PE20081636A1 - ANTHRANILAMIDE INHIBITORS FOR AURORA KINASE - Google Patents
ANTHRANILAMIDE INHIBITORS FOR AURORA KINASEInfo
- Publication number
- PE20081636A1 PE20081636A1 PE2008000182A PE2008000182A PE20081636A1 PE 20081636 A1 PE20081636 A1 PE 20081636A1 PE 2008000182 A PE2008000182 A PE 2008000182A PE 2008000182 A PE2008000182 A PE 2008000182A PE 20081636 A1 PE20081636 A1 PE 20081636A1
- Authority
- PE
- Peru
- Prior art keywords
- phenyl
- amino
- inhibitors
- aurora kinase
- pyrimidinyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE ANTRANILAMIDA DE FORMULA (I) DONDE R1 ES H, COOH, ALCOXI(C1-C6), CF3, ENTRE OTROS; R2 ES H, HALO, ALQUILO(C1-C3), CN, ENTRE OTROS; R3 ES H, FENILO, MORFOLINO-CH2CH2-FENILO, ENTRE OTROS; R4 ES HALO, ALQUILO(C1-C3) O ALCOXI(C1-C3); r ES DE 1 A 3; s ES DE 0 A 2. SON COMPUESTOS PREFERIDOS: 2-{[5-FLUORO-2-({3-[2-(4-MORFOLINIL)ETIL]FENIL}AMINO)-4-PIRIMIDINIL]AMINO}-N-(2-HIDROXIETIL)BENZAMIDA, (3R)-1-({2-[(5-FLUORO-2-{[3-(4-METIL-1-PIPERAZINIL)FENIL]AMINO}-4-PIRIMIDINIL)AMINO]FENIL}CARBONIL)-3-PIRROLIDINOL, (3R)-1-[(2-{[5-METIL-2-({3-[2-(4-MORFOLINIL)ETIL]FENIL}AMINO)-4-PIRIMIDINIL]AMINO}FENIL)CARBONIL]-3-PIRROLIDINOL, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA AURORA QUINASA SIENDO UTILES EN EL TRATAMIENTO DE CANCERREFERS TO COMPOUNDS DERIVED FROM ANTRANYLAMIDE OF FORMULA (I) WHERE R1 IS H, COOH, ALCOXY (C1-C6), CF3, AMONG OTHERS; R2 IS H, HALO, (C1-C3) ALKYL, CN, AMONG OTHERS; R3 IS H, PHENYL, MORPHOLINO-CH2CH2-PHENYL, AMONG OTHERS; R4 IS HALO, (C1-C3) ALKYL OR (C1-C3) ALCOXY; r IS FROM 1 TO 3; s IS FROM 0 TO 2. PREFERRED COMPOUNDS ARE: 2 - {[5-FLUORO-2 - ({3- [2- (4-MORPHOLINYL) ETHYL] PHENYL} AMINO) -4-PYRIMIDINYL] AMINO} -N- ( 2-HYDROXYETHYL) BENZAMIDE, (3R) -1 - ({2 - [(5-FLUORO-2 - {[3- (4-METHYL-1-PIPERAZINYL) PHENYL] AMINO} -4-PYRIMIDINYL) AMINO] PHENYL} CARBONYL) -3-PYRROLIDINOL, (3R) -1 - [(2 - {[5-METHYL-2 - ({3- [2- (4-MORPHOLINYL) ETHYL] PHENYL} AMINO) -4-PYRIMIDINYL] AMINO} PHENYL) CARBONYL] -3-PYRROLIDINOL, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS ARE INHIBITORS OF AURORA KINASE, BEING USEFUL IN THE TREATMENT OF CANCER
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88667607P | 2007-01-26 | 2007-01-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20081636A1 true PE20081636A1 (en) | 2009-01-10 |
Family
ID=39644890
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008000182A PE20081636A1 (en) | 2007-01-26 | 2008-01-24 | ANTHRANILAMIDE INHIBITORS FOR AURORA KINASE |
Country Status (10)
Country | Link |
---|---|
US (2) | US7884098B2 (en) |
EP (1) | EP2121637A4 (en) |
JP (1) | JP5337712B2 (en) |
AR (1) | AR065015A1 (en) |
AU (1) | AU2008207809B2 (en) |
CA (1) | CA2676257A1 (en) |
CL (1) | CL2008000197A1 (en) |
PE (1) | PE20081636A1 (en) |
TW (1) | TW200902010A (en) |
WO (1) | WO2008092049A1 (en) |
Families Citing this family (49)
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AR065015A1 (en) * | 2007-01-26 | 2009-05-13 | Smithkline Beecham Corp | ANTRANILAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND USES FOR THE TREATMENT OF CANCER |
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US11351168B1 (en) | 2008-06-27 | 2022-06-07 | Celgene Car Llc | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
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US8933227B2 (en) | 2009-08-14 | 2015-01-13 | Boehringer Ingelheim International Gmbh | Selective synthesis of functionalized pyrimidines |
