PL2646448T3 - Makrocykliczne inhibitory kinazy - Google Patents
Makrocykliczne inhibitory kinazyInfo
- Publication number
- PL2646448T3 PL2646448T3 PL11794899T PL11794899T PL2646448T3 PL 2646448 T3 PL2646448 T3 PL 2646448T3 PL 11794899 T PL11794899 T PL 11794899T PL 11794899 T PL11794899 T PL 11794899T PL 2646448 T3 PL2646448 T3 PL 2646448T3
- Authority
- PL
- Poland
- Prior art keywords
- kinase inhibitors
- macrocyclic kinase
- macrocyclic
- inhibitors
- kinase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41760110P | 2010-11-29 | 2010-11-29 | |
| PCT/US2011/062290 WO2012074951A1 (en) | 2010-11-29 | 2011-11-29 | Macrocyclic kinase inhibitors |
| EP11794899.2A EP2646448B1 (en) | 2010-11-29 | 2011-11-29 | Macrocyclic kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2646448T3 true PL2646448T3 (pl) | 2017-12-29 |
Family
ID=45346560
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL11794899T PL2646448T3 (pl) | 2010-11-29 | 2011-11-29 | Makrocykliczne inhibitory kinazy |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9133224B2 (pl) |
| EP (1) | EP2646448B1 (pl) |
| JP (1) | JP6000273B2 (pl) |
| ES (1) | ES2645508T3 (pl) |
| PL (1) | PL2646448T3 (pl) |
| PT (1) | PT2646448T (pl) |
| WO (1) | WO2012074951A1 (pl) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201100441A (en) | 2009-06-01 | 2011-01-01 | Osi Pharm Inc | Amino pyrimidine anticancer compounds |
| JP6000273B2 (ja) | 2010-11-29 | 2016-09-28 | オーエスアイ・ファーマシューティカルズ，エルエルシー | 大環状キナーゼ阻害剤 |
| US10738346B2 (en) | 2017-03-09 | 2020-08-11 | Elitechgroup, Inc. | Nitrodiarylethenes as fluorescence quenchers for nucleic acid probes |
| WO2023229430A1 (ko) * | 2022-05-27 | 2023-11-30 | 보로노이 주식회사 | 헤테로아릴 유도체 화합물 및 이의 용도 |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002523497A (ja) | 1998-08-29 | 2002-07-30 | アストラゼネカ・アクチエボラーグ | ピリミジン化合物 |
| CA2400447C (en) | 2000-02-17 | 2008-04-22 | Amgen Inc. | Kinase inhibitors |
| GB0004888D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0004890D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| AP2002002643A0 (en) | 2000-03-06 | 2002-12-31 | Warner Lambert Co | 5-alkylpyrido[2,3-d]pyrimidines tyrosine kinase inhibitors |
| CN100480242C (zh) | 2001-05-29 | 2009-04-22 | 舍林股份公司 | Cdk抑制性嘧啶化合物、其制备方法以及作为药物的应用 |
| WO2003000186A2 (en) | 2001-06-21 | 2003-01-03 | Ariad Pharmaceuticals, Inc. | Novel phenylamino-pyrimidines and uses thereof |
| WO2003030909A1 (en) | 2001-09-25 | 2003-04-17 | Bayer Pharmaceuticals Corporation | 2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer |
| DE10239042A1 (de) * | 2002-08-21 | 2004-03-04 | Schering Ag | Makrozyclische Pyrimidine, deren Herstellung und Verwendung als Arzneimittel |
| UA80767C2 (en) | 2002-12-20 | 2007-10-25 | Pfizer Prod Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
| US7109337B2 (en) | 2002-12-20 | 2006-09-19 | Pfizer Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
| SI1625121T1 (sl) | 2002-12-20 | 2010-04-30 | Pfizer Prod Inc | Derivati pirimidina za zdravljenje abnormalne rasti celic |
| ES2325440T3 (es) | 2003-02-20 | 2009-09-04 | Smithkline Beecham Corporation | Compuestos de pirimidina. |
| EA010727B1 (ru) | 2003-02-26 | 2008-10-30 | Суджен, Инк. | Аминогетероарильные соединения в качестве ингибиторов протеинкиназ |
