FI113771B - Enantiomeriskt ren (1S,6S) -2-oxa-5,8-diazabicyklo[4.3.0]nonan - Google Patents

Enantiomeriskt ren (1S,6S) -2-oxa-5,8-diazabicyklo[4.3.0]nonan Download PDF

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Publication number
FI113771B
FI113771B FI20020059A FI20020059A FI113771B FI 113771 B FI113771 B FI 113771B FI 20020059 A FI20020059 A FI 20020059A FI 20020059 A FI20020059 A FI 20020059A FI 113771 B FI113771 B FI 113771B
Authority
FI
Finland
Prior art keywords
diazabicyclo
oxa
acid
nonane
oxo
Prior art date
Application number
FI20020059A
Other languages
English (en)
Finnish (fi)
Other versions
FI20020059A (sv
Inventor
Rainer Endermann
Karl Georg Metzger
Ingo Haller
Thomas Philipps
Uwe Petersen
Thomas Schenke
Andreas Krebs
Klaus Grohe
Klaus-Dieter Bremm
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27203290&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI113771(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE4200414A external-priority patent/DE4200414A1/de
Priority claimed from DE4208792A external-priority patent/DE4208792A1/de
Priority claimed from DE4208789A external-priority patent/DE4208789A1/de
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of FI20020059A publication Critical patent/FI20020059A/sv
Application granted granted Critical
Publication of FI113771B publication Critical patent/FI113771B/sv

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Fodder In General (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)

Claims (2)

113771 Patenttivaatimus Enantiomeeripuhdas (IS,6S)-2-oksa-5,8-diatsabisyk-lo [4.3.0]nonaani, jolla on kaava VI c 5 H N H........ί-^-Ή <VIc> HN_f O 10
15 Enantiomeriskt ren (IS,6S)-2-oxa-5,8-diazabicyklo- [4.3.0]nonan med formeln VI c * H N j H.......H (VIc) ’ HN _/ O »
FI20020059A 1992-01-10 2002-01-11 Enantiomeriskt ren (1S,6S) -2-oxa-5,8-diazabicyklo[4.3.0]nonan FI113771B (sv)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DE4200414A DE4200414A1 (de) 1992-01-10 1992-01-10 Chinolon- und naphthyridon-carbonsaeure-derivate
DE4200414 1992-01-10
DE4208792 1992-03-19
DE4208792A DE4208792A1 (de) 1992-03-19 1992-03-19 Enantiomerenreine chinolincarbonsaeure-derivate
DE4208789A DE4208789A1 (de) 1992-03-19 1992-03-19 Enantiomerenreine chinolincarbonsaeure-derivate
DE4208789 1992-03-19

Publications (2)

Publication Number Publication Date
FI20020059A FI20020059A (sv) 2002-01-11
FI113771B true FI113771B (sv) 2004-06-15

Family

ID=27203290

Family Applications (3)

Application Number Title Priority Date Filing Date
FI930049A FI104174B (sv) 1992-01-10 1993-01-07 Förfarande för framställning av terapeutiskt användbara 7-£S,S|-2,8-diazabicyklo£4.3.0|nonanisomer av 1,4-dihydro-4-oxo-3-kinolinkarboxylsyra
FI990207A FI110943B (sv) 1992-01-10 1999-02-03 Enantiomeriskt rena 2,8-diazabicyklo[4.3.0]nonanderivat
FI20020059A FI113771B (sv) 1992-01-10 2002-01-11 Enantiomeriskt ren (1S,6S) -2-oxa-5,8-diazabicyklo[4.3.0]nonan

Family Applications Before (2)

Application Number Title Priority Date Filing Date
FI930049A FI104174B (sv) 1992-01-10 1993-01-07 Förfarande för framställning av terapeutiskt användbara 7-£S,S|-2,8-diazabicyklo£4.3.0|nonanisomer av 1,4-dihydro-4-oxo-3-kinolinkarboxylsyra
FI990207A FI110943B (sv) 1992-01-10 1999-02-03 Enantiomeriskt rena 2,8-diazabicyklo[4.3.0]nonanderivat

Country Status (16)

Country Link
EP (1) EP0550903A1 (sv)
JP (3) JPH05271229A (sv)
KR (1) KR100251886B1 (sv)
CN (3) CN1043142C (sv)
AU (1) AU669502B2 (sv)
CA (1) CA2086914C (sv)
CZ (1) CZ289076B6 (sv)
FI (3) FI104174B (sv)
HU (1) HU219488B (sv)
MX (1) MX9207604A (sv)
MY (1) MY115416A (sv)
NO (1) NO301420B1 (sv)
NZ (1) NZ245640A (sv)
PL (1) PL174853B1 (sv)
SK (3) SK285155B6 (sv)
TW (1) TW209865B (sv)

