MXPA01006474A - Derivados colquinol como agentes perjudiciales vasculares. - Google Patents

Derivados colquinol como agentes perjudiciales vasculares.

Info

Publication number
MXPA01006474A
MXPA01006474A MXPA01006474A MXPA01006474A MXPA01006474A MX PA01006474 A MXPA01006474 A MX PA01006474A MX PA01006474 A MXPA01006474 A MX PA01006474A MX PA01006474 A MXPA01006474 A MX PA01006474A MX PA01006474 A MXPA01006474 A MX PA01006474A
Authority
MX
Mexico
Prior art keywords
compounds
formula
vascular damaging
hydrogen
3alkyl
Prior art date
Application number
MXPA01006474A
Other languages
English (en)
Inventor
Francis Thomas Boyle
Original Assignee
Angiogene Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angiogene Pharm Ltd filed Critical Angiogene Pharm Ltd
Publication of MXPA01006474A publication Critical patent/MXPA01006474A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A61K31/6615—Compounds having two or more esterified phosphorus acid groups, e.g. inositol triphosphate, phytic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

La invencion se relaciona al uso de los compuestos de la formula (I): en donde X es -C(O)-,-C(S)-,-C=NOH o - CH(R7)- en donde R7 es hidrogeno, hidroxi, alcoxi de C1-7, -OR8 o -NR8R9 (en donde R8 es un grupo -Y1R10 (en donde Y1 es un enlace directo, -C (O) -, -C (S) -, -S-, -C (O) O-, -C (O) NR11-, - SO2- o -SO2NR12- (en donde R11 y R12, que pueden ser el mismo o diferente, cada uno independientemente representa hidrogeno, alquilo de C1-3, alcoxi de C1-3 alquilo de C2-3) y R10 se selecciona de uno de los siguientes nueve grupos: R1, R2 y R3 son como se definieron en la presente y son preferiblemente metilo; R4, R5 y R6 son como se definieron en la presente, con la condicion de que R5 no es hidroxi, alcoxi, alcoxi sustituido, -OPO3H2, -O-alcanoilo de C1-7 o benciloxi; y sales del mismo en la fabricacion de un medicamento para el uso en la produccion de un efecto dañino vascular en los animales de sangre caliente tales como humanos. La presente invencion a demas se relaciona a los compuestos de la formula (I), las composiciones farmaceuticas que las contiene, el proceso para su preparacion y al metodo para el tratamiento de los compuestos para producir un efecto dañino vascular en el animal de sangre caliente tal como un humano. Los compuestos de la formula (I) y las sales farmaceuticamente aceptables del mimo pueden ser utiles en el tratamiento de un numero de estados de enfermedad incluyendo cancer y artritis reumatoide.
MXPA01006474A 1999-01-07 1999-12-24 Derivados colquinol como agentes perjudiciales vasculares. MXPA01006474A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9900334.5A GB9900334D0 (en) 1999-01-07 1999-01-07 Tricylic vascular damaging agents
PCT/GB1999/004436 WO2000040529A1 (en) 1999-01-07 1999-12-24 Colchinol derivatives as vascular damaging agents

Publications (1)

Publication Number Publication Date
MXPA01006474A true MXPA01006474A (es) 2003-06-06

Family

ID=10845715

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA01006474A MXPA01006474A (es) 1999-01-07 1999-12-24 Derivados colquinol como agentes perjudiciales vasculares.

Country Status (22)

Country Link
US (2) US7135502B1 (es)
EP (1) EP1140745B1 (es)
JP (1) JP2002534400A (es)
KR (1) KR20010101402A (es)
CN (1) CN1398247A (es)
AT (1) ATE252529T1 (es)
AU (1) AU760830B2 (es)
BR (1) BR9916790A (es)
CA (1) CA2355302A1 (es)
DE (1) DE69912313T2 (es)
DK (1) DK1140745T3 (es)
ES (1) ES2211206T3 (es)
GB (2) GB9900334D0 (es)
HK (1) HK1040703A1 (es)
IL (1) IL143978A0 (es)
MX (1) MXPA01006474A (es)
MY (1) MY130755A (es)
NO (1) NO20013367L (es)
NZ (1) NZ512398A (es)
PT (1) PT1140745E (es)
WO (1) WO2000040529A1 (es)
ZA (1) ZA200105065B (es)

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AU776511B2 (en) 1999-02-18 2004-09-09 Baylor University Compositions and methods for use in targeting vascular destruction
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MY130755A (en) 2007-07-31
DE69912313D1 (de) 2003-11-27
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EP1140745A1 (en) 2001-10-10
EP1140745B1 (en) 2003-10-22
ZA200105065B (en) 2002-09-20
AU760830B2 (en) 2003-05-22
GB9930610D0 (en) 2000-02-16
DE69912313T2 (de) 2004-08-26
PT1140745E (pt) 2004-03-31
AU1882300A (en) 2000-07-24
KR20010101402A (ko) 2001-11-14
CA2355302A1 (en) 2000-07-13
GB9900334D0 (en) 1999-02-24
JP2002534400A (ja) 2002-10-15
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DK1140745T3 (da) 2004-02-23
NO20013367D0 (no) 2001-07-06
US7135502B1 (en) 2006-11-14
HK1040703A1 (zh) 2002-06-21
IL143978A0 (en) 2002-04-21
ATE252529T1 (de) 2003-11-15
US20060128633A1 (en) 2006-06-15
CN1398247A (zh) 2003-02-19
NO20013367L (no) 2001-09-05

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