PL2693881T3 - Podstawione analogi N-fenylopirymidyno-2-aminy jako inhibitory kinazy AXL - Google Patents

Podstawione analogi N-fenylopirymidyno-2-aminy jako inhibitory kinazy AXL

Info

Publication number
PL2693881T3
PL2693881T3 PL12763555T PL12763555T PL2693881T3 PL 2693881 T3 PL2693881 T3 PL 2693881T3 PL 12763555 T PL12763555 T PL 12763555T PL 12763555 T PL12763555 T PL 12763555T PL 2693881 T3 PL2693881 T3 PL 2693881T3
Authority
PL
Poland
Prior art keywords
phenylpyrimidin
inhibitors
substituted
axl kinase
amine analogs
Prior art date
Application number
PL12763555T
Other languages
English (en)
Inventor
David J. Bearss
Hariprasad Vankayalapati
Alexis MOLLARD
Steven L. Warner
Sunil Sharma
Original Assignee
University Of Utah Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of Utah Research Foundation filed Critical University Of Utah Research Foundation
Publication of PL2693881T3 publication Critical patent/PL2693881T3/pl

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • C07D239/42One nitrogen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48Two nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
PL12763555T 2011-04-01 2012-03-31 Podstawione analogi N-fenylopirymidyno-2-aminy jako inhibitory kinazy AXL PL2693881T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161471090P 2011-04-01 2011-04-01
PCT/US2012/031768 WO2012135800A1 (en) 2011-04-01 2012-03-31 Substituted n-phenylpyrimidin-2-amine analogs as inhibitors of the axl kinase
EP12763555.5A EP2693881B1 (en) 2011-04-01 2012-03-31 Substituted n-phenylpyrimidin-2-amine analogs as inhibitors of the axl kinase

Publications (1)

Publication Number Publication Date
PL2693881T3 true PL2693881T3 (pl) 2020-03-31

Family

ID=46931967

Family Applications (1)

Application Number Title Priority Date Filing Date
PL12763555T PL2693881T3 (pl) 2011-04-01 2012-03-31 Podstawione analogi N-fenylopirymidyno-2-aminy jako inhibitory kinazy AXL

Country Status (11)

Country Link
US (1) US8901120B2 (pl)
EP (2) EP3628665B1 (pl)
JP (2) JP6118794B2 (pl)
BR (1) BR112013025387B1 (pl)
CY (1) CY1122556T1 (pl)
DK (1) DK2693881T3 (pl)
ES (2) ES2937952T3 (pl)
HU (1) HUE046988T2 (pl)
PL (1) PL2693881T3 (pl)
PT (1) PT2693881T (pl)
WO (1) WO2012135800A1 (pl)

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Also Published As

Publication number Publication date
PT2693881T (pt) 2019-12-09
ES2759615T3 (es) 2020-05-11
ES2937952T3 (es) 2023-04-03
JP6118794B2 (ja) 2017-04-19
WO2012135800A1 (en) 2012-10-04
BR112013025387B1 (pt) 2021-07-27
BR112013025387A2 (pt) 2016-07-19
EP3628665B1 (en) 2022-11-02
DK2693881T3 (da) 2019-12-09
CY1122556T1 (el) 2021-01-27
US8901120B2 (en) 2014-12-02
HUE046988T2 (hu) 2020-04-28
JP2017075188A (ja) 2017-04-20
US20120283261A1 (en) 2012-11-08
EP2693881B1 (en) 2019-09-04
EP2693881A1 (en) 2014-02-12
EP3628665A1 (en) 2020-04-01
EP2693881A4 (en) 2014-11-19
JP2014509661A (ja) 2014-04-21

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