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JP3372994B2 (ja) 1993-06-11 2003-02-04 富士写真フイルム株式会社 ハロゲン化銀カラー写真感光材料の処理方法
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CN1343128B (zh) 1999-03-17 2010-04-21 第一制药株式会社 药物组合物
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IT1398952B1 (it) * 2010-03-19 2013-03-28 F S I Fabbrica Italiana Sint Processo di preparazione della moxifloxacina e suoi sali
CN101941969B (zh) * 2010-09-30 2012-05-23 江苏正大丰海制药有限公司 盐酸莫西沙星的制备方法
CN102675307A (zh) * 2011-03-17 2012-09-19 苏州中科天马肽工程中心有限公司 一种制备手性化合物8-苯乙基-2,8-二氮杂二环[4.3.0]壬烷的方法
CN102675308A (zh) * 2011-03-17 2012-09-19 苏州中科天马肽工程中心有限公司 一种制备8-苄基-2,8-二氮杂二环[4.3.0]壬烷的方法
ITTO20110705A1 (it) 2011-07-29 2013-01-30 Italiana Sint Spa Procedimento di preparazione della moxifloxacina cloridrato e relativi intermedi
CN102964346B (zh) * 2011-09-01 2015-04-22 中国中化股份有限公司 一种制备(S,S)-八氢-6H-吡咯并[3,4-b]吡啶的方法
CN103044418B (zh) * 2011-10-14 2015-02-04 上海朴颐化学科技有限公司 (s,s)-2,8-二氮杂双环[4,3,0]壬烷的不对称合成方法、相关原料及制备方法
CN102408427B (zh) * 2011-10-22 2012-12-12 浙江普洛康裕制药有限公司 莫西沙星中间体〔1s，6r〕—8—苄基—7，9—二氧—2，8—二氮杂双环［4．3．0］壬烷的制备方法
BRPI1106900A2 (pt) 2011-12-26 2013-11-05 Ems Sa Composição farmacêutica sólida compreendendo antibótico da familia das quinolonas e processo de sua obtenção
FR2992218B1 (fr) 2012-06-22 2015-01-23 Rivopharm Sa Composition pharmaceutique de chlorhydrate de moxifloxacine et procede de preparation
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CN103012452B (zh) * 2012-12-25 2015-12-02 浙江新和成股份有限公司 一种莫西沙星及其盐酸盐的制备方法
UA106556C2 (uk) * 2013-05-13 2014-09-10 Наталья Николаевна Деркач СПОСІБ ОДЕРЖАННЯ (1-ЦИКЛОПРОПІЛ-6-ФТОР-1,4-ДИГІДРО-8-МЕТОКСІ-7-[(4aS,7aS)-ОКТАГІДРО-6Н-ПІРОЛО[3,4-b]-4-ОКСО-3-ХІНОЛІНКАРБОНОВОЇ КИСЛОТИ
CN103724262B (zh) * 2013-12-10 2016-05-18 广东省第二人民医院 一种氟喹诺酮银化合物及其制备方法和用途
CN104860944A (zh) * 2015-06-09 2015-08-26 内蒙古东北六药集团有限公司 盐酸莫西沙星的生产方法
CN108872413B (zh) * 2018-04-27 2021-06-08 山东齐都药业有限公司 检测(s,s)-2,8-二氮杂双环[4,3,0]壬烷中对映异构体含量的方法
CN110627768B (zh) * 2018-06-22 2021-11-09 扬子江药业集团有限公司 一种莫西沙星降解杂质j的制备方法
CN110183445B (zh) * 2019-06-28 2021-08-24 昆明学院 莫西沙星及其衍生物的合成方法
RU2713932C1 (ru) * 2019-10-31 2020-02-11 федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) Соединения фторхинолонового ряда на основе производных пиридоксина, обладающие антибактериальными свойствами
CN112939849B (zh) * 2019-12-11 2022-05-03 浙江新和成股份有限公司 一种(s,s)-2,8-二氮杂双环[4.3.0]壬烷中间体及其制备方法和应用
CN110981874A (zh) * 2020-03-05 2020-04-10 北京四环生物制药有限公司 一种盐酸莫西沙星的制备方法
CN112409352B (zh) * 2020-11-20 2022-05-24 华南理工大学 一类莫西沙星类药物衍生物及其制备方法和应用
CN112574197B (zh) * 2020-12-07 2021-12-31 泰安汉威集团有限公司 一种化合物c的手性纯化方法

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Also Published As

Publication number Publication date
TW209865B (sv) 1993-07-21
JP2003026574A (ja) 2003-01-29
SK285155B6 (sk) 2006-07-07
CA2086914A1 (en) 1993-07-11
HU219488B (hu) 2001-04-28
KR100251886B1 (ko) 2000-07-01
CZ289076B6 (cs) 2001-10-17
PL174853B1 (pl) 1998-09-30
FI20020059A (sv) 2002-01-11
CN1212256A (zh) 1999-03-31
AU3105493A (en) 1993-07-15
FI990207A0 (sv) 1999-02-03
NO301420B1 (no) 1997-10-27
FI104174B1 (sv) 1999-11-30
MX9207604A (es) 1993-10-01
FI990207A (sv) 1999-02-03
JPH05271229A (ja) 1993-10-19
JP2003048890A (ja) 2003-02-21
SK282971B6 (sk) 2003-01-09
CN1074218A (zh) 1993-07-14
SK285223B6 (sk) 2006-09-07
MY115416A (en) 2003-06-30
CN1043142C (zh) 1999-04-28
PL297338A1 (en) 1993-09-06
FI930049A0 (fi) 1993-01-07
HUT64065A (en) 1993-11-29
JP4111431B2 (ja) 2008-07-02
HU9300034D0 (en) 1993-04-28
NO924978D0 (no) 1992-12-22
SK396692A3 (en) 2002-09-10
SK2232000A3 (sk) 2006-05-04
CA2086914C (en) 2005-03-15
CN1192440A (zh) 1998-09-09
FI104174B (sv) 1999-11-30
CN1061351C (zh) 2001-01-31
CZ396692A3 (en) 1993-08-11
NZ245640A (en) 1995-03-28
FI110943B (sv) 2003-04-30
CN1075499C (zh) 2001-11-28
KR930016421A (ko) 1993-08-26
EP0550903A1 (de) 1993-07-14
NO924978L (no) 1993-07-12
AU669502B2 (en) 1996-06-13
FI930049A (fi) 1993-07-11
SK2212000A3 (sk) 2006-05-04

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