MX2022012992A - Inhibidores de kif18a para el tratamiento de enfermedades neoplasicas. - Google Patents
Inhibidores de kif18a para el tratamiento de enfermedades neoplasicas.Info
- Publication number
- MX2022012992A MX2022012992A MX2022012992A MX2022012992A MX2022012992A MX 2022012992 A MX2022012992 A MX 2022012992A MX 2022012992 A MX2022012992 A MX 2022012992A MX 2022012992 A MX2022012992 A MX 2022012992A MX 2022012992 A MX2022012992 A MX 2022012992A
- Authority
- MX
- Mexico
- Prior art keywords
- subject
- kif18a
- tumor
- methods
- neoplastic disease
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title abstract 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 5
- 239000003112 inhibitor Substances 0.000 title abstract 5
- 230000001613 neoplastic effect Effects 0.000 title abstract 5
- 206010028980 Neoplasm Diseases 0.000 abstract 8
- 101001091231 Homo sapiens Kinesin-like protein KIF18A Proteins 0.000 abstract 4
- 229940126262 KIF18A Drugs 0.000 abstract 4
- 102100034895 Kinesin-like protein KIF18A Human genes 0.000 abstract 4
- 201000011510 cancer Diseases 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 230000001939 inductive effect Effects 0.000 abstract 2
- 230000005907 cancer growth Effects 0.000 abstract 1
- 210000001082 somatic cell Anatomy 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 230000004614 tumor growth Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Abstract
En el presente documento se proporcionan métodos para tratar a un sujeto que tiene una enfermedad neoplásica, que comprenden administrar al sujeto un inhibidor de KIF18A en una cantidad eficaz para tratar la enfermedad neoplásica y una enfermedad neoplásica en un sujeto. También se proporcionan métodos para inducir o aumentar la regresión tumoral en un sujeto con un tumor y métodos para reducir el crecimiento tumoral o del cáncer en un sujeto. En aspectos de ejemplo, el método comprende administrar al sujeto un inhibidor de KIF18A. En el presente documento también se proporcionan métodos para inducir o aumentar la muerte de células tumorales o cancerosas en un sujeto que comprenden administrar al sujeto un inhibidor de KIF18A. Ventajosamente, los inhibidores de KIF18A tratan selectivamente la enfermedad neoplásica, inducen o aumentan la regresión tumoral y/o inducen o aumentan la muerte de células tumorales o cancerosas sin una toxicidad manifiesta para las células somáticas normales.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063009637P | 2020-04-14 | 2020-04-14 | |
US202063055111P | 2020-07-22 | 2020-07-22 | |
US202063085607P | 2020-09-30 | 2020-09-30 | |
PCT/US2021/027042 WO2021211549A1 (en) | 2020-04-14 | 2021-04-13 | Kif18a inhibitors for treatment of neoplastic diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022012992A true MX2022012992A (es) | 2022-11-08 |
Family
ID=75660432
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022012992A MX2022012992A (es) | 2020-04-14 | 2021-04-13 | Inhibidores de kif18a para el tratamiento de enfermedades neoplasicas. |
Country Status (13)
Country | Link |
---|---|
US (1) | US20230151432A1 (es) |
EP (1) | EP4136263A1 (es) |
JP (1) | JP2023521802A (es) |
KR (1) | KR20230011932A (es) |
CN (1) | CN115667551A (es) |
AU (1) | AU2021257801A1 (es) |
BR (1) | BR112022020817A2 (es) |
CA (1) | CA3177740A1 (es) |
CL (1) | CL2022002808A1 (es) |
IL (1) | IL297242A (es) |
MX (1) | MX2022012992A (es) |
TW (1) | TW202203919A (es) |
