ATE307576T1 - Fenofibrathaltige arzneizusammensetzung mit erhöhter bioverfügbarkeit und verfahren zu deren herstellung - Google Patents

Fenofibrathaltige arzneizusammensetzung mit erhöhter bioverfügbarkeit und verfahren zu deren herstellung

Info

Publication number
ATE307576T1
ATE307576T1 AT02018029T AT02018029T ATE307576T1 AT E307576 T1 ATE307576 T1 AT E307576T1 AT 02018029 T AT02018029 T AT 02018029T AT 02018029 T AT02018029 T AT 02018029T AT E307576 T1 ATE307576 T1 AT E307576T1
Authority
AT
Austria
Prior art keywords
production
composition containing
medicinal composition
increased bioavailability
containing fenofibrate
Prior art date
Application number
AT02018029T
Other languages
English (en)
Inventor
Andre Stamm
Pawan Seth
Original Assignee
Fournier Lab Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9502710&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE307576(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Fournier Lab Sa filed Critical Fournier Lab Sa
Application granted granted Critical
Publication of ATE307576T1 publication Critical patent/ATE307576T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT02018029T 1997-01-17 1998-01-16 Fenofibrathaltige arzneizusammensetzung mit erhöhter bioverfügbarkeit und verfahren zu deren herstellung ATE307576T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9700479A FR2758459B1 (fr) 1997-01-17 1997-01-17 Composition pharmaceutique de fenofibrate presentant une biodisponibilite elevee et son procede de preparation

Publications (1)

Publication Number Publication Date
ATE307576T1 true ATE307576T1 (de) 2005-11-15

Family

ID=9502710

Family Applications (4)

Application Number Title Priority Date Filing Date
AT02018031T ATE324885T1 (de) 1997-01-17 1998-01-16 Verfahren zur herstellung von fenofibrathaltigen arzneizusammensetzungen mit erhöhter bioverfügbarkeit
AT02018028T ATE291911T1 (de) 1997-01-17 1998-01-16 Fenofibrathaltige suspension in einer hydrophilen polymerlösung
AT98900125T ATE233556T1 (de) 1997-01-17 1998-01-16 Fenofibrathaltige arzneizusammensetzung mit hoher bioverfügbarkeit und herstellungsverfahren
AT02018029T ATE307576T1 (de) 1997-01-17 1998-01-16 Fenofibrathaltige arzneizusammensetzung mit erhöhter bioverfügbarkeit und verfahren zu deren herstellung

Family Applications Before (3)

Application Number Title Priority Date Filing Date
AT02018031T ATE324885T1 (de) 1997-01-17 1998-01-16 Verfahren zur herstellung von fenofibrathaltigen arzneizusammensetzungen mit erhöhter bioverfügbarkeit
AT02018028T ATE291911T1 (de) 1997-01-17 1998-01-16 Fenofibrathaltige suspension in einer hydrophilen polymerlösung
AT98900125T ATE233556T1 (de) 1997-01-17 1998-01-16 Fenofibrathaltige arzneizusammensetzung mit hoher bioverfügbarkeit und herstellungsverfahren

Country Status (36)

Country Link
US (18) US6074670A (de)
EP (6) EP1273294B1 (de)
JP (6) JP4219988B2 (de)
KR (2) KR100391104B1 (de)
CN (2) CN1278678C (de)
AR (1) AR011411A1 (de)
AT (4) ATE324885T1 (de)
BR (1) BR9806738A (de)
CA (5) CA2372561A1 (de)
CY (4) CY2396B1 (de)
CZ (1) CZ297251B6 (de)
DE (5) DE69811855T2 (de)
DK (5) DK2050445T4 (de)
DZ (1) DZ2398A1 (de)
EE (1) EE04042B1 (de)
EG (1) EG23978A (de)
ES (5) ES2195308T3 (de)
FR (1) FR2758459B1 (de)
HK (3) HK1023071A1 (de)
HU (3) HU228849B1 (de)
ID (1) ID22528A (de)
IL (1) IL130790A0 (de)
IN (1) IN187906B (de)
IS (1) IS5097A (de)
MA (1) MA26466A1 (de)
NO (2) NO329200B1 (de)
NZ (1) NZ336462A (de)
PL (1) PL194802B1 (de)
PT (4) PT952829E (de)
RU (3) RU2238089C2 (de)
SK (1) SK285847B6 (de)
TN (1) TNSN98009A1 (de)
TR (1) TR199901660T2 (de)
UA (1) UA61096C2 (de)
WO (1) WO1998031361A1 (de)
ZA (1) ZA98324B (de)

