AR065015A1 - Derivados de antranilamida, composiciones farmaceuticas que los contienen, y usos para el tratamiento del cancer - Google Patents
Derivados de antranilamida, composiciones farmaceuticas que los contienen, y usos para el tratamiento del cancerInfo
- Publication number
- AR065015A1 AR065015A1 ARP080100292A ARP080100292A AR065015A1 AR 065015 A1 AR065015 A1 AR 065015A1 AR P080100292 A ARP080100292 A AR P080100292A AR P080100292 A ARP080100292 A AR P080100292A AR 065015 A1 AR065015 A1 AR 065015A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- halo
- alkoxy
- hydroxy
- alkylamino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Compuesto de antranilamida caracterizado por la siguiente estructura (1): o una de sus sales farmacéuticamente aceptables; en la que cada R1 es independientemente H, (CH2)nN(R5)2, -O-(CH2)pN(R5)2, C(O)N(R5)2, -(CH2)nSO2(NH)QR6, COOH, alquilo C1-6, alcoxi C1-6, halo, o CN; con la salvedad que por lo menos un R1 es -(CH2)n-N(R5)2, -O-(CH2)pN(R5)2, C(O)N(R5)2, -(CH2)nSO2(NH)qR6, o COOH; n es 0, 1, 2 o 3; p es 2 o 3; q es 0 o 1; r es 1, 2 o 3; s es 0, 1 o 2; R2 es H, halo; alquilo C1-3, alcoxi C1- 3, CN, nitro o CF3; cada R3 es independientemente H, heterocicloalquilo, cicloalquilo, fenilo, morfolino-CH2CH2-fenilo o alquilo C1-6 opcionalmente sustituido con hidroxi, amino, alquilamino C1-6, di-alquilamino C1-6, trifluormetilotetrahidrofuranilo, piridinilo o imidazolilo; o cada R3, junto con el nitrogeno al que está unido forma un grupo cíclico de 5 o 6 miembros opcionalmente sustituido con hidroxi, alquilo C1-6, hidroxi-alquilo C1-3, morfolino, -C(O)CH3, di-alquilamino C1-2 o -C(O)NH2 y R4 es halo, alquilo C1-3 o alcoxi C1-3; cada R5 es independientemente alquilo C1-6 o -C(O)CH3 o, junto con el nitrogeno al que está unido, forma un grupo cíclico de 5 o 6 miembros opcionalmente sustituido con hidroxi, alquilo C1-6, hidroxi-alquilo C1-3, morfolino, -C(O)CH3, di-alquilamino C1-2 o -C(O)NH2; y R6 es alquilo C1-6, (R7)x-fenil-(C(O))y-, o (R8)z-heteroaril-(C(O))y-, donde x es 0, 1, 2 o 3; z es 0, 1 o 2; y es 0 o 1; R7 es halo, alquilo C1-3 o alcoxi C1-3; y R8 es halo, alquilo C1-3 o alcoxi C1-3. composicion que lo comprende. Uso para preparar un medicamento util para tratar enfermedades asociadas con la actividad de Aurora quinasas, tales como el cáncer.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88667607P | 2007-01-26 | 2007-01-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR065015A1 true AR065015A1 (es) | 2009-05-13 |
Family
ID=39644890
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080100292A AR065015A1 (es) | 2007-01-26 | 2008-01-24 | Derivados de antranilamida, composiciones farmaceuticas que los contienen, y usos para el tratamiento del cancer |
Country Status (10)
Country | Link |
---|---|
US (2) | US7884098B2 (es) |
EP (1) | EP2121637A4 (es) |
JP (1) | JP5337712B2 (es) |
AR (1) | AR065015A1 (es) |
AU (1) | AU2008207809B2 (es) |
CA (1) | CA2676257A1 (es) |
CL (1) | CL2008000197A1 (es) |
PE (1) | PE20081636A1 (es) |
TW (1) | TW200902010A (es) |
WO (1) | WO2008092049A1 (es) |
