BR112012032462A2 - agente antitumoral empregando compostos que, em combinação, têm efeito inibidor de quinase. - Google Patents

agente antitumoral empregando compostos que, em combinação, têm efeito inibidor de quinase.

Info

Publication number
BR112012032462A2
BR112012032462A2 BR112012032462A BR112012032462A BR112012032462A2 BR 112012032462 A2 BR112012032462 A2 BR 112012032462A2 BR 112012032462 A BR112012032462 A BR 112012032462A BR 112012032462 A BR112012032462 A BR 112012032462A BR 112012032462 A2 BR112012032462 A2 BR 112012032462A2
Authority
BR
Brazil
Prior art keywords
combination
antitumor agent
inhibiting effect
kinase inhibiting
agent employing
Prior art date
Application number
BR112012032462A
Other languages
English (en)
Inventor
Takayuki Nakagawa
Tomohiro Matsushima
Yasuhiro Funahashi
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of BR112012032462A2 publication Critical patent/BR112012032462A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Abstract

agente antitumoral empregando compostos que, em combinação, têm efeito inibidor de quinase.é revelado um agente antitumoral que emprega um composto representado pela fórmula (i) ou um sal farmaceuticamente aceitável desse, em combinação com um composto representado pela fórmula (ii), ou um sal farmaceuticamente aceitável desse. o agente antitumoral exibe um surpreendente efeito antitumoral em comparação aos casos em que cada um dos compostos acima mencionados é utilizado individualmente. ademais, o agente antitumoral exibe efeito antitumoral contra vários tipos de câncer. (nas fórmulas, r^1^ representa um grupo azetidinil ou similar; r^2^ a r^5^ representam, cada um, um átomo de hidrogênio ou um átomo de halogênio; r^6^ representa um grupo cicloalquila c~3-8~ ou similar; r^7^ representa um átomo de hidrogênio ou similar; e r^8^ representa um átomo de halogênio ou similar.)
BR112012032462A 2010-06-25 2011-06-23 agente antitumoral empregando compostos que, em combinação, têm efeito inibidor de quinase. BR112012032462A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2010145030 2010-06-25
JP2010273921 2010-12-08
PCT/JP2011/064430 WO2011162343A1 (ja) 2010-06-25 2011-06-23 キナーゼ阻害作用を有する化合物の併用による抗腫瘍剤

Publications (1)

Publication Number Publication Date
BR112012032462A2 true BR112012032462A2 (pt) 2016-11-08

Family

ID=45371509

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012032462A BR112012032462A2 (pt) 2010-06-25 2011-06-23 agente antitumoral empregando compostos que, em combinação, têm efeito inibidor de quinase.

Country Status (13)

Country Link
US (1) US9012458B2 (pt)
EP (1) EP2586443B1 (pt)
JP (1) JP5898074B2 (pt)
KR (1) KR101677790B1 (pt)
CN (1) CN102958523B (pt)
AU (1) AU2011270165B2 (pt)
BR (1) BR112012032462A2 (pt)
CA (1) CA2802644C (pt)
ES (1) ES2573515T3 (pt)
IL (1) IL223695A (pt)
MX (1) MX2012014776A (pt)
RU (1) RU2560683C2 (pt)
WO (1) WO2011162343A1 (pt)

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PL3263106T3 (pl) 2015-02-25 2024-04-02 Eisai R&D Management Co., Ltd. Sposób tłumienia goryczy pochodnej chinoliny
KR20170122809A (ko) 2015-03-04 2017-11-06 머크 샤프 앤드 돔 코포레이션 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
CN106046007B (zh) * 2015-04-07 2019-02-05 广东众生睿创生物科技有限公司 酪氨酸激酶抑制剂及包含该酪氨酸激酶抑制剂的药物组合物
WO2016204193A1 (ja) 2015-06-16 2016-12-22 株式会社ＰＲＩＳＭ Ｐｈａｒｍａ 抗がん剤
RU2718048C2 (ru) * 2015-08-20 2020-03-30 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Противоопухолевое терапевтическое средство
CN107115344B (zh) * 2017-03-23 2019-06-14 广东众生睿创生物科技有限公司 酪氨酸激酶抑制剂在制备用于预防和/或治疗纤维化疾病的药物中的用途

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