HRP20150790T1 - Režimi imunoterapije koji ovise o statusu apoe - Google Patents
Režimi imunoterapije koji ovise o statusu apoe Download PDFInfo
- Publication number
- HRP20150790T1 HRP20150790T1 HRP20150790TT HRP20150790T HRP20150790T1 HR P20150790 T1 HRP20150790 T1 HR P20150790T1 HR P20150790T T HRP20150790T T HR P20150790TT HR P20150790 T HRP20150790 T HR P20150790T HR P20150790 T1 HRP20150790 T1 HR P20150790T1
- Authority
- HR
- Croatia
- Prior art keywords
- humanized antibody
- antibody according
- humanized
- patient
- seq
- Prior art date
Links
- 101150037123 APOE gene Proteins 0.000 title 1
- 101100216294 Danio rerio apoeb gene Proteins 0.000 title 1
- 230000001419 dependent effect Effects 0.000 title 1
- 238000009169 immunotherapy Methods 0.000 title 1
- 108010060159 Apolipoprotein E4 Proteins 0.000 claims 5
- 108700028369 Alleles Proteins 0.000 claims 4
- 210000004556 brain Anatomy 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 208000037259 Amyloid Plaque Diseases 0.000 claims 3
- 102000009091 Amyloidogenic Proteins Human genes 0.000 claims 3
- 108010048112 Amyloidogenic Proteins Proteins 0.000 claims 3
- 230000003942 amyloidogenic effect Effects 0.000 claims 3
- 238000011321 prophylaxis Methods 0.000 claims 3
- 238000011282 treatment Methods 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 206010030113 Oedema Diseases 0.000 claims 1
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000000982 vasogenic effect Effects 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06Q—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
- G06Q99/00—Subject matter not provided for in other groups of this subclass
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Business, Economics & Management (AREA)
- Physics & Mathematics (AREA)
- Theoretical Computer Science (AREA)
- General Physics & Mathematics (AREA)
- General Business, Economics & Management (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (13)
1. Humanizirani oblik 3D6 antitijela koji sadrži humani konstantni dio teškog lanca sa mutacijama L234A, L235A i G237A, pri čemu su pozicije numerirane prema EU sustavu numeracije, naznačen time da 3D6 je antitijelo proizvedeno od ATCC pripojni broj PTA-5130.
2. Humanizirano antitijelo prema zahtjevu 1, naznačeno time da je izotip humani IgG1, IgG2 ili IgG4, poželjno IgG1.
3. Humanizirano antitijelo prema zahtjevu 1, naznačeno time da sadrži varijabilni dio lakog lanca sa zrelom sekvencom SEQ ID NO:2, i varijabilni dio teškog lanca sa zrelom sekvencom SEQ ID NO:3, pri čemu antitijelo ima humani IgG izotip.
4. Humanizirano antitijelo prema zahtjevu 1, naznačeno time da sadrži humanizirani laki lanac sa aminokiselinskom sekvencom koja sadrži SEQ ID NO:48 i humanizirani teški lanac sa aminokiselinskom sekvencom koja sadrži SEQ ID NO:66 ili 67.
5. Farmaceutski sastav, naznačen time da sadrži humanizirano antitijelo prema bilo kojem od zahtjeva 1-4.
6. Izolirana nukleinska kiselina koja kodira humanizirano antitijelo prema bilo kojem od zahtjeva 1-4, sa sekvencom koja sadrži SEQ ID NO:68, pod uvjetom da nukleotidi 1- 57 koji kodiraju signalnu sekvencu mogu a i ne moraju biti prisutni.
7. Humanizirano antitijelo prema bilo kojem od patentnih zahtjeva 1 do 4 za upotrebu u postupku liječenja ili obavljanja profilakse amiloidogene bolesti, naznačeno time da amiloidne naslage Aβ u mozgu kod pacijenta imaju nula ApoE4 alela.
8. Humanizirano antitijelo prema zahtjevu 7, naznačeno time da je za upotrebu prema zahtjevu 7, pri čemu se pacijentu koji ima nula ApoE4 alela daje doza od 0.5-2 mg/kg antitijela.
9. Humanizirano antitijelo prema bilo kojem od patentnih zahtjeva 1 do 4 za upotrebu u postupku liječenja ili obavljanja profilakse amiloidogene bolesti, naznačeno time da amiloidne naslage Aβ u mozgu, kod pacijenta imaju jedan ili dva ApoE4 alela.
10. Humanizirano antitijelo prema zahtjevu 9, za upotrebu prema zahtjevu 9, naznačeno time da se pacijentu koji ima jedan ili dva ApoE4 alela daje doza od 0.15-1 mg/kg antitijela.
