US755047A
(en)
*
|
1902-03-17 |
1904-03-22 |
Alexander Roth Robertson |
Bottle-seal.
|
EP0009517A1
(en)
|
1978-10-04 |
1980-04-16 |
THE PROCTER & GAMBLE COMPANY |
Vaginal contraceptive
|
DE10075033I2
(de)
|
1993-11-30 |
2001-08-02 |
Searle & Co |
substituierte Pyrazolyl-benzolsulfonamide zur Behandlung von Entzündungen.
|
US5844092A
(en)
|
1994-03-18 |
1998-12-01 |
Genentech, Inc. |
Human TRK receptors and neurotrophic factor inhibitors
|
US5877016A
(en)
|
1994-03-18 |
1999-03-02 |
Genentech, Inc. |
Human trk receptors and neurotrophic factor inhibitors
|
US5430021A
(en)
|
1994-03-18 |
1995-07-04 |
Pharmavene, Inc. |
Hydrophobic drug delivery systems
|
CA2253871C
(en)
|
1996-05-08 |
2005-04-26 |
Biogen, Inc. |
Ret ligand (retl) for stimulating neural and renal growth
|
US6677135B1
(en)
|
1996-05-08 |
2004-01-13 |
Biogen, Inc. |
Ret ligand (RetL) for stimulating neutral and renal growth
|
CA2206201A1
(en)
|
1996-05-29 |
1997-11-29 |
Yoshiaki Isobe |
Pyrazole derivatives and their pharmaceutical use
|
US6682921B1
(en)
|
1996-08-21 |
2004-01-27 |
New York University |
Crystals of the tyrosine kinase domain of non-insulin receptor tyrosine kinases
|
JP3898296B2
(ja)
|
1996-08-28 |
2007-03-28 |
ポーラ化成工業株式会社 |
ピロロピラゾロピリミジン化合物及びこれを有効成分とする医薬
|
CN1248259A
(zh)
|
1997-04-25 |
2000-03-22 |
武田药品工业株式会社 |
稠合的哒嗪衍生物、其生产方法和用途
|
US6531152B1
(en)
|
1998-09-30 |
2003-03-11 |
Dexcel Pharma Technologies Ltd. |
Immediate release gastrointestinal drug delivery system
|
UA74546C2
(en)
*
|
1999-04-06 |
2006-01-16 |
Boehringer Ingelheim Ca Ltd |
Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition
|
AU7103900A
(en)
|
1999-09-01 |
2001-03-26 |
Biogen, Inc. |
Ret ligand 5 (retl5) compositions and uses thereof
|
US6534085B1
(en)
|
1999-09-23 |
2003-03-18 |
Bioresponse L.L.C. |
Phytochemicals for promoting weight loss
|
FI20000403A0
(fi)
|
2000-02-22 |
2000-02-22 |
Hannu Sariola |
GDNF perhesukuisten yhdisteiden käyttö kivessyövän hoitoon tarkoitettujen tuotteiden valmistamiseksi
|
CA2412494C
(en)
|
2000-06-22 |
2012-10-23 |
Genentech, Inc. |
Agonist anti-trk-c monoclonal antibodies
|
TWI312347B
(en)
|
2001-02-08 |
2009-07-21 |
Eisai R&D Man Co Ltd |
Bicyclic nitrogen-containing condensed ring compounds
|
AU2002308722B2
(en)
|
2001-05-30 |
2007-05-17 |
Genentech, Inc. |
Anti-NGF antibodies for the treatment of various disorders
|
WO2003020698A2
(en)
|
2001-09-06 |
2003-03-13 |
Prochon Biotech Ltd. |
Protein tyrosine kinase inhibitors
|
US20030199525A1
(en)
|
2002-03-21 |
2003-10-23 |
Hirst Gavin C. |
Kinase inhibitors
|
US7662826B2
(en)
|
2002-04-23 |
2010-02-16 |
Shionogi & Co., Ltd. |
Pyrazolo [1,5-a] pyrimidine derivative and nad (p) h oxidase inhibitor containing the same
|
US7449488B2
(en)
|
2002-06-04 |
2008-11-11 |
Schering Corporation |
Pyrazolopyrimidines as protein kinase inhibitors
|
US20060116381A1
(en)
|
2002-07-24 |
2006-06-01 |
Fagin James A |
4-4(methylpiperazin-1-ylmethyl)-n-[4-methyl-3-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-ben-zamide for treating mutated-ret kinase associated diseases
|
JP4024624B2
(ja)
|
2002-08-26 |
2007-12-19 |
富士通株式会社 |
半導体装置の製造方法及び製造装置
|
US8580782B2
(en)
|
2002-09-04 |
2013-11-12 |
Merck Sharp & Dohme Corp. |
Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
|
US7119200B2
(en)
|
2002-09-04 |
2006-10-10 |
Schering Corporation |
Pyrazolopyrimidines as cyclin dependent kinase inhibitors
|
WO2004022561A1
(en)
|
2002-09-04 |
2004-03-18 |
Schering Corporation |
Pyrazolopyrimidines as cyclin-dependent kinase inhibitors
|
US7196078B2
(en)
|
2002-09-04 |
2007-03-27 |
Schering Corpoartion |
Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors
|
RU2357967C2
(ru)
*
|
2002-09-16 |
2009-06-10 |
Глаксо Груп Лимитед |
ПРОИЗВОДНЫЕ ПИРАЗОЛО[3, 4-b]ПИРИДИНА, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ (ВАРИАНТЫ), ПРИМЕНЕНИЕ (ВАРИАНТЫ), КОМПОЗИЦИЯ (ВАРИАНТЫ)
|
WO2004052286A2
(en)
|
2002-12-11 |
2004-06-24 |
Merck & Co., Inc. |
Tyrosine kinase inhibitors
|
AU2003299651A1
(en)
*
|
2002-12-11 |
2004-06-30 |
Merck And Co., Inc. |
Tyrosine kinase inhibitors
|
GB0303910D0
(en)
|
2003-02-20 |
2003-03-26 |
Merck Sharp & Dohme |
Therapeutic agents
|
WO2004082458A2
(en)
|
2003-02-21 |
2004-09-30 |
The Johns Hopkins University |
Tyrosine kinome
|
JP2004277337A
(ja)
*
|
2003-03-14 |
2004-10-07 |
Sumitomo Pharmaceut Co Ltd |
ピラゾロ[1,5−a]ピリミジン誘導体
|
EP1608652A1
(en)
|
2003-03-31 |
2005-12-28 |
Vernalis (Cambridge) Limited |
Pyrazolopyrimidine compounds and their use in medicine
|
WO2004089415A2
(en)
|
2003-04-11 |
2004-10-21 |
Novo Nordisk A/S |
COMBINATIONS OF AN 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITOR AND A GLUCOCORTICOID RECEPTOR AGONIST
|
EP1615697A2
(en)
|
2003-04-11 |
2006-01-18 |
Novo Nordisk A/S |
New pyrazolo[1,5-a] pyrimidine derivatives and pharmaceutical use thereof
|
US20060094699A1
(en)
|
2003-04-11 |
2006-05-04 |
Kampen Gita Camilla T |
Combination therapy using an 11beta-hydroxysteroid dehydrogenase type 1 inhibitor and a glucocorticoid receptor agonist to minimize the side effects associated with glucocorticoid receptor agonist therapy
|
KR20060011977A
(ko)
|
2003-04-28 |
2006-02-06 |
가르파마 컴퍼니 리미티드 |
갈렉틴 9 유도 인자
|
JO2785B1
(en)
*
|
2003-05-27 |
2014-03-15 |
شركة جانسين فارماسوتيكا ان. في |
Quinazoline derivatives
|
JP2005008581A
(ja)
|
2003-06-20 |
2005-01-13 |
Kissei Pharmaceut Co Ltd |
新規なピラゾロ[1,5−a]ピリミジン誘導体、それを含有する医薬組成物およびそれらの用途
|
GEP20104887B
(en)
|
2003-07-15 |
2010-02-10 |
Medarex Inc |
Human anti-ngf neutralizing antibodies as selective ngf pathway inhibitors
|
BRPI0414571A
(pt)
*
|
2003-09-22 |
2006-11-07 |
Boehringer Ingelheim Int |
peptìdeos macrocìclicos ativos contra o vìrus da hepatite c
|
US20090143399A1
(en)
|
2003-10-14 |
2009-06-04 |
Arizona Board Of Regents On Behalf Of The University Of Arizona |
Protein Kinase Inhibitors
|
US7491794B2
(en)
*
|
2003-10-14 |
2009-02-17 |
Intermune, Inc. |
Macrocyclic compounds as inhibitors of viral replication
|
MY141220A
(en)
|
2003-11-17 |
2010-03-31 |
Astrazeneca Ab |
Pyrazole derivatives as inhibitors of receptor tyrosine kinases
|
PL1687305T3
(pl)
|
2003-11-21 |
2008-12-31 |
Novartis Ag |
Pochodne 1H-imidazochinolin jako inhibitory kinaz białkowych
|
TW200529849A
(en)
|
2003-11-28 |
2005-09-16 |
Novartis Ag |
Diaryl urea derivatives in the treatment of protein kinase dependent diseases
|
MXPA06007017A
(es)
*
|
2003-12-18 |
2006-08-31 |
Janssen Pharmaceutica Nv |
Derivados de pirido y pirimidopirimidina como agentes antiproliferativos.