WO (1) | WO2021211549A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW202321213A (zh) * | 2021-07-21 | 2023-06-01 | 美商安進公司 | Kif18a抑制劑化合物之鹽和固態形式 |
WO2023088441A1 (zh) * | 2021-11-19 | 2023-05-25 | 微境生物医药科技(上海)有限公司 | Kif18a抑制剂 |
WO2023146973A1 (en) * | 2022-01-26 | 2023-08-03 | Amgen Inc. | Synthesis of a kif18a inhibitor |
WO2023174175A1 (zh) * | 2022-03-17 | 2023-09-21 | 微境生物医药科技(上海)有限公司 | Kif18a抑制剂 |
WO2023212714A1 (en) | 2022-04-29 | 2023-11-02 | Amgen Inc. | Kif18a inhibition for treatment of cancer |
WO2024002328A1 (zh) * | 2022-06-30 | 2024-01-04 | 勤浩医药(苏州)有限公司 | 一种含氮化合物及其应用 |
CN117466899A (zh) * | 2022-07-29 | 2024-01-30 | 武汉人福创新药物研发中心有限公司 | Kif18a抑制剂及用途 |
WO2024051812A1 (zh) * | 2022-09-09 | 2024-03-14 | 先声再明医药有限公司 | 酰胺类化合物、其组合物及用途 |
WO2024078569A1 (zh) * | 2022-10-13 | 2024-04-18 | 浙江海正药业股份有限公司 | 芳香酰胺类衍生物及其制备方法和用途 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT72878B (en) | 1980-04-24 | 1983-03-29 | Merck & Co Inc | Process for preparing mannich-base hydroxamic acid pro-drugs for the improved delivery of non-steroidal anti-inflammatory agents |
JP2006507841A (ja) * | 2002-11-14 | 2006-03-09 | ダーマコン, インコーポレイテッド | 機能的siRNAおよび超機能的siRNA |
US7423018B2 (en) * | 2002-12-13 | 2008-09-09 | University Of Massachusetts | Kinesin-like proteins and methods of use |
EP2295543A1 (en) * | 2009-09-11 | 2011-03-16 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Method for the preparation of an influenza virus |
JP2017517520A (ja) * | 2014-05-29 | 2017-06-29 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | Wee1阻害剤を用いた癌を処置する方法 |
GB201709840D0 (en) * | 2017-06-20 | 2017-08-02 | Inst Of Cancer Research: Royal Cancer Hospital | Methods and medical uses |
PE20211475A1 (es) * | 2018-12-20 | 2021-08-05 | Amgen Inc | Inhibidores de kif18a |
US20220372018A1 (en) * | 2019-08-02 | 2022-11-24 | Amgen Inc. | Kif18a inhibitors |
AU2020324963A1 (en) * | 2019-08-02 | 2022-02-24 | Amgen Inc. | KIF18A inhibitors |
WO2021026098A1 (en) * | 2019-08-02 | 2021-02-11 | Amgen Inc. | Kif18a inhibitors |
-
2021
- 2021-04-13 EP EP21721377.6A patent/EP4136263A1/en active Pending
- 2021-04-13 IL IL297242A patent/IL297242A/en unknown
- 2021-04-13 TW TW110113180A patent/TW202203919A/zh unknown
- 2021-04-13 JP JP2022562070A patent/JP2023521802A/ja active Pending
- 2021-04-13 CN CN202180035738.XA patent/CN115667551A/zh active Pending
- 2021-04-13 KR KR1020227038326A patent/KR20230011932A/ko active Search and Examination
- 2021-04-13 WO PCT/US2021/027042 patent/WO2021211549A1/en unknown
- 2021-04-13 MX MX2022012992A patent/MX2022012992A/es unknown
- 2021-04-13 AU AU2021257801A patent/AU2021257801A1/en active Pending
- 2021-04-13 US US17/918,209 patent/US20230151432A1/en active Pending
- 2021-04-13 BR BR112022020817A patent/BR112022020817A2/pt unknown
- 2021-04-13 CA CA3177740A patent/CA3177740A1/en active Pending
-
2022
- 2022-10-12 CL CL2022002808A patent/CL2022002808A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
EP4136263A1 (en) | 2023-02-22 |
AU2021257801A1 (en) | 2022-10-27 |
CL2022002808A1 (es) | 2023-05-26 |
US20230151432A1 (en) | 2023-05-18 |
CN115667551A (zh) | 2023-01-31 |
IL297242A (en) | 2022-12-01 |
CA3177740A1 (en) | 2021-10-21 |
TW202203919A (zh) | 2022-02-01 |
WO2021211549A1 (en) | 2021-10-21 |
BR112022020817A2 (pt) | 2023-03-07 |
KR20230011932A (ko) | 2023-01-25 |
JP2023521802A (ja) | 2023-05-25 |
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