ATE278023T1 - Nicht humane, transgenische säugetiere mit sich entwickelnder neurologischer krankheit - Google Patents

Nicht humane, transgenische säugetiere mit sich entwickelnder neurologischer krankheit

Info

Publication number: ATE278023T1
Authority: AT; Austria
Prior art keywords: human; neurological disease; transgenic mammals; animal; developing neurological
Prior art date: 1994-01-27

Application number

AT95911583T

Other languages

English (en)

Inventor

Karen Hsiao

David R Borchelt

Sangra M Sisodia

Original Assignee

Univ Minnesota

Univ Johns Hopkins

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-01-27

Filing date

1995-01-27

Publication date

2004-10-15

1995-01-27 Application filed by Univ Minnesota, Univ Johns Hopkins filed Critical Univ Minnesota

2004-10-15 Application granted granted Critical

2004-10-15 Publication of ATE278023T1 publication Critical patent/ATE278023T1/de

Links

230000009261 transgenic effect Effects 0.000 title abstract 2
241000124008 Mammalia Species 0.000 title 1
208000012902 Nervous system disease Diseases 0.000 title 1
208000025966 Neurological disease Diseases 0.000 title 1
DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical group C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 abstract 1
210000004602 germ cell Anatomy 0.000 abstract 1
210000001082 somatic cell Anatomy 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0312—Animal model for Alzheimer's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Biotechnology (AREA)
Veterinary Medicine (AREA)
Environmental Sciences (AREA)
General Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Wood Science & Technology (AREA)
Toxicology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Plant Pathology (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Medicinal Chemistry (AREA)
Pathology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Endocrinology (AREA)
Physics & Mathematics (AREA)
Diabetes (AREA)
Neurology (AREA)
Biodiversity & Conservation Biology (AREA)
Microbiology (AREA)
Animal Husbandry (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Investigating Or Analysing Biological Materials (AREA)

AT95911583T 1994-01-27 1995-01-27 Nicht humane, transgenische säugetiere mit sich entwickelnder neurologischer krankheit ATE278023T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US18906494A	1994-01-27	1994-01-27
PCT/US1995/001088 WO1995020666A2 (en)	1994-01-27	1995-01-27	Transgenic non-human mammals with progressive neurologic disease

Publications (1)

Publication Number	Publication Date
ATE278023T1 true ATE278023T1 (de)	2004-10-15

Family

ID=22695766

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95911583T ATE278023T1 (de)	1994-01-27	1995-01-27	Nicht humane, transgenische säugetiere mit sich entwickelnder neurologischer krankheit

Country Status (8)

Country	Link
US (1)	US6262335B1 (de)
EP (1)	EP0742831B1 (de)
JP (1)	JPH09511388A (de)
AT (1)	ATE278023T1 (de)
AU (1)	AU1909695A (de)
CA (1)	CA2182311A1 (de)
DE (1)	DE69533583T2 (de)
WO (1)	WO1995020666A2 (de)

Families Citing this family (46)