11. Humanizirano antitijelo prema bilo kojem od patentnih zahtjeva 7 do 10 za upotrebu prema tim patentnim zahtjevima, naznačeno time da se kod pacijenta prati vazogeni edem, po mogućnosti pomoću MRI.
12. Humanizirano antitijelo prema bilo kojem od patentnih zahtjeva 7 do 11, za upotrebu prema tim patentnim zahtjevima, naznačeno time da je amiloidogena bolest koju karakteriziraju amiloidne naslage Aβ u mozgu Alzheimerova bolest.
13. Antitijelo prema bilo kojem od patentnih zahtjeva 1 do 4, za primjenu u liječenju ili profilaksi bolesti koju karakteriziraju amiloidne naslage u mozgu pacijenta, prema najmanje jednom od prvog i drugog režima, pri čemu se za izbor režima koristi određivanje broja kopija ApoE4.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99942307P | 2007-10-17 | 2007-10-17 | |
| US8382708P | 2008-07-25 | 2008-07-25 | |
| PCT/US2008/080382 WO2009052439A2 (en) | 2007-10-17 | 2008-10-17 | Immunotherapy regimes dependent on apoe status |
| EP08839961.3A EP2207565B1 (en) | 2007-10-17 | 2008-10-17 | Immunotherapy regimes dependent on apoe status |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20150790T1 true HRP20150790T1 (hr) | 2015-08-28 |
Family
ID=40568093
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20150790TT HRP20150790T1 (hr) | 2007-10-17 | 2015-07-17 | Režimi imunoterapije koji ovise o statusu apoe |
Country Status (32)
| Country | Link |
|---|---|
| US (3) | US20090155256A1 (hr) |
| EP (2) | EP2207565B1 (hr) |
| JP (2) | JP5745853B2 (hr) |
| KR (1) | KR101197839B1 (hr) |
| CN (2) | CN101969988A (hr) |
| AR (1) | AR071732A1 (hr) |
| AU (1) | AU2008311823A1 (hr) |
| BR (1) | BRPI0818000A2 (hr) |
| CA (2) | CA2940337A1 (hr) |
| CL (1) | CL2008003089A1 (hr) |
| CO (1) | CO6331295A2 (hr) |
| CY (1) | CY1116552T1 (hr) |
| DK (1) | DK2207565T3 (hr) |
| EA (2) | EA201590833A1 (hr) |
| ES (1) | ES2547230T3 (hr) |
| HK (2) | HK1146234A1 (hr) |
| HR (1) | HRP20150790T1 (hr) |
| HU (1) | HUE025684T2 (hr) |
| IL (1) | IL205127A (hr) |
| JO (1) | JO3076B1 (hr) |
| MX (1) | MX2010004250A (hr) |
| MY (1) | MY156454A (hr) |
| PA (1) | PA8800801A1 (hr) |
| PE (1) | PE20090971A1 (hr) |
| PL (1) | PL2207565T3 (hr) |
| PT (1) | PT2207565E (hr) |
| RS (1) | RS54130B1 (hr) |
| SG (2) | SG10201607589XA (hr) |
| SI (1) | SI2207565T1 (hr) |
| TW (2) | TW201206479A (hr) |
| WO (1) | WO2009052439A2 (hr) |
| ZA (1) | ZA201002544B (hr) |
Families Citing this family (99)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| US6787523B1 (en) * | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
| TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
| MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
| US20060188512A1 (en) * | 2003-02-01 | 2006-08-24 | Ted Yednock | Active immunization to generate antibodies to solble a-beta |
| CA2582194A1 (en) * | 2004-10-05 | 2006-04-20 | Neuralab Limited | Methods and compositions for improving recombinant protein production |
| PE20061329A1 (es) | 2004-12-15 | 2006-12-08 | Neuralab Ltd | Anticuerpos ab humanizados para mejorar la cognicion |
| GT200600031A (es) * | 2005-01-28 | 2006-08-29 | Formulacion anticuerpo anti a beta | |
| WO2006106905A1 (ja) | 2005-03-31 | 2006-10-12 | Chugai Seiyaku Kabushiki Kaisha | 会合制御によるポリペプチド製造方法 |
| RU2415865C2 (ru) * | 2005-06-17 | 2011-04-10 | Вайет | СПОСОБЫ ОЧИСТКИ БЕЛКОВ, СОДЕРЖАЩИХ ОБЛАСТЬ Fc |
| US11046784B2 (en) | 2006-03-31 | 2021-06-29 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
| DK2009101T3 (en) | 2006-03-31 | 2018-01-15 | Chugai Pharmaceutical Co Ltd | Antibody modification method for purification of a bispecific antibody |
| US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
