PE20081636A1 - Inhibidores de antranilamida para aurora quinasa - Google Patents

Inhibidores de antranilamida para aurora quinasa

Info

Publication number
PE20081636A1
PE20081636A1 PE2008000182A PE2008000182A PE20081636A1 PE 20081636 A1 PE20081636 A1 PE 20081636A1 PE 2008000182 A PE2008000182 A PE 2008000182A PE 2008000182 A PE2008000182 A PE 2008000182A PE 20081636 A1 PE20081636 A1 PE 20081636A1
Authority
PE
Peru
Prior art keywords
phenyl
amino
inhibitors
aurora kinase
pyrimidinyl
Prior art date
Application number
PE2008000182A
Other languages
English (en)
Inventor
Jeffrey Michael Axten
Deborah L Bryan
David Harold Drewry
Thomas H Faitg
Timothy Francis Gallagher
Neil W Johnson
Jiri Kasparec
Jeffrey M Ralph
Domingos J Silva
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39644890&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20081636(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of PE20081636A1 publication Critical patent/PE20081636A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE ANTRANILAMIDA DE FORMULA (I) DONDE R1 ES H, COOH, ALCOXI(C1-C6), CF3, ENTRE OTROS; R2 ES H, HALO, ALQUILO(C1-C3), CN, ENTRE OTROS; R3 ES H, FENILO, MORFOLINO-CH2CH2-FENILO, ENTRE OTROS; R4 ES HALO, ALQUILO(C1-C3) O ALCOXI(C1-C3); r ES DE 1 A 3; s ES DE 0 A 2. SON COMPUESTOS PREFERIDOS: 2-{[5-FLUORO-2-({3-[2-(4-MORFOLINIL)ETIL]FENIL}AMINO)-4-PIRIMIDINIL]AMINO}-N-(2-HIDROXIETIL)BENZAMIDA, (3R)-1-({2-[(5-FLUORO-2-{[3-(4-METIL-1-PIPERAZINIL)FENIL]AMINO}-4-PIRIMIDINIL)AMINO]FENIL}CARBONIL)-3-PIRROLIDINOL, (3R)-1-[(2-{[5-METIL-2-({3-[2-(4-MORFOLINIL)ETIL]FENIL}AMINO)-4-PIRIMIDINIL]AMINO}FENIL)CARBONIL]-3-PIRROLIDINOL, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA AURORA QUINASA SIENDO UTILES EN EL TRATAMIENTO DE CANCER
PE2008000182A 2007-01-26 2008-01-24 Inhibidores de antranilamida para aurora quinasa PE20081636A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US88667607P 2007-01-26 2007-01-26

Publications (1)

Publication Number Publication Date
PE20081636A1 true PE20081636A1 (es) 2009-01-10

Family

ID=39644890

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000182A PE20081636A1 (es) 2007-01-26 2008-01-24 Inhibidores de antranilamida para aurora quinasa

Country Status (10)

