MX339811B - Conjugados e inhibidores de cinasa de proteina. - Google Patents
Conjugados e inhibidores de cinasa de proteina.Info
- Publication number
- MX339811B MX339811B MX2012003332A MX2012003332A MX339811B MX 339811 B MX339811 B MX 339811B MX 2012003332 A MX2012003332 A MX 2012003332A MX 2012003332 A MX2012003332 A MX 2012003332A MX 339811 B MX339811 B MX 339811B
- Authority
- MX
- Mexico
- Prior art keywords
- protein kinase
- inhibitors
- irreversibly
- conjugates
- protein
- Prior art date
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Abstract
La presente invención se refiere a conjugados de proteína que contienen una proteína cinasa conteniendo un residuo de cisteína en el sitio de unión ATP y un inhibidor que está covalente e irreversiblemente unido dicho residuo de cisteína, de manera que la actividad de la proteína cinasa es irreversiblemente inhibida. La presente invención también se refiere a compuestos que irreversiblemente inhiben cinasas de proteína.
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US24298809P | 2009-09-16 | 2009-09-16 | |
PCT/US2010/048916 WO2011034907A2 (en) | 2009-09-16 | 2010-09-15 | Protein kinase conjugates and inhibitors |
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MX2012003332A MX2012003332A (es) | 2012-08-03 |
MX339811B true MX339811B (es) | 2016-06-08 |
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MX2012003332A MX339811B (es) | 2009-09-16 | 2010-09-15 | Conjugados e inhibidores de cinasa de proteina. |
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US (2) | US9556426B2 (es) |
EP (1) | EP2478361A4 (es) |
JP (4) | JP5806670B2 (es) |
KR (1) | KR20120093220A (es) |
CN (2) | CN105063001A (es) |
AU (2) | AU2010295690B2 (es) |
BR (1) | BR112012005962A8 (es) |
CA (1) | CA2773985A1 (es) |
IL (1) | IL218678A0 (es) |
IN (1) | IN2012DN02534A (es) |
MX (1) | MX339811B (es) |
NZ (2) | NZ598705A (es) |
RU (1) | RU2012114902A (es) |
SG (1) | SG179172A1 (es) |
WO (1) | WO2011034907A2 (es) |
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