MX349463B - Anticuerpos anti-pd-1, pd-l1 y pd-l2 humanos y usos de los mismos. - Google Patents

Anticuerpos anti-pd-1, pd-l1 y pd-l2 humanos y usos de los mismos.

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Publication number
MX349463B
MX349463B MX2013007065A MX2013007065A MX349463B MX 349463 B MX349463 B MX 349463B MX 2013007065 A MX2013007065 A MX 2013007065A MX 2013007065 A MX2013007065 A MX 2013007065A MX 349463 B MX349463 B MX 349463B
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MX
Mexico
Prior art keywords
human anti
antibodies
uses therefor
novel human
prognosing
Prior art date
Application number
MX2013007065A
Other languages
English (en)
Inventor
Rafi Ahmed
Francis J Carr
Timothy D Jones
James P Gregson
Gordon J Freeman
Original Assignee
Univ Emory
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Emory filed Critical Univ Emory
Publication of MX349463B publication Critical patent/MX349463B/es

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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Abstract

La presente invención se refiere a un anticuerpo aislado o fragmentado de enlace de antígeno del mismo, que comprende: a) una secuencia de región variable de cadena pesada que comprende las tres secuencias CDR de SEQ ID Nos: 7-9; o b) una secuencia de región variable de cadena ligera que comprende las tres secuencias CDR de SEQ ID Nos: 10-12, en donde el anticuerpo aislado o fragmento de enlace de antígeno del mismo, se enlaza a una proteína de PD-1 que tiene la secuencia de aminoácidos de SEQ ID NO: 2 y el anticuerpo aislado o fragmento de enlace de antígeno del mismo es quimérico, humanizado, compuesto o humano.
MX2013007065A 2008-09-26 2009-09-25 Anticuerpos anti-pd-1, pd-l1 y pd-l2 humanos y usos de los mismos. MX349463B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10053408P 2008-09-26 2008-09-26
PCT/US2009/058475 WO2010036959A2 (en) 2008-09-26 2009-09-25 Human anti-pd-1, pd-l1, and pd-l2 antibodies and uses therefor

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Publication Number Publication Date
MX349463B true MX349463B (es) 2017-07-31

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MX2011003195A MX2011003195A (es) 2008-09-26 2009-09-25 Anticuerpos anti-pd-1, pd-l1 y pd-l2 humanos y usos de los mismos.
MX2013007065A MX349463B (es) 2008-09-26 2009-09-25 Anticuerpos anti-pd-1, pd-l1 y pd-l2 humanos y usos de los mismos.

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US (5) US8552154B2 (es)
EP (3) EP3133086B1 (es)
JP (4) JP6087503B2 (es)
KR (4) KR102097887B1 (es)
CN (2) CN108484767B (es)
AU (4) AU2009296392B2 (es)
BR (1) BRPI0919377A2 (es)
CA (2) CA2998281C (es)
DK (1) DK2342226T3 (es)
ES (1) ES2592216T3 (es)
HU (1) HUE030807T2 (es)
IL (3) IL211830A (es)
MX (2) MX2011003195A (es)
PL (1) PL2342226T3 (es)
SI (1) SI2342226T1 (es)
WO (1) WO2010036959A2 (es)

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WO2009114335A2 (en) * 2008-03-12 2009-09-17 Merck & Co., Inc. Pd-1 binding proteins
EP2990487A1 (en) 2008-05-08 2016-03-02 Asuragen, INC. Compositions and methods related to mirna modulation of neovascularization or angiogenesis
EP2288379A4 (en) 2008-05-19 2012-08-08 Advaxis DOUBLE RELEASE SYSTEM FOR HETEROLOGIST ANTIGENE
US9017660B2 (en) 2009-11-11 2015-04-28 Advaxis, Inc. Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors
US9650639B2 (en) 2008-05-19 2017-05-16 Advaxis, Inc. Dual delivery system for heterologous antigens
CA2998281C (en) 2008-09-26 2022-08-16 Dana-Farber Cancer Institute, Inc. Human anti-pd-1 antobodies and uses therefor
MX2011009632A (es) 2009-03-30 2011-10-19 Eisai R&D Man Co Ltd Composicion de liposoma.
US10016617B2 (en) 2009-11-11 2018-07-10 The Trustees Of The University Of Pennsylvania Combination immuno therapy and radiotherapy for the treatment of Her-2-positive cancers
TW201134488A (en) * 2010-03-11 2011-10-16 Ucb Pharma Sa PD-1 antibodies
US8993731B2 (en) 2010-03-11 2015-03-31 Ucb Biopharma Sprl PD-1 antibody
WO2012138377A2 (en) 2010-10-01 2012-10-11 Trustees Of The University Of Pennsylvania The use of listeria vaccine vectors to reverse vaccine unresponsiveness in parasitically infected individuals
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