DK3341379T3 - EZH2-hæmmere - Google Patents
EZH2-hæmmere Download PDFInfo
- Publication number
- DK3341379T3 DK3341379T3 DK16757513T DK16757513T DK3341379T3 DK 3341379 T3 DK3341379 T3 DK 3341379T3 DK 16757513 T DK16757513 T DK 16757513T DK 16757513 T DK16757513 T DK 16757513T DK 3341379 T3 DK3341379 T3 DK 3341379T3
- Authority
- DK
- Denmark
- Prior art keywords
- ezh2 inhibitors
- ezh2
- inhibitors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15382433 | 2015-08-27 | ||
EP15382615 | 2015-12-11 | ||
PCT/US2016/047989 WO2017035060A1 (en) | 2015-08-27 | 2016-08-22 | Inhibitors of ezh2 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3341379T3 true DK3341379T3 (da) | 2019-12-02 |
Family
ID=56801893
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK16757513T DK3341379T3 (da) | 2015-08-27 | 2016-08-22 | EZH2-hæmmere |
Country Status (31)
Country | Link |
---|---|
US (1) | US9718838B2 (da) |
EP (1) | EP3341379B1 (da) |
JP (1) | JP6704040B2 (da) |
KR (1) | KR20180030704A (da) |
CN (1) | CN107922434B (da) |
AU (1) | AU2016313541A1 (da) |
BR (1) | BR112018003108A2 (da) |
CA (1) | CA2994428A1 (da) |
CO (1) | CO2018002033A2 (da) |
CR (1) | CR20180104A (da) |
CY (1) | CY1122364T1 (da) |
DK (1) | DK3341379T3 (da) |
DO (1) | DOP2018000058A (da) |
EC (1) | ECSP18014798A (da) |
ES (1) | ES2756603T3 (da) |
HR (1) | HRP20192101T1 (da) |
HU (1) | HUE047630T2 (da) |
IL (1) | IL257061A (da) |
LT (1) | LT3341379T (da) |
MD (1) | MD3341379T2 (da) |
ME (1) | ME03650B (da) |
MX (1) | MX2018002484A (da) |
PE (1) | PE20181025A1 (da) |
PH (1) | PH12018500423A1 (da) |
PL (1) | PL3341379T3 (da) |
PT (1) | PT3341379T (da) |
RS (1) | RS59615B1 (da) |
SI (1) | SI3341379T1 (da) |
TN (1) | TN2018000058A1 (da) |
TW (1) | TW201718598A (da) |
WO (1) | WO2017035060A1 (da) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5483515B2 (ja) * | 1999-04-22 | 2014-05-07 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | インテグリンα−4サブユニットのアンタゴニストを使用する線維症の処置のための方法 |
UY36758A (es) * | 2015-06-30 | 2016-12-30 | Glaxosmithkline Ip No 2 Ltd | Inhibidores del potenciador del homólogo zeste 2 |
US10604531B2 (en) * | 2016-05-05 | 2020-03-31 | Glaxosmithkline Intellectual Property (No.2) Limited | Enhancer of zeste homolog 2 inhibitors |
EP3469099A1 (en) * | 2016-06-08 | 2019-04-17 | F. Hoffmann-La Roche AG | Diagnostic and therapeutic methods for cancer |
US10266542B2 (en) | 2017-03-15 | 2019-04-23 | Mirati Therapeutics, Inc. | EZH2 inhibitors |
CN109942556A (zh) * | 2017-12-21 | 2019-06-28 | 上海青煜医药科技有限公司 | 嘧啶酮化合物及其应用 |
DK3746446T3 (da) | 2018-01-31 | 2022-06-27 | Mirati Therapeutics Inc | PRC2-inhibitorer |
US20210188813A1 (en) * | 2018-04-24 | 2021-06-24 | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. | Ezh2 inhibitor and pharmaceutically acceptable salts and polymorphic substances thereof, and application of ezh2 inhibitor |
JP2021531340A (ja) | 2018-07-09 | 2021-11-18 | フォンダシヨン、アジール、デ、アブグルスFondation Asile Des Aveugles | 眼障害を治療するためのprc2サブユニットの阻害 |