Families Citing this family (49)
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PT1656372E (pt) | 2003-07-30 | 2013-06-27 | Rigel Pharmaceuticals Inc | Métodos para o tratamento ou prevenção de doenças autoimunes com compostos de 2,4-pirimidinadiamina |
TW200902010A (en) * | 2007-01-26 | 2009-01-16 | Smithkline Beecham Corp | Anthranilamide inhibitors of aurora kinase |
WO2008118823A2 (en) * | 2007-03-26 | 2008-10-02 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
WO2009127642A2 (en) * | 2008-04-15 | 2009-10-22 | Cellzome Limited | Use of lrrk2 inhibitors for neurodegenerative diseases |
US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
SI2300013T1 (en) | 2008-05-21 | 2018-03-30 | Adriad Pharmacaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
DK2361248T3 (en) | 2008-06-27 | 2019-01-14 | Celgene Car Llc | Heteroberl compounds and uses thereof |
US11351168B1 (en) | 2008-06-27 | 2022-06-07 | Celgene Car Llc | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
ES2659725T3 (es) | 2009-05-05 | 2018-03-19 | Dana-Farber Cancer Institute, Inc. | Inhibidores de EGFR y procedimiento de tratamiento de trastornos |
CN101585781B (zh) * | 2009-07-08 | 2012-08-08 | 北京颖新泰康国际贸易有限公司 | 一种邻氨基-n,n-二甲基苯甲酰胺的制备方法 |
US8729265B2 (en) | 2009-08-14 | 2014-05-20 | Boehringer Ingelheim International Gmbh | Regioselective preparation of 2-amino-5-trifluoromethylpyrimidine derivatives |
US8933227B2 (en) | 2009-08-14 | 2015-01-13 | Boehringer Ingelheim International Gmbh | Selective synthesis of functionalized pyrimidines |
EP3144298A1 (en) | 2010-08-10 | 2017-03-22 | Celgene Avilomics Research, Inc. | Besylate salt of a btk inhibitor |
CN101973956B (zh) * | 2010-09-26 | 2013-07-31 | 合肥星宇化学有限责任公司 | 靛红酸酐的合成方法及n-异丙基-2-氨基苯甲酰胺的合成方法 |
JP5956999B2 (ja) | 2010-11-01 | 2016-07-27 | セルジーン アヴィロミクス リサーチ, インコーポレイテッド | ヘテロアリール化合物およびその使用 |
MX2013004894A (es) | 2010-11-01 | 2013-10-17 | Celgene Avilomics Res Inc | Compuestos heterociclicos y usos de los mismos. |
US8796255B2 (en) | 2010-11-10 | 2014-08-05 | Celgene Avilomics Research, Inc | Mutant-selective EGFR inhibitors and uses thereof |
CN102173999A (zh) * | 2011-02-28 | 2011-09-07 | 盐城工学院 | 一种2-氨基-n,n-二甲基苯甲酰胺的合成方法 |
US9249124B2 (en) * | 2011-03-30 | 2016-02-02 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Aurora kinase inhibitors and methods of making and using thereof |
HUE046988T2 (hu) | 2011-04-01 | 2020-04-28 | Univ Utah Res Found | Szubsztituált N-fenilpirimidin-2-amin analógok mint AXL kináz inhibitorok |
JP5999177B2 (ja) | 2011-05-04 | 2016-09-28 | アリアド・ファーマシューティカルズ・インコーポレイテッド | Egfr発動性がんの細胞増殖阻害用化合物 |
AR088570A1 (es) | 2011-10-28 | 2014-06-18 | Celgene Avilomics Res Inc | Metodos para tratar una enfermedad o trastorno relacionado con la tirosina quinasa de bruton |
US20140323346A1 (en) * | 2011-11-21 | 2014-10-30 | Garvan Institute Of Medical Research | Binding agent |
MX356179B (es) | 2012-03-15 | 2018-05-17 | Celgene Avilomics Res Inc | Sales de un inhibidor de cinasa del receptor del factor de crecimiento epidermico. |
JP6317319B2 (ja) | 2012-03-15 | 2018-04-25 | セルジーン シーエーアール エルエルシー | 上皮成長因子受容体キナーゼ阻害剤の固体形態 |
