MX2020002646A - Inhibidores de enpp1 y su uso para el tratamiento del cancer. - Google Patents
Inhibidores de enpp1 y su uso para el tratamiento del cancer.Info
- Publication number
- MX2020002646A MX2020002646A MX2020002646A MX2020002646A MX2020002646A MX 2020002646 A MX2020002646 A MX 2020002646A MX 2020002646 A MX2020002646 A MX 2020002646A MX 2020002646 A MX2020002646 A MX 2020002646A MX 2020002646 A MX2020002646 A MX 2020002646A
- Authority
- MX
- Mexico
- Prior art keywords
- enpp1
- subject
- cancer
- methods
- inhibitor
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 6
- 201000011510 cancer Diseases 0.000 title abstract 5
- 239000003112 inhibitor Substances 0.000 title abstract 5
- 101150017770 ENPP1 gene Proteins 0.000 title 1
- 101000812677 Homo sapiens Nucleotide pyrophosphatase Proteins 0.000 abstract 6
- 102100039306 Nucleotide pyrophosphatase Human genes 0.000 abstract 6
- 238000000034 method Methods 0.000 abstract 6
- 239000000203 mixture Substances 0.000 abstract 2
- 238000001959 radiotherapy Methods 0.000 abstract 2
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- RFCBNSCSPXMEBK-INFSMZHSSA-N c-GMP-AMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]3[C@@H](O)[C@H](N4C5=NC=NC(N)=C5N=C4)O[C@@H]3COP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 RFCBNSCSPXMEBK-INFSMZHSSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000005855 radiation Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
- C07F9/165—Esters of thiophosphoric acids
- C07F9/1651—Esters of thiophosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
- C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
- C07F9/3826—Acyclic unsaturated acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
- C07F9/44—Amides thereof
- C07F9/4403—Amides thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4407—Amides of acyclic saturated acids which can have further substituents on alkyl
Abstract
Se proporcionan compuestos, composiciones y métodos para la inhibición de ENPP1. Aspectos de los métodos de la presente incluyen poner en contacto una muestra con un inhibidor de ENPP1 para inhibir la actividad de hidrólisis de cGAMP de ENPP1. En algunos casos, el inhibidor de ENPP1 es impermeable a las células. También se proporcionan composiciones y métodos para tratar el cáncer. Aspectos de los métodos incluyen administrarle a un sujeto una cantidad terapéuticamente eficaz de un inhibidor de ENPP1 para tratar el cáncer del sujeto. En determinados casos, el cáncer es un cáncer de tumor sólido. También se proporcionan métodos para administrar radioterapia a un sujeto ya sea antes o después de administrar un inhibidor de ENPP1. La radioterapia puede administrarse a una dosificación y/o frecuencia eficaz para reducir el daño de radiación al sujeto. En determinados casos, el método se realiza en combinación con un agente quimioterapéutico, o un inhibidor del punto de control o ambos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762556117P | 2017-09-08 | 2017-09-08 | |
| PCT/US2018/050018 WO2019051269A1 (en) | 2017-09-08 | 2018-09-07 | ENPP1 INHIBITORS AND THEIR USE FOR THE TREATMENT OF CANCER |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020002646A true MX2020002646A (es) | 2020-09-25 |
Family
ID=63714052
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020002646A MX2020002646A (es) | 2017-09-08 | 2018-09-07 | Inhibidores de enpp1 y su uso para el tratamiento del cancer. |
| MX2023007193A MX2023007193A (es) | 2017-09-08 | 2020-03-06 | Inhibidores de enpp1 y su uso para el tratamiento del cancer. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023007193A MX2023007193A (es) | 2017-09-08 | 2020-03-06 | Inhibidores de enpp1 y su uso para el tratamiento del cancer. |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US11701371B2 (es) |