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US5586226A (en) *	1990-05-16	1996-12-17	Canon Kabushiki Kaisha	Control method and device for a unicolor printer
US5877399A (en) *	1994-01-27	1999-03-02	Johns Hopkins University	Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease
US5789655A (en) *	1994-05-13	1998-08-04	The Regents Of The University Of California	Transgenic animals expressing artificial epitope-tagged proteins
US5777194A (en) *	1995-04-26	1998-07-07	Cephalon, Inc.	Gene-targeted mice with humanized Aβ sequence and Swedish FAD mutation
AU6264996A (en) *	1995-06-07	1996-12-30	Athena Neurosciences, Inc.	Method for identifying alzheimer's disease therapeutics usin g transgenic animal models
US6717031B2 (en)	1995-06-07	2004-04-06	Kate Dora Games	Method for selecting a transgenic mouse model of alzheimer's disease
WO1999009150A1 (en) *	1996-08-15	1999-02-25	Bayer Corporation	Method of introducing modifications into a gene
GB9706463D0 (en)	1997-03-27	1997-05-14	Medical Res Council	A model of inflamation in the central nervous system for use in the study of disease
US6905686B1 (en)	1997-12-02	2005-06-14	Neuralab Limited	Active immunization for treatment of alzheimer's disease
US6710226B1 (en)	1997-12-02	2004-03-23	Neuralab Limited	Transgenic mouse assay to determine the effect of Aβ antibodies and Aβ Fragments on alzheimer's disease characteristics
US7964192B1 (en) *	1997-12-02	2011-06-21	Janssen Alzheimer Immunotherapy	Prevention and treatment of amyloidgenic disease
US6761888B1 (en) *	2000-05-26	2004-07-13	Neuralab Limited	Passive immunization treatment of Alzheimer's disease
US6787523B1 (en)	1997-12-02	2004-09-07	Neuralab Limited	Prevention and treatment of amyloidogenic disease
US7179892B2 (en) *	2000-12-06	2007-02-20	Neuralab Limited	Humanized antibodies that recognize beta amyloid peptide
US6913745B1 (en)	1997-12-02	2005-07-05	Neuralab Limited	Passive immunization of Alzheimer's disease
US6750324B1 (en)	1997-12-02	2004-06-15	Neuralab Limited	Humanized and chimeric N-terminal amyloid beta-antibodies
US20080050367A1 (en)	1998-04-07	2008-02-28	Guriq Basi	Humanized antibodies that recognize beta amyloid peptide
US6923964B1 (en)	1997-12-02	2005-08-02	Neuralab Limited	Active immunization of AScr for prion disorders
US7790856B2 (en)	1998-04-07	2010-09-07	Janssen Alzheimer Immunotherapy	Humanized antibodies that recognize beta amyloid peptide
TWI239847B (en) *	1997-12-02	2005-09-21	Elan Pharm Inc	N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
US20030147882A1 (en) *	1998-05-21	2003-08-07	Alan Solomon	Methods for amyloid removal using anti-amyloid antibodies
US6787637B1 (en)	1999-05-28	2004-09-07	Neuralab Limited	N-Terminal amyloid-β antibodies
UA81216C2 (en) *	1999-06-01	2007-12-25		Prevention and treatment of amyloid disease
WO2001053340A2 (en) *	2000-01-21	2001-07-26	Pharmacia & Upjohn Company	Transgenic mouse model of human neurodegenerative disease
DK1292187T3 (da) *	2000-06-20	2006-08-21	Univ Toronto	Transgen dyremodel for neurodegenerative lidelser
US7371920B2 (en) *	2000-06-20	2008-05-13	The Governing Council Of The University Of Toronto	Transgenic mouse model of neurodegenerative disorders
PE20020574A1 (es) *	2000-12-06	2002-07-02	Wyeth Corp	Anticuerpos humanizados que reconocen el peptido amiloideo beta
US7700751B2 (en)	2000-12-06	2010-04-20	Janssen Alzheimer Immunotherapy	Humanized antibodies that recognize β-amyloid peptide
EP1764734A1 (de) *	2001-02-22	2007-03-21	Sony Corporation	Inhaltbereitstellungs-/Erfassungssystem
GB0120344D0 (en) *	2001-08-21	2001-10-17	Smithkline Beecham Plc	Compounds
EP1469717A4 (de) *	2001-12-20	2007-08-22	Univ California	Dreifach transgenes mausmodell für morbus alzheimer
MY139983A (en)	2002-03-12	2009-11-30	Janssen Alzheimer Immunotherap	Humanized antibodies that recognize beta amyloid peptide
WO2003097674A1 (en) *	2002-05-17	2003-11-27	Pipeline Biotech A/S	A purified polypeptide, isolated nucleic acids encoding said polypeptide, vectors and use thereof
BRPI0407058A (pt) *	2003-02-01	2006-01-17	Neuralab Ltd	Métodos de profilaxia e de tratamento de uma doença, composição farmacêutica, e, uso de um fragmento
TWI306458B (en)	2003-05-30	2009-02-21	Elan Pharma Int Ltd	Humanized antibodies that recognize beta amyloid peptide
CA2590337C (en)	2004-12-15	2017-07-11	Neuralab Limited	Humanized amyloid beta antibodies for use in improving cognition
EP1838854B1 (de) *	2004-12-15	2012-10-31	Janssen Alzheimer Immunotherapy	Antikörper, die Amyloid-Peptide erkennen
US8784810B2 (en)	2006-04-18	2014-07-22	Janssen Alzheimer Immunotherapy	Treatment of amyloidogenic diseases
JP4942081B2 (ja)	2006-06-20	2012-05-30	独立行政法人理化学研究所	アルツハイマー病モデル動物およびその用途
US8003097B2 (en)	2007-04-18	2011-08-23	Janssen Alzheimer Immunotherapy	Treatment of cerebral amyloid angiopathy
ES2498040T3 (es)	2007-07-27	2014-09-24	Janssen Alzheimer Immunotherapy	Tratamiento de enfermedades amiloidogénicas con anticuerpos anti-beta humanizados
JO3076B1 (ar)	2007-10-17	2017-03-15	Janssen Alzheimer Immunotherap	نظم العلاج المناعي المعتمد على حالة apoe
US9067981B1 (en)	2008-10-30	2015-06-30	Janssen Sciences Ireland Uc	Hybrid amyloid-beta antibodies
US8008539B1 (en)	2009-03-19	2011-08-30	University Of South Florida	Generation of transgenic human soluble amyloid precursor protein alpha expressing mice
EP3004872B1 (de)	2013-06-04	2017-10-18	Virginia Commonwealth University	Mda-9/syntenin-promotor zur abbildung und behandlung metastatischer krebszellen
US9750823B2 (en)	2013-06-04	2017-09-05	Virginia Commonwealth University	Use of a truncated CCN1 promoter for cancer diagnostics, therapeutics and theranostics

