SG11201406759YA - Imidazothiadiazole derivatives as protease activated receptor 4 (par4) inhibitors for treating platelet aggregation - Google Patents
Imidazothiadiazole derivatives as protease activated receptor 4 (par4) inhibitors for treating platelet aggregationInfo
- Publication number
- SG11201406759YA SG11201406759YA SG11201406759YA SG11201406759YA SG11201406759YA SG 11201406759Y A SG11201406759Y A SG 11201406759YA SG 11201406759Y A SG11201406759Y A SG 11201406759YA SG 11201406759Y A SG11201406759Y A SG 11201406759YA SG 11201406759Y A SG11201406759Y A SG 11201406759YA
- Authority
- SG
- Singapore
- Prior art keywords
- par4
- inhibitors
- platelet aggregation
- activated receptor
- protease activated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261638591P | 2012-04-26 | 2012-04-26 | |
| PCT/US2013/037892 WO2013163244A1 (en) | 2012-04-26 | 2013-04-24 | Imidazothiadiazole derivatives as protease activated receptor 4 (par4) inhibitors for treating platelet aggregation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201406759YA true SG11201406759YA (en) | 2014-11-27 |
Family
ID=48225152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201406759YA SG11201406759YA (en) | 2012-04-26 | 2013-04-24 | Imidazothiadiazole derivatives as protease activated receptor 4 (par4) inhibitors for treating platelet aggregation |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9862730B2 (en) |
| EP (1) | EP2847200B1 (en) |
| JP (1) | JP6181744B2 (en) |
| KR (1) | KR20150003767A (en) |
| CN (1) | CN104540835B (en) |
| AU (1) | AU2013251683A1 (en) |
| BR (1) | BR112014026493A2 (en) |
| CA (1) | CA2871637A1 (en) |
| EA (1) | EA201491967A1 (en) |
| ES (1) | ES2625029T3 (en) |
| IL (1) | IL235140A0 (en) |
| MX (1) | MX2014012454A (en) |
| SG (1) | SG11201406759YA (en) |
| WO (1) | WO2013163244A1 (en) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2855489B1 (en) | 2012-04-26 | 2017-01-04 | Bristol-Myers Squibb Company | Imidazothiadiazole and imidazopyridazine derivatives as protease activated receptor 4 (par4) inhibitors for treating platelet aggregation |
| NZ631027A (en) | 2012-04-26 | 2016-03-31 | Bristol Myers Squibb Co | Imidazothiadiazole and imidazopyrazine derivatives as protease activated receptor 4 (par4) inhibitors for treating platelet aggregation |
| US9598419B1 (en) | 2014-06-24 | 2017-03-21 | Universite De Montreal | Imidazotriazine and imidazodiazine compounds |
| US9617279B1 (en) | 2014-06-24 | 2017-04-11 | Bristol-Myers Squibb Company | Imidazooxadiazole compounds |
| HRP20211778T1 (en) * | 2014-08-29 | 2022-03-18 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
| WO2016125621A1 (en) * | 2015-02-03 | 2016-08-11 | 住友化学株式会社 | Benzimidazole compound, and use thereof for noxious arthropod control |
| WO2016125622A1 (en) * | 2015-02-03 | 2016-08-11 | 住友化学株式会社 | Benzoxazole compound, and use thereof for noxious arthropod control |
| ES2929208T3 (en) | 2015-02-26 | 2022-11-25 | Univ Montreal | Imidazothiadiazole compounds as PAR4 inhibitors |
| EP3262052A1 (en) | 2015-02-26 | 2018-01-03 | Bristol-Myers Squibb Company | Benzothiazole and benzothiophne compounds |
| US9789087B2 (en) | 2015-08-03 | 2017-10-17 | Thomas Jefferson University | PAR4 inhibitor therapy for patients with PAR4 polymorphism |
| WO2017050259A1 (en) | 2015-09-23 | 2017-03-30 | Xw Laboratories Inc. | Prodrugs of gamma-hydroxybutyric acid, compositions and uses thereof |
