BR112014026493A2 - derivados de imidazotiadiazol como inibidores do receptor ativado por protease 4 (par4) para tratar a agregação de plaqueta - Google Patents
derivados de imidazotiadiazol como inibidores do receptor ativado por protease 4 (par4) para tratar a agregação de plaquetaInfo
- Publication number
- BR112014026493A2 BR112014026493A2 BR112014026493A BR112014026493A BR112014026493A2 BR 112014026493 A2 BR112014026493 A2 BR 112014026493A2 BR 112014026493 A BR112014026493 A BR 112014026493A BR 112014026493 A BR112014026493 A BR 112014026493A BR 112014026493 A2 BR112014026493 A2 BR 112014026493A2
- Authority
- BR
- Brazil
- Prior art keywords
- inhibitors
- platelet aggregation
- par4
- derivatives
- activated receptor
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Abstract
resumo patente de invenção: "derivados de imidazotiadiazol como inibidores do receptor ativado por protease 4 (par4) para tratar a agregação de plaqueta". a presente invenção fornece compostos de imidazotiadiazol de fórmula (i) em que a, b, d, rx, r1, r2, r3, x1, x2 e s são como definidos aqui, ou um estereoisômero, tautômero, sal farmaceuticamente aceitável ou forma de solvato dos mesmos, em que todas as variáveis são como definidas aqui. estes compostos são inibidores da agregação de plaqueta e desse modo podem ser usados como medicamentos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261638591P | 2012-04-26 | 2012-04-26 | |
PCT/US2013/037892 WO2013163244A1 (en) | 2012-04-26 | 2013-04-24 | Imidazothiadiazole derivatives as protease activated receptor 4 (par4) inhibitors for treating platelet aggregation |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112014026493A2 true BR112014026493A2 (pt) | 2017-06-27 |
Family
ID=48225152
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014026493A BR112014026493A2 (pt) | 2012-04-26 | 2013-04-24 | derivados de imidazotiadiazol como inibidores do receptor ativado por protease 4 (par4) para tratar a agregação de plaqueta |
Country Status (14)
Country | Link |
---|---|
US (1) | US9862730B2 (pt) |
EP (1) | EP2847200B1 (pt) |
JP (1) | JP6181744B2 (pt) |
KR (1) | KR20150003767A (pt) |
CN (1) | CN104540835B (pt) |
AU (1) | AU2013251683A1 (pt) |
BR (1) | BR112014026493A2 (pt) |
CA (1) | CA2871637A1 (pt) |
EA (1) | EA201491967A1 (pt) |
ES (1) | ES2625029T3 (pt) |
IL (1) | IL235140A0 (pt) |
MX (1) | MX2014012454A (pt) |
SG (1) | SG11201406759YA (pt) |
WO (1) | WO2013163244A1 (pt) |
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KR102468661B1 (ko) * | 2016-07-14 | 2022-11-17 | 브리스톨-마이어스 스큅 컴퍼니 | Par4 억제제로서의 트리시클릭 헤테로아릴-치환된 퀴놀린 및 아자퀴놀린 화합물 |
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CN112074522B (zh) * | 2018-05-16 | 2022-08-26 | 深圳信立泰药业股份有限公司 | 作为用于治疗血小板聚集的蛋白酶激活受体4(par4)抑制剂的化合物 |
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US9605002B2 (en) | 2012-07-18 | 2017-03-28 | University Of Notre Dame Du Lac | 5,5-heteroaromatic anti-infective compounds |
-
2013
- 2013-04-24 US US14/396,807 patent/US9862730B2/en active Active
- 2013-04-24 CA CA2871637A patent/CA2871637A1/en not_active Abandoned
- 2013-04-24 MX MX2014012454A patent/MX2014012454A/es unknown
- 2013-04-24 CN CN201380033512.1A patent/CN104540835B/zh active Active
- 2013-04-24 EA EA201491967A patent/EA201491967A1/ru unknown
- 2013-04-24 ES ES13719361.1T patent/ES2625029T3/es active Active
- 2013-04-24 SG SG11201406759YA patent/SG11201406759YA/en unknown
- 2013-04-24 AU AU2013251683A patent/AU2013251683A1/en not_active Abandoned
- 2013-04-24 BR BR112014026493A patent/BR112014026493A2/pt not_active IP Right Cessation
- 2013-04-24 WO PCT/US2013/037892 patent/WO2013163244A1/en active Application Filing
- 2013-04-24 EP EP13719361.1A patent/EP2847200B1/en active Active
- 2013-04-24 KR KR20147030173A patent/KR20150003767A/ko not_active Application Discontinuation
- 2013-04-24 JP JP2015509094A patent/JP6181744B2/ja active Active
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2014
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Also Published As
Publication number | Publication date |
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JP6181744B2 (ja) | 2017-08-16 |
CN104540835A (zh) | 2015-04-22 |
AU2013251683A1 (en) | 2014-12-18 |
SG11201406759YA (en) | 2014-11-27 |
WO2013163244A8 (en) | 2014-04-03 |
JP2015518004A (ja) | 2015-06-25 |
US9862730B2 (en) | 2018-01-09 |
KR20150003767A (ko) | 2015-01-09 |
WO2013163244A1 (en) | 2013-10-31 |
EP2847200A1 (en) | 2015-03-18 |
CN104540835B (zh) | 2017-08-08 |
US20150133446A1 (en) | 2015-05-14 |
ES2625029T3 (es) | 2017-07-18 |
EP2847200B1 (en) | 2017-03-29 |
MX2014012454A (es) | 2015-03-13 |
EA201491967A1 (ru) | 2015-03-31 |
CA2871637A1 (en) | 2013-10-31 |
IL235140A0 (en) | 2014-12-31 |
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