| GB0305929D0 (en) | 2003-03-14 | 2003-04-23 | Novartis Ag | Organic compounds |
| WO2005016894A1 (en) | 2003-08-15 | 2005-02-24 | Novartis Ag | 2, 4-pyrimidinediamines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders |
| EP1656378A4 (en) | 2003-08-15 | 2011-05-11 | Irm Llc | COMPOUNDS AND COMPOSITIONS INHIBITING TYROSINE KINASE RECEPTOR ACTIVITY |
| MXPA06002552A (es) | 2003-09-05 | 2006-06-20 | Pfizer Prod Inc | Sintesis selectivas de pirimidinas sustituidas con cf3. |
| WO2005111024A1 (en) | 2004-05-14 | 2005-11-24 | Pfizer Products Inc. | Pyrimidine derivatives for the treatment of abnormal cell growth |
| US7521457B2 (en) | 2004-08-20 | 2009-04-21 | Boehringer Ingelheim International Gmbh | Pyrimidines as PLK inhibitors |
| GB0419160D0 (en) * | 2004-08-27 | 2004-09-29 | Novartis Ag | Organic compounds |
| GB0419161D0 (en) | 2004-08-27 | 2004-09-29 | Novartis Ag | Organic compounds |
| MY169441A (en) * | 2004-12-08 | 2019-04-11 | Janssen Pharmaceutica Nv | 2,4, (4,6) pyrimidine derivatives |
| WO2006076442A2 (en) | 2005-01-14 | 2006-07-20 | Janssen Pharmaceutica N.V. | Triazolopyrimidine derivatives |
| DE102005008310A1 (de) | 2005-02-17 | 2006-08-24 | Schering Ag | Verwendung von CDKII Inhibitoren zur Fertilitätskontrolle |
| US20070203161A1 (en) | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| EP1940843A4 (en) | 2005-08-11 | 2010-09-15 | Ariad Pharma Inc | UNSATURATED HETEROCYCLIC DERIVATIVES |
| JP4332590B2 (ja) | 2005-12-21 | 2009-09-16 | ファイザー・プロダクツ・インク | 異常細胞増殖を治療するためのピリミジン誘導体 |
| WO2008051547A1 (en) | 2006-10-23 | 2008-05-02 | Cephalon, Inc. | Fused bicyclic derivatives of 2,4-diaminopyrimidine as alk and c-met inhibitors |
| NZ577197A (en) | 2006-12-08 | 2011-02-25 | Irm Llc | Pyrimidine compounds especially 4-phenylamino-2-arylamino-pyrimidine derivatives and compositions as protein kinase inhibitors |
| WO2008079073A1 (en) | 2006-12-22 | 2008-07-03 | Astrazeneca Ab | Indazolyl sulphonamide derivatives for the treatment of glucocorticoid receptor mediated disorders |
| MX2009007944A (es) | 2007-01-26 | 2009-08-07 | Irm Llc | Compuestos y composiciones de purina como inhibidores de quinasa para el tratamiento de enfermedades relacionadas con plasmodium. |
| JP2010532312A (ja) | 2007-01-30 | 2010-10-07 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | １−ｈ−ピラゾロ（３，４ｂ）ピリミジン誘導体および有糸***キナーゼの調節剤としてのその使用 |
| EP2144878A2 (en) | 2007-03-22 | 2010-01-20 | Vertex Pharmaceuticals Incorporated | N-heterocyclic compounds useful as inhibitors of janus kinases |
| CA2684447C (en) | 2007-04-18 | 2012-01-24 | Pfizer Products Inc. | Sulfonyl amide derivatives for the treatment of abnormal cell growth |
| EA200901488A1 (ru) | 2007-05-09 | 2010-04-30 | Новартис Аг | Замещенные имидазолопиридазины, как ингибиторы липидкиназы |
| US7981903B2 (en) | 2007-08-08 | 2011-07-19 | Glaxosmithkline Llc | 2-[2-{phenylamino}-1H-pyrrolo[2,3-D]pyrimidin-4-yl)amino] benzamide derivatives as IGF-1R inhibitors for the treatment of cancer |
| EP2231620A1 (en) | 2007-12-03 | 2010-09-29 | Boehringer Ingelheim International GmbH | Diaminopyridines for the treatment of diseases which are characterised by excessive or anomal cell proliferation |
