BR112017025781A2 - derivados de 2-(pirazolopiridin-3-il)pirimidina como inibidores de jak - Google Patents

derivados de 2-(pirazolopiridin-3-il)pirimidina como inibidores de jak

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Publication number
BR112017025781A2
BR112017025781A2 BR112017025781-5A BR112017025781A BR112017025781A2 BR 112017025781 A2 BR112017025781 A2 BR 112017025781A2 BR 112017025781 A BR112017025781 A BR 112017025781A BR 112017025781 A2 BR112017025781 A2 BR 112017025781A2
Authority
BR
Brazil
Prior art keywords
pyrazolopyridin
pyrimidine derivatives
jak inhibitors
jak
inhibitors
Prior art date
Application number
BR112017025781-5A
Other languages
English (en)
Inventor
Esteve Trias Cristina
Taltavull Moll Joan
Gonzalez Rodriguez Jacob
Vidal Juan Bernat
Original Assignee
Almirall, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall, S.A. filed Critical Almirall, S.A.
Publication of BR112017025781A2 publication Critical patent/BR112017025781A2/pt

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members

Abstract

são descritos novos derivados de 2-(pirazolopiridin-3-il)pirimidina; bem como processos para sua preparação, composições farmacêuticas que compreende os mesmos e seu uso em terapia como inibidores de quinases janus (jak).
BR112017025781-5A 2015-06-11 2016-06-10 derivados de 2-(pirazolopiridin-3-il)pirimidina como inibidores de jak BR112017025781A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15382305 2015-06-11
EP15382305.9 2015-06-11
PCT/EP2016/063391 WO2016198663A1 (en) 2015-06-11 2016-06-10 2-(pyrazolopyridin-3-yl)pyrimidine derivatives as jak inhibitors

Publications (1)

Publication Number Publication Date
BR112017025781A2 true BR112017025781A2 (pt) 2018-08-14

Family

ID=53476802

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017025781-5A BR112017025781A2 (pt) 2015-06-11 2016-06-10 derivados de 2-(pirazolopiridin-3-il)pirimidina como inibidores de jak

Country Status (22)

Country Link
US (1) US10759793B2 (pt)
EP (1) EP3307272A1 (pt)
JP (1) JP2018516954A (pt)
KR (1) KR20180012854A (pt)
CN (1) CN107667106A (pt)
AR (1) AR104963A1 (pt)
AU (1) AU2016275716C1 (pt)
BR (1) BR112017025781A2 (pt)
CA (1) CA2987328A1 (pt)
CL (1) CL2017003107A1 (pt)
CO (1) CO2017011996A2 (pt)
CR (1) CR20170557A (pt)
EA (1) EA035312B1 (pt)
HK (1) HK1246667A1 (pt)
IL (1) IL255668A (pt)
MA (1) MA42592A (pt)
MX (1) MX2017015029A (pt)
PE (1) PE20180279A1 (pt)
PH (1) PH12017502236A1 (pt)
SG (1) SG10201911926UA (pt)
TW (1) TW201705961A (pt)
WO (1) WO2016198663A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116327921A (zh) 2015-08-24 2023-06-27 葛兰素史密斯克莱知识产权（第2 号）有限公司 生物医药组合物
US20190029987A1 (en) * 2016-02-12 2019-01-31 Universitat Zurich Dimethyl fumarate (dmf) for prevention or treatment of gout, acne, diabetes, vitiligo and/or pyoderma gangrenosum
AU2017359561B2 (en) * 2016-11-08 2022-02-03 Cancer Research Technology Limited Pyrimidinone derivatives as Cdc7 inhibitors
US20180235931A1 (en) * 2017-01-17 2018-08-23 Menlo Therapeutics Inc. Use of neurokinin-1 antagonists as antitussives
WO2018160138A1 (en) * 2017-03-02 2018-09-07 Aslan Pharmaceuticals Pte Ltd Dhodh inhibitor for treating haematological cancer
US11311548B2 (en) 2017-03-02 2022-04-26 Aslan Pharmaceuticals Pte. Ltd. Cancer therapy
WO2018200786A1 (en) * 2017-04-26 2018-11-01 Yale University Compositions and methods for treating vitiligo
CN108514637A (zh) * 2018-05-07 2018-09-11 山东省眼科研究所 Stat3抑制剂s31-201在治疗干眼症中的应用
CN109810991B (zh) * 2019-03-02 2021-11-12 昆明理工大学 二氢蝶酸合酶基因folP的用途
IL298589A (en) * 2020-06-02 2023-01-01 Nerre Therapeutics Ltd Neurokinin (nk)-1 receptor antagonists for use in the treatment of pulmonary fibrosis promoted by mechanical lung injury
KR20240009964A (ko) * 2021-05-03 2024-01-23 인사이트 코포레이션 결절성 양진 치료를 위한 jak1 경로 억제제

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54128591A (en) 1978-03-25 1979-10-05 Kyowa Hakko Kogyo Co Ltd Cephalosporin analog
EP2338888A1 (en) 2009-12-24 2011-06-29 Almirall, S.A. Imidazopyridine derivatives as JAK inhibitors
UY33213A (es) * 2010-02-18 2011-09-30 Almirall Sa Derivados de pirazol como inhibidores de jak
EP2397482A1 (en) 2010-06-15 2011-12-21 Almirall, S.A. Heteroaryl imidazolone derivatives as jak inhibitors
AR086042A1 (es) * 2011-04-28 2013-11-13 Galapagos Nv Compuesto util para el tratamiento de enfermedades degenerativas e inflamatorias y composicion farmaceutica
WO2013025628A1 (en) * 2011-08-15 2013-02-21 Ligand Pharmaceuticals Incorporated Janus kinase inhibitor compounds and methods
WO2013041042A1 (en) * 2011-09-22 2013-03-28 Merck Sharp & Dohme Corp. Pyrazole carboxamides as janus kinase inhibitors
WO2015086693A1 (en) * 2013-12-11 2015-06-18 Almirall, S.A. Pyrazolopyrimidin-2-yl derivatives as jak inhibitors

Also Published As

Publication number Publication date
PE20180279A1 (es) 2018-02-07
IL255668A (en) 2018-01-31
CO2017011996A2 (es) 2018-03-28
KR20180012854A (ko) 2018-02-06
WO2016198663A1 (en) 2016-12-15
AU2016275716B2 (en) 2020-01-23
CL2017003107A1 (es) 2018-04-02
US20180162856A1 (en) 2018-06-14
AU2016275716A1 (en) 2017-12-07
JP2018516954A (ja) 2018-06-28
HK1246667A1 (zh) 2018-09-14
CR20170557A (es) 2018-02-06
CA2987328A1 (en) 2016-12-15
PH12017502236A1 (en) 2018-06-11
CN107667106A (zh) 2018-02-06
EP3307272A1 (en) 2018-04-18
EA035312B1 (ru) 2020-05-27
NZ737314A (en) 2021-02-26
US10759793B2 (en) 2020-09-01
MX2017015029A (es) 2018-04-13
AR104963A1 (es) 2017-08-30
MA42592A (fr) 2018-06-20
SG10201911926UA (en) 2020-01-30
AU2016275716C1 (en) 2020-10-15
EA201792689A1 (ru) 2018-07-31
TW201705961A (zh) 2017-02-16

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