CN111909157B (zh) * | 2019-05-07 | 2023-02-03 | 南京药石科技股份有限公司 | Ezh2抑制剂及其用途 |
Family Cites Families (60)
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WO2002007712A2 (en) * | 2000-07-24 | 2002-01-31 | Pharmacia & Upjohn Company | Self-emulsifying drug delivery systems for extremely water-insoluble, lipophilic drugs |
CA2420164A1 (en) * | 2000-10-20 | 2002-05-02 | Bristol-Myers Squibb Pharma Company | Acylsemicarbazides and their use as cyclin dependent kinase (cdk) inhibitors |
WO2003026574A2 (en) * | 2001-09-24 | 2003-04-03 | Au Jessie L-S | Methods and compositions to determine the chemosensitizing dose of suramin used in combination therapy |
EP1620449A4 (en) | 2003-02-14 | 2008-10-01 | Smithkline Beecham Corp | NUCLEIC ACIDS WITH DIFFERENTIAL EXPRESSION THAT CORRELATE WITH KSP EXPRESSION |
US8846935B2 (en) | 2010-05-07 | 2014-09-30 | Glaxosmithkline Llc | Indazoles |
BR112012028556A2 (pt) | 2010-05-07 | 2014-04-01 | Glaxosmithkline Llc | Indóis |
WO2012005805A1 (en) | 2010-05-07 | 2012-01-12 | Glaxosmithkline Llc | Azaindazoles |
US9175331B2 (en) | 2010-09-10 | 2015-11-03 | Epizyme, Inc. | Inhibitors of human EZH2, and methods of use thereof |
RU2618475C2 (ru) | 2010-09-10 | 2017-05-03 | Эпизайм, Инк. | Ингибиторы ezh2 человека и способы их применения |
US20130310379A1 (en) | 2010-11-19 | 2013-11-21 | Constellation Pharmaceuticals | Modulators of methyl modifying enzymes, compositions and uses thereof |
JP5908493B2 (ja) | 2010-12-01 | 2016-04-26 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーGlaxoSmithKline LLC | インドール |
WO2012118812A2 (en) | 2011-02-28 | 2012-09-07 | Epizyme, Inc. | Substituted 6,5-fused bicyclic heteroaryl compounds |
TWI598336B (zh) | 2011-04-13 | 2017-09-11 | 雅酶股份有限公司 | 經取代之苯化合物 |
JO3438B1 (ar) | 2011-04-13 | 2019-10-20 | Epizyme Inc | مركبات بنزين مستبدلة بأريل أو أريل غير متجانس |
EP2755962B1 (en) | 2011-09-13 | 2017-03-01 | Glaxosmithkline LLC | Azaindazoles |
CA2850570A1 (en) | 2011-09-30 | 2013-04-04 | Glaxosmithkline Llc | Methods of treating cancer |
WO2013067302A1 (en) | 2011-11-04 | 2013-05-10 | Glaxosmithkline Intellectual Property (No. 2) Limited | Method of treatment |
AU2012332297B2 (en) | 2011-11-04 | 2016-01-07 | Glaxosmithkline Intellectual Property (No.2) Limited | Method of treatment |
WO2013067300A1 (en) | 2011-11-04 | 2013-05-10 | Glaxosmithkline Intellectual Property (No. 2) Limited | Method of treatment |
WO2013075083A1 (en) | 2011-11-18 | 2013-05-23 | Constellation Pharmaceuticals | Modulators of methyl modifying enzymes, compositions and uses thereof |
US9051269B2 (en) | 2011-11-18 | 2015-06-09 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
WO2013078320A1 (en) | 2011-11-21 | 2013-05-30 | Constellation Pharmaceuticals | Modulators of methyl modifying enzymes, compositions and uses thereof |
CA2862289C (en) | 2012-02-10 | 2019-11-26 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
ES2718900T3 (es) | 2012-03-12 | 2019-07-05 | Epizyme Inc | Inhibidores de EZH2 humana y métodos de uso de los mismos |