| US20100317663A1 (en) * | 2008-02-19 | 2010-12-16 | Jerry Leroy Adams | Anilinopyridines as inhibitors of fak |
| WO2009132202A2 (en) * | 2008-04-24 | 2009-10-29 | Incyte Corporation | Macrocyclic compounds and their use as kinase inhibitors |
| EP3210609A1 (en) | 2008-05-21 | 2017-08-30 | Ariad Pharmaceuticals, Inc. | Phosphorous derivatives as kinase inhibitors |
| MX2011002470A (es) | 2008-09-08 | 2011-04-05 | Merck Patent Gmbh | Pirimidinas macrociclicas como inhibidores de aurora cinasa. |
| TW201100441A (en) | 2009-06-01 | 2011-01-01 | Osi Pharm Inc | Amino pyrimidine anticancer compounds |
| JP6000273B2 (ja) | 2010-11-29 | 2016-09-28 | オーエスアイ・ファーマシューティカルズ，エルエルシー | 大環状キナーゼ阻害剤 |
| BR112013027734A2 (pt) | 2011-05-04 | 2017-08-08 | Ariad Pharma Inc | compostos para a inibição de proliferação celular em cânceres impulsionados pelo egfr, método e composição farmacêutica |
| CA2836851C (en) | 2011-06-07 | 2016-06-21 | Christopher J. Helal | Pyrazolo[3,4-d]pyrimidine compounds and their use as pde2 inhibitors and/or cyp3a4 inhibitors |
-
2011
- 2011-11-29 JP JP2013542087A patent/JP6000273B2/ja not_active Expired - Fee Related
- 2011-11-29 PL PL11794899T patent/PL2646448T3/pl unknown
- 2011-11-29 US US13/990,045 patent/US9133224B2/en active Active
- 2011-11-29 PT PT117948992T patent/PT2646448T/pt unknown
- 2011-11-29 EP EP11794899.2A patent/EP2646448B1/en active Active
- 2011-11-29 ES ES11794899.2T patent/ES2645508T3/es active Active
- 2011-11-29 WO PCT/US2011/062290 patent/WO2012074951A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| ES2645508T3 (es) | 2017-12-05 |
| US20130261086A1 (en) | 2013-10-03 |
| EP2646448A1 (en) | 2013-10-09 |
| WO2012074951A1 (en) | 2012-06-07 |
| US9133224B2 (en) | 2015-09-15 |
| PT2646448T (pt) | 2017-10-04 |
| EP2646448B1 (en) | 2017-08-30 |
| JP6000273B2 (ja) | 2016-09-28 |
| JP2013545769A (ja) | 2013-12-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1198764A1 (zh) | 大環 激酶抑制劑 | |
| EP2552208A4 (en) | IMIDAZOLYL-IMIDAZOLES AS KINASE INHIBITORS | |
| HK1199838A1 (en) | Macrocyclic lrrk2 kinase inhibitors lrrk2 | |
| HK1200828A1 (en) | Kinase inhibitors | |
| HK1179477A1 (en) | Kinase inhibitors | |
| ZA201203842B (en) | Kinase inhibitors | |
| EP2552214A4 (en) | PYRAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | |
| EP2552211A4 (en) | INDAZOLYL-PYRIMIDINE AS KINASEHEMMER | |
| HUE048834T2 (hu) | Kináz inhibitorok | |
| GB201009731D0 (en) | Kinase inhibitors | |
| HK1182327A1 (en) | Solid dispersions containing kinase inhibitors | |
| EP2558099A4 (en) | Kinase Inhibitors | |
| GB201016880D0 (en) | Phosphodiesterase inhibitors | |
| IL229028A0 (en) | Kinase inhibitors | |
| HK1199873A1 (en) | Kinase inhibitors | |
| EP2571884A4 (en) | SELECTIVE MTOR KINASE HEMMER | |
| EP2629616A4 (en) | SUBSTITUTED AMINO-TRIAZOLYL-PDE10-HEMMER | |
| EP2480076A4 (en) | IMIDAZOTHIAZOLIC INHIBITORS OF KINASES | |
| EP2531197A4 (en) | SOLID FORMS OF MACROCYCLIC CHINESE INHIBITORS | |
| PL2646448T3 (pl) | Makrocykliczne inhibitory kinazy | |
| GB0914726D0 (en) | Kinase inhibitors | |
| PL2760867T3 (pl) | Makrocykliczne inhibitory kinaz FLT3 | |
| GB201009730D0 (en) | Kinase inhibitor compounds | |
| GB201018597D0 (en) | Inhibitors |