DK3207043T6 - Dihydropyrrolopyridin-inhibitorer af ror-gamma - Google Patents

Dihydropyrrolopyridin-inhibitorer af ror-gamma Download PDF

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Publication number
DK3207043T6
DK3207043T6 DK15785013.2T DK15785013T DK3207043T6 DK 3207043 T6 DK3207043 T6 DK 3207043T6 DK 15785013 T DK15785013 T DK 15785013T DK 3207043 T6 DK3207043 T6 DK 3207043T6
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Prior art keywords
ror gamma
dihydropyrrolopyridine
inhibitors
dihydropyrrolopyridine inhibitors
ror
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DK15785013.2T
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English (en)
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DK3207043T3 (da
Inventor
David A Claremon
Lawrence Wayne Dillard
Chengguo Dong
Yi Fan
Lanqi Jia
Stephen D Lotesta
Andrew Marcus
Suresh B Singh
Colin M Tice
Jing Yuan
Wei Zhao
Yajun Zheng
Linghang Zhuang
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Vitae Pharmaceuticals Llc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61P9/12—Antihypertensives
DK15785013.2T 2014-10-14 2015-10-14 Dihydropyrrolopyridin-inhibitorer af ror-gamma DK3207043T6 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462063912P 2014-10-14 2014-10-14
US201462074406P 2014-11-03 2014-11-03
PCT/US2015/055420 WO2016061160A1 (en) 2014-10-14 2015-10-14 Dihydropyrrolopyridine inhibitors of ror-gamma

Publications (2)

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DK3207043T3 DK3207043T3 (da) 2019-04-01
DK3207043T6 true DK3207043T6 (da) 2020-01-20

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US (3) US9796710B2 (da)
EP (1) EP3207043B3 (da)
JP (1) JP6564029B2 (da)
KR (1) KR20170066628A (da)
CN (1) CN107074852B (da)
AU (1) AU2015333610B2 (da)
BR (1) BR112017007460A2 (da)
CA (1) CA2963140A1 (da)
CL (1) CL2017000902A1 (da)
CO (1) CO2017004525A2 (da)
CY (1) CY1121413T1 (da)
DK (1) DK3207043T6 (da)
EA (1) EA031967B1 (da)
EC (1) ECSP17029371A (da)
ES (1) ES2715458T7 (da)
HU (1) HUE042335T2 (da)
IL (1) IL251584B (da)
MX (1) MX371304B (da)
MY (1) MY182454A (da)
PH (1) PH12017500583A1 (da)
PL (1) PL3207043T6 (da)
PT (1) PT3207043T (da)
SG (1) SG11201702362SA (da)
SI (1) SI3207043T1 (da)
TW (1) TWI675032B (da)
UA (1) UA118989C2 (da)
WO (1) WO2016061160A1 (da)
ZA (1) ZA201702237B (da)

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MA42923A (fr) 2015-09-24 2021-04-28 Hoffmann La Roche Composés bicycliques comme inhibiteurs mixtes de atx/ca
EP3377482B1 (en) 2015-11-20 2021-05-12 Vitae Pharmaceuticals, LLC Modulators of ror-gamma
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TWI757266B (zh) 2016-01-29 2022-03-11 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
JP2020059651A (ja) * 2016-12-26 2020-04-16 科研製薬株式会社 ピラゾール誘導体及びそれを含有する医薬
MA49879A (fr) 2017-03-16 2020-06-24 Hoffmann La Roche Composés hétérocycliques utiles en tant qu'inhibiteurs doubles d'atx/ca
CN110382484B (zh) 2017-03-16 2022-12-06 豪夫迈·罗氏有限公司 新的作为atx抑制剂的二环化合物
WO2018229155A1 (en) 2017-06-14 2018-12-20 Astrazeneca Ab 2,3-dihydroisoindole-1-carboxamides useful as ror-gamma modulators
JP2020142989A (ja) * 2017-06-21 2020-09-10 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 イミダゾール誘導体及びそれを含有する医薬
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WO2019063015A1 (zh) 2017-09-30 2019-04-04 正大天晴药业集团股份有限公司 作为RORγ抑制剂的磺酰基取代的双环化合物
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