|
JP5138938B2
(ja)
|
2003-12-19 |
2013-02-06 |
プレキシコン インコーポレーテッド |
Ret調節剤の開発のための化合物および方法
|
GB0330043D0
(en)
|
2003-12-24 |
2004-01-28 |
Pharmacia Italia Spa |
Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions comprising them
|
GB0330042D0
(en)
|
2003-12-24 |
2004-01-28 |
Pharmacia Italia Spa |
Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions them
|
US20050222171A1
(en)
|
2004-01-22 |
2005-10-06 |
Guido Bold |
Organic compounds
|
PE20051089A1
(es)
|
2004-01-22 |
2006-01-25 |
Novartis Ag |
Derivados de pirazolo [1,5-a] pirimidin-7-il-amina como inhibidores de quinasa de proteina
|
WO2005099363A2
(en)
|
2004-03-26 |
2005-10-27 |
Whitehead Institute For Biomedical Research |
Methods of diagnosing, preventing and treating cancer metastasis
|
UA91677C2
(ru)
*
|
2004-03-30 |
2010-08-25 |
Интермюн, Инк. |
Макроциклические соединения как ингибиторы вирусной репликации
|
US8709296B2
(en)
|
2004-06-25 |
2014-04-29 |
Mitsubishi Materials Corporation |
Metal colloidal particles, metal colloid and use of metal colloid
|
BRPI0514094A
(pt)
|
2004-08-02 |
2008-05-27 |
Osi Pharm Inc |
composto, composição, e, método de tratamento de distúrbio hiperproliferativo
|
PE20060664A1
(es)
|
2004-09-15 |
2006-08-04 |
Novartis Ag |
Amidas biciclicas como inhibidores de cinasa
|
WO2007011410A1
(en)
|
2004-10-29 |
2007-01-25 |
North Carolina State University |
Production of an asporogenic strain of bacillus licheniformis and its use for the production of keratinase
|
WO2006050076A1
(en)
|
2004-10-29 |
2006-05-11 |
Janssen Pharmaceutica, N.V. |
Pyrimidinyl substituted fused-pyrrolyl compounds useful in treating kinase disorders
|
US7452847B2
(en)
|
2004-11-02 |
2008-11-18 |
Ricoh Company, Ltd. |
Reversible thermosensitive recording medium, reversible thermosensitive recording label, reversible thermosensitive recording device, image processing apparatus, and image processing method
|
US7528138B2
(en)
|
2004-11-04 |
2009-05-05 |
Vertex Pharmaceuticals Incorporated |
Pyrazolo[1,5-a]pyrimidines useful as inhibitors of protein kinases
|
JO3088B1
(ar)
*
|
2004-12-08 |
2017-03-15 |
Janssen Pharmaceutica Nv |
مشتقات كوينازولين كبيرة الحلقات و استعمالها بصفتها موانع كينيز متعددة الاهداف
|
DE102005003687A1
(de)
|
2005-01-26 |
2006-07-27 |
Sphingo Tec Gmbh |
Immunoassay zur Bestimmung der Freisetzung von Neurotensin in die Zirkulation
|
GB0501999D0
(en)
|
2005-02-01 |
2005-03-09 |
Sentinel Oncology Ltd |
Pharmaceutical compounds
|
CN101119996A
(zh)
|
2005-02-16 |
2008-02-06 |
阿斯利康(瑞典)有限公司 |
化学化合物
|
BRPI0608160A2
(pt)
|
2005-02-16 |
2010-11-09 |
Astrazeneca Ab |
anticorpo isolado, célula hospedeira, método de inibir o crescimento de células psma+, e, uso de um anticorpo anti-psma defucosilado
|
WO2006089298A2
(en)
|
2005-02-18 |
2006-08-24 |
Attenuon, Llc |
Pyrimidine-fused diazepine derivatives and indole-fused pteridines
|
EP1869049B1
(en)
|
2005-03-21 |
2009-03-04 |
Eli Lilly And Company |
Imidazopyridazine compounds
|
GB0507575D0
(en)
|
2005-04-14 |
2005-05-18 |
Novartis Ag |
Organic compounds
|
US7402579B2
(en)
|
2005-04-15 |
2008-07-22 |
Cylene Pharmaceuticals, Inc. |
Quinobenzoxazine analogs and compositions
|
EP1877057A1
(en)
|
2005-04-27 |
2008-01-16 |
AstraZeneca AB |
Use of pyrazolyl-pyrimidine derivatives in the treatment of pain
|
EP1899323A2
(en)
|
2005-05-16 |
2008-03-19 |
AstraZeneca AB |
Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors
|
US20100047777A1
(en)
|
2005-05-26 |
2010-02-25 |
The Johns Hopkins University |
Methods for identifying mutations in coding and non-coding dna
|
JP2008542382A
(ja)
|
2005-05-31 |
2008-11-27 |
ザ ファール ファミリー トラスト (デイティド 9 ジュライ 1996) |
癌および他の疾患の処置用プロテインキナーゼ阻害剤としての置換ビアリール複素環誘導体
|
US7541367B2
(en)
|
2005-05-31 |
2009-06-02 |
Janssen Pharmaceutica, N.V. |
3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders
|
CN100406650C
(zh)
|
2005-06-05 |
2008-07-30 |
徐斌 |
一种抗特大变位的模块式梳型桥梁伸缩缝装置
|
ITRM20050290A1
(it)
|
2005-06-07 |
2006-12-08 |
Lay Line Genomics Spa |
Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato.
|
ES2371397T3
(es)
|
2005-06-22 |
2011-12-30 |
Plexxikon, Inc. |
Derivados de pirrolo[2,3-b]piridina como inhibidores de proteínas cinasas.
