IT1283110B1 - Composti a scheletro colchicinico,loro uso come farmaci e composizioni che li contengono - Google Patents

Composti a scheletro colchicinico,loro uso come farmaci e composizioni che li contengono

Info

Publication number
IT1283110B1
IT1283110B1 IT96MI001168A ITMI961168A IT1283110B1 IT 1283110 B1 IT1283110 B1 IT 1283110B1 IT 96MI001168 A IT96MI001168 A IT 96MI001168A IT MI961168 A ITMI961168 A IT MI961168A IT 1283110 B1 IT1283110 B1 IT 1283110B1
Authority
IT
Italy
Prior art keywords
pct
colchycine
drugs
compositions
contain
Prior art date
Application number
IT96MI001168A
Other languages
English (en)
Inventor
Ezio Bombardelli
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Publication of ITMI961168A0 publication Critical patent/ITMI961168A0/it
Priority to IT96MI001168A priority Critical patent/IT1283110B1/it
Priority to EP97924965A priority patent/EP0906262B1/en
Priority to PT97924965T priority patent/PT906262E/pt
Priority to AT97924965T priority patent/ATE222228T1/de
Priority to ES97924965T priority patent/ES2182084T3/es
Priority to US09/180,875 priority patent/US6080739A/en
Priority to CA002252717A priority patent/CA2252717C/en
Priority to SI9730296T priority patent/SI0906262T1/xx
Priority to PCT/EP1997/002577 priority patent/WO1997047577A1/en
Priority to HU0001827A priority patent/HUP0001827A3/hu
Priority to CZ19984010A priority patent/CZ294365B6/cs
Priority to DK97924965T priority patent/DK0906262T3/da
Priority to KR1019980709961A priority patent/KR100306430B1/ko
Priority to JP50110898A priority patent/JP3285361B2/ja
Priority to RU99100326/04A priority patent/RU2181354C2/ru
Priority to PL97330284A priority patent/PL187528B1/pl
Priority to SK41-2003A priority patent/SK283737B6/sk
Priority to AU30278/97A priority patent/AU723752B2/en
Priority to SK1679-98A priority patent/SK283736B6/sk
Priority to DE69714735T priority patent/DE69714735T2/de
Priority to CN97194988A priority patent/CN1122657C/zh
Publication of ITMI961168A1 publication Critical patent/ITMI961168A1/it
Application granted granted Critical
Publication of IT1283110B1 publication Critical patent/IT1283110B1/it
Priority to NO19985676A priority patent/NO311252B1/no
Priority to HK99104798A priority patent/HK1019587A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
    • C07C2603/34—Benzoheptalenes; Hydrogenated benzoheptalenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IT96MI001168A 1996-06-07 1996-06-07 Composti a scheletro colchicinico,loro uso come farmaci e composizioni che li contengono IT1283110B1 (it)

Priority Applications (23)

