MX351028B - Determinadadas entidades, composiciones y metodos quimicos. - Google Patents

Determinadadas entidades, composiciones y metodos quimicos.

Info

Publication number
MX351028B
MX351028B MX2013010738A MX2013010738A MX351028B MX 351028 B MX351028 B MX 351028B MX 2013010738 A MX2013010738 A MX 2013010738A MX 2013010738 A MX2013010738 A MX 2013010738A MX 351028 B MX351028 B MX 351028B
Authority
MX
Mexico
Prior art keywords
chemical entities
methods
compositions
certain chemical
kinase activity
Prior art date
Application number
MX2013010738A
Other languages
English (en)
Inventor
Christian Rommel
Yi Liu
Pingda Ren
Troy Edward Wilson
Liansheng Li
Katrina Chan
Original Assignee
Intellikine Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intellikine Llc filed Critical Intellikine Llc
Publication of MX351028B publication Critical patent/MX351028B/es

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/36—Sulfur atom
    • C07D473/38—Sulfur atom attached in position 6
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Epidemiology (AREA)
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  • Diabetes (AREA)
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  • Mycology (AREA)
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  • Endocrinology (AREA)
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  • Radiology & Medical Imaging (AREA)
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  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)

Abstract

Las entidades químicas que modulan la actividad de la cinasa PI3, las composiciones farmacéuticas que contienen las entidades químicas y los métodos de usar estas entidades químicas para tratar enfermedades y afecciones asociadas con la actividad de la cinasa PO se describen en la presente.
MX2013010738A 2009-07-15 2012-01-12 Determinadadas entidades, composiciones y metodos quimicos. MX351028B (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12/503,776 US8193182B2 (en) 2008-01-04 2009-07-15 Substituted isoquinolin-1(2H)-ones, and methods of use thereof

Publications (1)

Publication Number Publication Date
MX351028B true MX351028B (es) 2017-09-28

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MX2012000626A MX2012000626A (es) 2009-07-15 2010-07-15 Determinadas entidades, composiciones y métodos químicos.
MX2013010738A MX351028B (es) 2009-07-15 2012-01-12 Determinadadas entidades, composiciones y metodos quimicos.

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MX2012000626A MX2012000626A (es) 2009-07-15 2010-07-15 Determinadas entidades, composiciones y métodos químicos.

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US (12) US8193182B2 (es)
EP (4) EP2918589B1 (es)
JP (2) JP5944313B2 (es)
KR (1) KR101680406B1 (es)
CN (3) CN109912599B (es)
AU (1) AU2010274075B2 (es)
BR (1) BR112012000968B8 (es)
CA (1) CA2768307C (es)
CY (1) CY1116424T1 (es)
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HK (2) HK1170491A1 (es)
HR (1) HRP20150586T1 (es)
HU (1) HUS2100048I1 (es)
IL (2) IL217181A (es)
IN (1) IN2012DN00943A (es)
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MX (2) MX2012000626A (es)
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NL (1) NL301140I2 (es)
NZ (3) NZ597595A (es)
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RU (2) RU2582676C3 (es)
SG (2) SG10201503886WA (es)
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WO (1) WO2011008302A1 (es)
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