|
US20070025540A1
(en)
|
2005-07-07 |
2007-02-01 |
Roger Travis |
Call center routing based on talkativeness
|
GB0515026D0
(en)
|
2005-07-21 |
2005-08-31 |
Novartis Ag |
Organic compounds
|
JP5249028B2
(ja)
*
|
2005-07-25 |
2013-07-31 |
インターミューン・インコーポレーテッド |
C型肝炎ウイルス複製の新規大環状阻害剤
|
US20100216798A1
(en)
|
2005-07-29 |
2010-08-26 |
Astellas Pharma Inc |
Fused heterocycles as lck inhibitors
|
CN101232871A
(zh)
|
2005-08-03 |
2008-07-30 |
伊士曼化工公司 |
生育酚聚乙二醇琥珀酸酯粉末及其制备方法
|
EP1926734A1
(en)
|
2005-08-22 |
2008-06-04 |
Amgen Inc. |
Pyrazolopyridine and pyrazolopyrimidine compounds useful as kinase enzymes modulators
|
WO2007025090A2
(en)
|
2005-08-25 |
2007-03-01 |
Kalypsys, Inc. |
Heterobicyclic and - tricyclic inhibitors of mapk/erk kinase
|
EA017318B1
(ru)
|
2005-08-25 |
2012-11-30 |
Креабилис Терапеутикс С.П.А. |
Полимерные конъюгаты индолокарбазола и его производных
|
DE102005042742A1
(de)
|
2005-09-02 |
2007-03-08 |
Schering Ag |
Substituierte Imidazo[1,2b]pyridazine als Kinase-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel
|
US20070078136A1
(en)
|
2005-09-22 |
2007-04-05 |
Bristol-Myers Squibb Company |
Fused heterocyclic compounds useful as kinase modulators
|
JP5152922B2
(ja)
|
2005-10-06 |
2013-02-27 |
メルク・シャープ・アンド・ドーム・コーポレーション |
プロテインキナーゼを阻害するためのピラゾロ[1,5−a]ピリミジン誘導体の使用およびプロテインキナーゼを阻害する方法
|
US7645762B2
(en)
|
2005-10-06 |
2010-01-12 |
Schering Corporation |
Substituted pyrazolo[1,5-a] pyrimidines as protein kinase inhibitors
|
DK1999129T3
(da)
*
|
2005-10-11 |
2011-02-07 |
Intermune Inc |
Forbindelser og fremgangsmåder til inhibering af replikationen af hepatitis C-virus
|
WO2007057782A2
(en)
|
2005-10-11 |
2007-05-24 |
Centre National De La Recherche Scientifique (Cnrs) |
3 -hydroxyflavone derivatives for the detection and the quantification of cell apoptosis
|
JP5376950B2
(ja)
|
2005-10-21 |
2013-12-25 |
エクセリクシス, インク. |
カゼインキナーゼii(ck2)モジュレーターとしてのピリミジオン類
|
CA2628474A1
(en)
|
2005-11-03 |
2007-05-10 |
Sgx Pharmaceuticals, Inc. |
Pyrimidinyl-thiophene kinase modulators
|
EP1785420A1
(en)
|
2005-11-14 |
2007-05-16 |
4Sc Ag |
Thiazole analogues and uses thereof
|
US20070149523A1
(en)
|
2005-11-14 |
2007-06-28 |
Jan Ehlert |
Thiazole Analogues and Uses Thereof
|
WO2007057397A1
(en)
|
2005-11-15 |
2007-05-24 |
Boehringer Ingelheim International Gmbh |
Treatment of cancer
|
GB0524436D0
(en)
|
2005-11-30 |
2006-01-11 |
Novartis Ag |
Organic compounds
|
EP1963316A2
(en)
|
2005-12-08 |
2008-09-03 |
Novartis AG |
Pyrazolo[1,5-a]pyridine-3-carboxylic acids as ephb and vegfr2 kinase inhibitors
|
WO2007084815A2
(en)
|
2006-01-19 |
2007-07-26 |
Janssen Pharmaceutica, N.V. |
Substituted thienopyrimidine kinase inhibitors
|
KR101452520B1
(ko)
|
2006-01-27 |
2014-10-21 |
샹하이 헨그루이 파마수티컬 컴퍼니 리미티드 |
피롤로[3,2-c]피리딘-4-온 2-인돌린온 단백질 키나제 억제제
|
KR100846988B1
(ko)
|
2006-03-06 |
2008-07-16 |
제일약품주식회사 |
신규한 티에노피리미딘 유도체 또는 이의 약학적으로허용가능한 염, 이의 제조방법 및 이를 함유하는 약학조성물
|
CA2645137A1
(en)
|
2006-03-07 |
2007-09-13 |
James F. Blake |
Heterobicyclic pyrazole compounds and methods of use
|
CA2644356A1
(en)
|
2006-03-16 |
2007-09-27 |
Novartis Ag |
Heterocyclic organic compounds for the treatment of in particular melanoma
|
KR101449057B1
(ko)
|
2006-03-17 |
2014-10-10 |
암비트 바이오사이언시즈 코포레이션 |
질환 치료용 이미다졸로티아졸 화합물
|
GB0606805D0
(en)
|
2006-04-04 |
2006-05-17 |
Novartis Ag |
Organic compounds
|
NZ572812A
(en)
|
2006-04-26 |
2010-09-30 |
Hoffmann La Roche |
THIENO [3, 2-D] PYRIMIDINE Indazole DERIVATIVE USEFUL AS PI3K INHIBITOR
|
CN101460175A
(zh)
|
2006-05-15 |
2009-06-17 |
Irm责任有限公司 |
用于fgf受体激酶抑制剂的组合物和方法
|
US7389632B2
(en)
|
2006-06-10 |
2008-06-24 |
Uhlmann Pac-Systeme Gmbh & Co. Kg |
Apparatus for distributing small objects in a fill station
|
EP1873157A1
(en)
*
|
2006-06-21 |
2008-01-02 |
Bayer Schering Pharma Aktiengesellschaft |
Pyrazolopyrimidines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
|
TW201345908A
(zh)
|
2006-07-05 |
2013-11-16 |
Mitsubishi Tanabe Pharma Corp |
吡唑并〔1,5-a〕嘧啶化合物
|
EP2058309A4
(en)
|
2006-08-04 |
2010-12-22 |
Takeda Pharmaceutical |
CONDENSED HETEROCYCLIC COMPOUND
|
US7531539B2
(en)
|
2006-08-09 |
2009-05-12 |
Bristol-Myers Squibb Company |
Pyrrolotriazine kinase inhibitors
|
US8063225B2
(en)
|
2006-08-14 |
2011-11-22 |
Chembridge Corporation |
Tricyclic compound derivatives useful in the treatment of neoplastic diseases, inflammatory disorders and immunomodulatory disorders
|
EP2063962A2
(en)
|
2006-09-07 |
2009-06-03 |
Biogen Idec MA Inc. |
Irak modulators for treating an inflammatory condition, cell proliferative disorder, immune disorder
|
WO2008031551A2
(en)
|
2006-09-12 |
2008-03-20 |
Novartis Forschungsstiftung, Zweigniederlassung |
Non-neuroendocrine cancer therapy
|
JP5568304B2
(ja)
|
2006-09-15 |
2014-08-06 |
タイロジェネクス,インコーポレイテッド |
キナーゼ阻害剤化合物
|
US20090286779A1
(en)
|
2006-09-29 |
2009-11-19 |
Novartis Ag |
Pyrazolopyrimidines as lipid kinase inhibitors
|
US20120225057A1
(en)
|
2006-10-11 |
2012-09-06 |
Deciphera Pharmaceuticals, Llc |
Methods and compositions for the treatment of myeloproliferative diseases and other proliferative diseases
|
EP1918291A1
(en)
|
2006-10-30 |
2008-05-07 |
Novartis AG |
3-Aminocarbonyl-substituted fused pyrazolo-derivatives as protein kinase modulators
|
RU2009120389A
(ru)
|
2006-10-30 |
2010-12-10 |
Новартис АГ (CH) |
Гетероциклические соединения в качестве противовоспалительных агентов
|
CN101600718B
(zh)
|
2006-11-06 |
2013-07-03 |
特雷罗药物股份有限公司 |
咪唑并[1,2-b]哒嗪和吡唑并[1,5-a]嘧啶衍生物及其作为蛋白激酶抑制剂的用途
|
PL2848610T3
(pl)
|
2006-11-15 |
2018-01-31 |
Ym Biosciences Australia Pty |
Inhibitory aktywności kinazy
|
US20080199426A1
(en)
|
2007-01-11 |
2008-08-21 |
Sukhatme Vikas P |
Methods and compositions for the treatment and diagnosis of vascular inflammatory disorders or endothelial cell disorders
|
EP2114403A2
(en)
|
2007-01-19 |
2009-11-11 |
Bayer Healthcare, LLC |
Treatment of cancers having resistance to chemotherapeutic agents
|
RU2481340C2
(ru)
*
|