| WO2017066863A1 (en) | 2015-10-19 | 2017-04-27 | Universite De Montreal | Heterocyclic compounds as inhibitors of platelet aggregation |
| US20190119300A1 (en) * | 2016-04-18 | 2019-04-25 | Vanderbilt University | Substituted and fused 6-membered protease activated receptor 4 (par-4) antagonists |
| CN109689649B (en) | 2016-07-14 | 2022-07-19 | 百时美施贵宝公司 | Bicyclic heteroaryl substituted compounds |
| CN109689642B (en) | 2016-07-14 | 2022-04-12 | 百时美施贵宝公司 | Monocyclic heteroaryl substituted compounds |
| KR102468661B1 (en) * | 2016-07-14 | 2022-11-17 | 브리스톨-마이어스 스큅 컴퍼니 | Tricyclic Heteroaryl-Substituted Quinoline and Azaquinoline Compounds as PAR4 Inhibitors |
| KR102460385B1 (en) | 2016-07-14 | 2022-10-27 | 브리스톨-마이어스 스큅 컴퍼니 | Bicyclic Heteroaryl Substituted Compounds |
| WO2018176343A1 (en) | 2017-03-30 | 2018-10-04 | Xw Laboratories Inc. | Bicyclic heteroaryl derivatives and preparation and uses thereof |
| WO2019046912A1 (en) | 2017-09-11 | 2019-03-14 | Monash University | Binding proteins to the human thrombin receptor, par4 |
| WO2019149205A1 (en) * | 2018-01-31 | 2019-08-08 | 江苏恒瑞医药股份有限公司 | Benzoheteroaryl derivative and preparation method and medical application thereof |
| CN110218218B (en) * | 2018-03-01 | 2022-04-08 | 江苏恒瑞医药股份有限公司 | Benzofuran derivative, preparation method and medical application thereof |
| CN112074522B (en) * | 2018-05-16 | 2022-08-26 | 深圳信立泰药业股份有限公司 | Compounds as protease activated receptor 4(PAR4) inhibitors for the treatment of platelet aggregation |
| WO2019218956A1 (en) * | 2018-05-16 | 2019-11-21 | 深圳信立泰药业股份有限公司 | Compound acting as protease-activated receptor 4 (par4) inhibitor for treating platelet aggregation |
| CN112074523B (en) * | 2018-05-16 | 2022-08-09 | 深圳信立泰药业股份有限公司 | Compounds as protease activated receptor 4(PAR4) inhibitors for the treatment of platelet aggregation |
| CN110627817B (en) * | 2018-06-25 | 2022-03-29 | 中国药科大学 | Imidazocyclic PAR4 antagonist and medical application thereof |
| ES2947089T3 (en) | 2018-09-30 | 2023-08-01 | Xwpharma Ltd | Compounds as neuronal histamine receptor 3 antagonists and uses thereof |
| AR117472A1 (en) | 2018-12-21 | 2021-08-11 | Celgene Corp | RIPK2 TIENOPYRIDINE INHIBITORS |
| CN111349105B (en) * | 2018-12-24 | 2023-04-07 | 江苏恒瑞医药股份有限公司 | Benzofuran derivative, preparation method and medical application thereof |
| CN111362970A (en) * | 2018-12-25 | 2020-07-03 | 天津药物研究院有限公司 | Benzofuran derivative and preparation method and application thereof |
| CN110407697A (en) * | 2019-08-28 | 2019-11-05 | 上海毕得医药科技有限公司 | A kind of synthetic method of 4- formoxyl -3- methyl hydroxybenzoate |
| CN115244028A (en) | 2019-12-20 | 2022-10-25 | 凯瑞康宁生物工程有限公司 | Synthetic method of 4-valyloxy butyric acid |
| KR20230011359A (en) | 2020-06-18 | 2023-01-20 | 엑스더블유파마 리미티드 | Controlled release granulates of water-soluble active pharmaceutical ingredients |
| US11357734B2 (en) | 2020-06-18 | 2022-06-14 | XWPharma Ltd. | Pharmaceutical granulations of water-soluble active pharmaceutical ingredients |
| US11896573B2 (en) | 2020-07-24 | 2024-02-13 | XWPharma Ltd. | Pharmaceutical compositions and pharmacokinetics of a gamma-hydroxybutyric acid derivative |
| CA3194665A1 (en) | 2020-10-05 | 2022-04-14 | Jia-Ning Xiang | Modified release compositions of a gamma-hydroxybutyric acid derivative |
