BR112018008966A2 - compostos inibidores de jak quinase para o tratamento de doença respiratória - Google Patents

compostos inibidores de jak quinase para o tratamento de doença respiratória

Info

Publication number
BR112018008966A2
BR112018008966A2 BR112018008966-4A BR112018008966A BR112018008966A2 BR 112018008966 A2 BR112018008966 A2 BR 112018008966A2 BR 112018008966 A BR112018008966 A BR 112018008966A BR 112018008966 A2 BR112018008966 A2 BR 112018008966A2
Authority
BR
Brazil
Prior art keywords
treatment
jak kinase
compounds
kinase inhibitor
respiratory disease
Prior art date
Application number
BR112018008966-4A
Other languages
English (en)
Other versions
BR112018008966B1 (pt
Inventor
R. Fatheree Paul
R. Jacobsen John
Beausoleil Anne-Marie
E.L. BRANDT Gary
Fleury Melissa
Jiang Lan
Smith Cameron
D.E. Sullivan Steven
Jean Van Orden Lori
Colson Pierre-Jean
Timothy Fass Gene
Rapta Miroslav
Benjamin Noah
Dabros Marta
R. Thalladi Venkat
Original Assignee
Theravance Biopharma R&D Ip, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Biopharma R&D Ip, Llc filed Critical Theravance Biopharma R&D Ip, Llc
Publication of BR112018008966A2 publication Critical patent/BR112018008966A2/pt
Publication of BR112018008966B1 publication Critical patent/BR112018008966B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

a invenção fornece compostos de fórmula (i): em que x é (i) e as variáveis são definidas no relatório descritivo, ou um sal farmaceuticamente aceitável destes, que são úteis como inibidores de jak quinase. a invenção também fornece composições farmacêuticas que compreendem esses compostos, métodos de uso desses compostos para tratar doenças respiratórias, e processos e intermediários úteis para a preparação desses compostos.
BR112018008966-4A 2015-11-03 2016-11-02 Compostos inibidores de jak quinase, hidrato cristalino, composição farmacêutica, processos, método de preparação do hidrato cristalino e uso dos referidos compostos e hidrato cristalino no tratamento de doença respiratória BR112018008966B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562250113P 2015-11-03 2015-11-03
US62/250,113 2015-11-03
PCT/US2016/059999 WO2017079205A1 (en) 2015-11-03 2016-11-02 Jak kinase inhibitor compounds for treatment of respiratory disease

Publications (2)

Publication Number Publication Date
BR112018008966A2 true BR112018008966A2 (pt) 2018-11-27
BR112018008966B1 BR112018008966B1 (pt) 2023-05-02

Family

ID=57442794

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018008966-4A BR112018008966B1 (pt) 2015-11-03 2016-11-02 Compostos inibidores de jak quinase, hidrato cristalino, composição farmacêutica, processos, método de preparação do hidrato cristalino e uso dos referidos compostos e hidrato cristalino no tratamento de doença respiratória

Country Status (21)