2007-02-08 |
2013-05-10 |
Тиботек Фармасьютикалз Лтд. |
Пиримидин-замещенные макроциклические ингибиторы hcv
|
US20080234267A1
(en)
|
2007-03-20 |
2008-09-25 |
Karen Elizabeth Lackey |
Compounds and Methods of Treatment
|
US20080234262A1
(en)
|
2007-03-21 |
2008-09-25 |
Wyeth |
Pyrazolopyrimidine analogs and their use as mtor kinase and pi3 kinase inhibitors
|
WO2008116898A1
(en)
|
2007-03-28 |
2008-10-02 |
Biovitrum Ab (Publ) |
Pyrazolo [1,5-a]pyrimidines as inhibitors of stearoyl-coa desaturase
|
CN103214482B
(zh)
|
2007-04-03 |
2016-06-29 |
阵列生物制药公司 |
作为受体酪氨酸激酶抑制剂的咪唑并[1,2-a]吡啶化合物
|
US20110189167A1
(en)
|
2007-04-20 |
2011-08-04 |
Flynn Daniel L |
Methods and Compositions for the Treatment of Myeloproliferative Diseases and other Proliferative Diseases
|
JP5160637B2
(ja)
|
2007-05-04 |
2013-03-13 |
アイアールエム・リミテッド・ライアビリティ・カンパニー |
c−kitおよびPDGFRキナーゼインヒビターとしての化合物および組成物
|
WO2008138184A1
(fr)
|
2007-05-14 |
2008-11-20 |
Shanghai Hengrui Pharmaceutical Co.Ltd. |
Dérivés de pyrrolo-azacycles, leur procédé de fabrication et leur utilisation en tant qu'inhibiteurs de protéine kinases
|
EP2170827B1
(en)
*
|
2007-06-21 |
2013-08-14 |
Janssen Pharmaceutica, N.V. |
Indolin-2-ones and aza-indolin-2-ones
|
WO2009003136A1
(en)
|
2007-06-26 |
2008-12-31 |
Rigel Pharmaceuticals, Inc. |
Substituted pyrimidine-2, 4 -diamines for treating cell proliferative disorders
|
WO2009012262A1
(en)
|
2007-07-16 |
2009-01-22 |
The Regents Of The University Of California |
Protein kinase modulating compounds and methods for making and using them
|
CN103923072B
(zh)
|
2007-07-20 |
2017-05-31 |
内尔维阿诺医学科学有限公司 |
作为具有激酶抑制剂活性的取代的吲唑衍生物
|
WO2009021137A2
(en)
|
2007-08-07 |
2009-02-12 |
Purdue Research Foundation |
Kinase inhibitors and uses thereof
|
CA2695997C
(en)
|
2007-08-10 |
2016-11-22 |
Regeneron Pharmaceuticals, Inc. |
High affinity human antibodies to human nerve growth factor
|
EP2025678A1
(en)
|
2007-08-17 |
2009-02-18 |
Oncalis AG |
Pyrazolo[3,4-d]pyrimidine compounds and their use as modulators of protein kinase
|
WO2009042646A1
(en)
|
2007-09-24 |
2009-04-02 |
Curis, Inc. |
Anti-proliferative agents
|
CN101883774A
(zh)
|
2007-10-16 |
2010-11-10 |
惠氏有限责任公司 |
噻吩并嘧啶和吡唑并嘧啶化合物及其用作mtor激酶和pi3激酶抑制剂的用途
|
EP2214706A1
(en)
|
2007-10-23 |
2010-08-11 |
Novartis AG |
Use of trkb antibodies for the treatment of respiratory disorders
|
WO2009060197A1
(en)
|
2007-11-08 |
2009-05-14 |
Centro Nacional De Investigaciones Oncologicas (Cnio) |
Imidazopyridazines for use as protein kinase inhibitors
|
WO2009070567A1
(en)
|
2007-11-28 |
2009-06-04 |
Schering Corporation |
2-fluoropyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
|
JP5420568B2
(ja)
|
2008-01-17 |
2014-02-19 |
アイアールエム・リミテッド・ライアビリティ・カンパニー |
改良された抗TrkB抗体
|
TW200938542A
(en)
|
2008-02-01 |
2009-09-16 |
Irm Llc |
Compounds and compositions as kinase inhibitors
|
US20090209496A1
(en)
|
2008-02-15 |
2009-08-20 |
David Chaplin |
Methods and compositions for enhancing the efficacy of rtk inhibitors
|
AU2009226153B2
(en)
|
2008-03-19 |
2014-02-20 |
Chembridge Corporation |
Novel tyrosine kinase inhibitors
|
EP2300469B1
(en)
|
2008-05-13 |
2015-06-24 |
Novartis AG |
Fused nitrogen containing heterocycles and compositions thereof as kinase inhibitors
|
WO2009155527A2
(en)
|
2008-06-19 |
2009-12-23 |
Progenics Pharmaceuticals, Inc. |
Phosphatidylinositol 3 kinase inhibitors
|
US8629135B2
(en)
|
2008-07-14 |
2014-01-14 |
Queen's University At Kingston |
Pharmaceutical compositions comprising RET inhibitors and methods for the treatment of cancer
|
JP5677296B2
(ja)
|
2008-07-29 |
2015-02-25 |
ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ |
グリオーマの治療のためのcdk阻害剤の使用
|
US20100075916A1
(en)
|
2008-09-05 |
2010-03-25 |
Auspex Pharmaceuticals, Inc. |
Substituted quinazoline inhibitors of growth factor receptor tyrosine kinases
|
EP2161271A1
(en)
|
2008-09-08 |
2010-03-10 |
Università Degli Studi Di Milano - Bicocca |
Alpha-carboline inhibitors of NMP-ALK, RET, and Bcr-Abl
|
US8450322B2
(en)
|
2008-09-22 |
2013-05-28 |
Array Biopharma Inc. |
Substituted imidazo[1,2b]pyridazine compounds as Trk kinase inhibitors
|
ES2435918T3
(es)
|
2008-09-26 |
2013-12-26 |
National Health Research Institutes |
Compuestos multicíclicos condensados como inhibidores de las proteína-cinasas
|
EP3372605B1
(en)
*
|
2008-10-22 |
2021-11-03 |
Array Biopharma, Inc. |
Substituted pyrazolo[1,5-a]pyrimidine compounds as trk kinase inhibitors
|
ES2545541T3
(es)
|
2008-10-31 |
2015-09-11 |
Genentech, Inc. |
Compuestos de pirazolopirimidina inhibidores de JAK y métodos
|
US8551963B2
(en)
|
2008-11-06 |
2013-10-08 |
Ambit Biosciences Corporation |
Imidazolothiazole compounds and methods of use thereof
|
JP2012509859A
(ja)
|
2008-11-24 |
2012-04-26 |
ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ |
中皮腫の治療のためのcdk阻害物質
|
KR101061599B1
(ko)
|
2008-12-05 |
2011-09-02 |
한국과학기술연구원 |
비정상 세포 성장 질환의 치료를 위한 단백질 키나아제 저해제인 신규 인다졸 유도체, 이의 약학적으로 허용가능한염 및 이를 유효성분으로 함유하는 약학적 조성물
|
PT2881402T
(pt)
|
2009-02-12 |
2017-08-23 |
Cell Signaling Technology Inc |
Expressão de ros mutante em cancro de fígado humano
|
TWI410418B
(zh)
|
2009-04-29 |
2013-10-01 |
Ind Tech Res Inst |
氮雜薁化合物、藥學組合物與抑制一細胞中蛋白質激酶之活性的方法
|
NO3009428T3
(es)
|
2009-05-08 |
2018-07-21 |
|
|
WO2010144909A1
(en)
|
2009-06-12 |
2010-12-16 |
Novartis Ag |
Fused heterocyclic compounds and their uses
|
AR077468A1
(es)
|
2009-07-09 |
2011-08-31 |
Array Biopharma Inc |
Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
|
KR101256018B1
(ko)
|
2009-08-20 |
2013-04-18 |
한국과학기술연구원 |
단백질 키나아제 저해활성을 갖는 1,3,6-치환된 인돌 화합물
|
KR101147550B1
(ko)
|
2009-10-22 |
2012-05-17 |
한국과학기술연구원 |
단백질 키나아제 저해활성을 가지는 2,7-치환된 티에노[3,2-d]피리미딘 화합물
|
KR101116756B1
(ko)
|
2009-10-27 |
2012-03-13 |
한국과학기술연구원 |
단백질 키나아제 저해활성을 갖는 신규의 1,6-치환된 인돌 화합물
|
EP2493313B1
(en)
|
2009-10-29 |
2017-12-13 |
Genosco |
Kinase inhibitors
|
MX2012005332A
(es)
|
2009-11-13 |
2012-10-15 |
Oscotec Inc |
Inhibidores de cinasa.