JP6469567B2 (ja) | 2012-05-05 | 2019-02-13 | アリアド・ファーマシューティカルズ・インコーポレイテッド | Egfr発動性がんの細胞増殖阻害用化合物 |
GB201214106D0 (en) * | 2012-08-07 | 2012-09-19 | Univ Strathclyde | Immunomodulatory compounds |
WO2014081906A2 (en) | 2012-11-21 | 2014-05-30 | Ptc Therapeutics, Inc. | Substituted reverse pyrimidine bmi-1 inhibitors |
EP2935226A4 (en) | 2012-12-21 | 2016-11-02 | Celgene Avilomics Res Inc | HETEROARYL COMPOUNDS AND USES THEREOF |
CN105188371A (zh) | 2013-02-08 | 2015-12-23 | 西建阿维拉米斯研究公司 | Erk抑制剂及其用途 |
KR102334260B1 (ko) | 2013-03-14 | 2021-12-02 | 스미토모 다이니폰 파마 온콜로지, 인크. | Jak2 및 alk2 억제제 및 이들의 사용 방법 |
US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
US9492471B2 (en) | 2013-08-27 | 2016-11-15 | Celgene Avilomics Research, Inc. | Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase |
EP3039015B1 (en) | 2013-08-30 | 2019-10-30 | PTC Therapeutics, Inc. | Substituted pyrimidine bmi-1 inhibitors |
US10584115B2 (en) | 2013-11-21 | 2020-03-10 | Ptc Therapeutics, Inc. | Substituted pyridine and pyrazine BMI-1 inhibitors |
US9415049B2 (en) | 2013-12-20 | 2016-08-16 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
ES2741785T3 (es) | 2014-08-13 | 2020-02-12 | Celgene Car Llc | Formas y composiciones de un inhibidor de ERK |
CN105017160B (zh) * | 2015-06-24 | 2017-12-29 | 温州医科大学 | 一种嘧啶类egfrt790m抑制剂及其合成方法和应用 |
CN106187914B (zh) * | 2016-07-12 | 2019-03-15 | 黄河三角洲京博化工研究院有限公司 | 一种2,4-二氯-5-甲氧基嘧啶的制备方法 |
EP4285906A3 (en) * | 2016-12-19 | 2024-03-13 | Epizyme, Inc. | Amine-substituted heterocyclic compounds as ehmt2 inhibitors and methods of use thereof |
WO2018195450A1 (en) | 2017-04-21 | 2018-10-25 | Epizyme, Inc. | Combination therapies with ehmt2 inhibitors |
BR112020020246A8 (pt) | 2018-04-05 | 2022-10-18 | Sumitomo Dainippon Pharma Oncology Inc | Inibidores de cinase axl e uso dos mesmos |
WO2019232225A1 (en) * | 2018-05-30 | 2019-12-05 | Promega Corporation | Broad-spectrum kinase binding agents |
KR20210038906A (ko) | 2018-07-26 | 2021-04-08 | 스미토모 다이니폰 파마 온콜로지, 인크. | 비정상적 acvr1 발현과 연관된 질환을 치료하는 방법 및 그에 사용하기 위한 acvr1 억제제 |
EP3845533A4 (en) | 2018-08-27 | 2022-04-27 | Sumitomo Dainippon Pharma Co., Ltd. | OPTICALLY ACTIVE AZABICYCLIC DERIVATIVES |
EP4153770A2 (en) * | 2020-05-22 | 2023-03-29 | Promega Corporation | Enhancement of kinase target engagement |
CN113061117B (zh) * | 2021-03-30 | 2023-02-10 | 长治学院 | 一种2-((5-氯-2-(4-吗啉甲基苯胺基)嘧啶-4-基)氨基)苯甲酰胺衍生物 |
WO2023134582A1 (zh) * | 2022-01-14 | 2023-07-20 | 上海立森印迹医药技术有限公司 | 一种嘧啶-2,4-二胺衍生物及其制备方法和用途 |
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US6797706B1 (en) | 1999-06-09 | 2004-09-28 | Yamanouchi Pharmaceutical Co., Ltd. | Heterocyclecarboxamide derivative |
GB0004887D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
IL158783A0 (en) * | 2001-05-08 | 2004-05-12 | Schering Ag | Selective anthranilamide pyridine amides as inhibitors of vegfr-2 and vegfr-3 |
ATE389638T1 (de) | 2001-11-01 | 2008-04-15 | Janssen Pharmaceutica Nv | Aminobenzamidderivate als inhibitoren der glycogensynthasekinase-3- |
