PE20071240A1 - Compuestos derivados de hidantoina para el tratamiento de trastornos inflamatorios - Google Patents

Compuestos derivados de hidantoina para el tratamiento de trastornos inflamatorios

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Publication number
PE20071240A1
PE20071240A1 PE2007000036A PE2007000036A PE20071240A1 PE 20071240 A1 PE20071240 A1 PE 20071240A1 PE 2007000036 A PE2007000036 A PE 2007000036A PE 2007000036 A PE2007000036 A PE 2007000036A PE 20071240 A1 PE20071240 A1 PE 20071240A1
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PE
Peru
Prior art keywords
alpha
tace
present
arilo
absent
Prior art date
Application number
PE2007000036A
Other languages
English (en)
Inventor
Brian J Lavey
Joseph A Kozlowski
Guowei Zhou
Ling Tong
Wensheng Yu
Michael K C Wong
Bandarpelle B Shankar
Neng-Yang Shih
M Arshad Siddiqui
Kristin E Rosner
Chaoyang Dai
Janeta Popovici-Muller
Vinay M Girijavallabhan
Dansu Li
Razia Rizvi
De-Yi Yang
Seong-Heon Kim
Aneta M Micula
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38038495&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20071240(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of PE20071240A1 publication Critical patent/PE20071240A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE HIDANTOINA DE FORMULA (I), EN DONDE EL ANILLO A ES ARILO O HETEROARILO; X ES -(C(R3)2)m- Y -N(R3)-, ENTRE OTROS; T ESTA AUSENTE O PRESENTE, ES ALQUILO, ARILO Y HETEROARILO, DONDE CADA UNO DE DICHOS ARILO O HETEROARILO CONTIENE DOS RADICALES EN CARBONO ADYACENTES, QUE OPCIONALMENTE PUEDEN TOMARSE JUNTO CON LOS C AL QUE ESTAN UNIDOS Y FORMAR UN ARILO O HETEROARILO DE 5 A 8 MIEMBROS, LOS QUE ESTAN OPCIONALMENTE SUSTITUIDOS CON 1 A 4 R10; U ESTA AUSENTE O PRESENTE, ES -O-, -O-C(O)NH-, ENTRE OTROS; V ESTA AUSENTE O PRESENTE, ES ALQUILO, ALQUINILO, CICLOALQUILO, ARILO, ENTRE OTROS, OPCIONALMENTE SUSTUIDOS; Y ES -(C(R4)2)n-, -O-, ENTRE OTROS; Z ES UN ENLACE COVALENTE, ENTRE OTROS; m Y n SON INDEPENDIENTEMENTE DE 1 A 3; R1 Y R2 SON INDEPENDIENTEMENTE H, CIANO, -C(O)OH, -C(O)O-ALQUILO, ALQUINILO, ENTRE OTROS; CON LA SALVEDAD DE QUE AL MENOS UN T, U Y V ESTE PRESENTE. ESTOS COMPUESTOS SON INHIBIDORES DE METALOPROTEINASAS DE MATRIZ (MMP), DESINTEGRINA Y METALOPROTEASAS (ADAM) Y/O ENZIMA CONVERTIDORA DEL FACTOR DE NECROSIS TUMORAL ALFA (TACE) PREVINIENDO ASI LA LIBERACION DEL FACTOR DE NECROSIS TUMORAL ALFA (TNF-ALFA), SIENDO UTILES EN EL TRATAMIENTO ENFERMEDADES INFLAMATORIAS
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