|
KR101094446B1
(ko)
|
2009-11-19 |
2011-12-15 |
한국과학기술연구원 |
단백질 키나아제 저해활성을 가지는 2,4,7-치환된 티에노[3,2-d]피리미딘 화합물
|
US9180127B2
(en)
|
2009-12-29 |
2015-11-10 |
Dana-Farber Cancer Institute, Inc. |
Type II Raf kinase inhibitors
|
KR101347303B1
(ko)
|
2010-01-29 |
2014-01-06 |
한미사이언스 주식회사 |
단백질 키나아제 저해활성을 갖는 티에노[3,2-d]피리미딘 유도체
|
KR101483215B1
(ko)
|
2010-01-29 |
2015-01-16 |
한미약품 주식회사 |
단백질 키나아제 저해활성을 갖는 비시클릭 헤테로아릴 유도체
|
WO2011101408A1
(en)
|
2010-02-18 |
2011-08-25 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Method for preventing cancer metastasis
|
JP2013526852A
(ja)
|
2010-04-06 |
2013-06-27 |
カリス ライフ サイエンシズ ルクセンブルク ホールディングス |
疾患に対する循環バイオマーカー
|
US8383793B2
(en)
|
2010-04-15 |
2013-02-26 |
St. Jude Children's Research Hospital |
Methods and compositions for the diagnosis and treatment of cancer resistant to anaplastic lymphoma kinase (ALK) kinase inhibitors
|
TWI619713B
(zh)
|
2010-04-21 |
2018-04-01 |
普雷辛肯公司 |
用於激酶調節的化合物和方法及其適應症
|
US8543395B2
(en)
|
2010-05-18 |
2013-09-24 |
Shazam Entertainment Ltd. |
Methods and systems for performing synchronization of audio with corresponding textual transcriptions and determining confidence values of the synchronization
|
RU2594742C2
(ru)
|
2010-05-20 |
2016-08-20 |
Эррэй Биофарма Инк. |
Макроциклические соединения в качестве ингибиторов киназы trk
|
PT3333188T
(pt)
|
2010-08-19 |
2022-03-28 |
Zoetis Belgium S A |
Anticorpos de anti-ngf e a sua utilização
|
US8637516B2
(en)
|
2010-09-09 |
2014-01-28 |
Irm Llc |
Compounds and compositions as TRK inhibitors
|
WO2012034095A1
(en)
|
2010-09-09 |
2012-03-15 |
Irm Llc |
Compounds and compositions as trk inhibitors
|
WO2012037155A2
(en)
|
2010-09-13 |
2012-03-22 |
Gtx, Inc. |
Tyrosine kinase inhibitors
|
WO2012047017A2
(ko)
|
2010-10-05 |
2012-04-12 |
크리스탈지노믹스(주) |
2,3-디히드로-이소인돌-1-온 유도체 및 이를 포함하는 조성물
|
WO2012075340A2
(en)
|
2010-12-01 |
2012-06-07 |
Alderbio Holdings Llc |
Anti-ngf compositions and use thereof
|
US8618146B2
(en)
|
2011-01-03 |
2013-12-31 |
Dr. Reddy's Laboratories Limited |
Epothilone compound formulations
|
CN102093421B
(zh)
|
2011-01-28 |
2014-07-02 |
北京康辰药业有限公司 |
一种含磷取代基的喹啉类化合物及其制备方法、以及含有该化合物的药物组合物及其应用
|
WO2012116217A1
(en)
|
2011-02-25 |
2012-08-30 |
Irm Llc |
Compounds and compositions as trk inhibitors
|
WO2012135631A1
(en)
|
2011-03-30 |
2012-10-04 |
Arrien Pharmaeuticals Llc |
Substituted 5-(pyrazin-2-yl)-1h-pyrazolo [3, 4-b] pyridine and pyrazolo [3, 4-b] pyridine derivatives as protein kinase inhibitors
|
EP2693881B1
(en)
|
2011-04-01 |
2019-09-04 |
University of Utah Research Foundation |
Substituted n-phenylpyrimidin-2-amine analogs as inhibitors of the axl kinase
|
CN105130967B
(zh)
|
2011-05-13 |
2018-04-17 |
阵列生物制药公司 |
作为trka激酶抑制剂的吡咯烷基脲和吡咯烷基硫脲化合物
|
RU2477723C2
(ru)
|
2011-06-16 |
2013-03-20 |
Общество С Ограниченной Ответственностью "Фьюжн Фарма" |
Ингибиторы протеинкиназ (варианты), их применение для лечения онкологических заболеваний и фармацевтическая композиция на их основе
|
WO2013016720A2
(en)
|
2011-07-28 |
2013-01-31 |
Gerinda Therapeutics, Inc. |
Novel substituted biarylheterocycle derivatives as protein kinase inhibitors for the treatment of cancer and other diseases
|
US9216172B2
(en)
|
2011-08-04 |
2015-12-22 |
National Cancer Center |
Method for determining effectiveness of cancer treatment by assessing the presence of a KIF5B-RET chimeric gene
|
ES2704126T3
(es)
|
2011-08-23 |
2019-03-14 |
Found Medicine Inc |
Moléculas de fusión KIF5B-RET y usos de las mismas
|
MX370814B
(es)
|
2011-09-02 |
2020-01-08 |
Univ California |
Pirazolo[3,4-d]pirimidinas sustituidas y usos de las mismas.