| EP (2) | EP3678668B1 (es) |
| JP (2) | JP7292740B2 (es) |
| KR (1) | KR20200066292A (es) |
| CN (2) | CN117883449A (es) |
| AU (2) | AU2018330188C1 (es) |
| BR (1) | BR112020004559A2 (es) |
| CA (1) | CA3074268A1 (es) |
| DK (1) | DK3678668T3 (es) |
| EA (1) | EA202090595A1 (es) |
| IL (3) | IL272948B2 (es) |
| MA (1) | MA50082A (es) |
| MX (2) | MX2020002646A (es) |
| SG (1) | SG11202001728YA (es) |
| WO (1) | WO2019051269A1 (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220056052A1 (en) * | 2018-12-28 | 2022-02-24 | Riboscience Llc | Quinazoline derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors |
| AU2020350190A1 (en) | 2019-09-16 | 2022-05-12 | Aten Porus Lifesciences Pvt. Ltd. | 2-amino-s6-substituted thiopurine compounds as inhibitors of the ENPP1 protein |
| EP4034094A4 (en) * | 2019-09-23 | 2024-01-24 | Nanjing Zhengxiang Pharmaceuticals Co Ltd | PHOSPHODIESTERASE INHIBITORS AND THEIR USE |
| KR20220138399A (ko) * | 2020-02-04 | 2022-10-12 | 스팅레이 테라퓨릭스, 인크. | 엑토뉴클레오티드 피로포스파타제/포스포디에스테라제 1(enpp1)의 억제제 및 이의 사용 방법 |
| TW202322824A (zh) | 2020-02-18 | 2023-06-16 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| WO2021203772A1 (en) * | 2020-04-09 | 2021-10-14 | Betta Pharmaceuticals Co., Ltd | Ectonucleotide pyrophosphatase-phosphodiesterase 1 inhibitors,compositions and uses thereof |
| KR20230019431A (ko) * | 2020-05-04 | 2023-02-08 | 볼라스트라 쎄라퓨틱스, 인코포레이티드 | Enpp1의 이미노 설파논 억제제 |
| CN115515939A (zh) | 2020-05-08 | 2022-12-23 | 谛希诺生物科技有限公司 | 具有抑制外核苷酸焦磷酸酶-磷酸二酯酶的活性的新型酞嗪衍生物及它们的用途 |
| KR20210136874A (ko) | 2020-05-08 | 2021-11-17 | 주식회사 티씨노바이오사이언스 | 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 프탈라진 유도체 및 이들의 용도 |
| TW202214640A (zh) * | 2020-06-16 | 2022-04-16 | 美商佛拉斯托醫療公司 | Ｅｎｐｐ１之雜環抑制劑 |
| IL300976A (en) * | 2020-09-03 | 2023-04-01 | Immunesensor Therapeutics Inc | Quinoline compounds as CGAS antagonists |
| WO2022125613A1 (en) * | 2020-12-09 | 2022-06-16 | Stingray Therapeutics, Inc. | Phosphonates as inhibitors of enpp1 and cdnp |
| EP4276100A1 (en) | 2020-12-29 | 2023-11-15 | Txinno Bioscience Inc. | Novel naphthyridinone derivative having inhibitory activity against ectonucleotide pyrophosphatase-phosphodiesterase and use thereof |
| KR20220095154A (ko) | 2020-12-29 | 2022-07-06 | 주식회사 티씨노바이오사이언스 | 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 나프티리딘온 유도체 및 이들의 용도 |
| KR20220110118A (ko) | 2021-01-29 | 2022-08-05 | 주식회사 티씨노바이오사이언스 | 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 벤조트리아졸 유도체 및 이들의 용도 |
| WO2022164249A1 (ko) | 2021-01-29 | 2022-08-04 | 주식회사 티씨노바이오사이언스 | 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 벤조트리아졸 유도체 및 이들의 용도 |
| WO2022197734A1 (en) * | 2021-03-16 | 2022-09-22 | Riboscience Llc | Bicyclic heteroaryl boronate derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors |
| CN117120444A (zh) | 2021-04-16 | 2023-11-24 | 吉利德科学公司 | 使用酰胺制备卡巴核苷的方法 |
| CN115536696B (zh) * | 2021-06-29 | 2023-07-14 | 上海齐鲁制药研究中心有限公司 | Enpp1抑制剂 |
| WO2023035001A1 (en) * | 2021-09-03 | 2023-03-09 | Angarus Therapeutics, Inc. | Enpp1 inhibitors and immune cells expressing chimeric antigen receptors |
| WO2023077083A1 (en) * | 2021-10-29 | 2023-05-04 | Angarus Therapeutics, Inc. | Enpp1 inhibitors as inhibitors of metastasis |
| WO2023197987A1 (zh) * | 2022-04-11 | 2023-10-19 | 上海齐鲁制药研究中心有限公司 | Enpp1抑制剂 |
| US20230346771A1 (en) | 2022-04-29 | 2023-11-02 | Petragen, Inc. | Inhibitors of enpp1 and modulation of bone growth |
| CN114767863B (zh) * | 2022-04-29 | 2024-01-30 | 西北工业大学 | 一种enpp2基因或蛋白在调控结直肠癌细胞中的应用 |