| TW202300139A (en) | 2021-03-19 | 2023-01-01 | 凱瑞康寧生技股份有限公司 | Pharmacokinetics of combined release formulations of a gamma-hydroxybutyric acid derivative |
| CN113150005B (en) * | 2021-04-09 | 2022-08-30 | 中国药科大学 | Quinoxaline compound, preparation method and application thereof in medicine |
| CN115521282B (en) * | 2022-08-23 | 2023-10-27 | 大理大学 | Synthesis process of coumarin compound E-Suberenol |
| CN115636742B (en) * | 2022-11-11 | 2024-04-09 | 江西亚太科技发展有限公司 | Recrystallization method |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2823686A1 (en) | 1978-05-31 | 1979-12-06 | Bayer Ag | IMIDAZO SQUARE BRACKETS ON 2.1 SQUARE BRACKETS FOR SQUARE BRACKETS ON 1.3.4 SQUARE BRACKETS FOR -THIADIAZOLE |
| DE3020421A1 (en) | 1980-05-29 | 1981-12-10 | Bayer Ag, 5090 Leverkusen | IMIDAZOAZOLALIC ACID AMIDES, NEW INTERMEDIATE PRODUCTS FOR THEIR PRODUCTION, THEIR PRODUCTION AND THEIR USE IN MEDICINAL PRODUCTS |
| NO811630L (en) | 1980-05-29 | 1981-11-30 | Bayer Ag | IMIDAZOAZOLYLIC ACID AMOIDS, NEW INTERMEDIATE PRODUCTS FOR THEIR PREPARATION, THEIR PREPARATION AND THEIR USE AS A MEDICINE |
| DE3446778A1 (en) | 1984-12-21 | 1986-07-03 | Dr. Karl Thomae Gmbh, 7950 Biberach | NEW IMIDAZO DERIVATIVES, THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
| US4925849A (en) | 1987-06-15 | 1990-05-15 | Fujisawa Pharmaceutical Company, Ltd. | Pharmaceutically useful pyrazolopyridines |
| GB8901423D0 (en) | 1989-01-23 | 1989-03-15 | Fujisawa Pharmaceutical Co | Pyrazolopyridine compound and processes for preparation thereof |
| CA2060138A1 (en) | 1991-01-29 | 1992-07-30 | Youichi Shiokawa | New use of the adenosine antagonist |
| JP2928079B2 (en) | 1994-02-14 | 1999-07-28 | 永信薬品工業股▲ふん▼有限公司 | 1- (Substituted benzyl) -3- (substituted aryl) condensed pyrazoles, their production and use |
| AU3275999A (en) | 1998-03-10 | 1999-09-27 | Ono Pharmaceutical Co. Ltd. | Carboxylic acid derivatives and drugs containing the same as the active ingredient |
| JP2003511456A (en) | 1999-10-08 | 2003-03-25 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | Bicyclic imidazo-5-yl-amine derivatives |
| DE19948434A1 (en) | 1999-10-08 | 2001-06-07 | Gruenenthal Gmbh | Substance library containing bicyclic imidazo-5-amines and / or bicyclic imidazo-3-amines |
| DE10019714A1 (en) | 2000-04-20 | 2002-01-10 | Gruenenthal Gmbh | Salts of bicyclic, N-acylated imidazo-3-amines and imidazo-5-amines |
| US6387942B2 (en) | 2000-06-19 | 2002-05-14 | Yung Shin Pharmaceutical Ind. Co. Ltd | Method of treating disorders related to protease-activated receptors-induced cell activation |
| WO2003040114A1 (en) | 2001-11-06 | 2003-05-15 | Bristol-Myers Squibb Company | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method |
| CA2364985A1 (en) * | 2001-12-14 | 2003-06-14 | John W. Gillard | Imidazo(2,1-b)thiadiazole sulfonamides |
| US7867629B2 (en) | 2003-01-10 | 2011-01-11 | Idemitsu Kosan Co., Ltd. | Nitrogenous heterocyclic derivative and organic electroluminescent element employing the same |
| EP1636242A1 (en) | 2003-06-13 | 2006-03-22 | Aegera Therapeutics Inc. | Acylated imidazo (2,1-b) -1,3,4,-thiadia zole-2-sulfonamides, and uses thereof |
| US20060135571A1 (en) | 2003-06-13 | 2006-06-22 | Jaquith James B | Imidazo(2,1-b)-1,3,4-thiadiazole sulfoxides and sulfones |
