ITTO20110705A1 - Procedimento di preparazione della moxifloxacina cloridrato e relativi intermedi - Google Patents

Procedimento di preparazione della moxifloxacina cloridrato e relativi intermedi

Info

Publication number
ITTO20110705A1
ITTO20110705A1 IT000705A ITTO20110705A ITTO20110705A1 IT TO20110705 A1 ITTO20110705 A1 IT TO20110705A1 IT 000705 A IT000705 A IT 000705A IT TO20110705 A ITTO20110705 A IT TO20110705A IT TO20110705 A1 ITTO20110705 A1 IT TO20110705A1
Authority
IT
Italy
Prior art keywords
moxifloxacine
chloridrate
procedure
preparation
related intermediates
Prior art date
Application number
IT000705A
Other languages
English (en)
Inventor
Gianni Gottardo
Sergio Osti
Pierluigi Padovan
Original Assignee
Italiana Sint Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Italiana Sint Spa filed Critical Italiana Sint Spa
Priority to IT000705A priority Critical patent/ITTO20110705A1/it
Priority to EP12175485.7A priority patent/EP2551268B1/en
Priority to RU2012128887/04A priority patent/RU2012128887A/ru
Priority to US13/543,896 priority patent/US8664398B2/en
Publication of ITTO20110705A1 publication Critical patent/ITTO20110705A1/it
Priority to US14/158,939 priority patent/US8975408B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IT000705A 2011-07-29 2011-07-29 Procedimento di preparazione della moxifloxacina cloridrato e relativi intermedi ITTO20110705A1 (it)

Priority Applications (5)

Application Number Priority Date Filing Date Title
IT000705A ITTO20110705A1 (it) 2011-07-29 2011-07-29 Procedimento di preparazione della moxifloxacina cloridrato e relativi intermedi
EP12175485.7A EP2551268B1 (en) 2011-07-29 2012-07-09 Process for the preparation of moxifloxacin hydrochloride and intermediates thereof
RU2012128887/04A RU2012128887A (ru) 2011-07-29 2012-07-09 Способ получения гидрохлорида моксифлоксацина и его промежуточных продуктов
US13/543,896 US8664398B2 (en) 2011-07-29 2012-07-09 Moxifloxacin hydrochloride compounds and intermediates and methods for making same
US14/158,939 US8975408B2 (en) 2011-07-29 2014-01-20 Moxifloxacin hydrochloride compounds and intermediates and methods for making same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT000705A ITTO20110705A1 (it) 2011-07-29 2011-07-29 Procedimento di preparazione della moxifloxacina cloridrato e relativi intermedi

Publications (1)

Publication Number Publication Date
ITTO20110705A1 true ITTO20110705A1 (it) 2013-01-30

Family

ID=44584490

Family Applications (1)

Application Number Title Priority Date Filing Date
IT000705A ITTO20110705A1 (it) 2011-07-29 2011-07-29 Procedimento di preparazione della moxifloxacina cloridrato e relativi intermedi

Country Status (4)

Country Link
US (2) US8664398B2 (it)
EP (1) EP2551268B1 (it)
IT (1) ITTO20110705A1 (it)
RU (1) RU2012128887A (it)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103396416B (zh) * 2013-07-17 2015-06-17 南京优科生物医药研究有限公司 一种莫西沙星杂质f的制备方法
CN104513237A (zh) * 2013-09-30 2015-04-15 重庆药友制药有限责任公司 一种制备n-甲基莫西沙星的新方法
CN103664940A (zh) * 2014-01-09 2014-03-26 北京恩成康泰生物科技有限公司 一种莫西沙星杂质的制备方法
CN104016981B (zh) * 2014-06-23 2016-03-23 南京正大天晴制药有限公司 一种盐酸莫西沙星结构类似物及其制备方法
CN104807935B (zh) * 2015-04-30 2016-06-08 成都百裕科技制药有限公司 一种盐酸莫西沙星中间体及其对映异构体的分离检测方法
CN111024831B (zh) * 2018-10-09 2023-05-02 江苏正大丰海制药有限公司 一种高效液相色谱法分离盐酸莫西沙星及其杂质的方法
CN111089906B (zh) * 2018-10-23 2023-06-02 江苏正大丰海制药有限公司 一种莫西沙星盐酸盐与莫西沙星酒石酸盐的分离方法
CN113588837B (zh) * 2021-08-10 2023-03-10 山东鲁抗医药股份有限公司 一种盐酸莫西沙星有关物质的检测方法
CN113820409B (zh) * 2021-09-01 2022-10-21 河北国龙制药有限公司 一种莫西沙星母核中有关物质的检测方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1992626A1 (en) * 2007-05-10 2008-11-19 Sandoz AG Process for the preparation of moxifloxacin hydrochloride

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW209865B (it) 1992-01-10 1993-07-21 Bayer Ag
KR100531065B1 (ko) * 1997-09-25 2005-11-28 바이엘 악티엔게젤샤프트 활성제 방출이 제어된 의약 제제
US6383471B1 (en) * 1999-04-06 2002-05-07 Lipocine, Inc. Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents
US20060264635A1 (en) 2003-08-05 2006-11-23 Chava Satyanarayana Process for the preparation of moxifloxacin hydrochloride
US7759362B2 (en) * 2004-04-21 2010-07-20 Institut Of Medicinal Biotechnology Chinese Academy Of Medical Sciences Quinolonecarboxylic acid compounds, preparation methods and pharmaceutical uses thereof
WO2006134491A2 (en) 2005-06-14 2006-12-21 Aurobindo Pharma Limited New crystalline form of moxifloxacin hydrochloride and process for its preparation
ES2284380B1 (es) 2006-03-10 2008-11-01 Quimica Sintetica S.A. Procedimiento para la preparacion de moxifloxacino y moxifloxacino clorhidrato.
IN2014MN02582A (it) 2006-11-13 2015-09-11 Cipla Ltd
IT1393337B1 (it) 2009-03-06 2012-04-20 Italiana Sint Spa Sintesi di (4as, 7as)-ottaidro-1h-pirrolo[3,4-b]piridina
CN101817820B (zh) * 2009-07-30 2011-10-05 重庆博腾制药科技股份有限公司 一种盐酸莫西沙星的合成方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1992626A1 (en) * 2007-05-10 2008-11-19 Sandoz AG Process for the preparation of moxifloxacin hydrochloride

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LALITHA DEVI M ET AL: "A Validated, Specific Stability-Indicating RP-LC Method for Moxifloxacin and Its Related Substances", CHROMATOGRAPHIA ; AN INTERNATIONAL JOURNAL FOR RAPID COMMUNICATION IN CHROMATOGRAPHY, ELECTROPHORESIS AND ASSOCIATED TECHNIQUES, VIEWEG VERLAG, WI, vol. 69, no. 9-10, 21 March 2009 (2009-03-21), pages 993 - 999, XP019666785, ISSN: 1612-1112 *
RAVINDRA KUMAR Y ET AL: "STRUCTURAL IDENTIFICATION AND CHARACTERIZATION OF IMPURITIES IN MOXIFLOXACIN", JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, NEW YORK, NY, US, vol. 34, 1 January 2003 (2003-01-01), pages 1125 - 1129, XP001167148, ISSN: 0731-7085 *

Also Published As

Publication number Publication date
EP2551268A1 (en) 2013-01-30
EP2551268B1 (en) 2017-01-18
RU2012128887A (ru) 2014-03-20
US8664398B2 (en) 2014-03-04
US20130059880A1 (en) 2013-03-07
US8975408B2 (en) 2015-03-10
US20140135501A1 (en) 2014-05-15

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