| WO2024028727A1 (en) * | 2022-08-01 | 2024-02-08 | Sravathi Ai Technology Private Limited | Novel ectonucleotide pyrophosphatase / phosphodiesterase 1 (enpp-1) inhibitors and uses thereof |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA228044A (en) | 1923-01-16 | Thomas Noble Boughton | Die for forming bolts | |
| CA190896A (en) | 1919-02-24 | 1919-06-17 | Josephat C. Bergeron | Advertising device |
| DE3319795A1 (de) | 1983-06-01 | 1984-12-06 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von phosphonsaeureestern |
| US5599902A (en) | 1994-11-10 | 1997-02-04 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Cancer inhibitory peptides |
| DK0831100T3 (da) | 1995-04-21 | 2001-01-02 | Teikoku Hormone Mfg Co Ltd | Nye peptidderivater |
| US6323315B1 (en) | 1999-09-10 | 2001-11-27 | Basf Aktiengesellschaft | Dolastatin peptides |
| US6960580B2 (en) * | 2001-03-08 | 2005-11-01 | Millennium Pharmaceuticals, Inc. | Nitrogenous heterocyclic substituted quinoline compounds |
| EP1391213A1 (en) | 2002-08-21 | 2004-02-25 | Boehringer Ingelheim International GmbH | Compositions and methods for treating cancer using maytansinoid CD44 antibody immunoconjugates and chemotherapeutic agents |
| NZ540698A (en) | 2002-12-24 | 2008-05-30 | Astrazeneca Ab | Phosphonooxy quinazoline derivatives and their pharmaceutical use |
| US20070004763A1 (en) | 2005-06-10 | 2007-01-04 | Nand Baindur | Aminoquinoline and aminoquinazoline kinase modulators |
| US10543207B2 (en) | 2008-12-31 | 2020-01-28 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| PL2621923T3 (pl) * | 2010-09-29 | 2017-08-31 | Intervet International B.V. | Związki n-heteroarylu z mostkami cyklicznymi do leczenia chorób pasożytniczych |
| EP2794630A4 (en) | 2011-12-22 | 2015-04-01 | Alios Biopharma Inc | SUBSTITUTED PHOSPHORTHIOAT NUCLEOTIDE ANALOGUE |
| CN105377867B (zh) | 2013-05-03 | 2019-11-12 | 加利福尼亚大学董事会 | I型干扰素的环状二核苷酸诱导 |
| AU2014268836B2 (en) | 2013-05-18 | 2018-08-02 | Aduro Biotech, Inc. | Compositions and methods for activating "stimulator of interferon gene"-dependent signalling |
| NZ730195A (en) * | 2014-09-22 | 2023-12-22 | National Health Res Inst | Heterocyclic compounds and use thereof |
| US10011600B2 (en) * | 2014-09-25 | 2018-07-03 | Araxes Pharma Llc | Methods and compositions for inhibition of Ras |
| CN105153153A (zh) | 2015-08-31 | 2015-12-16 | 吉林奥来德光电材料股份有限公司 | 一种新的芳香族胺类化合物及其制备与应用 |
| TWI659949B (zh) | 2016-05-16 | 2019-05-21 | 臺北醫學大學 | 組蛋白去乙醯酶6抑制劑及其用途 |
| WO2018119325A1 (en) | 2016-12-22 | 2018-06-28 | Mavupharma, Inc. | Compositions and methods of enhancing or augmenting type i ifn production |
| BR112019014335A2 (pt) | 2017-01-09 | 2020-02-27 | The Australian National University | Sinérgicos para pesticidas melhorados |
| US10518257B2 (en) | 2017-05-04 | 2019-12-31 | Exxonmobil Research And Engineering Company | Metal organic frameworks, their synthesis and use |
| WO2018229139A1 (en) | 2017-06-14 | 2018-12-20 | Fundación Para La Investigación Médica Aplicada | Novel compounds for use in cancer |
| PE20210128A1 (es) | 2017-08-31 | 2021-01-19 | Abbvie Inc | Inhibidores de la ectonucleotido pirofosfatasa-fosfodiesterasa 1 (enpp-1) y usos de los mismos |
| AU2020214628A1 (en) | 2019-02-01 | 2021-08-12 | The Board Of Trustees Of The Leland Stanford Junior University | ENPP1 inhibitors and methods of modulating immune response |
| CN114437128B (zh) * | 2022-01-28 | 2023-12-19 | 中国科学院长春应用化学研究所 | 一种胆碱磷酸修饰的紫杉醇药物及其制备方法和应用 |
-
2018
- 2018-09-07 US US16/645,300 patent/US11701371B2/en active Active
- 2018-09-07 EA EA202090595A patent/EA202090595A1/ru unknown