Application Number Priority Date Filing Date Title
IT96MI001168A IT1283110B1 (it) 1996-06-07 1996-06-07 Composti a scheletro colchicinico,loro uso come farmaci e composizioni che li contengono
KR1019980709961A KR100306430B1 (ko) 1996-06-07 1997-05-21 콜히친골격화합물과그들의의약품으로서의용도및이들을함유한조성물
RU99100326/04A RU2181354C2 (ru) 1996-06-07 1997-05-21 Производные колхицина, способы их получения и фармацевтические композиции на их основе
AT97924965T ATE222228T1 (de) 1996-06-07 1997-05-21 Colchicin-skelett verbindungen, ihre verwendung als arzneimittel und diese verbindungen enthaltende zusammensetzungen
ES97924965T ES2182084T3 (es) 1996-06-07 1997-05-21 Compuestos con esqueletos de colquicina, su uso como medicamentos y composiciones que los contienen.
US09/180,875 US6080739A (en) 1996-06-07 1997-05-21 Colchicine-skeleton compounds, their use as medicaments and compositions containing them
CA002252717A CA2252717C (en) 1996-06-07 1997-05-21 Colchicine-skeleton compounds, their use as medicaments and compositions containing them
SI9730296T SI0906262T1 (en) 1996-06-07 1997-05-21 Colchicine-skeleton compounds, their use as medicaments and compositions containing them
PCT/EP1997/002577 WO1997047577A1 (en) 1996-06-07 1997-05-21 Colchicine-skeleton compounds, their use as medicaments and compositions containing them
HU0001827A HUP0001827A3 (en) 1996-06-07 1997-05-21 Colchicine derivatives, process for producing them, pharmaceutical compositions containing them, and use thereof for producing pharmaceutical compositions
CZ19984010A CZ294365B6 (cs) 1996-06-07 1997-05-21 Deriváty kolchicinu, způsob výroby a farmaceutický prostředek
DK97924965T DK0906262T3 (da) 1996-06-07 1997-05-21 Colchicin-skelet-forbindelser, anvendelse deraf som lægemidler og sammensætninger, der indeholder dem
EP97924965A EP0906262B1 (en) 1996-06-07 1997-05-21 Colchicine-skeleton compounds, their use as medicaments and compositions containing them
JP50110898A JP3285361B2 (ja) 1996-06-07 1997-05-21 コルヒチン骨格化合物、それらの医薬としての用途、及びそれらを含有する組成物
PT97924965T PT906262E (pt) 1996-06-07 1997-05-21 Compostos com o esqueleto da colchicina, sua utilizacao como medicamentos e composicoes que os contem
PL97330284A PL187528B1 (pl) 1996-06-07 1997-05-21 Związki o szkielecie kolchicyny, ich zastosowaniejako leków i zawierające je kompozycje
SK41-2003A SK283737B6 (sk) 1996-06-07 1997-05-21 Kolchicínové zlúčeniny, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom a ich použitie
AU30278/97A AU723752B2 (en) 1996-06-07 1997-05-21 Colchicine-skeleton compounds, their use as medicaments and compositions containing them
SK1679-98A SK283736B6 (sk) 1996-06-07 1997-05-21 Kolchicínové zlúčeniny, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom a ich použitie
DE69714735T DE69714735T2 (de) 1996-06-07 1997-05-21 Colchicin-skelett verbindungen, ihre verwendung als arzneimittel und diese verbindungen enthaltende zusammensetzungen
CN97194988A CN1122657C (zh) 1996-06-07 1997-05-21 秋水仙素骨架化合物,其作为药物的用途以及含有该化合物的组合物
NO19985676A NO311252B1 (no) 1996-06-07 1998-12-04 Forbindelser med colchicinstruktur, deres anvendelse, fremstilling av legemidler og blandinger som inneholder dem
HK99104798A HK1019587A1 (en) 1996-06-07 1999-10-27 Colchicine-skeleton compounds, their use as medicaments and compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT96MI001168A IT1283110B1 (it) 1996-06-07 1996-06-07 Composti a scheletro colchicinico,loro uso come farmaci e composizioni che li contengono

Publications (3)

Publication Number Publication Date
ITMI961168A0 ITMI961168A0 (it) 1996-06-07
ITMI961168A1 ITMI961168A1 (it) 1997-12-07
IT1283110B1 true IT1283110B1 (it) 1998-04-07

Family

ID=11374396

Family Applications (1)

Application Number Title Priority Date Filing Date
IT96MI001168A IT1283110B1 (it) 1996-06-07 1996-06-07 Composti a scheletro colchicinico,loro uso come farmaci e composizioni che li contengono

Country Status (20)