|
WO2013036232A2
(en)
|
2011-09-08 |
2013-03-14 |
Deciphera Pharmaceuticals, Llc |
Methods and compositions for the treatment of myeloproliferative diseases and other proliferative diseases
|
WO2013042137A1
(en)
|
2011-09-19 |
2013-03-28 |
Aurigene Discovery Technologies Limited |
Bicyclic heterocycles as irak4 inhibitors
|
CN102408411B
(zh)
|
2011-09-19 |
2014-10-22 |
北京康辰药业股份有限公司 |
一种含喹啉基的羟肟酸类化合物及其制备方法、以及含有该化合物的药物组合物及其应用
|
WO2013059740A1
(en)
|
2011-10-21 |
2013-04-25 |
Foundation Medicine, Inc. |
Novel alk and ntrk1 fusion molecules and uses thereof
|
AU2012339753A1
(en)
|
2011-11-14 |
2014-06-19 |
Tesaro, Inc. |
Modulating certain tyrosine kinases
|
KR101849143B1
(ko)
|
2011-12-12 |
2018-04-16 |
닥터 레디스 레보러터리즈 리미티드 |
트로포미오신 수용체 키나제(Trk) 억제제인 치환된 피라졸로[1,5-a]피리딘
|
MY170988A
(en)
|
2011-12-30 |
2019-09-23 |
Hanmi Pharm Ind Co Ltd |
Thieno[3,2-d]pyrimidine derivatives having inhibitory activity for protein kinases
|
JP2015109806A
(ja)
|
2012-03-22 |
2015-06-18 |
アステラス製薬株式会社 |
新規ret融合体の検出法
|
JP6160613B2
(ja)
|
2012-04-26 |
2017-07-12 |
小野薬品工業株式会社 |
Trk阻害化合物
|
US20150099721A1
(en)
|
2012-05-10 |
2015-04-09 |
Synta Pharmaceuticals Corp. |
Treating cancer with hsp90 inhibitory compounds
|
CA2873979C
(en)
|
2012-05-23 |
2019-11-12 |
Nerviano Medical Sciences S.R.L. |
Process for the preparation of n-[5-(3,5-difluoro-benzyl)-1h-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide
|
TWI585088B
(zh)
|
2012-06-04 |
2017-06-01 |
第一三共股份有限公司 |
作爲激酶抑制劑之咪唑并[1,2-b]嗒衍生物
|
JPWO2014017491A1
(ja)
|
2012-07-26 |
2016-07-11 |
国立研究開発法人国立がん研究センター |
Cep55遺伝子とret遺伝子との融合遺伝子
|
EP2689778A1
(en)
|
2012-07-27 |
2014-01-29 |
Pierre Fabre Medicament |
Derivatives of azaindoles or diazaindoles for treating pain
|
US20150218652A1
(en)
|
2012-08-31 |
2015-08-06 |
The Regents Of The Unversity Of Colorado, A Body Corporate |
Methods for diagnosis and treatment of cancer
|
US20140121239A1
(en)
|
2012-09-07 |
2014-05-01 |
Exelixis, Inc. |
Method of treating lung adenocarcinoma
|
US20140084039A1
(en)
|
2012-09-24 |
2014-03-27 |
Electro Scientific Industries, Inc. |
Method and apparatus for separating workpieces
|
CA2885722C
(en)
|
2012-09-25 |
2020-06-02 |
Chugai Seiyaku Kabushiki Kaisha |
Ret inhibitor
|
JP2014082984A
(ja)
|
2012-10-23 |
2014-05-12 |
Astellas Pharma Inc |
新規ntrk2活性化変異の検出法
|
EP2917214B1
(en)
|
2012-11-07 |
2019-08-28 |
Nerviano Medical Sciences S.r.l. |
Substituted pyrimidinyl and pyridinyl-pyrrolopyridinones, process for their preparation and their use as kinase inhibitors
|
TWI598341B
(zh)
|
2012-11-12 |
2017-09-11 |
伊格尼塔公司 |
苯達莫司汀衍生物及其使用方法
|
US9822118B2
(en)
|
2012-11-13 |
2017-11-21 |
Array Biopharma Inc. |
Bicyclic heteroaryl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
|
WO2014078322A1
(en)
|
2012-11-13 |
2014-05-22 |
Array Biopharma Inc. |
Thiazolyl and oxazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
|
US9809578B2
(en)
|
2012-11-13 |
2017-11-07 |
Array Biopharma Inc. |
Pyrazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trkA kinase inhibitors
|
WO2014078372A1
(en)
|
2012-11-13 |
2014-05-22 |
Array Biopharma Inc. |
Pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
|
UA117573C2
(uk)
|
2012-11-13 |
2018-08-27 |
Ерей Біофарма Інк. |
Біциклічні сполуки сечовини, тіосечовини, гуанідину й ціаногуанідину, придатні для лікування болю
|
WO2014078331A1
(en)
|
2012-11-13 |
2014-05-22 |
Array Biopharma Inc. |
N-(arylalkyl)-n'-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
|
WO2014078325A1
(en)
|
2012-11-13 |
2014-05-22 |
Array Biopharma Inc. |
N-(monocyclic aryl),n'-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
|
RS57001B1
(sr)
|
2012-11-13 |
2018-05-31 |
Array Biopharma Inc |
Jedinjenja n-pirolidinil, n'-pirazolil- uree, tiouree, guanidina i cijanoguanidina kao inhibitori trka kinaze
|
WO2014078328A1
(en)
|
2012-11-13 |
2014-05-22 |
Array Biopharma Inc. |
N-bicyclic aryl,n'-pyrazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
|
WO2014083567A2
(en)
|
2012-11-29 |
2014-06-05 |
Yeda Research And Development Co. Ltd. |
Methods of preventing tumor metastasis, treating and prognosing cancer and identifying agents which are putative metastasis inhibitors
|
CN103848785B
(zh)
|
2012-12-04 |
2016-07-13 |
上海医药集团股份有限公司 |
一类氘代3-氰基喹啉类化合物、其药用组合物、制备方法及其用途
|
FR3000494B1
(fr)
|
2012-12-28 |
2015-08-21 |
Oribase Pharma |
Nouveaux derives d'azaindoles en tant qu'inhibiteurs de proteines kinases
|
AU2013371146C1
(en)
|
2012-12-28 |
2019-01-17 |
Crystalgenomics, Inc. |
2,3-dihydro-isoindole-1-on derivative as BTK kinase suppressant, and pharmaceutical composition including same
|
FR3000493A1
(fr)
|
2012-12-28 |
2014-07-04 |
Oribase Pharma |
Nouveaux inhibiteurs de proteines kinases
|
FR3000492B1
(fr)
|
2012-12-28 |
2015-09-11 |
Oribase Pharma |
Nouveaux derives azaindole en tant qu'inhibiteurs multikinases
|
US9127055B2
(en)
|
2013-02-08 |
2015-09-08 |
Astellas Pharma Inc. |
Method of treating pain with anti-human NGF antibody
|
US9463192B2
(en)
|
2013-02-19 |
2016-10-11 |
Ono Pharmaceutical Co., Ltd. |
Trk-inhibiting compound
|
WO2014130975A1
(en)
|
2013-02-22 |
2014-08-28 |
Bastian Boris C |
Fusion polynucleotides and fusion polypeptides associated with cancer and particularly melanoma and their uses as therapeutic and diagnostic targets
|
US20140243332A1
(en)
|
2013-02-27 |
2014-08-28 |
Oregon Health & Science University |
Methods of treating cancers characterized by aberrent ros1 activity
|
EP2971152B1
(en)
|
2013-03-15 |
2018-08-01 |
The Board Of Trustees Of The Leland Stanford Junior University |
Identification and use of circulating nucleic acid tumor markers
|
WO2014152777A2
(en)
|
2013-03-15 |
2014-09-25 |
Insight Genetics, Inc. |
Methods and compositions for the diagnosis and treatment of cancers resistant to ros1 inhibitors
|
KR20150129847A
(ko)
|
2013-03-15 |
2015-11-20 |
더 트러스티스 오브 컬럼비아 유니버시티 인 더 시티 오브 뉴욕 |
융합 단백질 및 이들의 방법
|
CN105051027A