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US4873191A (en)	1981-06-12	1989-10-10	Ohio University	Genetic transformation of zygotes
AU3056289A (en)	1988-01-13	1989-08-11	Mclean Hospital Corporation, The	Genetic constructs containing the alzheimer brain amyloid gene
EP0451700A1 (de)	1990-04-10	1991-10-16	Miles Inc.	Rekombinante APP Minigene zur Expression in Transgen-Mäusen als Alzheimer-Krankheitsmuster
US5387742A (en)	1990-06-15	1995-02-07	Scios Nova Inc.	Transgenic mice displaying the amyloid-forming pathology of alzheimer's disease
EP0550675A1 (de)	1990-09-28	1993-07-14	Cephalon, Inc.	Alzheimeramyloidvorläufersgen enthaltende transgentiere
CA2372251A1 (en)	1991-01-21	1992-08-06	Michael John Mullan	Test and model for alzheimer's disease
US5672805A (en)	1991-07-18	1997-09-30	The Regents Of The University Of California	Transgenic mice expressing the neurotoxic C-terminus of β-amyloid precursor protein
JPH07506720A (ja)	1992-01-07	1995-07-27	アテナ　ニューロサイエンシーズ，　インコーポレイテッド	アルツハイマー病のトランスジェニック動物モデル
US5604102A (en)	1992-04-15	1997-02-18	Athena Neurosciences, Inc.	Methods of screening for β-amyloid peptide production inhibitors
US5455169A (en)	1992-06-04	1995-10-03	Alzheimer's Institute Of America, Inc.	Nucleic acids for diagnosing and modeling Alzheimer's disease
PT730643E (pt)	1993-10-27	2001-06-29	Lilly Co Eli	Animais transgenicos portadores do alelo de app com mutacao sueca
JPH07132033A (ja)	1993-11-12	1995-05-23	Hoechst Japan Ltd	アルツハイマー病モデルトランスジェニック動物
US5877399A (en) *	1994-01-27	1999-03-02	Johns Hopkins University	Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease

1995
- 1995-01-27 CA CA002182311A patent/CA2182311A1/en not_active Abandoned
- 1995-01-27 DE DE69533583T patent/DE69533583T2/de not_active Expired - Lifetime
- 1995-01-27 AT AT95911583T patent/ATE278023T1/de not_active IP Right Cessation
- 1995-01-27 WO PCT/US1995/001088 patent/WO1995020666A2/en active IP Right Grant
- 1995-01-27 JP JP7520186A patent/JPH09511388A/ja active Pending
- 1995-01-27 EP EP95911583A patent/EP0742831B1/de not_active Expired - Lifetime
- 1995-01-27 AU AU19096/95A patent/AU1909695A/en not_active Abandoned
1998
- 1998-02-06 US US09/019,973 patent/US6262335B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0742831A1 (de)	1996-11-20
AU1909695A (en)	1995-08-15
US6262335B1 (en)	2001-07-17
JPH09511388A (ja)	1997-11-18
DE69533583T2 (de)	2005-10-06
EP0742831B1 (de)	2004-09-29
WO1995020666A2 (en)	1995-08-03
CA2182311A1 (en)	1995-08-03
WO1995020666A3 (en)	1995-09-28
DE69533583D1 (de)	2004-11-04

Legal Events

Date	Code	Title	Description
2005-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE278023T1 (de)	2004-10-15	Nicht humane, transgenische säugetiere mit sich entwickelnder neurologischer krankheit
ATE315085T1 (de)	2006-02-15	Transgene mäuse mit veränderter apolipoprotein e- expression und testverfahren.
BR9610843A (pt)	1999-07-13	Animais transgênicos para xenotransplante com reduzida rejeição mediada por anticorpo
BR9710652A (pt)	2000-01-11	Linhagens de célula de massa interna de célula derivadas de embriões de ungulados.
DE69600581T2 (de)	1999-04-01	Tierzuchtvorrichtung
NO881478D0 (no)	1988-04-06	Fiskeinnhegning for fiskeoppdrett.
DE60023451D1 (de)	2005-12-01	Aus nicht-menschlichen transgenen tieren gewonnene menschliche polyklonale antikörper
NO954483D0 (no)	1995-11-08	Inkubator for oppdrett av fiskeyngel
NO154411C (no)	1989-03-21	Maerkonstruksjon for fiskeoppdrett.
DE69728263D1 (de)	2004-04-29	Mit modifizierten h2-m transgene tiere
DE59814285D1 (de)	2008-10-23	Efficienter kerntransfer mit primordialen keimzellen
DE19780525D2 (de)	1999-10-28	Tierhaus für Kleintiere
ATE257173T1 (de)	2004-01-15	Thrombinrezeptor modifizierte transgene tiere
NO166751C (no)	1993-09-07	Anordning ved fiskeoppdrettsnett.
DK0977838T3 (da)	2004-08-30	H2-O modificerede transgene dyr
FR2715533B1 (fr)	1996-04-26	Batterie de cages étagées pour l'élevage d'animaux, équipée d'une installation de séchage des excréments.
IT1210180B (it)	1989-09-06	Habitat etologico per allevamento di roditori ed altri animali acquatici.
KR950000457U (ko)	1995-01-03	축산용 수정란 해빙용 포트
BE871521A (fr)	1979-02-15	Installation d'hebergement et d'elevage d'animaux aquatiques.
DE9418521U1 (de)	1995-01-12	Jungtiertränke
SE9702543D0 (sv)	1997-07-01	A milking stall
ES2156460A1 (es)	2001-06-16	Animal transgenico no humano que sobreexpresa el gen de la p-enolpiruvato carboxiquinasa para su utilizacion en el estudio de la diabetes mellitus y en el desarrollo de aproximaciones terapeuticas a la enfermedad.
BR9601656A (pt)	1998-03-31	Conjunto de alimentação paraaves reprodutoras de ovos ferteis
KR970011790U (ko)	1997-04-25	착유실 구조를 갖는 우사
KR970000085U (ko)	1997-01-21	찌몸체를 중심부에 탈부착 가능한 낚시찌