MX2016003486A - Inhibidores de glucosilceramida sintasa para el tratamiento de enfermedades. - Google Patents

Inhibidores de glucosilceramida sintasa para el tratamiento de enfermedades.

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Publication number
MX2016003486A
MX2016003486A MX2016003486A MX2016003486A MX2016003486A MX 2016003486 A MX2016003486 A MX 2016003486A MX 2016003486 A MX2016003486 A MX 2016003486A MX 2016003486 A MX2016003486 A MX 2016003486A MX 2016003486 A MX2016003486 A MX 2016003486A
Authority
MX
Mexico
Prior art keywords
diseases
treatment
glucosylceramide synthase
synthase inhibitors
compounds
Prior art date
Application number
MX2016003486A
Other languages
English (en)
Inventor
Bing Wang
Daniel Chu
Alexander James Bridges
Original Assignee
Biomarin Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomarin Pharm Inc filed Critical Biomarin Pharm Inc
Publication of MX2016003486A publication Critical patent/MX2016003486A/es

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    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • C07D311/12—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 3 and unsubstituted in position 7
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    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07B2200/07—Optical isomers

Abstract

Se describen en la presente compuestos de la Fórmula I, métodos para elaborar tales compuestos, composiciones farmacéuticas y medicamentos que contienen tales compuestos, y métodos para utilizar tales compuestos para tratar o prevenir enfermedades o padecimientos asociados con la enzima glucosilceramida sintasa (GCS).
MX2016003486A 2013-09-20 2014-09-19 Inhibidores de glucosilceramida sintasa para el tratamiento de enfermedades. MX2016003486A (es)

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PCT/US2014/056555 WO2015042397A1 (en) 2013-09-20 2014-09-19 Glucosylceramide synthase inhibitors for the treatment of diseases

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