Country Link
US (6) US10100049B2 (pt)
EP (1) EP3371186A1 (pt)
JP (1) JP6800969B2 (pt)
KR (1) KR20180073687A (pt)
CN (1) CN108349972B (pt)
AU (1) AU2016350816B2 (pt)
BR (1) BR112018008966B1 (pt)
CA (1) CA3001542C (pt)
CL (1) CL2018001145A1 (pt)
CO (1) CO2018005640A2 (pt)
EA (1) EA034914B1 (pt)
HK (1) HK1252685A1 (pt)
IL (1) IL258772B (pt)
MX (1) MX2018005446A (pt)
MY (1) MY195427A (pt)
NZ (1) NZ741737A (pt)
PH (1) PH12018500828A1 (pt)
SA (1) SA518391470B1 (pt)
TW (1) TWI710560B (pt)
UA (1) UA123633C2 (pt)
WO (1) WO2017079205A1 (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017077288A1 (en) 2015-11-03 2017-05-11 Topivert Pharma Limited 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors
PT3712152T (pt) 2015-11-03 2021-04-15 Topivert Pharma Ltd Derivados de 4,5,6,7-tetrahidro-1h-imidazo[4,5-c]piridina e 1,4,5,6,7,8-hexahidroimidazo[4,5-d]azepina como inibidores de janus quinase
CN108349972B (zh) 2015-11-03 2021-06-08 施万生物制药研发Ip有限责任公司 用于治疗呼吸疾病的jak激酶抑制剂化合物
AR111242A1 (es) 2017-03-09 2019-06-19 Theravance Biopharma R&D Ip Llc Compuestos de imidazo-piperidina fusionada que contienen una amida heterocíclica de 4 miembros como inhibidores de jak
RU2764979C2 (ru) * 2017-05-01 2022-01-24 ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи Способы лечения с использованием соединения-ингибитора jak
CA3059790A1 (en) * 2017-05-01 2018-11-08 Theravance Biopharma R&D Ip, Llc Crystalline forms of a jak inhibitor compound
AR111495A1 (es) 2017-05-01 2019-07-17 Theravance Biopharma R&D Ip Llc Compuestos de imidazo-piperidina fusionada como inhibidores de jak
US20200281857A1 (en) 2017-11-22 2020-09-10 Dauntless 1, Inc. Therapeutic compound formulations
EP3810094A1 (en) 2018-06-20 2021-04-28 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with a jak or other kinase inhibitor
KR20210056380A (ko) 2018-09-04 2021-05-18 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 Jak 억제제로서 5원 내지 7원 헤테로사이클릭 아마이드
BR112021004087A2 (pt) * 2018-09-04 2021-05-25 Theravance Biopharma R&D Ip, Llc processo para preparar inibidores de jak e seus intermediários
KR20210056381A (ko) 2018-09-04 2021-05-18 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 Jak 억제제로서 디메틸 아미노 아제티딘 아마이드
MX2021004582A (es) * 2018-10-29 2021-06-15 Theravance Biopharma R&D Ip Llc Compuesto 2-azabiciclo hexano inhibidor de jak.
BR112021016751B8 (pt) * 2019-02-25 2023-11-21 Henan Medinno Pharmaceutical Tech Co Ltd Compostos, composições farmacêuticas e usos dos compostos
CA3132371A1 (en) 2019-03-05 2020-09-10 Incyte Corporation Jak1 pathway inhibitors for the treatment of chronic lung allograft dysfunction
KR20210142154A (ko) 2019-03-21 2021-11-24 옹쎄오 암 치료를 위한 키나제 억제제와 조합된 dbait 분자
CA3159348A1 (en) 2019-11-08 2021-05-14 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
CN113121509B (zh) * 2019-12-30 2024-04-26 河南迈英诺医药科技有限公司 Jak抑制剂化合物及其用途
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
TW202144343A (zh) 2020-03-02 2021-12-01 美商施萬生物製藥研發 Ip有限責任公司 Jak抑制劑化合物之結晶水合物
WO2022178215A1 (en) 2021-02-19 2022-08-25 Theravance Biopharma R&D Ip, Llc Amino amide tetrahydro imidazo pyridines as jak inhibitors
CA3212635A1 (en) * 2021-03-26 2022-09-29 Theravance Biopharma R&D Ip, Llc Crystalline form of a dihydrochloride salt of a jak inhibitor compound
US20240092758A1 (en) * 2021-06-25 2024-03-21 Theravance Biopharma R&D Ip, Llc Imidazolo indazole compounds as jak inhibitors
CN114181055A (zh) * 2021-12-21 2022-03-15 苏州楚凯药业有限公司 1-苄氧基-4-溴-5-乙基-2-氟苯的制备方法
WO2023215478A1 (en) 2022-05-05 2023-11-09 Theravance Biopharma R&D Ip, Llc Nezulcitinib for delivery by nebulized oral inhalation

