BR112018070123A2 - oxiesterós e métodos de uso dos mesmos - Google Patents
oxiesterós e métodos de uso dos mesmosInfo
- Publication number
- BR112018070123A2 BR112018070123A2 BR112018070123A BR112018070123A BR112018070123A2 BR 112018070123 A2 BR112018070123 A2 BR 112018070123A2 BR 112018070123 A BR112018070123 A BR 112018070123A BR 112018070123 A BR112018070123 A BR 112018070123A BR 112018070123 A2 BR112018070123 A2 BR 112018070123A2
- Authority
- BR
- Brazil
- Prior art keywords
- oxiesterós
- methods
- compounds
- prevention
- variety
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
Abstract
os compostos são fornecidos de acordo com a fórmula (i), e seus sais farmaceuticamente aceitáveis, e composições farmacêuticas destes; em que a, r1, e r5 são como aqui definidos. os compostos da presente invenção são contemplados útil para a prevenção e tratamento de uma variedade de condições.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662317002P | 2016-04-01 | 2016-04-01 | |
PCT/US2017/025535 WO2017173358A1 (en) | 2016-04-01 | 2017-03-31 | Oxysterols and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112018070123A2 true BR112018070123A2 (pt) | 2019-02-05 |
Family
ID=59965335
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018070123A BR112018070123A2 (pt) | 2016-04-01 | 2017-03-31 | oxiesterós e métodos de uso dos mesmos |
Country Status (19)
Country | Link |
---|---|
US (2) | US20190330259A1 (pt) |
EP (1) | EP3436022B1 (pt) |
JP (3) | JP7112331B2 (pt) |
CN (2) | CN114272249A (pt) |
AU (2) | AU2017240157B2 (pt) |
BR (1) | BR112018070123A2 (pt) |
CA (1) | CA3019146C (pt) |
DK (1) | DK3436022T3 (pt) |
ES (1) | ES2921010T3 (pt) |
HR (1) | HRP20220716T1 (pt) |
HU (1) | HUE059491T2 (pt) |
LT (1) | LT3436022T (pt) |
MA (1) | MA44526A (pt) |
PL (1) | PL3436022T3 (pt) |
PT (1) | PT3436022T (pt) |
RS (1) | RS63280B1 (pt) |
RU (1) | RU2754130C2 (pt) |
SI (1) | SI3436022T1 (pt) |
WO (1) | WO2017173358A1 (pt) |
Families Citing this family (12)
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ES2699445T3 (es) | 2013-03-13 | 2019-02-11 | Sage Therapeutics Inc | Esteroides neuroactivos y métodos de utilización de los mismos |
RS62220B1 (sr) | 2015-07-06 | 2021-09-30 | Sage Therapeutics Inc | Oksisteroli i postupci njihovog korišćenja |
AU2017240157B2 (en) | 2016-04-01 | 2022-10-20 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
WO2017193046A1 (en) | 2016-05-06 | 2017-11-09 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
LT3481846T (lt) | 2016-07-07 | 2021-08-25 | Sage Therapeutics, Inc. | 11-pakeistieji 24-hidroksisteroliai, skirti naudoti gydant su nmda susijusias būkles |
ES2935057T3 (es) | 2016-09-30 | 2023-03-01 | Sage Therapeutics Inc | C7 oxisteroles sustituidos y estos compuestos para su uso como moduladores de la NMDA |
MA46566A (fr) * | 2016-10-18 | 2019-08-28 | Sage Therapeutics Inc | Oxystérols et leurs procédés d'utilisation |
CN114891056A (zh) | 2016-10-18 | 2022-08-12 | 萨奇治疗股份有限公司 | 氧甾醇及其使用方法 |
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CN114891056A (zh) | 2016-10-18 | 2022-08-12 | 萨奇治疗股份有限公司 | 氧甾醇及其使用方法 |
MA46566A (fr) * | 2016-10-18 | 2019-08-28 | Sage Therapeutics Inc | Oxystérols et leurs procédés d'utilisation |
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TW202110824A (zh) | 2019-05-24 | 2021-03-16 | 美商賽吉醫療公司 | 化合物、組合物及使用方法 |
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EP3436022A4 (en) | 2019-11-27 |
CA3019146C (en) | 2024-03-26 |
RS63280B1 (sr) | 2022-06-30 |
RU2754130C2 (ru) | 2021-08-27 |
JP7112331B2 (ja) | 2022-08-03 |
WO2017173358A1 (en) | 2017-10-05 |
JP2019510051A (ja) | 2019-04-11 |
MA44526A (fr) | 2021-06-02 |
CN109195604B (zh) | 2023-11-14 |
ES2921010T3 (es) | 2022-08-16 |
AU2022291419A1 (en) | 2023-02-02 |
DK3436022T3 (da) | 2022-06-20 |
LT3436022T (lt) | 2022-06-27 |
PL3436022T3 (pl) | 2022-08-08 |
HUE059491T2 (hu) | 2022-11-28 |
JP7308886B2 (ja) | 2023-07-14 |
HRP20220716T1 (hr) | 2022-09-02 |
AU2017240157A1 (en) | 2018-10-25 |
AU2017240157B2 (en) | 2022-10-20 |
US20190330259A1 (en) | 2019-10-31 |
JP2023126904A (ja) | 2023-09-12 |
US20210261598A1 (en) | 2021-08-26 |
JP2021167334A (ja) | 2021-10-21 |
CA3019146A1 (en) | 2017-10-05 |
CN109195604A (zh) | 2019-01-11 |
US11884697B2 (en) | 2024-01-30 |
PT3436022T (pt) | 2022-07-04 |
CN114272249A (zh) | 2022-04-05 |
EP3436022A1 (en) | 2019-02-06 |
RU2018138183A (ru) | 2020-05-12 |
RU2018138183A3 (pt) | 2020-05-26 |
SI3436022T1 (sl) | 2022-08-31 |
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