MX2023002248A - Uso de inhibidores de sos1 para tratar neoplasias malignas con mutaciones de shp2. - Google Patents

Uso de inhibidores de sos1 para tratar neoplasias malignas con mutaciones de shp2.

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Publication number
MX2023002248A
MX2023002248A MX2023002248A MX2023002248A MX2023002248A MX 2023002248 A MX2023002248 A MX 2023002248A MX 2023002248 A MX2023002248 A MX 2023002248A MX 2023002248 A MX2023002248 A MX 2023002248A MX 2023002248 A MX2023002248 A MX 2023002248A
Authority
MX
Mexico
Prior art keywords
shp2
treat malignancies
sos1
mutation
inhibitor
Prior art date
Application number
MX2023002248A
Other languages
English (en)
Inventor
David E Wildes
Ethan Ahler
Espinosa Carlos Ernesto Stahlhut
David Church Montgomery
Elsa Quintana
Grace J Lee
Shifrin Nataliya Tovbis
Original Assignee
Revolution Medicines Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Revolution Medicines Inc filed Critical Revolution Medicines Inc
Publication of MX2023002248A publication Critical patent/MX2023002248A/es

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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
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    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
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Abstract

En la presente se proporcionan métodos para tratar a un sujeto que tiene una enfermedad o trastorno asociado con células que tienen una mutación de SHP2, por ejemplo, una mutación de SHP2 activadora. La mutación de SHP2 puede causar resistencia a un inhibidor de SHP2, por ejemplo, un inhibidor de SHP2 alostérico. Los métodos de la presente proporcionan la administración al sujeto de una cantidad terapéuticamente eficaz de un inhibidor de SOS1 solo o en combinación con un agente terapéutico adicional.
MX2023002248A 2020-09-03 2021-09-03 Uso de inhibidores de sos1 para tratar neoplasias malignas con mutaciones de shp2. MX2023002248A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202063074045P 2020-09-03 2020-09-03
US202163135023P 2021-01-08 2021-01-08
US202163172791P 2021-04-09 2021-04-09
PCT/US2021/048960 WO2022060583A1 (en) 2020-09-03 2021-09-03 Use of sos1 inhibitors to treat malignancies with shp2 mutations

Publications (1)

Publication Number Publication Date
MX2023002248A true MX2023002248A (es) 2023-05-16

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MX2023002248A MX2023002248A (es) 2020-09-03 2021-09-03 Uso de inhibidores de sos1 para tratar neoplasias malignas con mutaciones de shp2.

Country Status (9)

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EP (1) EP4208261A1 (es)
JP (1) JP2023541236A (es)
KR (1) KR20230081726A (es)
CN (1) CN116209438A (es)
AU (1) AU2021344830A1 (es)
CA (1) CA3187757A1 (es)
IL (1) IL301062A (es)
MX (1) MX2023002248A (es)
WO (1) WO2022060583A1 (es)

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CN115368358A (zh) * 2022-09-01 2022-11-22 浙江九洲药业股份有限公司 一种Sotorasib新晶型及其制备方法与应用
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