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI262914B (en) 1999-07-02 2006-10-01 Agouron Pharma Compounds and pharmaceutical compositions for inhibiting protein kinases
WO2005009389A2 (en) 2003-07-23 2005-02-03 Exelixis, Inc. Anaplastic lymphoma kinase modulators and methods of use
US20050090529A1 (en) 2003-07-31 2005-04-28 Pfizer Inc 3,5 Disubstituted indazole compounds with nitrogen-bearing 5-membered heterocycles, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation
US7884109B2 (en) 2005-04-05 2011-02-08 Wyeth Llc Purine and imidazopyridine derivatives for immunosuppression
CA2673125C (en) 2006-10-19 2015-04-21 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
US8648069B2 (en) 2007-06-08 2014-02-11 Abbvie Inc. 5-substituted indazoles as kinase inhibitors
CN102131389A (zh) 2008-06-20 2011-07-20 健泰科生物技术公司 ***并吡啶jak抑制剂化合物和方法
WO2010039825A2 (en) 2008-10-01 2010-04-08 Array Biopharma Inc. IMIDAZO[1,2-a]PYRIDINE COMPOUNDS AS RECEPTOR TYROSINE KINASE INHIBITORS
CL2009001884A1 (es) * 2008-10-02 2010-05-14 Incyte Holdings Corp Uso de 3-ciclopentil-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo, inhibidor de janus quinasa, y uso de una composición que lo comprende para el tratamiento del ojo seco.
JP2010111624A (ja) 2008-11-06 2010-05-20 Shionogi & Co Ltd Ｔｔｋ阻害作用を有するインダゾール誘導体
US20120029190A1 (en) 2009-04-03 2012-02-02 Douglas Burdi Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof
CN102470135A (zh) 2009-07-28 2012-05-23 里格尔药品股份有限公司 抑制jak途径的组合物和方法
JP5822844B2 (ja) 2009-12-21 2015-11-24 サミュメッド リミテッド ライアビリティ カンパニー １Ｈ−ピラゾロ［３，４−ｂ］ピリジンおよびその治療的使用
EP2338888A1 (en) 2009-12-24 2011-06-29 Almirall, S.A. Imidazopyridine derivatives as JAK inhibitors
EP2643314B1 (en) 2010-11-25 2016-07-13 ratiopharm GmbH Novel salts and polymorphic forms of afatinib
US8575336B2 (en) 2011-07-27 2013-11-05 Pfizer Limited Indazoles
PH12017500997A1 (en) 2012-04-04 2018-02-19 Samumed Llc Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof
TW201513861A (zh) * 2013-01-17 2015-04-16 Galapagos Nv 用於治療退化性及發炎疾病之新穎化合物
MX368464B (es) 2013-12-05 2019-10-02 Pfizer Acrilamidas de pirrolo[2,3-d]pirimidinilo, pirrolo[2,3-b]pirazinil o y pirrolo[2,3-d]piridinilo.
GEP20186921B (en) 2014-05-14 2018-11-12 Pfizer Pyrazolopyridines and pyrazolopyrimidines
WO2016026078A1 (en) 2014-08-19 2016-02-25 Changzhou Jiekai Pharmatech Co., Ltd. Heterocyclic compounds as erk inhibitors
KR101663277B1 (ko) 2015-03-30 2016-10-06 주식회사 녹십자 TNIK, IKKε 및 TBK1 억제제로서의 피라졸계 유도체 및 이를 포함하는 약학적 조성물
WO2017077288A1 (en) 2015-11-03 2017-05-11 Topivert Pharma Limited 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors
PT3712152T (pt) 2015-11-03 2021-04-15 Topivert Pharma Ltd Derivados de 4,5,6,7-tetrahidro-1h-imidazo[4,5-c]piridina e 1,4,5,6,7,8-hexahidroimidazo[4,5-d]azepina como inibidores de janus quinase
CN108349972B (zh) 2015-11-03 2021-06-08 施万生物制药研发Ip有限责任公司 用于治疗呼吸疾病的jak激酶抑制剂化合物
AR111242A1 (es) 2017-03-09 2019-06-19 Theravance Biopharma R&D Ip Llc Compuestos de imidazo-piperidina fusionada que contienen una amida heterocíclica de 4 miembros como inhibidores de jak
CA3059790A1 (en) 2017-05-01 2018-11-08 Theravance Biopharma R&D Ip, Llc Crystalline forms of a jak inhibitor compound
RU2764979C2 (ru) 2017-05-01 2022-01-24 ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи Способы лечения с использованием соединения-ингибитора jak
AR111495A1 (es) 2017-05-01 2019-07-17 Theravance Biopharma R&D Ip Llc Compuestos de imidazo-piperidina fusionada como inhibidores de jak
KR20210056381A (ko) 2018-09-04 2021-05-18 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 Jak 억제제로서 디메틸 아미노 아제티딘 아마이드
KR20210056380A (ko) 2018-09-04 2021-05-18 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 Jak 억제제로서 5원 내지 7원 헤테로사이클릭 아마이드
BR112021004087A2 (pt) 2018-09-04 2021-05-25 Theravance Biopharma R&D Ip, Llc processo para preparar inibidores de jak e seus intermediários
MX2021004582A (es) 2018-10-29 2021-06-15 Theravance Biopharma R&D Ip Llc Compuesto 2-azabiciclo hexano inhibidor de jak.
CA3212635A1 (en) 2021-03-26 2022-09-29 Theravance Biopharma R&D Ip, Llc Crystalline form of a dihydrochloride salt of a jak inhibitor compound

