HRP20040684B1 - Spojevi 2,4-pirimidindiamina i njihova upotreba - Google Patents

Spojevi 2,4-pirimidindiamina i njihova upotreba

Info

Publication number
HRP20040684B1
HRP20040684B1 HRP20040684AA HRP20040684A HRP20040684B1 HR P20040684 B1 HRP20040684 B1 HR P20040684B1 HR P20040684A A HRP20040684A A HR P20040684AA HR P20040684 A HRP20040684 A HR P20040684A HR P20040684 B1 HRP20040684 B1 HR P20040684B1
Authority
HR
Croatia
Prior art keywords
compounds
release
methods
pyrimidinediamine compounds
receptor signaling
Prior art date
Application number
HRP20040684AA
Other languages
English (en)
Inventor
Rajinder Singh
Ankush Argade
Donald G. Payan
Susan Molineux
Sacha J. Holland
Jeffrey Clough
Holger Keim
Somasekhar Bhamidipati
Catherine Sylvain
Hui Li
Alexander B. Rossi
Original Assignee
Rigel Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32996332&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20040684(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rigel Pharmaceuticals, Inc. filed Critical Rigel Pharmaceuticals, Inc.
Publication of HRP20040684A2 publication Critical patent/HRP20040684A2/hr
Publication of HRP20040684B1 publication Critical patent/HRP20040684B1/hr

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/027—Organoboranes and organoborohydrides

Abstract

Ovaj izum omogućuje spojeve 2,4-pirimidindiamina koji inhibiraju IgE i/ili IgG receptor signalizirajuće kaskade koji vode oslobađanju kemijskih posrednika, međuproizvode i metode sinteziranja spojeva i metode korištenja spojeva u različitim kontekstima, uključujući i liječenje i prevenciju bolesti karakteriziranih, prouzročenih ili vezanih za oslobađanje kemijskih posrednika putem degranulacije i drugih procesa na koje utječe aktiviranje IgE i/ili IgG receptora signalizirajućih kaskada.
HRP20040684AA 2002-02-01 2004-07-23 Spojevi 2,4-pirimidindiamina i njihova upotreba HRP20040684B1 (hr)

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US35326702P 2002-02-01 2002-02-01
US35333302P 2002-02-01 2002-02-01
US39967302P 2002-07-29 2002-07-29
US43427702P 2002-12-17 2002-12-17
PCT/US2003/003022 WO2003063794A2 (en) 2002-02-01 2003-01-31 2,4-pyrimidinediamine compounds and their uses

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HRP20040684A2 HRP20040684A2 (hr) 2008-12-31
HRP20040684B1 true HRP20040684B1 (hr) 2014-07-04

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