Country Link
US (2) US7625903B2 (es)
EP (1) EP2121637A4 (es)
JP (1) JP5337712B2 (es)
AR (1) AR065015A1 (es)
AU (1) AU2008207809B2 (es)
CA (1) CA2676257A1 (es)
CL (1) CL2008000197A1 (es)
PE (1) PE20081636A1 (es)
TW (1) TW200902010A (es)
WO (1) WO2008092049A1 (es)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1849318B (zh) 2003-07-30 2011-10-12 里格尔药品股份有限公司 用2,4-嘧啶二胺化合物预防和治疗自体免疫疾病的方法
AR065015A1 (es) * 2007-01-26 2009-05-13 Smithkline Beecham Corp Derivados de antranilamida, composiciones farmaceuticas que los contienen, y usos para el tratamiento del cancer
US7834024B2 (en) 2007-03-26 2010-11-16 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the JAK pathway
WO2009127642A2 (en) * 2008-04-15 2009-10-22 Cellzome Limited Use of lrrk2 inhibitors for neurodegenerative diseases
US9273077B2 (en) 2008-05-21 2016-03-01 Ariad Pharmaceuticals, Inc. Phosphorus derivatives as kinase inhibitors
ES2645689T3 (es) 2008-05-21 2017-12-07 Ariad Pharmaceuticals, Inc. Derivados de fósforo como inhibidores de quinasas
US11351168B1 (en) 2008-06-27 2022-06-07 Celgene Car Llc 2,4-disubstituted pyrimidines useful as kinase inhibitors
RU2536584C2 (ru) 2008-06-27 2014-12-27 Авила Терапьютикс, Инк. Гетероарильные соединения и их применение
US8338439B2 (en) * 2008-06-27 2012-12-25 Celgene Avilomics Research, Inc. 2,4-disubstituted pyrimidines useful as kinase inhibitors
KR101705158B1 (ko) 2009-05-05 2017-02-09 다나-파버 캔서 인스티튜트 인크. Ｅｇｆｒ 억제제 및 질환 치료방법
CN101585781B (zh) * 2009-07-08 2012-08-08 北京颖新泰康国际贸易有限公司 一种邻氨基-n,n-二甲基苯甲酰胺的制备方法
US8933227B2 (en) 2009-08-14 2015-01-13 Boehringer Ingelheim International Gmbh Selective synthesis of functionalized pyrimidines
JP5539518B2 (ja) 2009-08-14 2014-07-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ２−アミノ−５−トリフルオロメチルピリミジン誘導体の位置選択的調製
US8563568B2 (en) 2010-08-10 2013-10-22 Celgene Avilomics Research, Inc. Besylate salt of a BTK inhibitor
CN101973956B (zh) * 2010-09-26 2013-07-31 合肥星宇化学有限责任公司 靛红酸酐的合成方法及n-异丙基-2-氨基苯甲酰胺的合成方法
JP5956999B2 (ja) 2010-11-01 2016-07-27 セルジーン アヴィロミクス リサーチ， インコーポレイテッド ヘテロアリール化合物およびその使用
CN103269704B (zh) 2010-11-01 2018-07-06 西建卡尔有限责任公司 杂环化合物和其用途
ES2665013T3 (es) 2010-11-10 2018-04-24 Celgene Car Llc Inhibidores de EGFR selectivos de mutante y usos de los mismos
CN102173999A (zh) * 2011-02-28 2011-09-07 盐城工学院 一种2-氨基-n,n-二甲基苯甲酰胺的合成方法
WO2012135641A2 (en) 2011-03-30 2012-10-04 H. Lee Moffitt Cancer Center And Research Institute Aurora kinase inhibitors and methods of making and using thereof
PL2693881T3 (pl) * 2011-04-01 2020-03-31 University Of Utah Research Foundation Podstawione analogi N-fenylopirymidyno-2-aminy jako inhibitory kinazy AXL
KR101884010B1 (ko) 2011-05-04 2018-07-31 어리어드 파마슈티칼스, 인코포레이티드 Egfr-유도된 암의 세포 증식을 억제하는 화합물
EP2770830A4 (en) 2011-10-28 2015-05-27 Celgene Avilomics Res Inc METHODS OF TREATING A DISEASE OR DISEASE ASSOCIATED WITH TYROSINE KINASE BTK (BRUTON'S TYROSINE KINASE)
WO2013075167A1 (en) * 2011-11-21 2013-05-30 Cancer Therapeutics Crc Pty Ltd Binding agent
RS57901B1 (sr) 2012-03-15 2019-01-31 Celgene Car Llc Soli inhibitora kinaze receptora epidermalnog faktora rasta
MX356753B (es) 2012-03-15 2018-06-12 Celgene Avilomics Res Inc Formas solidas de un inhibidor de cinasa del receptor del factor de crecimiento epidermico.
JP6469567B2 (ja) 2012-05-05 2019-02-13 アリアド・ファーマシューティカルズ・インコーポレイテッド Ｅｇｆｒ発動性がんの細胞増殖阻害用化合物
GB201214106D0 (en) * 2012-08-07 2012-09-19 Univ Strathclyde Immunomodulatory compounds
KR102455889B1 (ko) 2012-11-21 2022-10-17 피티씨 테라퓨틱스, 인크. 치환된 리버스 피리미딘 ｂｍｉ-1 저해제
WO2014100748A1 (en) 2012-12-21 2014-06-26 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
EA201591051A1 (ru) 2013-02-08 2016-06-30 Селджен Авиломикс Рисерч, Инк. Ингибиторы erk и варианты их применения
EP2970205B1 (en) 2013-03-14 2019-05-08 Tolero Pharmaceuticals, Inc. Jak2 and alk2 inhibitors and methods for their use
US9611283B1 (en) 2013-04-10 2017-04-04 Ariad Pharmaceuticals, Inc. Methods for inhibiting cell proliferation in ALK-driven cancers
US9492471B2 (en) 2013-08-27 2016-11-15 Celgene Avilomics Research, Inc. Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase
JP6524094B2 (ja) 2013-08-30 2019-06-05 ピーティーシー セラピューティクス， インコーポレイテッド 置換ピリミジンＢｍｉ−１阻害剤
WO2015076800A1 (en) 2013-11-21 2015-05-28 Ptc Therapeutics, Inc. Substituted pyridine and pyrazine bmi-1 inhibitors
US9415049B2 (en) 2013-12-20 2016-08-16 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
ES2741785T3 (es) 2014-08-13 2020-02-12 Celgene Car Llc Formas y composiciones de un inhibidor de ERK
CN105017160B (zh) * 2015-06-24 2017-12-29 温州医科大学 一种嘧啶类egfrt790m抑制剂及其合成方法和应用
CN106187914B (zh) * 2016-07-12 2019-03-15 黄河三角洲京博化工研究院有限公司 一种2,4-二氯-5-甲氧基嘧啶的制备方法
SG10201913464TA (en) * 2016-12-19 2020-03-30 Epizyme Inc Amine-substituted heterocyclic compounds as ehmt2 inhibitors and methods of use thereof
WO2018195450A1 (en) 2017-04-21 2018-10-25 Epizyme, Inc. Combination therapies with ehmt2 inhibitors
BR112020020246A8 (pt) 2018-04-05 2022-10-18 Sumitomo Dainippon Pharma Oncology Inc Inibidores de cinase axl e uso dos mesmos
WO2019232225A1 (en) * 2018-05-30 2019-12-05 Promega Corporation Broad-spectrum kinase binding agents
CN112512597A (zh) 2018-07-26 2021-03-16 大日本住友制药肿瘤公司 用于治疗与acvr1表达异常相关的疾病的方法以及用于此的acvr1抑制剂
SG11202101085PA (en) 2018-08-27 2021-03-30 Sumitomo Dainippon Pharma Co Ltd Optically active azabicyclic derivative
EP4153770A2 (en) * 2020-05-22 2023-03-29 Promega Corporation Enhancement of kinase target engagement
CN113061117B (zh) * 2021-03-30 2023-02-10 长治学院 一种2-((5-氯-2-(4-吗啉甲基苯胺基)嘧啶-4-基)氨基)苯甲酰胺衍生物
WO2023134582A1 (zh) * 2022-01-14 2023-07-20 上海立森印迹医药技术有限公司 一种嘧啶-2,4-二胺衍生物及其制备方法和用途