| US20050197371A1 (en) | 2003-11-13 | 2005-09-08 | Ambit Biosciences Corporation | Urea derivatives as PDGFR modulators |
| US20090023737A1 (en) | 2004-02-12 | 2009-01-22 | Neurogen Corporation | Imidazo-Pyridazines, Triazolo-Pyridazines and Related Benzodiazepine Receptor Ligands |
| CA2617319A1 (en) | 2005-06-24 | 2007-01-04 | The Trustees Of The University Of Pennsylvania | Radiolabeled-pegylation of ligands for use as imaging agents |
| CN101272784A (en) | 2005-09-29 | 2008-09-24 | 塞诺菲-安万特股份有限公司 | Phenyl- and pyridinyl- 1, 2 , 4 - oxadiazolone derivatives, processes for their preparation and their use as pharmaceuticals |
| NL2000397C2 (en) | 2006-01-05 | 2007-10-30 | Pfizer Prod Inc | Bicyclic heteroaryl compounds as PDE10 inhibitors. |
| MX2008011615A (en) | 2006-03-14 | 2008-09-22 | Amgen Inc | Bicyclic carboxylic acid derivatives useful for treating metabolic disorders. |
| AU2007240082A1 (en) | 2006-04-13 | 2007-10-25 | Aegera Therapeutics Inc. | Use of imidazo[2,1-b)]-1,3,4-thiadiazole-2-sulfonamide compounds to treat neuropathic pain |
| DE102006054757A1 (en) | 2006-11-21 | 2008-05-29 | Bayer Healthcare Ag | Novel aza-bicyclic compounds and their use |
| US7638541B2 (en) | 2006-12-28 | 2009-12-29 | Metabolex Inc. | 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine |
| EP1964841A1 (en) | 2007-02-28 | 2008-09-03 | sanofi-aventis | Imidazo[1,2-a]azine and their use as pharmaceuticals |
| PT2155747E (en) | 2007-05-10 | 2012-12-19 | Ge Healthcare Ltd | Imidazol (1,2-a)pyridines and related compounds with activity at cannabinoid cb2 receptors |
| WO2009017954A1 (en) | 2007-08-01 | 2009-02-05 | Phenomix Corporation | Inhibitors of jak2 kinase |
| MX2010001650A (en) | 2007-08-10 | 2010-08-02 | Glaxosmithkline Llc | Certain nitrogen containing bicyclic chemical entities for treating viral infections. |
| WO2009027733A1 (en) | 2007-08-24 | 2009-03-05 | Astrazeneca Ab | (2-pyridin-3-ylimidazo[1,2-b]pyridazin-6-yl) urea derivatives as antibacterial agents |
| GB0718735D0 (en) | 2007-09-25 | 2007-11-07 | Prolysis Ltd | Antibacterial agents |
| CA2710016A1 (en) | 2007-12-21 | 2009-07-02 | The University Of Sydney | Translocator protein ligands |
| CA2719507C (en) | 2008-03-31 | 2018-03-27 | Metabolex, Inc. | Oxymethylene aryl compounds and uses thereof |
| JP5449346B2 (en) * | 2008-07-15 | 2014-03-19 | サノフイ | Oxazolopyrimidines as Edg-1 receptor agonists |
| WO2010036629A2 (en) | 2008-09-26 | 2010-04-01 | National Health Research Institutes | Fused multicyclic compounds as protein kinase inhibitors |
| CA2740193A1 (en) | 2008-12-23 | 2010-07-01 | Abbott Laboratories | Anti-viral compounds |
| FR2948521B1 (en) | 2009-07-21 | 2012-01-27 | Dxo Labs | METHOD OF ESTIMATING A DEFECT OF AN IMAGE CAPTURE SYSTEM AND ASSOCIATED SYSTEMS |
| CN102781930B (en) * | 2009-12-18 | 2016-03-23 | 田边三菱制药株式会社 | Antiplatelet drug |
| CN102372701A (en) | 2010-08-10 | 2012-03-14 | 江苏恒瑞医药股份有限公司 | Azabicyclo hexane derivative, preparation method, and application of azabicyclo hexane derivative in medicine |
| UY33554A (en) | 2010-08-11 | 2012-02-29 | Millennium Pharm Inc | HETEROARILOS AND USES OF THE SAME |
| US9181236B2 (en) | 2011-08-22 | 2015-11-10 | Merck Sharp & Dohme Corp. | 2-spiro-substituted iminothiazines and their mono-and dioxides as bace inhibitors, compositions and their use |