- 2018-09-07 BR BR112020004559-4A patent/BR112020004559A2/pt unknown
- 2018-09-07 CA CA3074268A patent/CA3074268A1/en active Pending
- 2018-09-07 MA MA050082A patent/MA50082A/fr unknown
- 2018-09-07 MX MX2020002646A patent/MX2020002646A/es unknown
- 2018-09-07 SG SG11202001728YA patent/SG11202001728YA/en unknown
- 2018-09-07 EP EP18779884.8A patent/EP3678668B1/en active Active
- 2018-09-07 IL IL272948A patent/IL272948B2/en unknown
- 2018-09-07 DK DK18779884.8T patent/DK3678668T3/da active
- 2018-09-07 KR KR1020207007008A patent/KR20200066292A/ko not_active Application Discontinuation
- 2018-09-07 CN CN202311760294.3A patent/CN117883449A/zh active Pending
- 2018-09-07 EP EP24150802.7A patent/EP4327882A2/en active Pending
- 2018-09-07 IL IL302338A patent/IL302338A/en unknown
- 2018-09-07 JP JP2020513331A patent/JP7292740B2/ja active Active
- 2018-09-07 CN CN201880063793.8A patent/CN111372587B/zh active Active
- 2018-09-07 WO PCT/US2018/050018 patent/WO2019051269A1/en active Application Filing
- 2018-09-07 AU AU2018330188A patent/AU2018330188C1/en active Active
- 2018-09-07 IL IL311010A patent/IL311010A/en unknown
-
2020
- 2020-03-06 MX MX2023007193A patent/MX2023007193A/es unknown
-
2022
- 2022-09-30 US US17/957,392 patent/US11707471B2/en active Active
-
2023
- 2023-05-16 US US18/197,877 patent/US20230277570A1/en active Pending
- 2023-05-31 JP JP2023089900A patent/JP2023101715A/ja active Pending
-
2024
- 2024-01-10 AU AU2024200148A patent/AU2024200148A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2023007193A (es) | Inhibidores de enpp1 y su uso para el tratamiento del cancer. | |
| MX2021009269A (es) | Inhibidores de enpp1 y metodos para modular una respuesta inmunitaria. | |
| MX2023002248A (es) | Uso de inhibidores de sos1 para tratar neoplasias malignas con mutaciones de shp2. | |
| MX2016008201A (es) | Tratamiento del cancer usando combinaciones de inhibidores de erk y raf. | |
| PH12016500841A1 (en) | Combinations of checkpoint inhibitors and therapeutics to treat cancer | |
| MX2021005651A (es) | Combinacion farmaceutica para el tratamiento contra el cancer. | |
| WO2018102687A3 (en) | Combination therapy for treating cancer | |
| EA201391286A1 (ru) | Лечение солидных опухолей | |
| MY183661A (en) | Treatment of cancer with tor kinase inhibitors | |
| SG10201810401RA (en) | Pharmaceutical combinations for treating cancer | |
| EA201491699A1 (ru) | Лечение рака ингибиторами tor киназы | |
| PH12020551597A1 (en) | Treatment of hidradenitis suppurativa using jak inhibitors | |
| WO2015095838A3 (en) | Cancer treatments using combinations of mek type i and erk inhibitors | |
| MX2020001727A (es) | Terapia de combinacion. | |
| MX2019013862A (es) | Terapia de combinacion. | |
| MX2022015900A (es) | Inhibidores de alk2 para el tratamiento de la anemia. | |
| MX2021007565A (es) | Composiciones y metodos para la terapia contra el cancer. | |
| MY186840A (en) | Method for treating psoriasis patient which received anti-tnf-alpha antibody therapy | |
| MX2019002259A (es) | Inhibicion de la actividad de la olig2. | |
| MX2018010223A (es) | Terapia combinada para tratamiento de cancer de ovario. | |
| JOP20220122A1 (ar) | طريقة لعلاج سرطان باستخدام خلية مساعدة اصطناعية (aAVC) | |
| MX2021006778A (es) | Metodo novedoso para el tratamiento del cancer mediante inmunomodulacion. | |
| MX2020006808A (es) | Ubicar al complejo de signalosoma cbm induce a las celulas t reguladoras inflamar al microambiente tumoral. | |
| MX2021005189A (es) | Uso de tivozanib para tratar sujetos con cancer refractario. | |
| MX2022011725A (es) | Metodos para tratar una lesion pulmonar con inhibidores de cgrp. |