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60017898T2 (de) 1999-06-09 2006-01-12 Yamanouchi Pharmaceutical Co., Ltd. Neuartige heterocyclische carboxamidderivate
GB0004887D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
BR0209485A (pt) * 2001-05-08 2004-07-06 Schering Ag Antranilamidapiridinamidas seletivas como inibidores vegfr-2 e vegfr-3
MXPA04004176A (es) 2001-11-01 2004-09-06 Janssen Pharmaceutica Nv Derivados de aminobenzamida como inhibidores de cinasa 3beta de glicogeno sintasa.
GB0206215D0 (en) * 2002-03-15 2002-05-01 Novartis Ag Organic compounds
BR0308921B1 (pt) * 2002-03-28 2013-11-19 Composição de resinato de monômero de ácido graxo, seu processo de preparação, tinta de impressão e verniz de tinta de impressão
WO2004074244A2 (en) * 2003-02-20 2004-09-02 Smithkline Beecham Corporation Pyrimidine compounds
GB0305929D0 (en) 2003-03-14 2003-04-23 Novartis Ag Organic compounds
SG145749A1 (en) 2003-08-15 2008-09-29 Novartis Ag 2, 4-pyrimidinediamines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders
GB0321710D0 (en) 2003-09-16 2003-10-15 Novartis Ag Organic compounds
US20070105839A1 (en) * 2003-09-18 2007-05-10 Patricia Imbach 2, 4-Di (phenylamino) pyrimidines useful in the treatment of proliferative disorders
WO2005113494A2 (en) 2004-05-07 2005-12-01 Amgen Inc. Nitrogenated heterocyclic derivatives as protein kinase modulators and use for the treatment of angiogenesis and cancer
EP1598343A1 (de) 2004-05-19 2005-11-23 Boehringer Ingelheim International GmbH 2-Arylaminopyrimidine als PLK Inhibitoren
GB0419161D0 (en) 2004-08-27 2004-09-29 Novartis Ag Organic compounds
CA2640398A1 (en) 2006-01-30 2007-08-09 Exelixis, Inc. 4-aryl-2-amino-pyrimidines or 4-aryl-2-aminoalkyl-pyrimidines as jak-2 modulators and pharmaceutical compositions containing them
BRPI0720264B1 (pt) 2006-12-08 2022-03-03 Novartis Ag Compostos e composições como inibidores de proteína cinase
CN101563327A (zh) 2006-12-19 2009-10-21 健泰科生物技术公司 嘧啶类激酶抑制剂
AR065015A1 (es) * 2007-01-26 2009-05-13 Smithkline Beecham Corp Derivados de antranilamida, composiciones farmaceuticas que los contienen, y usos para el tratamiento del cancer
AU2008229147A1 (en) 2007-03-20 2008-09-25 Smithkline Beecham Corporation Chemical compounds