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KR20130099040A (en) | 2010-08-10 | 2013-09-05 | 셀진 아빌로믹스 리서치, 인코포레이티드 | Besylate salt of a btk inhibitor |
CN101973956B (en) * | 2010-09-26 | 2013-07-31 | 合肥星宇化学有限责任公司 | Methods for synthesizing isatoic anhydride and N-isopropyl-2-aminobenzamide |
US8975249B2 (en) | 2010-11-01 | 2015-03-10 | Celgene Avilomics Research, Inc. | Heterocyclic compounds and uses thereof |
EP2635285B1 (en) | 2010-11-01 | 2017-05-03 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
US8796255B2 (en) | 2010-11-10 | 2014-08-05 | Celgene Avilomics Research, Inc | Mutant-selective EGFR inhibitors and uses thereof |
CN102173999A (en) * | 2011-02-28 | 2011-09-07 | 盐城工学院 | Method for synthesizing 2-amino-N,N-dimethylbenzamide |
US9249124B2 (en) * | 2011-03-30 | 2016-02-02 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Aurora kinase inhibitors and methods of making and using thereof |
BR112013025387B1 (en) * | 2011-04-01 | 2021-07-27 | University Of Utah Research Foundation | REPLACED N-FENYLPYRIMIDIN-2-AMINE ANALOGUE COMPOUNDS AS KINASE AXL INHIBITORS, USE OF SUCH COMPOUNDS FOR THE TREATMENT OF AN UNCONTROLLED CELL PROLIFERATION DISORDER, AS WELL AS KIT INCLUDING SUCH COMPOUNDS |
BR112013027734A2 (en) | 2011-05-04 | 2017-08-08 | Ariad Pharma Inc | compounds for inhibition of cell proliferation in egfr-driven cancers, method and pharmaceutical composition |
CA2853498A1 (en) | 2011-10-28 | 2013-05-02 | Celgene Avilomics Research, Inc. | Methods of treating a bruton's tyrosine kinase disease or disorder |
WO2013075167A1 (en) * | 2011-11-21 | 2013-05-30 | Cancer Therapeutics Crc Pty Ltd | Binding agent |
RS57901B1 (en) | 2012-03-15 | 2019-01-31 | Celgene Car Llc | Salts of an epidermal growth factor receptor kinase inhibitor |
EP2825041B1 (en) | 2012-03-15 | 2021-04-21 | Celgene CAR LLC | Solid forms of an epidermal growth factor receptor kinase inhibitor |
JP6469567B2 (en) | 2012-05-05 | 2019-02-13 | アリアド・ファーマシューティカルズ・インコーポレイテッド | Compound for inhibiting cell proliferation of EGFR-activated cancer |
GB201214106D0 (en) * | 2012-08-07 | 2012-09-19 | Univ Strathclyde | Immunomodulatory compounds |
CU24387B1 (en) | 2012-11-21 | 2019-03-04 | Ptc Therapeutics Inc | BMI-1 INHIBITORS OF REPLACED PYRIMIDINE REPLACED |
EP2935226A4 (en) | 2012-12-21 | 2016-11-02 | Celgene Avilomics Res Inc | Heteroaryl compounds and uses thereof |
PE20151274A1 (en) | 2013-02-08 | 2015-09-12 | Celgene Avilomics Res Inc | ERK INHIBITORS AND THEIR USES |
CA2905993C (en) | 2013-03-14 | 2022-12-06 | Tolero Pharmaceuticals, Inc. | Substituted 4-amino-pyrimidinyl-2-amino-phenyl derivatives and pharmaceutical compositions thereof for use as jak2 and alk2 inhibitors |
US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
US9492471B2 (en) | 2013-08-27 | 2016-11-15 | Celgene Avilomics Research, Inc. | Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase |
CN105683166B (en) | 2013-08-30 | 2020-06-16 | Ptc医疗公司 | Substituted pyrimidine Bmi-1 inhibitors |
US10584115B2 (en) | 2013-11-21 | 2020-03-10 | Ptc Therapeutics, Inc. | Substituted pyridine and pyrazine BMI-1 inhibitors |
US9415049B2 (en) | 2013-12-20 | 2016-08-16 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
ES2741785T3 (en) | 2014-08-13 | 2020-02-12 | Celgene Car Llc | Forms and compositions of an ERK inhibitor |