| CL2007002070A1 (es) | 2006-07-14 | 2008-02-08 | Ac Immune S A Genentech Inc | Anticuerpo quimerico o humanizado, o fragmentos de ellos, que se adhieren especificamente a por lo menos un epitopo en la proteina beta-amiloide; molecula de acido nucleico que lo codifica; composicion que lo comprende; su uso para tratar enfermedade |
| US8003097B2 (en) | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
| US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
| US8048420B2 (en) | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
| SI2182983T1 (sl) * | 2007-07-27 | 2014-09-30 | Janssen Alzheimer Immunotherapy | Zdravljenje amiloidogenih bolezni s humaniziranimi protitelesi proti abeta |
| MY163473A (en) | 2007-09-26 | 2017-09-15 | Chugai Pharmaceutical Co Ltd | Modified antibody constant region |
| SI2202245T1 (sl) | 2007-09-26 | 2016-10-28 | Chugai Seiyaku Kabushiki Kaisha | Postopek modificiranja izoelektrične točke protitelesa preko aminokislinske substitucije v CDR |
| UA101167C2 (ru) * | 2007-10-05 | 2013-03-11 | Дженентек, Инк. | Фармацевтическая композиция, предназначенная для лечения глазной болезни |
| AU2008311367B2 (en) * | 2007-10-05 | 2014-11-13 | Ac Immune S.A. | Use of anti-amyloid beta antibody in ocular diseases |
| JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
| DK2236604T3 (en) | 2007-12-05 | 2016-10-03 | Chugai Pharmaceutical Co Ltd | The anti-NR10 antibody and use thereof |
| TWI440469B (zh) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
| US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
| US9925282B2 (en) | 2009-01-29 | 2018-03-27 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| JP5787446B2 (ja) | 2009-03-19 | 2015-09-30 | 中外製薬株式会社 | 抗体定常領域改変体 |
| WO2010107110A1 (ja) | 2009-03-19 | 2010-09-23 | 中外製薬株式会社 | 抗体定常領域改変体 |
| CN102459344A (zh) | 2009-05-15 | 2012-05-16 | 中外制药株式会社 | 抗axl抗体 |
| BRPI1011805A2 (pt) | 2009-06-18 | 2016-10-11 | Pfizer | anticorpos anti incisura-1 |
| GB0912394D0 (en) * | 2009-07-16 | 2009-08-26 | Univ Birmingham | Screening methods |
| US10150808B2 (en) | 2009-09-24 | 2018-12-11 | Chugai Seiyaku Kabushiki Kaisha | Modified antibody constant regions |
| US10053513B2 (en) | 2009-11-30 | 2018-08-21 | Janssen Biotech, Inc. | Antibody Fc mutants with ablated effector functions |
| PT2506871T (pt) | 2009-11-30 | 2016-11-07 | Janssen Biotech Inc | Mutantes de fc de anticorpos com funções efetoras inutilizadas |
| WO2011106732A1 (en) * | 2010-02-25 | 2011-09-01 | Wyeth Llc | Pet monitoring of ab-directed immunotherapy |
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| EP2543730B1 (en) | 2010-03-04 | 2018-10-31 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
| JP2013509985A (ja) * | 2010-04-13 | 2013-03-21 | バクスター、インターナショナル、インコーポレイテッド | アルツハイマー病の静脈内免疫グロブリン処置における脳室拡大速度の使用 |
| EP2560681A4 (en) * | 2010-04-22 | 2013-09-25 | Janssen Alzheimer Immunotherap | USE OF TAU FOR MONITORING IMMUNOTHERAPY |
| WO2012016173A2 (en) * | 2010-07-30 | 2012-02-02 | Ac Immune S.A. | Safe and functional humanized antibodies |
| CN103547594B (zh) | 2010-12-15 | 2016-05-11 | 惠氏有限责任公司 | 抗缺刻蛋白1抗体 |
| US20140302532A1 (en) | 2011-04-12 | 2014-10-09 | Quanterix Corporation | Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury |
| US10654916B2 (en) * | 2011-04-21 | 2020-05-19 | The Regents Of The University Of California, A California Corporation | Compositions and methods for the treatment of neuromyelitis optica |
| US20130209449A9 (en) | 2011-06-13 | 2013-08-15 | Abgenomics Cooperatief U.A. | Anti-psgl-1 antibodies and uses thereof |
| JP5404750B2 (ja) * | 2011-11-22 | 2014-02-05 | シャープ株式会社 | 認知症ケア支援方法、認知症情報出力装置、認知症ケア支援システム、及びコンピュータプログラム |
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