EA201270100A1 - Пиримидиноны в качестве ингибиторов pi3k - Google Patents

Пиримидиноны в качестве ингибиторов pi3k

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Publication number
EA201270100A1
EA201270100A1 EA201270100A EA201270100A EA201270100A1 EA 201270100 A1 EA201270100 A1 EA 201270100A1 EA 201270100 A EA201270100 A EA 201270100A EA 201270100 A EA201270100 A EA 201270100A EA 201270100 A1 EA201270100 A1 EA 201270100A1
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EA
Eurasian Patent Office
Prior art keywords
pyrimidinones
pi3k inhibitors
pi3k
disorders
activity
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EA201270100A
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English (en)
Other versions
EA021595B1 (ru
Inventor
Юнь-Лун Ли
Брайан В. Меткаф
Эндрю П. Комбс
Original Assignee
Инсайт Корпорейшн
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42575792&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201270100(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Инсайт Корпорейшн filed Critical Инсайт Корпорейшн
Publication of EA201270100A1 publication Critical patent/EA201270100A1/ru
Publication of EA021595B1 publication Critical patent/EA021595B1/ru

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    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Abstract

В настоящем изобретении представлены пиримидиноны, которые модулируют активность фосфоинозитид-3-киназ (PI3K) и являются пригодными для лечения заболеваний, связанных с активностью PI3K, включая, например, воспалительные нарушения, иммунно-патологические нарушения, рак и другие расстройства.
EA201270100A 2009-06-29 2010-06-28 Пиримидиноны в качестве ингибиторов pi3k EA021595B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22116009P 2009-06-29 2009-06-29
US25976509P 2009-11-10 2009-11-10
PCT/US2010/040150 WO2011008487A1 (en) 2009-06-29 2010-06-28 Pyrimidinones as pi3k inhibitors

Publications (2)

Publication Number Publication Date
EA201270100A1 true EA201270100A1 (ru) 2012-07-30
EA021595B1 EA021595B1 (ru) 2015-07-30

Family

ID=42575792

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201270100A EA021595B1 (ru) 2009-06-29 2010-06-28 Пиримидиноны в качестве ингибиторов pi3k

Country Status (33)

Country Link
US (6) US8940752B2 (ru)
EP (2) EP2448938B9 (ru)
JP (2) JP5677425B2 (ru)
KR (1) KR101763656B1 (ru)
CN (2) CN104945420A (ru)
AR (1) AR077280A1 (ru)
AU (2) AU2010273816B2 (ru)
BR (1) BRPI1015135B1 (ru)
CA (1) CA2766100C (ru)
CL (1) CL2011003346A1 (ru)
CO (1) CO6440529A2 (ru)
CR (1) CR20110686A (ru)
DK (1) DK2448938T5 (ru)
EA (1) EA021595B1 (ru)
ES (1) ES2486715T3 (ru)
HK (1) HK1208224A1 (ru)
HR (1) HRP20140754T2 (ru)
IL (2) IL217044A (ru)
ME (1) ME01838B (ru)
MX (1) MX2011013816A (ru)
MY (1) MY162507A (ru)
NZ (1) NZ597050A (ru)
PE (1) PE20120493A1 (ru)
PH (1) PH12015501221A1 (ru)
PL (1) PL2448938T3 (ru)
PT (1) PT2448938E (ru)
RS (1) RS53494B9 (ru)
SG (1) SG177384A1 (ru)
SI (1) SI2448938T1 (ru)
SM (1) SMT201400116B (ru)
TW (2) TW201602113A (ru)
WO (1) WO2011008487A1 (ru)
ZA (1) ZA201109340B (ru)

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