(zh)
|
2013-03-15 |
2015-11-11 |
葛兰素史密斯克莱知识产权发展有限公司 |
作为转染期间重排(ret)激酶抑制剂的吡啶衍生物
|
MA38394B1
(fr)
|
2013-03-15 |
2018-04-30 |
Glaxosmithkline Ip Dev Ltd |
Dérivés pyridine utilisés comme inhibiteurs de la kinase réarrangée au cours de la transfection (ret)
|
JP2016518123A
(ja)
|
2013-04-17 |
2016-06-23 |
ライフ テクノロジーズ コーポレーション |
癌に関連付けられる遺伝子融合物及び遺伝子変異型
|
SG11201600055PA
(en)
|
2013-07-11 |
2016-02-26 |
Betta Pharmaceuticals Co Ltd |
Protein tyrosine kinase modulators and methods of use
|
WO2015012397A1
(ja)
|
2013-07-26 |
2015-01-29 |
公益財団法人がん研究会 |
Ntrk3融合体の検出法
|
WO2015017533A1
(en)
|
2013-07-30 |
2015-02-05 |
Blueprint Medicines Corporation |
Ntrk2 fusions
|
JP6493681B2
(ja)
|
2013-08-20 |
2019-04-03 |
学校法人関西医科大学 |
肺がんで見出された新規融合遺伝子
|
EP3039021A1
(en)
|
2013-08-30 |
2016-07-06 |
Ambit Biosciences Corporation |
Biaryl acetamide compounds and methods of use thereof
|
JP6389884B2
(ja)
|
2013-10-24 |
2018-09-12 |
ジョージタウン・ユニバーシティGeorgetown University |
癌を治療するための方法及び組成物
|
WO2015064621A1
(ja)
|
2013-10-29 |
2015-05-07 |
公益財団法人がん研究会 |
新規融合体及びその検出法
|
ES2734213T3
(es)
|
2013-11-27 |
2019-12-04 |
Enplas Corp |
Emisor y tubo para riego por goteo
|
GB201321146D0
(en)
|
2013-11-29 |
2014-01-15 |
Cancer Rec Tech Ltd |
Quinazoline compounds
|
JP6992960B2
(ja)
|
2013-12-02 |
2022-02-03 |
ベルゲンビオ アーエスアー |
キナーゼ阻害剤の用途
|
CA2936079C
(en)
|
2014-01-24 |
2022-07-19 |
Tp Therapeutics, Inc. |
Diaryl macrocycles as modulators of protein kinases
|
PL3102555T3
(pl)
|
2014-02-05 |
2021-12-20 |
VM Oncology LLC |
Kompozycje związków i ich zastosowania
|
KR102354963B1
(ko)
|
2014-02-14 |
2022-01-21 |
엑셀리시스, 인코포레이티드 |
N-{4-[(6,7-다이메톡시퀴놀린-4-일)옥시]페닐}-n'-(4-플루오로페닐) 사이클로프로판-1,1-다이카복스아마이드의 결정질 고체 형태, 제조 방법 및 사용 방법
|
TWI672141B
(zh)
|
2014-02-20 |
2019-09-21 |
美商醫科泰生技 |
投予ros1突變癌細胞之分子
|
ES2746530T3
(es)
|
2014-05-15 |
2020-03-06 |
Array Biopharma Inc |
1-((3S,4R)-4-(3-fluorofenil)-1-(2-metoxietil)pirrolidín-3-il)-3-(4-metil-3-(2-metilpirimidín-5-il)-1-fenil-1H-pirazol-5- il)urea como un inhibidor de TrkA cinasa
|
WO2015183837A1
(en)
|
2014-05-27 |
2015-12-03 |
Brian Haynes |
Compositions, methods, and uses related to ntrk2-tert fusions
|
US20170114415A1
(en)
|
2014-05-30 |
2017-04-27 |
The Regents Of The University Of Colorado, A Body Corporate |
Activating ntrk1 gene fusions predictive of kinase inhibitor therapy
|
CN105222097A
(zh)
|
2014-06-26 |
2016-01-06 |
欧普照明股份有限公司 |
一种灯具及其光学模组
|
DK3169671T3
(da)
|
2014-07-17 |
2019-09-23 |
Sunshine Lake Pharma Co Ltd |
1-(5-(tert.-butyl)isoxazol-3-yl)-3-(4-((phenyl)ethynyl)phenyl)ureaderivater og relaterede forbindelser som flt3-inhibitorer til behandling af kræft
|
CA2955744A1
(en)
|
2014-08-01 |
2016-02-04 |
Pharmacyclics Llc |
Biomarkers for predicting response of dlbcl to treatment with a btk inhibitor
|
TWI560185B
(en)
|
2014-08-18 |
2016-12-01 |
Ono Pharmaceutical Co |
Acid addition salt of trk inhibitor compound
|
EP3191480A1
(en)
|
2014-09-08 |
2017-07-19 |
GlaxoSmithKline Intellectual Property Development Limited |
Crystalline forms of 2-(4-(4-ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fluorophenyl)-n-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)acetamide
|
LT3191450T
(lt)
|
2014-09-10 |
2019-06-10 |
Glaxosmithkline Intellectual Property Development Limited |
Piridono dariniai kaip transfekcijos metu pertvarkyti (ret) kinazės inhibitoriai
|
SG11201701695UA
(en)
|
2014-09-10 |
2017-04-27 |
Glaxosmithkline Ip Dev Ltd |
Novel compounds as rearranged during transfection (ret) inhibitors
|
TWI538914B
(zh)
|
2014-10-03 |
2016-06-21 |
國立交通大學 |
蛋白質激酶之選擇性抑制劑、其醫藥組成物及其用途
|
US9988452B2
(en)
|
2014-10-14 |
2018-06-05 |
Novartis Ag |
Antibody molecules to PD-L1 and uses thereof
|
LT3699181T
(lt)
|
2014-11-16 |
2023-05-10 |
Array Biopharma, Inc. |
Kristalinė (s)-n-(5-((r)-2-(2,5-difluorfenil)-pirolidin-1-il)-pirazolo[1,5-a] pirimidin-3-il)-3 -hidroksipirolidino-1-karboksamido vandenilio sulfato forma
|
RU2708674C2
(ru)
|
2014-12-15 |
2019-12-11 |
СиЭмДжи ФАРМАСЬЮТИКАЛ КО., ЛТД. |
Конденсированные кольцевые гетероарильные соединения и их применение в качестве ингибиторов trk
|
EP3233840B1
(en)
|
2014-12-16 |
2018-11-21 |
Eudendron S.r.l. |
Heterocyclic derivatives modulating activity of certain protein kinases
|
WO2016127074A1
(en)
|
2015-02-06 |
2016-08-11 |
Blueprint Medicines Corporation |
2-(pyridin-3-yl)-pyrimidine derivatives as ret inhibitors
|
KR101675984B1
(ko)
|
2015-02-23 |
2016-11-14 |
한양대학교 에리카산학협력단 |
티에노디아제핀 유도체 또는 이의 약학적으로 허용가능한 염, 및 이를 유효성분으로 포함하는 약학적 조성물
|
WO2016141169A1
(en)
|
2015-03-03 |
2016-09-09 |
Caris Mpi, Inc. |
Molecular profiling for cancer
|
JP2018513508A
(ja)
|
2015-03-16 |
2018-05-24 |
パーソナル ジノーム ダイアグノスティクス, インコーポレイテッド |
核酸を分析するためのシステムおよび方法
|
CN108137593B
(zh)
|
2015-04-21 |
2021-01-05 |
上海交通大学医学院附属瑞金医院 |
蛋白激酶抑制剂的制备和用途
|
IL302102A
(en)
|
2015-05-20 |
2023-06-01 |
Dana Farber Cancer Inst Inc |
shared neoantigens
|
CA2987281A1
(en)
|
2015-05-29 |
2016-12-08 |
Ignyta, Inc. |
Compositions and methods for treating patients with rtk mutant cells
|
JP2018526324A
(ja)
|
2015-06-01 |
2018-09-13 |
ロクソ オンコロジー, インコーポレイテッドLoxo Oncology, Inc. |
がんの診断および処置の方法
|
US9782400B2
(en)
|
2015-06-19 |
2017-10-10 |
Macau University Of Science And Technology |
Oncogenic ROS1 and ALK kinase inhibitor
|
AU2015101722A4
(en)
|
2015-06-19 |
2016-05-19 |
Macau University Of Science And Technology |
Oncogenic ros1 and alk kinase inhibitor
|
GB201511546D0
(en)
|
2015-07-01 |
2015-08-12 |
Immatics Biotechnologies Gmbh |
Novel peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers
|
WO2017004342A1
(en)
|
2015-07-02 |
2017-01-05 |
Tp Therapeutics, Inc. |
Chiral diaryl macrocycles as modulators of protein kinases
|
GB201512365D0
(en)
|
2015-07-15 |
2015-08-19 |
King S College London |
Novel therapy
|
MX2018000577A
(es)
|
2015-07-16 |
2018-09-05 |
Array Biopharma Inc |
Compuestos de pirazolo[1,5-a]piridina sustituidos como inhibidores de la ret quinasa.