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US6652881B2 (en) 2003-11-25
EP2050445B1 (de) 2013-06-26
CY2396B1 (en) 2004-09-10
ZA98324B (en) 1998-08-12
BR9806738A (pt) 2000-02-29
FR2758459A1 (fr) 1998-07-24
RU2196580C2 (ru) 2003-01-20
PL194802B1 (pl) 2007-07-31
US7041319B2 (en) 2006-05-09
US20090035379A1 (en) 2009-02-05
EE04042B1 (et) 2003-06-16
KR100391104B1 (ko) 2003-07-12
JP2009143967A (ja) 2009-07-02
US20040057997A1 (en) 2004-03-25
US20040058005A1 (en) 2004-03-25
RU2002109746A (ru) 2004-03-20
JP2005206614A (ja) 2005-08-04
DK1275387T3 (da) 2006-08-28
WO1998031361A1 (fr) 1998-07-23
US7037529B2 (en) 2006-05-02
DE69811855D1 (de) 2003-04-10
DK2050445T4 (da) 2021-10-18
DZ2398A1 (fr) 2003-06-04
ES2427252T3 (es) 2013-10-30
CN1278678C (zh) 2006-10-11
DK1273294T3 (da) 2006-03-13
HK1131051A1 (en) 2010-01-15
DE69834437T2 (de) 2006-11-16
JP2007326878A (ja) 2007-12-20
JP4219988B2 (ja) 2009-02-04
RU2238089C2 (ru) 2004-10-20
EP1273293B1 (de) 2005-03-30
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ATE291911T1 (de) 2005-04-15
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IS5097A (is) 1999-06-29
ES2241931T3 (es) 2005-11-01
ES2254569T3 (es) 2006-06-16
DE69832108D1 (de) 2005-12-01
EG23978A (fr) 2008-02-26
US8329214B2 (en) 2012-12-11
PT1275387E (pt) 2006-08-31
CA2372561A1 (fr) 1998-07-17
CZ253599A3 (cs) 1999-11-17
HK1065952A1 (en) 2005-03-11
HUP0000808A2 (hu) 2000-12-28
DE69832108T2 (de) 2006-09-21
CY2513B1 (en) 2005-12-23
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US20080064759A1 (en) 2008-03-13
IN187906B (de) 2002-07-20
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EP1273293A1 (de) 2003-01-08
HU227758B1 (hu) 2012-02-28
DE69829591T2 (de) 2006-02-09
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US20070190136A1 (en) 2007-08-16
US20030104051A1 (en) 2003-06-05
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CN1243438A (zh) 2000-02-02
NZ336462A (en) 2000-09-29
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UA61096C2 (uk) 2003-11-17
DE69834437D1 (de) 2006-06-08
JP2001511156A (ja) 2001-08-07
PT2050445E (pt) 2013-08-23
HU230685B1 (en) 2017-08-28
DK2050445T3 (da) 2013-09-08
ES2195308T3 (es) 2003-12-01
PT952829E (pt) 2003-07-31
US20020168413A1 (en) 2002-11-14
EP0952829A1 (de) 1999-11-03
CN1496738B (zh) 2011-03-30
AU731964B2 (en) 2001-04-05
JP2009120623A (ja) 2009-06-04
EP1275387B1 (de) 2006-05-03
US20070184103A1 (en) 2007-08-09
US20030104060A1 (en) 2003-06-05
ATE324885T1 (de) 2006-06-15
EP2050445B2 (de) 2021-07-21
ID22528A (id) 1999-10-28
JP2011173927A (ja) 2011-09-08
CA2448623A1 (fr) 1998-07-17
ATE233556T1 (de) 2003-03-15
EP2050445A2 (de) 2009-04-22
US8343540B2 (en) 2013-01-01
US6277405B1 (en) 2001-08-21
NO993519D0 (no) 1999-07-16
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US6596317B2 (en) 2003-07-22
JP4943975B2 (ja) 2012-05-30
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US20040057998A1 (en) 2004-03-25
NO993519L (no) 1999-09-16
DK1273293T3 (da) 2005-06-27
MA26466A1 (fr) 2004-12-20
ES2427252T5 (es) 2022-02-14
PL334748A1 (en) 2000-03-13
KR100415897B1 (ko) 2004-01-24
TR199901660T2 (xx) 1999-09-21
CA2219475A1 (fr) 1998-07-17
US6589552B2 (en) 2003-07-08
CY2547B1 (fr) 2008-07-02
US20080063726A1 (en) 2008-03-13
US20040058004A1 (en) 2004-03-25
US20040092597A1 (en) 2004-05-13
EP0952829B1 (de) 2003-03-05
NO20100034L (no) 1999-09-16
US6074670A (en) 2000-06-13
HU228849B1 (hu) 2013-06-28
FR2758459B1 (fr) 1999-05-07
HK1023071A1 (en) 2000-09-01
IL130790A0 (en) 2001-01-28
CY2560B1 (fr) 2008-07-02
TNSN98009A1 (fr) 2005-03-15
AR011411A1 (es) 2000-08-16
SK96299A3 (en) 2000-08-14
CZ297251B6 (cs) 2006-10-11
DE69811855T2 (de) 2003-12-18
US20020114839A1 (en) 2002-08-22

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