Also Published As

Publication number Publication date
TW201726673A (zh) 2017-08-01
US10100049B2 (en) 2018-10-16
CA3001542A1 (en) 2017-05-11
US20220306624A1 (en) 2022-09-29
BR112018008966B1 (pt) 2023-05-02
EA201891091A1 (ru) 2018-12-28
US10526330B2 (en) 2020-01-07
US10183942B2 (en) 2019-01-22
US20190106420A1 (en) 2019-04-11
NZ741737A (en) 2023-11-24
EP3371186A1 (en) 2018-09-12
SA518391470B1 (ar) 2021-03-31
CL2018001145A1 (es) 2018-07-06
CO2018005640A2 (es) 2018-05-31
US20210130351A1 (en) 2021-05-06
US11718616B2 (en) 2023-08-08
AU2016350816B2 (en) 2020-06-25
WO2017079205A1 (en) 2017-05-11
HK1252685A1 (zh) 2019-05-31
US20170121327A1 (en) 2017-05-04
US11299492B2 (en) 2022-04-12
MY195427A (en) 2023-01-20
CA3001542C (en) 2021-02-16
JP6800969B2 (ja) 2020-12-16
JP2018531982A (ja) 2018-11-01
CN108349972A (zh) 2018-07-31
KR20180073687A (ko) 2018-07-02
IL258772B (en) 2021-01-31
US10913740B2 (en) 2021-02-09
EA034914B1 (ru) 2020-04-06
US20180319796A1 (en) 2018-11-08
TWI710560B (zh) 2020-11-21
UA123633C2 (uk) 2021-05-05
AU2016350816A1 (en) 2018-05-17
PH12018500828A1 (en) 2018-10-29
US20200087303A1 (en) 2020-03-19
IL258772A (en) 2018-06-28
CN108349972B (zh) 2021-06-08
MX2018005446A (es) 2018-08-01

Similar Documents

Publication Publication Date Title
BR112018008966A2 (pt) compostos inibidores de jak quinase para o tratamento de doença respiratória
PH12018500041A1 (en) Substituted aza compoounds as irak-4 inhibitors
CO2017012267A2 (es) Compuestos de naftiridina como inhibidores de la quinasa jak
PH12019550050A1 (en) Isoxazole analogs as fxr agonists and methods of use thereof
PH12018500040A1 (en) Indazole and azaindazole compounds as irak-4 inhibitors
PH12019501985A1 (en) Fused imidazo-piperidine jak inhibitors
BR112021007788A8 (pt) Composto inibidor de jak 2-azabiciclo hexano
PH12016502382A1 (en) Substituted indazole compounds as irak4 inhibitors
CO2021002977A2 (es) Dimetilaminoazetidinaminas como inhibidores de jak
BR112017003054A2 (pt) compostos de aminopirimidinila como inibidores de jak
EA201691803A1 (ru) Ингибиторы калликреина плазмы человека
EA201791576A1 (ru) Ингибитор jak
CO2018011408A2 (es) Compuestos de pirimidina como inhibidores de la quinasa jak
EA201500182A1 (ru) 4-МЕТИЛ-2,3,5,9,9b-ПЕНТААЗАЦИКЛОПЕНТА[a]НАФТАЛИНЫ
CO2021002976A2 (es) Amidas heterocíclicas de 5 a 7 miembros como inhibidores de jak
BR112017008103A2 (pt) composto, composição farmacêutica, métodos para tratar uma doença e uma condição, e, uso de um composto ou de um sal farmaceuticamente aceitável do mesmo e de um segundo agente ativo.
BR112017021583A2 (pt) métodos para o tratamento de transtornos inflamatórios
BR112017006264A2 (pt) derivados de nucleosídeo substituído com 4?-vinila como inibidores de replicação de rna do vírus sincitial respiratório
CR20170426A (es) Inhibidores de bace 1
BR112017021589A2 (pt) métodos para o tratamento de transtornos cardiovasculares
EA202192822A1 (ru) Нафтиридиновые соединения в качестве ингибиторов jak киназы
BR112016018544A8 (pt) Compostos ciclopropilaminas, composição farmacêutica que os compreende, seus usos no tratamento de câncer ou uma doença viral ou um beta-globinopatia e método de inibição de lsd1
EA202091668A2 (ru) Ингибиторы калликреина плазмы человека

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 02/11/2016, OBSERVADAS AS CONDICOES LEGAIS