WO2013155434A1 (en) | 2012-04-12 | 2013-10-17 | E. I. Du Pont De Nemours And Company | Can tap |
KR20230004871A (ko) | 2012-04-13 | 2023-01-06 | 에피자임, 인코포레이티드 | 암 치료용 병용 요법 |
SG11201406468YA (en) | 2012-04-13 | 2015-01-29 | Epizyme Inc | Salt form of a human hi stone methyltransf erase ezh2 inhibitor |
WO2013173441A2 (en) | 2012-05-16 | 2013-11-21 | Glaxosmithkline Llc | Enhancer of zeste homolog 2 inhibitors |
WO2013181462A1 (en) * | 2012-05-31 | 2013-12-05 | Amgen Inc. | Use of amg 900 for the treatment of cancer |
JP6254169B2 (ja) | 2012-09-28 | 2017-12-27 | ファイザー・インク | ベンズアミドおよびヘテロベンズアミド化合物 |
NZ706836A (en) | 2012-10-15 | 2019-02-22 | Epizyme Inc | Methods of treating cancer |
PE20150887A1 (es) | 2012-10-15 | 2015-06-04 | Epizyme Inc | Compuestos de benceno sustituidos |
EP2931707A4 (en) | 2012-12-13 | 2016-07-20 | Glaxosmithkline Llc | AMPLIFIER OF ZEST HOMOLOG 2 INHIBITORS |
EP2934531A4 (en) | 2012-12-19 | 2016-06-15 | Glaxosmithkline Llc | COMBINATION |
US20150344427A1 (en) | 2012-12-21 | 2015-12-03 | Epizyme, Inc. | 1,4-pyridone compounds |
WO2014100665A1 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | 1,4-pyridone bicyclic heteroaryl compounds |
UA111305C2 (uk) * | 2012-12-21 | 2016-04-11 | Пфайзер Інк. | Конденсовані лактами арилу та гетероарилу |
CN105102446B (zh) | 2013-02-11 | 2018-01-23 | 星座制药公司 | 甲基修饰酶的调节剂、其组合物及用途 |
EP2970305B1 (en) | 2013-03-15 | 2017-02-22 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
EP2991980B1 (en) | 2013-04-30 | 2019-01-02 | Glaxosmithkline Intellectual Property (No. 2) Limited | Enhancer of zeste homolog 2 inhibitors |
US9556157B2 (en) | 2013-07-10 | 2017-01-31 | Glaxosmithkline Intellectual Property (No.2) Limited | Enhancer of zeste homolog 2 inhibitors |
WO2015010078A2 (en) | 2013-07-19 | 2015-01-22 | Epizyme, Inc. | Substituted 6,5-fused bicyclic heteroaryl compounds |
US10150764B2 (en) | 2013-07-19 | 2018-12-11 | Epizyme, Inc. | Substituted benzene compounds |
EP3033334A1 (en) | 2013-08-15 | 2016-06-22 | Constellation Pharmaceuticals, Inc. | Indole derivatives as modulators of methyl modifying enzymes, compositions and uses thereof |
JP2016533364A (ja) | 2013-10-18 | 2016-10-27 | エピザイム,インコーポレイティド | 癌を処置する方法 |
US9738630B2 (en) | 2013-11-19 | 2017-08-22 | Bristol-Myers Squibb Company | Inhibitors of lysine methyl transferase |
US9822103B2 (en) | 2013-11-22 | 2017-11-21 | Bristol-Myers Squibb Company | Inhibitors of lysine methyl transferase |
WO2015104677A1 (en) | 2014-01-10 | 2015-07-16 | Piramal Enterprises Limited | Heterocyclic compounds as ezh2 inhibitors |
KR102302830B1 (ko) | 2014-03-17 | 2021-09-15 | 다이이찌 산쿄 가부시키가이샤 | 1,3-벤조디옥솔 유도체 |
CN106999498B (zh) | 2014-06-17 | 2021-06-08 | Epizyme股份有限公司 | 用于治疗淋巴瘤的ezh2抑制剂 |
WO2015193768A1 (en) | 2014-06-17 | 2015-12-23 | Pfizer Inc. | Aryl fused lactams as ezh2 modulators |
CR20160574A (es) | 2014-06-17 | 2017-02-23 | Pfizer | Compuestos de dihidroisoquinolinona sustituida |
MX2016017097A (es) | 2014-06-19 | 2017-05-01 | Memorial Sloan Kettering Cancer Center | Biomarcadores para la respuesta a inhibidores del mejorador del homologo 2 de zeste (ezh2). |