|
EP3120851A1
(en)
|
2015-07-21 |
2017-01-25 |
Pangaea Biotech S.L. |
4-amino-6-(2,6-dichlorophenyl)-8-methyl-2-(phenylamino)-pyrido[2,3-d]pyrimidin-7(8h)-one for treatment of solid cancers
|
KR101766194B1
(ko)
|
2015-08-07 |
2017-08-10 |
한국과학기술연구원 |
RET 키나아제 저해제인 신규 3-(이속사졸-3-일)-피라졸로[3,4-d]피리미딘-4-아민 화합물
|
US10550124B2
(en)
|
2015-08-13 |
2020-02-04 |
San Diego State University Foundation |
Atropisomerism for increased kinase inhibitor selectivity
|
MA41559A
(fr)
|
2015-09-08 |
2017-12-26 |
Taiho Pharmaceutical Co Ltd |
Composé de pyrimidine condensé ou un sel de celui-ci
|
WO2017049462A1
(zh)
|
2015-09-22 |
2017-03-30 |
合肥中科普瑞昇生物医药科技有限公司 |
一类新型的flt3激酶抑制剂及其用途
|
CN105255927B
(zh)
|
2015-09-30 |
2018-07-27 |
温州医科大学附属第一医院 |
一种kiaa1217-ret融合基因
|
TN2019000271A1
(en)
|
2015-10-26 |
2021-01-07 |
Univ Colorado Regents |
Point mutations in trk inhibitor-resistant cancer and methods relating to the same
|
EA038890B1
(ru)
|
2015-11-02 |
2021-11-03 |
Блюпринт Медсинс Корпорейшн |
Ингибиторы ret
|
JP2018537980A
(ja)
|
2015-12-08 |
2018-12-27 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
癌治療のための非小細胞肺癌(nsclc)および甲状腺癌患者を選択するためのバイオマーカーとしてret融合遺伝子を使用する方法
|
WO2017122815A1
(ja)
|
2016-01-15 |
2017-07-20 |
公益財団法人がん研究会 |
新規融合体及びその検出法
|
US20170224662A1
(en)
|
2016-01-22 |
2017-08-10 |
The Medicines Company |
Aqueous Formulations and Methods of Preparation and Use Thereof
|
TWI620748B
(zh)
|
2016-02-05 |
2018-04-11 |
National Health Research Institutes |
氨基噻唑化合物及其用途
|
PT3269370T
(pt)
|
2016-02-23 |
2020-03-05 |
Taiho Pharmaceutical Co Ltd |
Novo composto de pirimidina condensada ou sal do mesmo
|
WO2017145050A1
(en)
|
2016-02-23 |
2017-08-31 |
Glaxosmithkline Intellectual Property Development Limited |
Pyridylpyridone derivative useful as a ret kinase inhibitor in the treatment of ibs and cancer
|
JPWO2017155018A1
(ja)
|
2016-03-11 |
2019-01-17 |
小野薬品工業株式会社 |
Trk阻害剤抵抗性の癌治療剤
|
WO2017161269A1
(en)
|
2016-03-17 |
2017-09-21 |
Blueprint Medicines Corporation |
Inhibitors of ret receptor tyrosine kinases
|
US10045991B2
(en)
|
2016-04-04 |
2018-08-14 |
Loxo Oncology, Inc. |
Methods of treating pediatric cancers
|
MA44610A
(fr)
|
2016-04-04 |
2019-02-13 |
Loxo Oncology Inc |
Formulations liquides de (s)-n-(5-((r)-2-(2,5-difluorophényl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
|
WO2017178845A1
(en)
|
2016-04-15 |
2017-10-19 |
Cancer Research Technology Limited |
Heterocyclic compounds as ret kinase inhibitors
|
EP3442980B1
(en)
|
2016-04-15 |
2021-06-09 |
Cancer Research Technology Limited |
Heterocyclic compounds as ret kinase inhibitors
|
EP3445361A1
(en)
|
2016-04-19 |
2019-02-27 |
Exelixis, Inc. |
Triple negative breast cancer treatment method
|
CN109790143A
(zh)
|
2016-05-10 |
2019-05-21 |
C4医药公司 |
用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体
|
HUE053643T2
(hu)
|
2016-05-18 |
2021-07-28 |
Loxo Oncology Inc |
(S)-N-(5 -((R)-2-(2,5-difluor-fenil)-pirrolidin-1-il)-pirazolo[1,5-A] pirimidin-3-il)-3-hidroxi-pirrolidin-1-karboxamid elõkészítése
|
WO2017201156A1
(en)
|
2016-05-18 |
2017-11-23 |
Duke University |
Method of treating kras wild-type metastatic colorectal cell carcinoma using cabozantinib plus panitumumab
|
CN109312406A
(zh)
|
2016-06-01 |
2019-02-05 |
豪夫迈·罗氏有限公司 |
预测肺癌患者中对alk抑制剂疗法的响应的间变性淋巴瘤激酶中的新型突变
|
US10227329B2
(en)
|
2016-07-22 |
2019-03-12 |
Blueprint Medicines Corporation |
Compounds useful for treating disorders related to RET
|
TWI704148B
(zh)
|
2016-10-10 |
2020-09-11 |
美商亞雷生物製藥股份有限公司 |
作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物
|
JOP20190092A1
(ar)
|
2016-10-26 |
2019-04-25 |
Array Biopharma Inc |
عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها
|
CA3049452A1
(en)
|
2017-01-20 |
2018-07-26 |
Gisela Schwab |
Combinations of cabozantinib and atezolizumab to treat cancer
|
CN108456163A
(zh)
|
2017-02-20 |
2018-08-28 |
中国科学院上海药物研究所 |
含邻氨基杂芳环炔基的化合物及其制备方法和用途
|
JOP20190213A1
(ar)
|
2017-03-16 |
2019-09-16 |
Array Biopharma Inc |
مركبات حلقية ضخمة كمثبطات لكيناز ros1
|
MA50456A
(fr)
|
2017-10-26 |
2020-09-02 |
Array Biopharma Inc |
Formulations d'un inhibiteur de kinase trk macrocyclique
|