| NZ631027A (en) | 2012-04-26 | 2016-03-31 | Bristol Myers Squibb Co | Imidazothiadiazole and imidazopyrazine derivatives as protease activated receptor 4 (par4) inhibitors for treating platelet aggregation |
| EP2855489B1 (en) | 2012-04-26 | 2017-01-04 | Bristol-Myers Squibb Company | Imidazothiadiazole and imidazopyridazine derivatives as protease activated receptor 4 (par4) inhibitors for treating platelet aggregation |
| US9605002B2 (en) | 2012-07-18 | 2017-03-28 | University Of Notre Dame Du Lac | 5,5-heteroaromatic anti-infective compounds |
-
2013
- 2013-04-24 US US14/396,807 patent/US9862730B2/en active Active
- 2013-04-24 CA CA2871637A patent/CA2871637A1/en not_active Abandoned
- 2013-04-24 MX MX2014012454A patent/MX2014012454A/en unknown
- 2013-04-24 CN CN201380033512.1A patent/CN104540835B/en active Active
- 2013-04-24 EA EA201491967A patent/EA201491967A1/en unknown
- 2013-04-24 ES ES13719361.1T patent/ES2625029T3/en active Active
- 2013-04-24 SG SG11201406759YA patent/SG11201406759YA/en unknown
- 2013-04-24 AU AU2013251683A patent/AU2013251683A1/en not_active Abandoned
- 2013-04-24 BR BR112014026493A patent/BR112014026493A2/en not_active IP Right Cessation
- 2013-04-24 WO PCT/US2013/037892 patent/WO2013163244A1/en active Application Filing
- 2013-04-24 EP EP13719361.1A patent/EP2847200B1/en active Active
- 2013-04-24 KR KR20147030173A patent/KR20150003767A/en not_active Application Discontinuation
- 2013-04-24 JP JP2015509094A patent/JP6181744B2/en active Active
-
2014
- 2014-10-19 IL IL235140A patent/IL235140A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP6181744B2 (en) | 2017-08-16 |
| CN104540835A (en) | 2015-04-22 |
| AU2013251683A1 (en) | 2014-12-18 |
| BR112014026493A2 (en) | 2017-06-27 |
| WO2013163244A8 (en) | 2014-04-03 |
| JP2015518004A (en) | 2015-06-25 |
| US9862730B2 (en) | 2018-01-09 |
| KR20150003767A (en) | 2015-01-09 |
| WO2013163244A1 (en) | 2013-10-31 |
| EP2847200A1 (en) | 2015-03-18 |
| CN104540835B (en) | 2017-08-08 |
| US20150133446A1 (en) | 2015-05-14 |
| ES2625029T3 (en) | 2017-07-18 |
| EP2847200B1 (en) | 2017-03-29 |
| MX2014012454A (en) | 2015-03-13 |
| EA201491967A1 (en) | 2015-03-31 |
| CA2871637A1 (en) | 2013-10-31 |
| IL235140A0 (en) | 2014-12-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL235140A0 (en) | Imidazothiadiazole derivatives as protease activated receptor 4 (par4) inhibitors for treating platelet aggregation | |
| ZA201407799B (en) | Imidazothiadiazole an imidazopyrazine derivatives as protease activated receptor 2(par4) inhibitors for treating platelet aggregation | |
| IL235141A0 (en) | Imidazothiadiazole and imidazopyridazine derivatives as protease activated receptor 4 (par4) inhibitors for treating platelet aggregation | |
| HRP20181429T1 (en) | Novel benzimidazole derivatives as kinase inhibitors | |
| HK1211027A1 (en) | Pyrrolotriazinone derivatives as pi3k inhibitors pi3k | |
| ME02576B (en) | Tetrahydropyrrolothiazine derivatives as bace inhibitors | |
| AP2015008236A0 (en) | Azaindole derivatives which acht as PI3K inhibitors | |
| HK1212331A1 (en) | 4-carboxamido-isoindolinone derivatives as selective parp-1 inhibitors parp-1 4-- | |
| EP2872143A4 (en) | Di-and tri-heteroaryl derivatives as inhibitors of protein aggregation | |
| PL2830980T3 (en) | Device for the creation of packaged units | |
| IL232938A0 (en) | Pharmaceutical composition used for reducing damage caused by free radicals |