazolesulfonamides and substituted indolesulfonamides as mglur4 potentiators |
KR101194995B1 (ko) * | 2009-10-14 | 2012-10-29 | 주식회사 이큐스앤자루 | 신규한 2-페닐-벤즈이미다졸 또는 2-페닐-벤즈옥사졸 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 항바이러스용 약학적 조성물 |
WO2011099832A2 (en) * | 2010-02-12 | 2011-08-18 | Crystalgenomics, Inc. | Novel benzimidazole compound, preparation method thereof and pharmaceutical composition comprising the same |
EP3011960B1 (en) | 2010-06-01 | 2020-04-15 | Summit Therapeutics plc | Compounds for the treatment of clostridium difficile-associated disease |
AU2013207510A1 (en) * | 2012-01-06 | 2014-07-31 | The Regents Of The University Of California | Compositions, methods of use, and methods of treatment |
PL2935248T3 (pl) | 2012-12-21 | 2018-07-31 | Plexxikon Inc | Związki i sposoby modulacji kinaz i wskazania dla nich |
US9296754B2 (en) | 2013-03-15 | 2016-03-29 | Novartis Ag | Compounds and compositions for the treatment of parasitic diseases |
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- 2007-10-16 PE PE2007001396A patent/PE20080888A1/es not_active Application Discontinuation
- 2007-10-17 EP EP07854118.2A patent/EP2074089B1/en not_active Not-in-force
- 2007-10-17 ES ES07854118.2T patent/ES2440253T3/es active Active
- 2007-10-17 KR KR1020097010003A patent/KR20090071642A/ko not_active Application Discontinuation
- 2007-10-17 JP JP2009533499A patent/JP5298022B2/ja not_active Expired - Fee Related
- 2007-10-17 TW TW096138922A patent/TW200829563A/zh unknown
- 2007-10-17 WO PCT/US2007/081607 patent/WO2008048991A2/en active Application Filing
- 2007-10-17 RU RU2009118489/04A patent/RU2009118489A/ru not_active Application Discontinuation
- 2007-10-17 CL CL200702974A patent/CL2007002974A1/es unknown
- 2007-10-17 US US12/446,088 patent/US8222248B2/en not_active Expired - Fee Related
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- 2007-10-17 AU AU2007311087A patent/AU2007311087B2/en not_active Ceased
- 2007-10-17 CA CA002666880A patent/CA2666880A1/en not_active Abandoned
- 2007-10-17 MX MX2009004047A patent/MX2009004047A/es not_active Application Discontinuation
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PE20080888A1 (es) | 2008-08-26 |
KR20090071642A (ko) | 2009-07-01 |
JP2010506950A (ja) | 2010-03-04 |
EP2074089B1 (en) | 2013-09-18 |
EP2074089A2 (en) | 2009-07-01 |
CA2666880A1 (en) | 2008-04-28 |
AU2007311087B2 (en) | 2012-03-01 |
WO2008048991A3 (en) | 2008-07-10 |
WO2008048991A2 (en) | 2008-04-24 |
CL2007002974A1 (es) | 2008-05-23 |
MX2009004047A (es) | 2009-07-21 |
BRPI0718478A2 (pt) | 2013-11-26 |
AU2007311087A1 (en) | 2008-04-24 |
ES2440253T3 (es) | 2014-01-28 |
JP5298022B2 (ja) | 2013-09-25 |
RU2009118489A (ru) | 2010-11-27 |
TW200829563A (en) | 2008-07-16 |
US8222248B2 (en) | 2012-07-17 |
US20110046133A1 (en) | 2011-02-24 |
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