HUE029906T2 - Benzoxazol kináz inhibitorok és alkalmazási eljárások - Google Patents

Benzoxazol kináz inhibitorok és alkalmazási eljárások Download PDF

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Publication number
HUE029906T2
HUE029906T2 HUE09823947A HUE09823947A HUE029906T2 HU E029906 T2 HUE029906 T2 HU E029906T2 HU E09823947 A HUE09823947 A HU E09823947A HU E09823947 A HUE09823947 A HU E09823947A HU E029906 T2 HUE029906 T2 HU E029906T2
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cancer
compound
compounds
cell
acid
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HUE09823947A
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English (en)
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Pingda Ren
Yi Liu
Liansheng Li
Katrina Chan
Troy Edward Wilson
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Intellikine Llc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

Claims (7)

  1. t-fonzeaazo! kináz inhibitorok es a1ka!íría-zási eljárások Szabadalmi igénypontok 1. A
    mak®mt§ vegyUÎeîMgy valamely gyôgyàszaîiiag elfogadható sep.
  2. 2, Soyógyászati készítmény, mely teíipasan hatásos mennyiségű 1 > igénypont szerinti vegyib letet vagy győgyászatiiag elfogadható sóját és egy gyógyszérészethég^^# hordozói tartalmaz. 3, 4z ! ; igénypont szerinti vegyidet vagy gyógyászatilag elfogadható sója iák. kezelésében tótténő alkal mázsáim 4. Λ 3, ipnypont szerinti gyógyásá^Ét.:á||zlteé|iy' íák.|p|l^éhí5« történő alkalmazásra A vegyület vagy gyógyászatiig elfogadható SÓJaiáJi igénypont szerinti alkalmazásra vagy gyógyászati készítmény a 4. igénypont szerinti alkalmazásra, ahol a rák tibroszarkóma, has·* lyálmirigyrák. veserák, roájrák, melanoma, nasöpfsSryngealis rák, gyomorrák, petefészekrák, leukemia, mlélótna, mellrák, prosztatarak, vastag- ás végbélrák, tüdőrák, gliöblaatöma, húgyvezetékrák, hólyagrák, mesotb^dtia^^jÄ, nyakrák, és mlhnyakták.
  3. 6. A végyilét vagy gyégyászatílag elfogadható áója a 3 : igénypont szmííníi alkaiffîazâsra vagy gyógyászati készítmény a 4. igénypont szerinti alkalmazásra, ahol a rák vesarák.
  4. 7, A vegyólet vagy gyogylszatbag élfopóhaíó sója a 3. igénypont szerinti alfcaimazlsta vagy gvogyaszati készítmény a 4. igénypont szerinti alkalmazásra, ahol a tik veséiét karcinóma. I, A vegyPM vagy gyógyászailíag elfopdható sója a 3 Igénypont szetmlí alkateazásra vagy gyógyászai kteteény a 4 Igénypont szarinti alkalmazásra, ahol a rák mellrák, f. A. vegyillet vagy gyógyászailíag elfogadható sója a 3, igénypont szerinti alkalmazásra vagy gyógyászai készliánény a 4. igénypont szerinti alkalmazásra, ahol a rák húgyvezeték rák. 1$, A vegyxiet vagy gyógyászatilag elíbg^iható sója a 3. igénypont szerinti alkalmazásra vágy gyógyászati készítmény a 4. igénypont szerinti alkalmazásra, ahol a rák hólyagrák. il. A vegytilétvágy gyógyászatilágelfogadhatósójaa3. igénypont szerimi alkalmazásra vagy gyógyászai készítmény a 4, igénypont szerinti alkalmazásra, ahol a rák vastag" és vég" bélrák. 12 A vegyólet vagy gyógyászatiiag éiÉ>|Âaiô sója a 3. igénypont szerinti alkalmazásra vagy gyógyászati készítmény a 4. igénypont szerinti alkalmazásra, ahol a rák tüdőrák.
  5. 13. Asója a 3. Igénypont szerinti alkalmazásra vagy gyógyászati készítmény a 4. igénypont szerinti alkalmazásra, ahol a rák nem-kissejtes tudórák,
  6. 14, A végyölet vagy gyógyászatiíag mtbgaóható sópa 3. igénypont szerinti alkalmazásra V&Í0 gyógyászati készítmény a 4. igénypont szerinti alkalmazásra, ahol a rák kissejtes tüdő" rák. II, A vagyület vagy gyógyászatiíag elfogadható sója a 3. igénypont szerinti alkalmazásra vagy gyógyászán: készítmény a 4, igénypont szerinti alkalmazásra, ahol a rák gliohlastofna.
  7. 16. A agyúiét vagy gyógyápstllag elfogadható sója a 3. igéKypöHt ^eriiníi alkalmazásra vagy -gyógyászati készítmény a 4. igénypont szerinti alkalmazásra, ahol a rák nőgyógyászati rák. 1.7, A vegyüld vagy gyögyászatiiag elfogadható soja a 3> igénypont szeáni älkalrnazlarä vágy gyógyászati készítmény g 4> igénypont szerintiaíkalnaazasra, ahol a rák. méhnyakrák. 18. A. yegyülei vagy gyógyászaíilag elfogadható sója a 3. igénypont szerinti alkalmazásra vagy gyógyászati készítmény a 4. igénypont szerinti alkalmazásra, ahol a rák gyoniorrák.
HUE09823947A 2008-11-03 2009-11-02 Benzoxazol kináz inhibitorok és alkalmazási eljárások HUE029906T2 (hu)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US19820008P 2008-11-03 2008-11-03
US20192308P 2008-12-16 2008-12-16
US21426109P 2009-04-20 2009-04-20
US23065509P 2009-07-31 2009-07-31
US12/586,241 US8476431B2 (en) 2008-11-03 2009-09-17 Benzoxazole kinase inhibitors and methods of use
US12/586,309 US8476282B2 (en) 2008-11-03 2009-09-17 Benzoxazole kinase inhibitors and methods of use

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HUE029906T2 true HUE029906T2 (hu) 2017-04-28

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US (6) US8476282B2 (hu)
EP (2) EP2365750B1 (hu)
JP (8) JP5897333B2 (hu)
KR (2) KR101737192B1 (hu)
CN (2) CN102271513B (hu)
AU (1) AU2009310364B2 (hu)
BR (1) BRPI0920500B1 (hu)
CA (1) CA2741898C (hu)
CY (1) CY1117913T1 (hu)
DK (1) DK2365750T3 (hu)
ES (1) ES2588197T3 (hu)
HK (1) HK1162855A1 (hu)
HR (1) HRP20161074T1 (hu)
HU (1) HUE029906T2 (hu)
IL (3) IL212586A (hu)
LT (1) LT2365750T (hu)
MX (3) MX361811B (hu)
MY (2) MY166032A (hu)
NZ (2) NZ609221A (hu)
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PT (1) PT2365750T (hu)
SG (2) SG10201501702WA (hu)
SI (1) SI2365750T1 (hu)
SM (1) SMT201600278B (hu)
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