WO2005056524A3 - Therapeutic agents useful for treating pain - Google Patents

Therapeutic agents useful for treating pain Download PDF

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Publication number
WO2005056524A3
WO2005056524A3 PCT/US2004/041378 US2004041378W WO2005056524A3 WO 2005056524 A3 WO2005056524 A3 WO 2005056524A3 US 2004041378 W US2004041378 W US 2004041378W WO 2005056524 A3 WO2005056524 A3 WO 2005056524A3
Authority
WO
WIPO (PCT)
Prior art keywords
treating pain
therapeutic agents
agents useful
compound
pharmaceutically acceptable
Prior art date
Application number
PCT/US2004/041378
Other languages
French (fr)
Other versions
WO2005056524A2 (en
Inventor
Bin Shao
Original Assignee
Euro Celtique Sa
Bin Shao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique Sa, Bin Shao filed Critical Euro Celtique Sa
Publication of WO2005056524A2 publication Critical patent/WO2005056524A2/en
Publication of WO2005056524A3 publication Critical patent/WO2005056524A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Abstract

The Invention provides a compound of formula (I), (where A, X, Y, Z, R3, R4, R5, R6, m and n are disclosed herein) or a pharmaceutically acceptable salt thereof (the compound or pharmaceutically acceptable salt thereof being a 'Piperazine Compound'); pharmaceutical compositions comprising an effective amount of a Piperazine Compound; and methods for treating pain, as well as other conditions, comprising administering to an animal in need thereof an effective amount of a Piperazine Compound.
PCT/US2004/041378 2003-12-09 2004-12-09 Therapeutic agents useful for treating pain WO2005056524A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52858103P 2003-12-09 2003-12-09
US60/528,581 2003-12-09

Publications (2)

Publication Number Publication Date
WO2005056524A2 WO2005056524A2 (en) 2005-06-23
WO2005056524A3 true WO2005056524A3 (en) 2005-09-22

Family

ID=34676853

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/041378 WO2005056524A2 (en) 2003-12-09 2004-12-09 Therapeutic agents useful for treating pain

Country Status (1)

Country Link
WO (1) WO2005056524A2 (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
US9388185B2 (en) 2012-08-10 2016-07-12 Incyte Holdings Corporation Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
US9533984B2 (en) 2013-04-19 2017-01-03 Incyte Holdings Corporation Bicyclic heterocycles as FGFR inhibitors
US9533954B2 (en) 2010-12-22 2017-01-03 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
US9580423B2 (en) 2015-02-20 2017-02-28 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
JP7381170B2 (en) 2018-02-23 2023-11-15 ベイジン タイド ファーマシューティカル カンパニー リミテッド Receptor inhibitors, pharmaceutical compositions containing the same, and uses thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005062987A1 (en) * 2005-12-28 2007-07-05 Grünenthal GmbH New substituted propiolic acid amides, useful for treatment and prevention of e.g. pain, anxiety and panic attacks, are inhibitors of the mGluR5 receptor
EP2114940A1 (en) * 2007-02-09 2009-11-11 AstraZeneca AB Aza-isoindolones and their use as metabotropic glutamate receptor potentiators - 613
ME02186B (en) 2009-12-23 2016-02-20 Takeda Pharmaceuticals Co Fused heteroaromatic pyrrolidinones as syk inhibitors
ES2523282T3 (en) * 2010-12-02 2014-11-24 Eli Lilly And Company 3-substituted 6- (pyridinylmethoxy) -pyrrolopyridine compounds
EP2723739B1 (en) 2011-06-22 2016-08-24 Takeda Pharmaceutical Company Limited Substituted 6-aza-isoindolin-1-one derivatives
PT3176170T (en) 2012-06-13 2019-02-05 Incyte Holdings Corp Substituted tricyclic compounds as fgfr inhibitors
BR112014031375A2 (en) 2012-06-20 2017-06-27 Novartis Ag modulators of the complementary reaction series and uses thereof
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
EP3617205B1 (en) 2015-02-20 2021-08-04 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
MA41551A (en) 2015-02-20 2017-12-26 Incyte Corp BICYCLIC HETEROCYCLES USED AS FGFR4 INHIBITORS
TWI788655B (en) 2015-02-27 2023-01-01 美商林伯士拉克許米公司 Tyk2 inhibitors and uses thereof
AR111960A1 (en) 2017-05-26 2019-09-04 Incyte Corp CRYSTALLINE FORMS OF A FGFR INHIBITOR AND PROCESSES FOR ITS PREPARATION
CN112867716A (en) 2018-05-04 2021-05-28 因赛特公司 Solid forms of FGFR inhibitors and methods for their preparation
CA3099116A1 (en) 2018-05-04 2019-11-07 Incyte Corporation Salts of an fgfr inhibitor
WO2020185532A1 (en) 2019-03-08 2020-09-17 Incyte Corporation Methods of treating cancer with an fgfr inhibitor
JOP20220083A1 (en) 2019-10-14 2023-01-30 Incyte Corp Bicyclic heterocycles as fgfr inhibitors
CA3162010A1 (en) 2019-12-04 2021-06-10 Incyte Corporation Derivatives of an fgfr inhibitor
CA3163875A1 (en) 2019-12-04 2021-06-10 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
RU2738707C1 (en) * 2020-06-02 2020-12-15 Федеральное государственное бюджетное образовательное учреждение высшего образования "Чувашский государственный университет имени И.Н. Ульянова" Method of producing furo[3,4-c]pyridine-1(3h)-one derivatives
US11939331B2 (en) 2021-06-09 2024-03-26 Incyte Corporation Tricyclic heterocycles as FGFR inhibitors

