BR112017021869A2 - compostos quinazolina substituídos e métodos de uso dos mesmos - Google Patents

compostos quinazolina substituídos e métodos de uso dos mesmos

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Publication number
BR112017021869A2
BR112017021869A2 BR112017021869A BR112017021869A BR112017021869A2 BR 112017021869 A2 BR112017021869 A2 BR 112017021869A2 BR 112017021869 A BR112017021869 A BR 112017021869A BR 112017021869 A BR112017021869 A BR 112017021869A BR 112017021869 A2 BR112017021869 A2 BR 112017021869A2
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compounds
methods
quinazoline compounds
substituted quinazoline
iii
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BR112017021869A
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English (en)
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Feng Jun
Li Liansheng
Ren Pingda
Wu Tao
Liu Yi
Liu Yuan
Oliver Long Yun
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Araxes Pharma Llc
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Publication of BR112017021869A2 publication Critical patent/BR112017021869A2/pt

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
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    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
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    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
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    • C07D487/10—Spiro-condensed systems
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Abstract

a presente invenção refere-se a compostos que têm atividade como inibidores de proteína kras com mutação de g12c. os compostos têm uma das seguintes estruturas (i), (ii) ou (iii): ; ou (i) (ii) (iii) ou um sal farmaceuticamente aceitável, estereoisômero ou pró-fármaco do mesmo, em que r1, r2a, r2b, r2c, r3a, r3b, r4a, r4b, r5a, r5b, r6, a, b, g1, g2, l1, l2, m1, m2, n, x, y, x e e são conforme definido no presente documento. métodos associados à preparação e uso de tais compostos, composições farmacêuticas que compreendem tais compostos e métodos para modular a atividade de proteína kras com mutação de g12c para o tratamento de distúrbios, como câncer, também são fornecidos
BR112017021869A 2015-04-10 2016-04-08 compostos quinazolina substituídos e métodos de uso dos mesmos BR112017021869A2 (pt)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201562145818P 2015-04-10 2015-04-10
US201562145705P 2015-04-10 2015-04-10
US201562255891P 2015-11-16 2015-11-16
US201562265316P 2015-12-09 2015-12-09
US201562265320P 2015-12-09 2015-12-09
PCT/US2016/026573 WO2016164675A1 (en) 2015-04-10 2016-04-08 Substituted quinazoline compounds and methods of use thereof

Publications (1)

Publication Number Publication Date
BR112017021869A2 true BR112017021869A2 (pt) 2018-12-11

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BR112017021869A BR112017021869A2 (pt) 2015-04-10 2016-04-08 compostos quinazolina substituídos e métodos de uso dos mesmos

Country Status (16)

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US (2) US10246424B2 (pt)
EP (1) EP3280708B1 (pt)
JP (2) JP2018513853A (pt)
KR (1) KR20180005178A (pt)
CN (1) CN107849022A (pt)
AU (1) AU2016245864C1 (pt)
BR (1) BR112017021869A2 (pt)
CA (1) CA2981530A1 (pt)
EA (1) EA201792214A1 (pt)
ES (1) ES2898765T3 (pt)
HK (1) HK1248231A1 (pt)
JO (1) JO3707B1 (pt)
MX (1) MX2017012979A (pt)
TW (1) TW201702232A (pt)
UY (1) UY36612A (pt)
WO (1) WO2016164675A1 (pt)

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