PE20090717A1 - Derivados de quinolina como inhibidores de la pi3 quinasa - Google Patents
Derivados de quinolina como inhibidores de la pi3 quinasaInfo
- Publication number
- PE20090717A1 PE20090717A1 PE2008000854A PE2008000854A PE20090717A1 PE 20090717 A1 PE20090717 A1 PE 20090717A1 PE 2008000854 A PE2008000854 A PE 2008000854A PE 2008000854 A PE2008000854 A PE 2008000854A PE 20090717 A1 PE20090717 A1 PE 20090717A1
- Authority
- PE
- Peru
- Prior art keywords
- kinase inhibitors
- quinoline derivatives
- pyridinasulfonamide
- quinolinyl
- pyridinyl
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
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- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C07D498/04—Ortho-condensed systems
Abstract
REFERIDO A UN COMPUESTO DE FORMULA I, DONDE R2 ES PIRIDINILO SUTITUIDO O NO; R1 ES HETROCICLOALQUILO, ARILO, ENTRE OTROS; R3 Y R4 SON CADA UNO H, HALOGENO, ACILO, ENTRE OTROS; n ES 1-2. SON COMPUESTOS PREFERIDOS 5-[4-(4-PIRIDINIL)-6-QUINOLINIL]-3-PIRIDINASULFONAMIDA; 2-AMINO-5-{4-[3-(AMINOSULFONIL)FENIL]-6-QUINOLINIL}-3-PIRIDINASULFONAMIDA, 2-AMINO-5-[4-(1H-PIRAZOL-4-IL)-6-QUINOLINIL]-3-PIRIDINASULFONAMIDA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y A UN PROCESO DE PREPARACION. DICHO COMPUESTO ES INHIBIDOR DE LA ACTIVIDAD/FUNCION DE PI3 QUINASAS, UTIL EN EL TRATAMIENTO DE TRANSTORNOS AUTOINMUNES, ENFERMEDADES INFLAMATORIAS, ENFERMEDADES CARDIOVASCULARES, ENTRE OTROS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US93876107P | 2007-05-18 | 2007-05-18 |
Publications (1)
Publication Number | Publication Date |
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PE20090717A1 true PE20090717A1 (es) | 2009-07-18 |
Family
ID=40088996
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PE2008000854A PE20090717A1 (es) | 2007-05-18 | 2008-05-14 | Derivados de quinolina como inhibidores de la pi3 quinasa |
Country Status (32)
Country | Link |
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US (6) | US8404837B2 (es) |
EP (3) | EP2596793B1 (es) |
JP (3) | JP4814396B2 (es) |
KR (1) | KR101458660B1 (es) |
CN (1) | CN101754759B (es) |
AR (1) | AR066614A1 (es) |
AU (1) | AU2008254915B2 (es) |
BR (1) | BRPI0811761A2 (es) |
CA (1) | CA2686016C (es) |
CL (1) | CL2008001457A1 (es) |
CO (1) | CO6241101A2 (es) |
CR (1) | CR11165A (es) |
CY (1) | CY1114070T1 (es) |
DK (1) | DK2162131T3 (es) |
EA (1) | EA019540B1 (es) |
ES (2) | ES2404557T3 (es) |
HK (1) | HK1137938A1 (es) |
HR (1) | HRP20130252T1 (es) |
IL (1) | IL202018A (es) |
JO (1) | JO2891B1 (es) |
MA (1) | MA31443B1 (es) |
MX (2) | MX2009012479A (es) |
MY (1) | MY158843A (es) |
NZ (1) | NZ580979A (es) |
PE (1) | PE20090717A1 (es) |
PL (1) | PL2162131T3 (es) |
PT (1) | PT2162131E (es) |
SI (1) | SI2162131T1 (es) |
TW (1) | TWI410417B (es) |
UA (1) | UA104408C2 (es) |
WO (2) | WO2008144463A1 (es) |
ZA (1) | ZA200907777B (es) |
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