Also Published As

Publication number Publication date
AU2008207809A1 (en) 2008-07-31
JP5337712B2 (ja) 2013-11-06
US7625903B2 (en) 2009-12-01
WO2008092049A1 (en) 2008-07-31
TW200902010A (en) 2009-01-16
AU2008207809B2 (en) 2013-04-18
US20100016318A1 (en) 2010-01-21
JP2010516780A (ja) 2010-05-20
US7884098B2 (en) 2011-02-08
CL2008000197A1 (es) 2008-08-01
AR065015A1 (es) 2009-05-13
CA2676257A1 (en) 2008-07-31
EP2121637A1 (en) 2009-11-25
US20080182852A1 (en) 2008-07-31
EP2121637A4 (en) 2010-10-06

Similar Documents

Publication Publication Date Title
PE20081636A1 (es) Inhibidores de antranilamida para aurora quinasa
PE20060215A1 (es) 4-fenilamino-quinazolin-6-il-amidas
PE20140502A1 (es) Pirimidinas sustituidas de diaminocarboxamida y diaminocarbonitrilo, composiciones de las mismas y metodos de tratamiento con las mismas
PE20110062A1 (es) N-(3-(3,5-dimetoxifenetil)-1h-pirazol-5-il)-4-(3,4-dimetilpiperazin-1-il)benzamida y sales del mismo
PE20091816A1 (es) Inhibidores de bace
AR104566A2 (es) Forma cristalina de la sal diclorhidrato de ((1s)-1-(((2s)-2-(5-(4-(2-((2s)-1-((2s)-2-((metoxicarbonil)amino)-3-metilbutanoil)-2-pirrolidinil)-1h-imidazol-5-il)-4-bifenilil)-1h-imidazol-2-il)-1-pirrolidinil)carbonil)-2-metilpropil)carbamato de metilo
PE20110875A1 (es) Derivados de isoindol como inhibidores de bace
ES2496592T3 (es) Proceso para la preparación de Imatinib y compuestos intermedios del mismo
PE20080362A1 (es) Derivados de ciclohexilpirazol-lactama como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1
PE20140609A1 (es) Diazacarbazoles y metodos de uso
EA200601896A1 (ru) Производные пролина и их применение в качестве ингибиторов дипептидилпептидазы iv
PE20110598A1 (es) Inhibidores de las enzimas de proteina cinasa activadas por mitogeno p38
PE20141375A1 (es) Activadores de glucoquinasa
NZ591449A (en) Picolinamide derivatives as kinase inhibitors
AR059249A1 (es) Compuesto amina trisustituido
PE20110341A1 (es) COMPUESTOS HETEROCICLICOS QUE MODULAN LA ACTIVIDAD DE LA ESTEROIL-CoA-DESATURASA
PE20120635A1 (es) Dihidropirazolonas sustituidas como inhibidores de hif-propil-4-hidroxilasas
PE20090972A1 (es) Inhibidores de quinasa c-fms
PE20100083A1 (es) Combinaciones de drogas que comprenden un inhibidor de dgat y un agonista de ppar
PE20090243A1 (es) Compuestos de imidazol sustituido como inhibidores de renina
RS52590B (en) SUBSTITUTIONED QUINOXALINE TYPE COMPONENTS WITH THE USED PIPERIDINE AND THEIR USE
PE20061394A1 (es) Metabolitos de n-(2-cloro-6-metilfenil)-2-[[6-[4-(2-hidroxietil)-1-piperazinil]-2-metil-4-pirimidinil]amino]-5-tiazolcarboxamidas
PE20080843A1 (es) Inhibidores de renina y metodo para su utilizacion
PE20110433A1 (es) Antagonistas de la via hedgehog de ftalazina disustituida
PE20091243A1 (es) Compuesto heterociclico fusionado

Legal Events

Date Code Title Description
FA Abandonment or withdrawal