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5110927A (en) * 1987-12-31 1992-05-05 The United States Of America As Represented By The Department Of Health And Human Services Prazosin analog with increased selectivity and duration of action
EP0494604A1 (en) * 1991-01-10 1992-07-15 Hoechst-Roussel Pharmaceuticals Incorporated 1-Piperazinyl-2-butenes and 2-butynes, intermediates thereof, a process for their preparation and their use as medicaments
EP0623616A1 (en) * 1993-05-04 1994-11-09 Egis Gyogyszergyar Rt. Heterocyclic compounds and process for the preparation thereof
EP0976753A1 (en) * 1997-03-24 2000-02-02 Kyowa Hakko Kogyo Co., Ltd. [1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE DERIVATIVES
WO2003022214A2 (en) * 2001-09-06 2003-03-20 Millennium Pharmaceuticals, Inc. Piperazine and homopiperazine compounds

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5110927A (en) * 1987-12-31 1992-05-05 The United States Of America As Represented By The Department Of Health And Human Services Prazosin analog with increased selectivity and duration of action
EP0494604A1 (en) * 1991-01-10 1992-07-15 Hoechst-Roussel Pharmaceuticals Incorporated 1-Piperazinyl-2-butenes and 2-butynes, intermediates thereof, a process for their preparation and their use as medicaments
EP0623616A1 (en) * 1993-05-04 1994-11-09 Egis Gyogyszergyar Rt. Heterocyclic compounds and process for the preparation thereof
EP0976753A1 (en) * 1997-03-24 2000-02-02 Kyowa Hakko Kogyo Co., Ltd. [1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE DERIVATIVES
WO2003022214A2 (en) * 2001-09-06 2003-03-20 Millennium Pharmaceuticals, Inc. Piperazine and homopiperazine compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MARK H. NORMAN, DOUGLAS J. MINICK, GREG C. RIGDON: "Effect of Linking Bridge Modifications on the Antipsychotic Profile of Some Phthalimide and Isoindolinone Derivatives", J. MED. CHEM., vol. 39, 1996, pages 149 - 157, XP002330280 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9533954B2 (en) 2010-12-22 2017-01-03 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
US9388185B2 (en) 2012-08-10 2016-07-12 Incyte Holdings Corporation Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
US9533984B2 (en) 2013-04-19 2017-01-03 Incyte Holdings Corporation Bicyclic heterocycles as FGFR inhibitors
US9580423B2 (en) 2015-02-20 2017-02-28 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
JP7381170B2 (en) 2018-02-23 2023-11-15 ベイジン タイド ファーマシューティカル カンパニー リミテッド Receptor inhibitors, pharmaceutical compositions containing the same, and uses thereof
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors

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Publication number Publication date
WO2005056524A2 (en) 2005-06-23

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