WO2015200650A1 (en) | 2014-06-25 | 2015-12-30 | Epizyme, Inc. | Substituted benzene and 6,5-fused bicyclic heteroaryl compounds |
WO2016066697A1 (en) | 2014-10-28 | 2016-05-06 | Glaxosmithkline Intellectual Property (No.2) Limited | Enhancer of zeste homolog 2 inhibitors |
TW201636344A (zh) | 2014-12-05 | 2016-10-16 | 美國禮來大藥廠 | Ezh2抑制劑 |
WO2016102493A1 (en) | 2014-12-22 | 2016-06-30 | Bayer Pharma Aktiengesellschaft | Imidazopyridine ezh2 inhibitors |
US20180037568A1 (en) | 2015-02-13 | 2018-02-08 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
WO2016140501A1 (en) | 2015-03-04 | 2016-09-09 | Kainos Medicine, Inc. | Pyridine n-oxide for enhancer of zeste homolog 2 inhibitors |
UY36758A (es) | 2015-06-30 | 2016-12-30 | Glaxosmithkline Ip No 2 Ltd | Inhibidores del potenciador del homólogo zeste 2 |
-
2016
- 2016-08-11 TW TW105125679A patent/TW201718598A/zh unknown
- 2016-08-22 RS RS20191526A patent/RS59615B1/sr unknown
- 2016-08-22 SI SI201630453T patent/SI3341379T1/sl unknown
- 2016-08-22 KR KR1020187005603A patent/KR20180030704A/ko not_active Application Discontinuation
- 2016-08-22 JP JP2018510778A patent/JP6704040B2/ja active Active
- 2016-08-22 AU AU2016313541A patent/AU2016313541A1/en not_active Abandoned
- 2016-08-22 LT LT16757513T patent/LT3341379T/lt unknown
- 2016-08-22 PL PL16757513T patent/PL3341379T3/pl unknown
- 2016-08-22 BR BR112018003108-9A patent/BR112018003108A2/pt not_active Application Discontinuation
- 2016-08-22 WO PCT/US2016/047989 patent/WO2017035060A1/en active Application Filing
- 2016-08-22 EP EP16757513.3A patent/EP3341379B1/en active Active
- 2016-08-22 CN CN201680049957.2A patent/CN107922434B/zh active Active
- 2016-08-22 CR CR20180104A patent/CR20180104A/es unknown
- 2016-08-22 PE PE2018000313A patent/PE20181025A1/es not_active Application Discontinuation
- 2016-08-22 MD MDE20180644T patent/MD3341379T2/ro unknown
- 2016-08-22 TN TNP/2018/000058A patent/TN2018000058A1/en unknown
- 2016-08-22 US US15/242,638 patent/US9718838B2/en active Active
- 2016-08-22 CA CA2994428A patent/CA2994428A1/en not_active Abandoned
- 2016-08-22 DK DK16757513T patent/DK3341379T3/da active
- 2016-08-22 HU HUE16757513A patent/HUE047630T2/hu unknown
- 2016-08-22 PT PT167575133T patent/PT3341379T/pt unknown
- 2016-08-22 ES ES16757513T patent/ES2756603T3/es active Active
- 2016-08-22 ME MEP-2019-322A patent/ME03650B/me unknown
- 2016-08-22 MX MX2018002484A patent/MX2018002484A/es unknown
-
2018
- 2018-01-21 IL IL257061A patent/IL257061A/en unknown
- 2018-02-22 DO DO2018000058A patent/DOP2018000058A/es unknown
- 2018-02-23 CO CONC2018/0002033A patent/CO2018002033A2/es unknown
- 2018-02-26 PH PH12018500423A patent/PH12018500423A1/en unknown
- 2018-02-26 EC ECIEPI201814798A patent/ECSP18014798A/es unknown
-
2019
- 2019-11-21 HR HRP20192101TT patent/HRP20192101T1/hr unknown
- 2019-12-04 CY CY20191101284T patent/CY1122364T1/el unknown
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