PE91098A1 - DERIVADOS DE PIRIDO[3,4-d]PIRIMIDINA - Google Patents

DERIVADOS DE PIRIDO[3,4-d]PIRIMIDINA

Info

Publication number
PE91098A1
PE91098A1 PE1997000610A PE00061097A PE91098A1 PE 91098 A1 PE91098 A1 PE 91098A1 PE 1997000610 A PE1997000610 A PE 1997000610A PE 00061097 A PE00061097 A PE 00061097A PE 91098 A1 PE91098 A1 PE 91098A1
Authority
PE
Peru
Prior art keywords
compounds
preference
formula
cancer
halogen
Prior art date
Application number
PE1997000610A
Other languages
English (en)
Inventor
George Stuart Cockerill
Stephen Barry Guntrip
Malcolm Clive Carter
Kathryn Jane Smith
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9614756.6A external-priority patent/GB9614756D0/en
Priority claimed from GBGB9625495.8A external-priority patent/GB9625495D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE91098A1 publication Critical patent/PE91098A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
    • C07C217/84—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • C07C217/86—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C07C317/36—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atoms of the amino groups bound to hydrogen atoms or to carbon atoms

Abstract

SE REFIEREN A COMPUESTOS DE FORMULA (I), EN DONDE "X" ES N o CH; "Y" ES WCH2, CH2W o W, EN DONDE "W" ES O, S(O)m o NRa; m ES 0; 1 o 2; Ra ES H o ALQUILO C1-C8; R1 ES UN ANILLO HETEROCICLICO DE 5 A 6 MIEMBROS, DE PREFERENCIA ES FURANO, ESTANDO R1 SUSTITUIDO POR UNO O MAS SUSTITUYENTES CARBAMOILO, "M1-M2-M3-M4", "M1-M5" O "M1-M2-M3`-M6", ENTRE OTROS; M1 ES ALQUILO C1-C4 EN DONDE UN GRUPO CH2 SE ENCUENTRA OPCIONALMENTE REEMPLAZADO POR CO; M2-M3-M4 ES DE PREFERENCIA METILSULFONILETILAMINO, M2-M3-M6 ES DE PREFERENCIA PIRIDILAMINO; "M1-M5" ES DE PREFERENCIA PIPERAZINILMETILO; R2 ES H, HALOGENO, CF3, ALQUILO C1-C4, ALCOXI C1-C4; R3 ES DE PREFERENCIA BENCILOXI; R5 ES H, HIDROXI O HALOGENO, ENTRE OTROS; n ES 1; 2 o 3; "U" ES DE PREFERENCIA PIRIDINA Y EL GRUPO R1 ESTA EN LA POSICION 6 DEL SISTEMA DEL ANILLO DE PIRIDOPIRIMIDINA. TAMBIEN SE REFIERE AL PROCEDIMIENTO DE PREPARACION DE LOS COMPUESTOS DE FORMULA (I) Y A LOS COMPUESTOS INTERMEDIOS PARA SU OBTENCION. LOS COMPUESTOS DE FORMULA (I) ACTUAN COMO INHIBIDORES DE LAS TIROSINA CINASAS PROTEICAS, DE MANERA SELECTIVA PARA LAS EGFr Y c-erB-2, ENTRE OTRAS, MINIMIZANDO ASI LOS EFECTOS COLATERALES POTENCIALES, SIENDO UTILES EN EL TRATAMIENTO DEL CANCER Y DE LA PSORIASIS
PE1997000610A 1996-07-13 1997-07-11 DERIVADOS DE PIRIDO[3,4-d]PIRIMIDINA PE91098A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9614756.6A GB9614756D0 (en) 1996-07-13 1996-07-13 Heterocyclic compounds
GBGB9625495.8A GB9625495D0 (en) 1996-12-07 1996-12-07 Heterocyclic compounds

Publications (1)

Publication Number Publication Date
PE91098A1 true PE91098A1 (es) 1999-01-15

Family

ID=26309691

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1997000610A PE91098A1 (es) 1996-07-13 1997-07-11 DERIVADOS DE PIRIDO[3,4-d]PIRIMIDINA

Country Status (22)

Country Link
US (1) US6207669B1 (es)
EP (1) EP0912572B1 (es)
JP (1) JP2000515136A (es)
KR (1) KR20000023813A (es)
CN (1) CN1230185A (es)
AP (1) AP9901435A0 (es)
AR (1) AR007855A1 (es)
AT (1) ATE231148T1 (es)
AU (1) AU3693697A (es)
BR (1) BR9710362A (es)
CA (1) CA2260058A1 (es)
CZ (1) CZ8799A3 (es)
DE (1) DE69718472T2 (es)
EA (1) EA199900021A1 (es)
ES (1) ES2191187T3 (es)
ID (1) ID19430A (es)
IS (1) IS4936A (es)
NO (1) NO990123L (es)
PE (1) PE91098A1 (es)
PL (1) PL331154A1 (es)
TR (1) TR199900048T2 (es)
WO (1) WO1998002437A1 (es)

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