Country Link
US (1) US6080739A (it)
EP (1) EP0906262B1 (it)
JP (1) JP3285361B2 (it)
KR (1) KR100306430B1 (it)
CN (1) CN1122657C (it)
AT (1) ATE222228T1 (it)
AU (1) AU723752B2 (it)
CZ (1) CZ294365B6 (it)
DE (1) DE69714735T2 (it)
DK (1) DK0906262T3 (it)
ES (1) ES2182084T3 (it)
HK (1) HK1019587A1 (it)
HU (1) HUP0001827A3 (it)
IT (1) IT1283110B1 (it)
NO (1) NO311252B1 (it)
PL (1) PL187528B1 (it)
PT (1) PT906262E (it)
RU (1) RU2181354C2 (it)
SK (2) SK283736B6 (it)
WO (1) WO1997047577A1 (it)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
FR2774290B1 (fr) * 1998-02-05 2000-06-16 Synthelabo Composition pharmaceutique pour l'administration par voie nasale de thiocolchicoside
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
IT1318401B1 (it) * 2000-03-17 2003-08-25 Indena Spa Derivati di n-desacetiltiocolchicina e composizioni farmaceutiche cheli contengono.
US6720323B2 (en) 2000-07-07 2004-04-13 Angiogene Pharmaceuticals Limited Colchinol derivatives as angiogenesis inhibitors
US6825236B2 (en) * 2003-04-14 2004-11-30 California Pacific Medical Center Colchicine derivatives
ITMI20040164A1 (it) * 2004-02-03 2004-05-03 Indena Spa Derivati di n.deacetiltiocolchicina loro uso e formulazioni farmaceutiche che li contengono
ATE489086T1 (de) * 2004-12-22 2010-12-15 Mestex Ag Mischung eines vanilloidrezeptoragonisten mit einer nervenregenerationshemmenden substanz, ihre verwendung für die herstellung eines schmerzmittels und verfahren zur applikation dieses mittels
ITRM20070088A1 (it) 2007-02-19 2008-08-20 Francesco Fringuelli Composti derivati della colchicina, procedimento per la loro preparazione e usi in campo medico.
US20110178180A1 (en) * 2010-01-18 2011-07-21 Kurt Nielsen Deuterium-enriched colchicine, thiocolchicine, and derivatives thereof; methods of preparation; and use thereof
ES2710153T3 (es) 2010-02-18 2019-04-23 Asan Found Derivados de la colchicina o sales farmacéuticamente aceptables de los mismos, método de preparación de dichos derivados y composición farmacéutica que comprende dichos derivados
KR101130754B1 (ko) 2010-06-25 2012-03-28 제일약품주식회사 난용성 트리사이클릭 유도체 화합물의 용해도가 향상된 약학적 조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL279678A (it) * 1961-06-14
FR3032M (fr) * 1963-06-19 1964-12-28 Roussel Uclaf Nouveaux médicaments doués notamment d'activité antimitotique.
US3442953A (en) * 1963-06-19 1969-05-06 Roussel Uclaf Novel 7-oxo-7-desacetylaminocolchicine compounds
US4349548A (en) * 1981-11-20 1982-09-14 Merck & Co., Inc. Octahydrobenzo[6,7]cyclohept[1,2-b]-1,4-oxazines, compositions and use

Also Published As

Publication number Publication date
KR100306430B1 (ko) 2001-11-30
ES2182084T3 (es) 2003-03-01
WO1997047577A1 (en) 1997-12-18
DE69714735T2 (de) 2003-04-24
DE69714735D1 (de) 2002-09-19
CN1219924A (zh) 1999-06-16
ITMI961168A0 (it) 1996-06-07
ITMI961168A1 (it) 1997-12-07
JP2000503669A (ja) 2000-03-28
EP0906262A1 (en) 1999-04-07
HK1019587A1 (en) 2000-02-18
PL330284A1 (en) 1999-05-10
EP0906262B1 (en) 2002-08-14
JP3285361B2 (ja) 2002-05-27
HUP0001827A3 (en) 2001-07-30
HUP0001827A2 (hu) 2001-05-28
NO985676D0 (no) 1998-12-04
CZ294365B6 (cs) 2004-12-15
KR20000016387A (ko) 2000-03-25
CZ401098A3 (cs) 1999-05-12
NO311252B1 (no) 2001-11-05
PL187528B1 (pl) 2004-07-30
AU3027897A (en) 1998-01-07
US6080739A (en) 2000-06-27
PT906262E (pt) 2002-11-29
DK0906262T3 (da) 2002-12-16
NO985676L (no) 1998-12-04
RU2181354C2 (ru) 2002-04-20
SK167998A3 (en) 1999-07-12
CN1122657C (zh) 2003-10-01
ATE222228T1 (de) 2002-08-15
SK283737B6 (sk) 2003-12-02
AU723752B2 (en) 2000-09-07
SK283736B6 (sk) 2003-12-02

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Legal Events

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0001 Granted