GB0206215D0 (en) | 2002-03-15 | 2002-05-01 | Novartis Ag | Organic compounds |
AU2003226126A1 (en) * | 2002-03-28 | 2003-10-13 | Arizona Chemical Company | Resinates from monomer fatty acids |
US7514446B2 (en) * | 2003-02-20 | 2009-04-07 | Smithkline Beecham Corporation | Pyrimidine compounds |
GB0305929D0 (en) | 2003-03-14 | 2003-04-23 | Novartis Ag | Organic compounds |
NZ585188A (en) | 2003-08-15 | 2011-09-30 | Novartis Ag | 2,4-Pyrimidinediamines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders |
GB0321710D0 (en) | 2003-09-16 | 2003-10-15 | Novartis Ag | Organic compounds |
WO2005026130A1 (en) | 2003-09-18 | 2005-03-24 | Novartis Ag | 2,4-di (phenylamino) pyrimidines useful in the treatment of proliferative disorders |
WO2005113494A2 (en) | 2004-05-07 | 2005-12-01 | Amgen Inc. | Nitrogenated heterocyclic derivatives as protein kinase modulators and use for the treatment of angiogenesis and cancer |
EP1598343A1 (de) | 2004-05-19 | 2005-11-23 | Boehringer Ingelheim International GmbH | 2-Arylaminopyrimidine als PLK Inhibitoren |
GB0419161D0 (en) | 2004-08-27 | 2004-09-29 | Novartis Ag | Organic compounds |
EP1979329A2 (en) | 2006-01-30 | 2008-10-15 | Exelixis, Inc. | 4-aryl-2-amino-pyrimidines or 4-aryl-2-aminoalkyl-pyrimidines as jak-2 modulators and methods of use |
KR101149295B1 (ko) | 2006-12-08 | 2012-07-05 | 아이알엠 엘엘씨 | 단백질 키나제 억제제로서의 화합물 |
WO2008079719A1 (en) | 2006-12-19 | 2008-07-03 | Genentech, Inc. | Pyrimidine kinase inhibitors |
TW200902010A (en) * | 2007-01-26 | 2009-01-16 | Smithkline Beecham Corp | Anthranilamide inhibitors of aurora kinase |
MX2009010045A (es) * | 2007-03-20 | 2009-12-04 | Smithkline Beecham Corp | Compuestos quimicos. |
-
2008
- 2008-01-24 TW TW097102587A patent/TW200902010A/zh unknown
- 2008-01-24 PE PE2008000182A patent/PE20081636A1/es not_active Application Discontinuation
- 2008-01-24 CL CL200800197A patent/CL2008000197A1/es unknown
- 2008-01-24 AR ARP080100292A patent/AR065015A1/es unknown
- 2008-01-25 WO PCT/US2008/051985 patent/WO2008092049A1/en active Application Filing
- 2008-01-25 EP EP08728247A patent/EP2121637A4/en not_active Withdrawn
- 2008-01-25 AU AU2008207809A patent/AU2008207809B2/en not_active Ceased
- 2008-01-25 JP JP2009547435A patent/JP5337712B2/ja not_active Expired - Fee Related
- 2008-01-25 US US12/524,009 patent/US7884098B2/en not_active Expired - Fee Related
- 2008-01-25 US US12/019,730 patent/US7625903B2/en not_active Expired - Fee Related
- 2008-01-25 CA CA002676257A patent/CA2676257A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP5337712B2 (ja) | 2013-11-06 |
EP2121637A1 (en) | 2009-11-25 |
AU2008207809B2 (en) | 2013-04-18 |
PE20081636A1 (es) | 2009-01-10 |
CA2676257A1 (en) | 2008-07-31 |
JP2010516780A (ja) | 2010-05-20 |
TW200902010A (en) | 2009-01-16 |
AU2008207809A1 (en) | 2008-07-31 |
CL2008000197A1 (es) | 2008-08-01 |
US20100016318A1 (en) | 2010-01-21 |
US7625903B2 (en) | 2009-12-01 |
US7884098B2 (en) | 2011-02-08 |
US20080182852A1 (en) | 2008-07-31 |
EP2121637A4 (en) | 2010-10-06 |
WO2008092049A1 (en) | 2008-07-31 |
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