CN105017160B (en) * | 2015-06-24 | 2017-12-29 | 温州医科大学 | A kind of miazines EGFRT790MInhibitor and its synthetic method and application |
CN106187914B (en) * | 2016-07-12 | 2019-03-15 | 黄河三角洲京博化工研究院有限公司 | A kind of preparation method of 2,4- dichloro-5-methoxy pyrimidine |
KR20190092542A (en) * | 2016-12-19 | 2019-08-07 | 에피자임, 인코포레이티드 | Amine-Substituted Heterocyclic Compounds as EHMT2 Inhibitors and Methods of Use thereof |
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US11013741B1 (en) | 2018-04-05 | 2021-05-25 | Sumitomo Dainippon Pharma Oncology, Inc. | AXL kinase inhibitors and use of the same |
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US6875842B2 (en) * | 2002-03-28 | 2005-04-05 | Arizona Chemical Company | Resinates from monomer |
ES2325440T3 (en) * | 2003-02-20 | 2009-09-04 | Smithkline Beecham Corporation | PIRIMIDINE COMPOUNDS. |
GB0305929D0 (en) | 2003-03-14 | 2003-04-23 | Novartis Ag | Organic compounds |
WO2005016894A1 (en) | 2003-08-15 | 2005-02-24 | Novartis Ag | 2, 4-pyrimidinediamines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders |
GB0321710D0 (en) | 2003-09-16 | 2003-10-15 | Novartis Ag | Organic compounds |
US20070105839A1 (en) * | 2003-09-18 | 2007-05-10 | Patricia Imbach | 2, 4-Di (phenylamino) pyrimidines useful in the treatment of proliferative disorders |
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EA200870217A1 (en) | 2006-01-30 | 2009-02-27 | Экселиксис, Инк. | 4-Aryl-2-aminopyrimidines or 4-aryl-2-aminoalkylpyrimidines as modulators JAK-2 and containing their pharmaceutical compositions |
DK2091918T3 (en) | 2006-12-08 | 2014-12-01 | Irm Llc | Compounds and Compositions as Protein Kinase Inhibitors |
AU2007337088A1 (en) * | 2006-12-19 | 2008-07-03 | Genentech, Inc. | Pyrimidine kinase inhibitors |
AR065015A1 (en) * | 2007-01-26 | 2009-05-13 | Smithkline Beecham Corp | ANTRANILAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND USES FOR THE TREATMENT OF CANCER |
AU2008229147A1 (en) | 2007-03-20 | 2008-09-25 | Smithkline Beecham Corporation | Chemical compounds |
-
2008
- 2008-01-24 AR ARP080100292A patent/AR065015A1/en unknown
- 2008-01-24 CL CL200800197A patent/CL2008000197A1/en unknown
- 2008-01-24 PE PE2008000182A patent/PE20081636A1/en not_active Application Discontinuation
- 2008-01-24 TW TW097102587A patent/TW200902010A/en unknown
- 2008-01-25 US US12/524,009 patent/US7884098B2/en not_active Expired - Fee Related
- 2008-01-25 EP EP08728247A patent/EP2121637A4/en not_active Withdrawn
- 2008-01-25 US US12/019,730 patent/US7625903B2/en not_active Expired - Fee Related
- 2008-01-25 JP JP2009547435A patent/JP5337712B2/en not_active Expired - Fee Related
- 2008-01-25 WO PCT/US2008/051985 patent/WO2008092049A1/en active Application Filing
- 2008-01-25 AU AU2008207809A patent/AU2008207809B2/en not_active Ceased
- 2008-01-25 CA CA002676257A patent/CA2676257A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2676257A1 (en) | 2008-07-31 |
US7625903B2 (en) | 2009-12-01 |
JP2010516780A (en) | 2010-05-20 |
US20100016318A1 (en) | 2010-01-21 |
CL2008000197A1 (en) | 2008-08-01 |
EP2121637A4 (en) | 2010-10-06 |
WO2008092049A1 (en) | 2008-07-31 |
US7884098B2 (en) | 2011-02-08 |
US20080182852A1 (en) | 2008-07-31 |
AU2008207809B2 (en) | 2013-04-18 |
JP5337712B2 (en) | 2013-11-06 |
EP2121637A1 (en) | 2009-11-25 |
AU2008207809A1 (en) | 2008-07-31 |
TW200902010A (en) | 2009-01-16 |
AR065015A1 (en) | 2009-05-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |