HRP20221035T1 - Heterociklički spojevi kao imunomodulatori - Google Patents
Heterociklički spojevi kao imunomodulatori Download PDFInfo
- Publication number
- HRP20221035T1 HRP20221035T1 HRP20221035TT HRP20221035T HRP20221035T1 HR P20221035 T1 HRP20221035 T1 HR P20221035T1 HR P20221035T T HRP20221035T T HR P20221035TT HR P20221035 T HRP20221035 T HR P20221035T HR P20221035 T1 HRP20221035 T1 HR P20221035T1
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- membered
- cancer
- cycloalkyl
- aryl
- Prior art date
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- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- 239000002955 immunomodulating agent Substances 0.000 title 1
- 229940121354 immunomodulator Drugs 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 62
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 44
- 125000001424 substituent group Chemical group 0.000 claims 29
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 24
- 206010028980 Neoplasm Diseases 0.000 claims 22
- 150000001875 compounds Chemical class 0.000 claims 21
- 201000011510 cancer Diseases 0.000 claims 19
- 150000003839 salts Chemical class 0.000 claims 19
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims 18
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 17
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 14
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 12
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 12
- -1 NR12R12 Chemical group 0.000 claims 12
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 11
- 229910052757 nitrogen Inorganic materials 0.000 claims 10
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 9
- 125000006568 (C4-C7) heterocycloalkyl group Chemical group 0.000 claims 9
- 229910052736 halogen Inorganic materials 0.000 claims 9
- 150000002367 halogens Chemical class 0.000 claims 9
- 125000001072 heteroaryl group Chemical group 0.000 claims 9
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 7
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 7
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims 6
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 5
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims 4
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 4
- 206010038389 Renal cancer Diseases 0.000 claims 4
- 201000010982 kidney cancer Diseases 0.000 claims 4
- 125000006708 (C5-C14) heteroaryl group Chemical group 0.000 claims 3
- 101150073096 NRAS gene Proteins 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 201000001441 melanoma Diseases 0.000 claims 3
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 2
- 125000006704 (C5-C6) cycloalkyl group Chemical group 0.000 claims 2
- 102000008096 B7-H1 Antigen Human genes 0.000 claims 2
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 2
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 2
- 208000030808 Clear cell renal carcinoma Diseases 0.000 claims 2
- 206010014733 Endometrial cancer Diseases 0.000 claims 2
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 2
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 2
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 2
- 206010039491 Sarcoma Diseases 0.000 claims 2
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 2
- 206010046458 Urethral neoplasms Diseases 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 206010073251 clear cell renal cell carcinoma Diseases 0.000 claims 2
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 201000007270 liver cancer Diseases 0.000 claims 2
- 208000014018 liver neoplasm Diseases 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 201000011330 nonpapillary renal cell carcinoma Diseases 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 230000000306 recurrent effect Effects 0.000 claims 2
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 201000002510 thyroid cancer Diseases 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- ASLOXZSRPQODHA-VWLOTQADSA-N (2S)-1-[[2-(2-cyano-3-phenylphenyl)-7-methyl-1,3-benzoxazol-5-yl]methyl]piperidine-2-carboxylic acid Chemical compound C(#N)C1=C(C=CC=C1C=1OC2=C(N=1)C=C(C=C2C)CN1[C@@H](CCCC1)C(=O)O)C1=CC=CC=C1 ASLOXZSRPQODHA-VWLOTQADSA-N 0.000 claims 1
- NKKKZVPYXOVVKY-DEOSSOPVSA-N (2S)-1-[[2-(2-methyl-3-phenylphenyl)-1,3-benzoxazol-5-yl]methyl]piperidine-2-carboxylic acid Chemical compound CC1=C(C=CC=C1C=1OC2=C(N=1)C=C(C=C2)CN1[C@@H](CCCC1)C(=O)O)C1=CC=CC=C1 NKKKZVPYXOVVKY-DEOSSOPVSA-N 0.000 claims 1
- FQXPNAAFCSYOKR-DEOSSOPVSA-N (2S)-1-[[2-(2-methyl-3-phenylphenyl)-1,3-benzoxazol-6-yl]methyl]piperidine-2-carboxylic acid Chemical compound CC1=C(C=CC=C1C=1OC2=C(N=1)C=CC(=C2)CN1[C@@H](CCCC1)C(=O)O)C1=CC=CC=C1 FQXPNAAFCSYOKR-DEOSSOPVSA-N 0.000 claims 1
- WXOGJKHSKFQFGH-VWLOTQADSA-N (2S)-1-[[2-[2-cyano-3-(2,3-dihydro-1,4-benzodioxin-6-yl)phenyl]-6-(cyanomethoxy)-1,3-benzoxazol-5-yl]methyl]piperidine-2-carboxylic acid Chemical compound C(#N)C1=C(C=CC=C1C1=CC2=C(OCCO2)C=C1)C=1OC2=C(N=1)C=C(C(=C2)OCC#N)CN1[C@@H](CCCC1)C(=O)O WXOGJKHSKFQFGH-VWLOTQADSA-N 0.000 claims 1
- IRAOBULKNPMMHM-VWLOTQADSA-N (2S)-1-[[2-[2-cyano-3-(2,3-dihydro-1,4-benzodioxin-6-yl)phenyl]-7-methyl-1,3-benzoxazol-5-yl]methyl]piperidine-2-carboxylic acid Chemical compound C(#N)C1=C(C=CC=C1C1=CC2=C(OCCO2)C=C1)C=1OC2=C(N=1)C=C(C=C2C)CN1[C@@H](CCCC1)C(=O)O IRAOBULKNPMMHM-VWLOTQADSA-N 0.000 claims 1
- GKMVSXNEUYMCFC-VWLOTQADSA-N (2S)-1-[[2-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]-7-methyl-1,3-benzoxazol-5-yl]methyl]piperidine-2-carboxylic acid Chemical compound O1CCOC2=C1C=CC(=C2)C=1C(=C(C=CC=1)C=1OC2=C(N=1)C=C(C=C2C)CN1[C@@H](CCCC1)C(=O)O)C GKMVSXNEUYMCFC-VWLOTQADSA-N 0.000 claims 1
- DCSUWIPRZKZFBT-MHZLTWQESA-N (2S)-1-[[6-(3-cyanopropoxy)-2-(2-methyl-3-phenylphenyl)-1,3-benzoxazol-5-yl]methyl]piperidine-2-carboxylic acid Chemical compound C(#N)CCCOC1=CC2=C(N=C(O2)C=2C(=C(C=CC=2)C2=CC=CC=C2)C)C=C1CN1[C@@H](CCCC1)C(=O)O DCSUWIPRZKZFBT-MHZLTWQESA-N 0.000 claims 1
- SIBPLBOHNSYTCP-VWLOTQADSA-N (2S)-1-[[6-(cyanomethoxy)-2-(2-methyl-3-phenylphenyl)-1,3-benzoxazol-5-yl]methyl]piperidine-2-carboxylic acid Chemical compound C(#N)COC1=CC2=C(N=C(O2)C=2C(=C(C=CC=2)C2=CC=CC=C2)C)C=C1CN1[C@@H](CCCC1)C(=O)O SIBPLBOHNSYTCP-VWLOTQADSA-N 0.000 claims 1
- ZXGOOJXOOLGUEA-VWLOTQADSA-N (2S)-1-[[6-(cyanomethoxy)-2-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]-1,3-benzoxazol-5-yl]methyl]piperidine-2-carboxylic acid Chemical compound C(#N)COC1=CC2=C(N=C(O2)C2=C(C(=CC=C2)C2=CC3=C(OCCO3)C=C2)C)C=C1CN1[C@@H](CCCC1)C(=O)O ZXGOOJXOOLGUEA-VWLOTQADSA-N 0.000 claims 1
- UWWIGOJLOPXCJZ-VWLOTQADSA-N (2S)-1-[[7-methyl-2-(2-methyl-3-phenylphenyl)-1,3-benzoxazol-5-yl]methyl]piperidine-2-carboxylic acid Chemical compound CC1=CC(=CC=2N=C(OC=21)C=1C(=C(C=CC=1)C1=CC=CC=C1)C)CN1[C@@H](CCCC1)C(=O)O UWWIGOJLOPXCJZ-VWLOTQADSA-N 0.000 claims 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 1
- SZFLERAWEJDTCX-UHFFFAOYSA-N 2-(2,3-dihydro-1,4-benzodioxin-6-yl)-6-[5-[(2-hydroxyethylamino)methyl]-7-methyl-1,3-benzoxazol-2-yl]benzonitrile Chemical compound O1CCOC2=C1C=CC(=C2)C1=C(C#N)C(=CC=C1)C=1OC2=C(N=1)C=C(C=C2C)CNCCO SZFLERAWEJDTCX-UHFFFAOYSA-N 0.000 claims 1
- HRHMBEUMFKXGIT-UHFFFAOYSA-N 2-[5-[(2-hydroxyethylamino)methyl]-7-methyl-1,3-benzoxazol-2-yl]-6-phenylbenzonitrile Chemical compound OCCNCC=1C=C(C2=C(N=C(O2)C2=C(C(=CC=C2)C2=CC=CC=C2)C#N)C=1)C HRHMBEUMFKXGIT-UHFFFAOYSA-N 0.000 claims 1
- ZNOWLLPAHTWELC-UHFFFAOYSA-N 2-[[2-(2-methyl-3-phenylphenyl)-1,3-benzoxazol-5-yl]methylamino]ethanol Chemical compound CC1=C(C=CC=C1C=1OC2=C(N=1)C=C(C=C2)CNCCO)C1=CC=CC=C1 ZNOWLLPAHTWELC-UHFFFAOYSA-N 0.000 claims 1
- VSLGIPZHVMRWRE-UHFFFAOYSA-N 2-[[2-(2-methyl-3-phenylphenyl)-6-(2-morpholin-4-ylethoxy)-1,3-benzoxazol-5-yl]methylamino]ethanol Chemical compound CC1=C(C=CC=C1C=1OC2=C(N=1)C=C(C(=C2)OCCN1CCOCC1)CNCCO)C1=CC=CC=C1 VSLGIPZHVMRWRE-UHFFFAOYSA-N 0.000 claims 1
- GEHNLXIJMMXQRC-UHFFFAOYSA-N 2-[[2-(2-methyl-3-phenylphenyl)-6-(pyridin-2-ylmethoxy)-1,3-benzoxazol-5-yl]methylamino]ethanol Chemical compound CC1=C(C=CC=C1C=1OC2=C(N=1)C=C(C(=C2)OCC1=NC=CC=C1)CNCCO)C1=CC=CC=C1 GEHNLXIJMMXQRC-UHFFFAOYSA-N 0.000 claims 1
- MHIGPOAVCFTBOP-UHFFFAOYSA-N 2-[[2-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]-7-methyl-1,3-benzoxazol-5-yl]methylamino]ethanol Chemical compound O1CCOC2=C1C=CC(=C2)C=1C(=C(C=CC=1)C=1OC2=C(N=1)C=C(C=C2C)CNCCO)C MHIGPOAVCFTBOP-UHFFFAOYSA-N 0.000 claims 1
- DXVDOQLHOJBECW-UHFFFAOYSA-N 2-[[2-[3-(2-fluorophenyl)-2-methylphenyl]-5-[(2-hydroxyethylamino)methyl]-1,3-benzoxazol-6-yl]oxy]acetonitrile Chemical compound FC1=C(C=CC=C1)C1=C(C(=CC=C1)C=1OC2=C(N=1)C=C(C(=C2)OCC#N)CNCCO)C DXVDOQLHOJBECW-UHFFFAOYSA-N 0.000 claims 1
- UXKBYCBXVYYRLV-UHFFFAOYSA-N 2-[[5-[(2-hydroxyethylamino)methyl]-2-(2-methyl-3-phenylphenyl)-1,3-benzoxazol-6-yl]oxy]acetonitrile Chemical compound OCCNCC=1C(=CC2=C(N=C(O2)C=2C(=C(C=CC=2)C2=CC=CC=C2)C)C=1)OCC#N UXKBYCBXVYYRLV-UHFFFAOYSA-N 0.000 claims 1
- VHHDHDGZDVIVEH-UHFFFAOYSA-N 2-[[6-methoxy-2-(2-methyl-3-phenylphenyl)-1,3-benzoxazol-5-yl]methylamino]ethanol Chemical compound COC1=CC2=C(N=C(O2)C=2C(=C(C=CC=2)C2=CC=CC=C2)C)C=C1CNCCO VHHDHDGZDVIVEH-UHFFFAOYSA-N 0.000 claims 1
- SSMMLRVAQHQCMT-UHFFFAOYSA-N 2-[[7-methyl-2-(2-methyl-3-phenylphenyl)-1,3-benzoxazol-5-yl]methylamino]ethanol Chemical compound CC1=CC(=CC=2N=C(OC=21)C=1C(=C(C=CC=1)C1=CC=CC=C1)C)CNCCO SSMMLRVAQHQCMT-UHFFFAOYSA-N 0.000 claims 1
- FWIXRKUGYYFFQG-UHFFFAOYSA-N 3-[[5-[(2-hydroxyethylamino)methyl]-2-(2-methyl-3-phenylphenyl)-1,3-benzoxazol-6-yl]oxymethyl]benzonitrile Chemical compound OCCNCC=1C(=CC2=C(N=C(O2)C=2C(=C(C=CC=2)C2=CC=CC=C2)C)C=1)OCC=1C=C(C#N)C=CC=1 FWIXRKUGYYFFQG-UHFFFAOYSA-N 0.000 claims 1
- COAGTFLTFZWZRK-UHFFFAOYSA-N 4-[[5-[(2-hydroxyethylamino)methyl]-7-methyl-2-(2-methyl-3-phenylphenyl)-1,3-benzoxazol-6-yl]oxy]butanenitrile Chemical compound OCCNCC=1C(=C(C2=C(N=C(O2)C=2C(=C(C=CC=2)C2=CC=CC=C2)C)C=1)C)OCCCC#N COAGTFLTFZWZRK-UHFFFAOYSA-N 0.000 claims 1
- 206010000830 Acute leukaemia Diseases 0.000 claims 1
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 206010005949 Bone cancer Diseases 0.000 claims 1
- 208000018084 Bone neoplasm Diseases 0.000 claims 1
- 206010006143 Brain stem glioma Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 101100240518 Caenorhabditis elegans nhr-12 gene Proteins 0.000 claims 1
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 201000003741 Gastrointestinal carcinoma Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 208000007766 Kaposi sarcoma Diseases 0.000 claims 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
- 206010052178 Lymphocytic lymphoma Diseases 0.000 claims 1
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 1
- 206010027480 Metastatic malignant melanoma Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 229910017711 NHRa Inorganic materials 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 208000000821 Parathyroid Neoplasms Diseases 0.000 claims 1
- 208000007913 Pituitary Neoplasms Diseases 0.000 claims 1
- 201000005746 Pituitary adenoma Diseases 0.000 claims 1
- 206010061538 Pituitary tumour benign Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 208000021712 Soft tissue sarcoma Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 206010042971 T-cell lymphoma Diseases 0.000 claims 1
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 206010046431 Urethral cancer Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 208000004354 Vulvar Neoplasms Diseases 0.000 claims 1
- 230000003187 abdominal effect Effects 0.000 claims 1
- 201000005188 adrenal gland cancer Diseases 0.000 claims 1
- 208000024447 adrenal gland neoplasm Diseases 0.000 claims 1
- 239000010425 asbestos Substances 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 208000025997 central nervous system neoplasm Diseases 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 208000024207 chronic leukemia Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 239000000470 constituent Substances 0.000 claims 1
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000000750 endocrine system Anatomy 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 201000003444 follicular lymphoma Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 230000002489 hematologic effect Effects 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 201000002313 intestinal cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 208000020984 malignant renal pelvis neoplasm Diseases 0.000 claims 1
- 208000026045 malignant tumor of parathyroid gland Diseases 0.000 claims 1
- 208000037819 metastatic cancer Diseases 0.000 claims 1
- 208000011575 metastatic malignant neoplasm Diseases 0.000 claims 1
- 208000021039 metastatic melanoma Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 210000003101 oviduct Anatomy 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 210000003899 penis Anatomy 0.000 claims 1
- 230000002085 persistent effect Effects 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 208000021310 pituitary gland adenoma Diseases 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 201000007444 renal pelvis carcinoma Diseases 0.000 claims 1
- 229910052895 riebeckite Inorganic materials 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 208000037959 spinal tumor Diseases 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 230000005747 tumor angiogenesis Effects 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
- 206010046885 vaginal cancer Diseases 0.000 claims 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Claims (16)
1. Spoj, naznačen time, da je predstavljen Formulom (IX):
[image]
ili njegova farmaceutski prihvatljiva sol, ili njegov steroizomer, gdje:
X3 je N ili CR3;
X6 je N ili CR6;
R9 je CH3 ili CN;
svaki od R3, R4, R5, R6 i R7 se neovisno bira od sljedećih: H, halogen, C1-6 alkil, C2-6 alkenil, C2-6 alkinil, C1-6 haloalkil, C1-6 haloalkoksi, C6-10aril, C3-10 cikloalkil, 5-14-člani heteroaril, 4-10-člani heterocikloalkil, C6-10 aril-C1-4 alkil-, C3-10 cikloalkil-C1-4 alkil-, (5-14-člani heteroaril)-C1-4 alkil-, (4-10-člani heterocikloalkil)-C1-4 alkil-, CN, NO2, ORa, SRa, NHORa, C(O)Ra, C(O)NRaRa, C(O)ORa, OC(O)Ra, OC(O)NRaRa, NHRa, NRaRa, NRaC(O)Ra, NRaC(O)ORa, NRaC(O)NRaRa, C(=NRa)Ra, C(=NRa)NRaRa, NRaC(=NRa)NRaRa, NRaS(O)Ra, NRaS(O)2Ra, NRaS(O)2NRaRa, S(O)Ra, S(O)NRaRa, S(O)2Ra, i S(O)2NRaRa, pri čemu je svaki C2-6 alkenil, C2-6 alkinil, C6-10 aril, C3-10 cikloalkil, 5-14-člani heteroaril, 4-10-člani heterocikloalkil, C6-10 aril-C1-4 alkil-, C3-10 cikloalkil-C1-4 alkil-, (5-14-člani heteroaril)-C1-4 alkil-, i (4-10-člani heterocikloalkil)-C1-4 alkil- od R3, R4, R5, R6 i R7,opcionalno supstituiran s 1, 2, 3 ili 4 Rb supstituenta, uz uvjet da je najmanje jedan od R3, R4, R5, R6 i R7, različit od H;
ili dva susjedna R7 supstituenta na fenilnom prstenu, kada su zajedno s atomima s kojima su vezani, tvore kondenzirani fenilni prsten, kondenzirani 5-člani do 7-člani heterocikloalkilni prsten, kondenzirani 5-člani ili 6-člani heteroarilni prsten ili kondenzirani C5-6 cikloalkilni prsten, pri čemu svaki kondenzirani 5-člani do 7-člani heterocikloalkilni prsten i kondenzirani 5-člani ili 6-člani heteroarilni prsten, ima 1-4 heteroatoma kao članove prstena koji se biraju od N, O i S, i gdje je svaki kondenzirani fenilni prsten, kondenzirani 5-člani do 7-člani heterocikloalkilni prsten, kondenzirani 5-člani ili 6-člani heteroarilni prsten i kondenzirani C5-6 cikloalkilni prsten, opcionalno supstituiran s 1, 2 ili 3 neovisno odabrana Rb supstituenta;
svaki Ra se neovisno bira od sljedećih: H, CN, C1-6 alkil, C1-4 haloalkil, C2-6 alkenil, C2-6 alkinil, C6-10 aril, C3-10 cikloalkil, 5-10-člani heteroaril, 4-10-člani heterocikloalkil, C6-10 aril-C1-4 alkil-, C3-10 cikloalkil-C1-4 alkil-, (5-10-člani heteroaril)-C1-4 alkil-, i (4-10-člani heterocikloalkil)-C1-4 alkil-, pri čemu je svaki C1-6 alkil, C2-6 alkenil, C2-6 alkinil, C6-10 aril, C3-10 cikloalkil, 5-10-člani heteroaril, 4-10-člani heterocikloalkil, C6-10 aril-C1-4 alkil-, C3-10 cikloalkil-C1-4 alkil-, (5-10-člani heteroaril)-C1-4 alkil-, i (4-10-člani heterocikloalkil)-C1-4 alkil- od Ra,opcionalno supstituiran s 1, 2, 3, 4 ili 5 Rd supstituenata;
svaki Rd se neovisno bira od sljedećih: C1-6 alkil, C1-6 haloalkil, halogen, C6-10 aril, 5-10-člani heteroaril, C3-10 cikloalkil, 4-10-člani heterocikloalkil, C6-10 aril-C1-4 alkil-, C3-10 cikloalkil-C1-4 alkil-, (5-10-člani heteroaril)-C1-4 alkil-, (4-10-člani heterocikloalkil)-C1-4 alkil-, CN, NH2, NHORe, ORe, SRe, C(O)Re, C(O)NReRe, C(O)ORe, OC(O)Re, OC(O)NReRe, NHRe, NReRe, NReC(O)Re, NReC(O)NReRe, NReC(O)ORe, C(=NRe)NReRe, NReC(=NRe)NReRe, NReC(=NOH)NReRe, NReC(=NCN)NReRe, S(O)Re, S(O)NReRe, S(O)2Re, NReS(O)2Re, NReS(O)2NReRe, i S(O)2NReRe, pri čemu je svaki C1-6 alkil, C1-6 haloalkil, C6-10 aril, 5-10-člani heteroaril, C3-10 cikloalkil, 4-10-člani heterocikloalkil, C6-10 aril-C1-4 alkil-, C3-10 cikloalkil-C1-4 alkil-, (5-10-člani heteroaril)-C1-4 alkil-, i (4-10-člani heterocikloalkil)-C1-4 alkil- od Rd,opcionalno supstituiran s 1-3 neovisno odabrana Rh supstituenta;
svaki Rb supstituent se neovisno bira od sljedećih: halogen, C1-4 alkil, C1-4 haloalkil, C1-4 haloalkoksi C6-10 aril, C3-10 cikloalkil, 5-10-člani heteroaril, 4-10-člani heterocikloalkil, C6-10 aril-C1-4 alkil-, C3-10 cikloalkil-C1-4 alkil-, (5-10-člani heteroaril)-C1-4 alkil-, (4-10-člani heterocikloalkil)-C1-4 alkil-, CN, OH, NH2, NHORc, ORc, SRc, C(O)Rc, C(O)NRcRc, C(O)ORc, OC(O)Rc, OC(O)NRcRc, C(=NRc)NRcRc, NHRc, NRcRc, NRcC(O)Rc, NRcC(O)ORc, NRcC(O)NRcRc, NRcS(O)Rc, NRcS(O)2Rc, NRcS(O)2NRcRc, S(O)Rc, S(O)NRcRc, S(O)2Rc, i S(O)2NRcRc, pri čemu je svaki C1-4 alkil, C1-4haloalkil, C1-4 haloalkoksi, C6-10 aril, C3-10 cikloalkil, 5-10-člani heteroaril, 4-10-člani heterocikloalkil, C6-10 aril-C1-4 alkil-, C3-10 cikloalkil-C1-4 alkil-, (5-10-člani heteroaril)-C1-4 alkil-, i (4-10-člani heterocikloalkil)-C1-4 alkil- od Rb,opcionalno nadalje supstituiran s 1-3 neovisno odabrana Rd supstituenta;
svaki Rc se neovisno bira od sljedećih: H, C1-6 alkil, C1-4 haloalkil, C2-6 alkenil, C2-6 alkinil, C6-10 aril, C3-10 cikloalkil, 5-10-člani heteroaril, 4-10-člani heterocikloalkil, C6-10 aril-C1-4 alkil-, C3-10 cikloalkil-C1-4 alkil-, (5-10-člani heteroaril)-C1-4 alkil-, i (4-10-člani heterocikloalkil)-C1-4 alkil-, pri čemu je svaki C1-6 alkil, C2-6 alkenil, C2-6 alkinil, C6-10 aril, C3-10 cikloalkil, 5-10-člani heteroaril, 4-10-člani heterocikloalkil, C6-10 aril-C1-4 alkil-, C3-10 cikloalkil-C1-4 alkil-, (5-10-člani heteroaril)-C1-4 alkil-, i (4-10-člani heterocikloalkil)-C1-4 alkil- od Rc,opcionalno supstituiran s 1, 2, 3, 4 ili 5 Rf supstituenata koji se neovisno biraju od sljedećih: C1-4 alkil, C1-4 haloalkil, C2-6 alkenil, C2-6 alkinil, C6-10 aril, C3-10 cikloalkil, 5-10-člani heteroaril, 4-10-člani heterocikloalkil, C6-10 aril-C1-4 alkil-, C3-10 cikloalkil-C1-4 alkil-, (5-10-člani heteroaril)-C1-4 alkil-, (4-10-člani heterocikloalkil)-C1-4 alkil-, halogen, CN, NHORg, ORg, SRg, C(O)Rg, C(O)NRgRg, C(O)ORg, OC(O)Rg, OC(O)NRgRg, NHRg, NRgRg, NRgC(O)Rg, NRgC(O)NRgRg, NRgC(O)ORg, C(=NRg)NRgRg, NRgC(=NRg)NRgRg, S(O)Rg, S(O)NRgRg, S(O)2Rg, NRgS(O)2Rg, NRgS(O)2NRgRg, i S(O)2NRgRg, pri čemu je svaki C1-4 alkil, C1-4haloalkil, C2-6 alkenil, C2-6 alkinil, C6-10 aril, C3-10 cikloalkil, 5-10-člani heteroaril, 4-10-člani heterocikloalkil, C6-10 aril-C1-4 alkil-, C3-10 cikloalkil-C1-4 alkil-, (5-10-člani heteroaril)-C1-4 alkil-, i (4-10-člani heterocikloalkil)-C1-4 alkil- od Rf, opcionalno supstituiran s 1, 2, 3, 4 ili 5 Rn supstituenata koji se neovisno biraju od sljedećih: C1-4 alkil, C1-4 haloalkil, halogen, CN, Ro, NHORo, ORo, SRo, C(O)Ro, C(O)NRoRo, C(O)ORo, OC(O)Ro, OC(O)NRoRo, NHRo, NRoRo, NRoC(O)Ro, NRoC(O)NRoRo, NRoC(O)ORo, C(=NRo)NRoRo, NRoC(=NRo)NRoRo, S(O)Ro, S(O)NRoRo, S(O)2Ro, NRoS(O)2Ro, NRoS(O)2NRoRo, i S(O)2NRoRo;
svaki Rg se neovisno bira od sljedećih: H, C1-6 alkil, C1-4 haloalkil, C2-6 alkenil, C2-6 alkinil, C6-10 aril, C3-10 cikloalkil, 5-10-člani heteroaril, 4-10-člani heterocikloalkil, C6-10 aril-C1-4 alkil-, C3-10 cikloalkil-C1-4 alkil-, (5-10-člani heteroaril)-C1-4 alkil-, i (4-10-člani heterocikloalkil)-C1-4 alkil-, pri čemu je svaki C1-6 alkil, C2-6 alkenil, C2-6 alkinil, C6-10 aril, C3-10 cikloalkil, 5-10-člani heteroaril, 4-10-člani heterocikloalkil, C6-10 aril-C1-4 alkil-, C3-10 cikloalkil-C1-4 alkil-, (5-10-člani heteroaril)-C1-4 alkil-, i (4-10-člani heterocikloalkil)-C1-4 alkil- od Rg,opcionalno supstituiran s 1-3 Rp supstituenta koji se neovisno biraju od sljedećih: C1-4 alkil, C3-6 cikloalkil, C6-10 aril, 5-člani ili 6-člani heteroaril, 4-7-člani heterocikloalkil, C1-4 haloalkil, C2-4 alkenil, i C2-4 alkinil, pri čemu su C1-4 alkil, C3-6 cikloalkil, C6-10 aril, 5-člani ili 6-člani heteroaril, 4-7-člani heterocikloalkil, C1-4 haloalkil, C2-4 alkenil, i C2-4 alkinil od Rp, opcionalno supstituirani s 1, 2 ili 3 Rq supstituenta;
ili bilo koja dva Ra supstituenta zajedno s dušikovim atomom s kojim su vezani, tvore 4-članu, 5-članu, 6-članu, 7-članu, 8-članu, 9-članu ili 10-članu heterocikloalkilnu skupinu koja je opcionalno supstituirana s 1, 2 ili 3 Rh supstituenta koji se neovisno biraju od sljedećih: C1-6 alkil, C3-10 cikloalkil, 4-7-člani heterocikloalkil, C6-10 aril, 5-6-člani heteroaril, C6-10 aril-C1-4 alkil-, C3-10 cikloalkil-C1-4 alkil-, (5-6-člani heteroaril)-C1-4 alkil-, (4-7-člani heterocikloalkil)-C1-4 alkil-, C1-6haloalkil, C1-6 haloalkoksi, C2-6 alkenil, C2-6 alkinil, halogen, CN, ORi, SRi, NHORi, C(O)Ri, C(O)NRiRi, C(O)ORi, OC(O)Ri, OC(O)NRiRi, NHRi, NRiRi, NRiC(O)Ri, NRiC(O)NRiRi, NRiC(O)ORi, C(=NRi)NRiRi, NRiC(=NRi)NRiRi, S(O)Ri, S(O)NRiRi, S(O)2Ri, NRiS(O)2Ri, NRiS(O)2NRiRi, i S(O)2NRiRi, pri čemu je svaki C1-6 alkil, C2-6 alkenil, C2-6 alkinil, C3-10 cikloalkil, 4-7-člani heterocikloalkil, C6-10 aril, 5-6-člani heteroaril, C6-10 aril-C1-4 alkil-, C3-10 cikloalkil-C1-4 alkil-, (5-6-člani heteroaril)-C1-4 alkil-, i (4-7-člani heterocikloalkil)-C1-4 alkil-od Rh nadalje opcionalno supstituiran s 1, 2 ili 3 Rj supstituenta koji se neovisno biraju od sljedećih: C3-6 cikloalkil, C6-10 aril, 5-člani ili 6-člani heteroaril, 4-7-člani heterocikloalkil, C2-4 alkenil, C2-4 alkinil, halogen, C1-4 alkil, C1-4haloalkil, CN, NHORk, ORk, SRk, C(O)Rk, C(O)NRkRk, C(O)ORk, OC(O)Rk, OC(O)NRkRk, NHRk, NRkRk, NRkC(O)Rk, NRkC(O)NRkRk, NRkC(O)ORk, C(=NRk)NRkRk, NRkC(=NRk)NRkRk, S(O)Rk, S(O)NRkRk, S(O)2Rk, NRkS(O)2Rk, NRkS(O)2NRkRk, i S(O)2NRkRk, gdje je svaki C1-4 alkil, C3-6 cikloalkil, C6-10 aril, 5-člani ili 6-člani heteroaril, 4-6-člani heterocikloalkil, C2-4 alkenil, C2-4 alkinil, C1-4haloalkil, i C1-4haloalkoksi od Rj,opcionalno supstituiran s 1, 2 ili 3 neovisno odabrana Rq supstituenta; ili dvije Rh skupine koje su vezane s istim ugljikovim atomom od 4-članog do 10-članog heterocikloalkila, zajedno s ugljikovim atomom s kojim su vezane, tvore C3-6 cikloalkil ili 4-člani do 6-člani heterocikloalkil koji ima 1-2 heteroatoma kao članove prstena odabrane od O, N i S;
ili bilo koja dva Rc supstituenta zajedno s dušikovim atomom s kojim su vezani, tvore 4-članu, 5-članu, 6-članu, ili 7-članu heterocikloalkilnu skupinu koja je opcionalno supstituirana s 1, 2 ili 3 neovisno odabrana Rh supstituenta;
ili bilo koja dva Re supstituenta zajedno s dušikovim atomom s kojim su vezani, tvore 4-članu, 5-članu, 6-članu, ili 7-članu heterocikloalkilnu skupinu koja je opcionalno supstituirana s 1, 2 ili 3 neovisno odabrana Rh supstituenta;
ili bilo koja dva Rg supstituenta zajedno s dušikovim atomom s kojim su vezani, tvore 4-članu, 5-članu, 6-članu, ili 7-članu heterocikloalkilnu skupinu koja je opcionalno supstituirana s 1, 2 ili 3 neovisno odabrana Rh supstituenta;
ili bilo koja dva Ro supstituenta zajedno s dušikovim atomom s kojim su vezani, tvore 4-članu, 5-članu, 6-članu, ili 7-članu heterocikloalkilnu skupinu koja je opcionalno supstituirana s 1, 2 ili 3 neovisno odabrana Rh supstituenta;
svaki od Re, Ri, Rk, Ro ili Rp se neovisno bira od sljedećih: H, C1-4 alkil, C3-6 cikloalkil, C6-10 aril, 5-člani ili 6-člani heteroaril, 4-7-člani heterocikloalkil, C1-4 haloalkil, C2-4 alkenil, i C2-4 alkinil, gdje je svaki C1-4 alkil, C3-6 cikloalkil, C6-10 aril, 5-člani ili 6-člani heteroaril, 4-7-člani heterocikloalkil, C2-4 alkenil, i C2-4 alkinil od Re, Ri, Rk, Ro ili Rp, opcionalno supstituiran s 1, 2 ili 3 Rq supstituenta;
svaki Rq se neovisno bira od sljedećih: OH, CN, -COOH, NH2, halogen, C1-6 haloalkil, C1-6 alkil, C1-6 alkoksi, C1-6 alkiltio, fenil, 5-6-člani heteroaril, 4-6-člani heterocikloalkil, C3-6 cikloalkil, NHR12, NR12R12, i C1-4 haloalkoksi, gdje je svaki C1-6 alkil, fenil, C3-6 cikloalkil, 4-6-člani heterocikloalkil, i 5-6-člani heteroaril od Rq, opcionalno supstituiran sa sljedećima: halogen, OH, CN, -COOH, NH2, C1-4 alkil, C1-4 alkoksi, C1-4 haloalkil, C1-4 haloalkoksi, fenil, C3-10 cikloalkil, 5-6-člani heteroaril i 4-6-člani heterocikloalkil, i svaki R12 jest neovisno C1-6 alkil; i
donji indeks n je cijeli broj od 1, 2, 3, 4 ili 5.
2. Spoj prema patentnom zahtjevu 1, ili njegova farmaceutski prihvatljiva sol ili njegov stereoizomer, naznačen time, da sastavni dio:
[image]
jest:
[image]
3. Spoj prema patentnom zahtjevu 1 ili zahtjevu 2, ili njegova farmaceutski prihvatljiva sol ili njegov stereoizomer, naznačen time, da:
(a) X3 je CH, R5 je H i X6 je CR6; ili
(b) X3 je CH i X6 je CR6.
4. Spoj prema bilo kojem od patentnih zahtjeva 1 do 3, ili njegova farmaceutski prihvatljiva sol ili njegov stereoizomer, naznačen time, da:
(a) R4 je -CH2-Rb; ili
(b) R4 je 2-hidroksietilaminometil; ili
(c) R4 je 2-hidroksietilaminometil, 2-karboksipiperidin-1-ilmetil, (S)-2-karboksipiperidin-1-ilmetil ili (R)-2-karboksipiperidin-1-ilmetil.
5. Spoj prema bilo kojem od patentnih zahtjeva 1 do 4, ili njegova farmaceutski prihvatljiva sol ili njegov stereoizomer, naznačen time, da R5 je -CH2-Rb.
6. Spoj prema bilo kojem od patentnih zahtjeva 1 do 4, ili njegova farmaceutski prihvatljiva sol ili njegov stereoizomer, naznačen time, da svaki R3 i R5 je H.
7. Spoj prema patentnom zahtjevu 4 ili 5, ili njegova farmaceutski prihvatljiva sol ili njegov stereoizomer, naznačen time, da:
(a) Rb je -NHRc; ili
(b) Rb je -NRcRc.
8. Spoj prema patentnom zahtjevu 7, ili njegova farmaceutski prihvatljiva sol ili njegov stereoizomer, naznačen time, da:
(a) Rc je C1-4 alkil koji je opcionalno supstituiran s Rd supstituentom; ili
(b) dva Rc supstituenta zajedno s dušikovim atomom s kojim su vezani, tvore 4-članu, 5-članu, 6-članu, ili 7-članu heterocikloalkilnu skupinu koja je opcionalno supstituirana s 1, 2, ili 3 neovisno odabrana Rh supstituenta; ili
(c) dva Rc supstituenta zajedno s dušikovim atomom s kojim su vezani, tvore 6-člani heterocikloalkil koji je supstituiran s jednim Rh supstituentom.
9. Spoj prema bilo kojem od patentnih zahtjeva 1 do 3, ili njegova farmaceutski prihvatljiva sol ili njegov stereoizomer, naznačen time, da se svaki od R4i R5 nevisno bira od sljedećih: 2-hidroksietilaminometil, 2-karboksipiperidin-1-ilmetil, (S)-2-karboksipiperidin-1-ilmetil, (R)-2-karboksipiperidin-1-ilmetil, (3-cijanofenil)metoksi, cijanometoksi, 2-cijanoetoksi, 3-cijanopropoksi, 2-morfolino-4-iletoksi i piridin-2-ilmetoksi.
10. Spoj prema patentnom zahtjevu 1, naznačen time, da se spoj bira od sljedećih:
(a)
(2S)-1-{[2-(2-metilbifenil-3-il)-1,3-benzoksazol-5-il]metil}piperidin-2-karboksilna kiselina;
2-({[2-(2-metilbifenil-3-il)-1,3-benzoksazol-5-il]metil}amino)etanol;
(2S)-1-{[7-metil-2-(2-metilbifenil-3-il)-1,3-benzoksazol-5-il]metil}piperidin-2-karboksilna kiselina;
2-({[7-metil-2-(2-metilbifenil-3-il)-1,3-benzoksazol-5-il]metil}amino)etanol;
(2S)-1-{[2-(2-cijanobifenil-3-il)-7-metil-1,3-benzoksazol-5-il]metil}piperidin-2-karboksilna kiselina;
3-(5-{[(2-hidroksietil)amino]metil}-7-metil-1,3-benzoksazol-2-il)bifenil-2-karbonitril;
(2S)-1-({2-[3-(2,3-dihidro-1,4-benzodioksin-6-il)-2-metilfenil]-7-metil-1,3-benzoksazol-5-il}metil)piperidin-2-karboksilna kiselina;
2-[({2-[3-(2,3-dihidro-1,4-benzodioksin-6-il)-2-metilfenil]-7-metil-1,3-benzoksazol-5-il}metil)amino]etanol;
(2S)-1-({2-[2-cijano-3-(2,3-dihidro-1,4-benzodioksin-6-il)fenil]-7-metil-1,3-benzoksazol-5-il}metil)piperidin-2-karboksilna kiselina; i
2-(2,3-dihidro-1,4-benzodioksin-6-il)-6-(5-{[(2-hidroksietil)amino]metil}-7-metil-1,3-benzoksazol-2-il)benzonitril;
ili njegova farmaceutski prihvatljiva sol; ili
(b)
(2S)-1-{[6-(cijanometoksi)-2-(2-metilbifenil-3-il)-1,3-benzoksazol-5-il]metil}piperidin-2-karboksilna kiselina;
{[5-{[(2-hidroksietil)amino]metil}-2-(2-metilbifenil-3-il)-1,3-benzoksazol-6-il]oksi}acetonitril;
(2S)-1-{[6-(3-cijanopropoksi)-2-(2-metilbifenil-3-il)-1,3-benzoksazol-5-il]metil}piperidin-2-karboksilna kiselina;
3-({[5-{[(2-hidroksietil)amino]metil}-2-(2-metilbifenil-3-il)-1,3-benzoksazol-6-il]oksi}metil)benzonitril;
2-({[2-(2-metilbifenil-3-il)-6-(piridin-2-ilmetoksi)-1,3-benzoksazol-5-il]metil}amino)etanol;
2-({[6-metoksi-2-(2-metilbifenil-3-il)-1,3-benzoksazol-5-il]metil}amino)etanol;
2-({[2-(2-metilbifenil-3-il)-6-(2-morfolin-4-iletoksi)-1,3-benzoksazol-5-il]metil}amino)etanol;
4-{[5-{[(2-hidroksietil)amino]metil}-7-metil-2-(2-metilbifenil-3-il)-1,3-benzoksazol-6-il]oksi}butan-nitril;
(2S)-1-({6-(cijanometoksi)-2-[3-(2,3-dihidro-1,4-benzodioksin-6-il)-2-metilfenil]-1,3-benzoksazol-5-il}metil)piperidin-2-karboksilna kiselina;
(2S)-1-{[2-[2-cijano-3-(2,3-dihidro-1,4-benzodioksin-6-il)fenil]-6-(cijanometoksi)-1,3-benzoksazol-5-il]metil}piperidin-2-karboksilna kiselina;
(2S)-1-{[2-(2-metilbifenil-3-il)-1,3-benzoksazol-6-il]metil}piperidin-2-karboksilna kiselina; i
[(2-(2’-fluoro-2-metilbifenil-3-il)-5-{[(2-hidroksietil)amino]metil}-1,3-benzoksazol-6-il)oksi]acetonitril;
ili njegova farmaceutski prihvatljiva sol.
11. Farmaceutski pripravak, naznačen time, da sadrži spoj prema bilo kojem od patentnih zahtjeva 1 do 9, ili njegovu farmaceutski prihvatljivu sol ili njegov stereoizomer, ili spoj prema patentnom zahtjevu 10, ili njegovu farmaceutski prihvatljivu sol, i najmanje jedan farmaceutski prihvatljiv nosač ili pomoćno sredstvo.
12. Spoj prema bilo kojem od patentnih zahtjeva 1 do 9, ili njegova farmaceutski prihvatljiva sol ili njegov stereoizomer; spoj prema patentnom zahtjevu 10, ili njegova farmaceutski prihvatljiva sol; ili pripravak prema patentnom zahtjevu 11, naznačen time, da je za uporabu u postupku inhibiranja rasta tumorskih stanica in vitro.
13. Spoj prema bilo kojem od patentnih zahtjeva 1 do 9, ili njegova farmaceutski prihvatljiva sol ili njegov stereoizomer; spoj prema patentnom zahtjevu 10, ili njegova farmaceutski prihvatljiva sol; ili pripravak prema patentnom zahtjevu 11, naznačen time, da je za uporabu u postupku liječenja bolesti ili poremećaja koji je povezan s inhibicijom interakcije PD-1/PD-L1, pri čemu je bolest ili poremećaj virusna infekcija ili rak.
14. Spoj ili pripravak prema patentnom zahtjevu 13, naznačen time, da bolest ili poremećaj je rak.
15. Spoj ili pripravak prema patentnom zahtjevu 14, naznačen time, da:
(a) rak se bira od sljedećih: rak kostiju, rak gušterače, rak kože, rak glave i vrata, kožni ili očni maligni melanom, rak tijela maternice, rak jajnika, rak rektuma, rak analne regije, rak abdomena, rak testisa, karcinom falopijevih cijevi, karcinom endometrija, endometrijski rak, karcinom cerviksa, karcinom vagine, karcinom vulve, rak jednjaka, rak malog crijeva, rak endokrinog sustava, rak tiroidne žlijezde, rak paratiroidne žlijezde, rak adrenalne žlijezde, sarkom mekog tkiva, rak mokraćne cijevi, rak penisa, kronične ili akutne leukemije, solidni tumori u djetinjstvu, limfocitni limfom, rak mokraćnog mjehura, rak bubrega, karcinom bubrežne zdjelice, neoplazma središnjeg živčanog sustava, primarni limfom središnjeg živčanog sustava, tumorska angiogeneza, tumor kralješnice, gliom moždanog debla, pituitarni adenom, Kaposijev sarkom, epidermoidni rak, rak rožnatih stanica, limfom T stanica, vrste raka koje su inducirane okolišem uključujući one koje su inducirane azbestom, melanom, metastatski maligni melanom, renalni rak, karcinom svijetlih stanica renalnih stanica, rak prostate, rak dojke, rak debelog crijeva, rak pluća, rak ne-malih stanica pluća, čvrsti tumori, rak jetre, rak želuca, tiroidni rak, glioblastom, sarkom, hematološke vrste raka, limfom, leukemija, akutna limfoblastična leukemija (ALL), akutna mijeloična leukemija (AML), kronična limfocitna leukemija (CLL), kronična mijeloična leukemija (CML), difuzni limfom velikih B stanica (DLBCL), limfom plaštenih stanica, ne-Hodgkinov limfom (NHL), ponavljajući ili uporni ne-Hodgkinov limfom (NHL), periodični folikularni ne-Hodgkinov limfom (NHL), Hodgkinov limfom, i multipli mijelom; ili
(b) rak je metastatski rak koji eksprimira PD-L1; ili
(c) rak je rak pluća; ili
(d) rak je rak ne-malih stanica pluća; ili
(e) rak je rak bubrega; ili
(f) rak je rak jetre; ili
(g) rak je melanom; ili
(h) rak je rak mokraćnog mjehura; ili
(i) rak je rak mokraćne cijevi; ili
(j) rak je renalni rak; ili
(k) rak je karcinom svijetlih stanica renalnih stanica.
16. Spoj prema bilo kojem od patentnih zahtjeva 1 do 9, ili njegova farmaceutski prihvatljiva sol ili njegov stereoizomer; spoj prema patentnom zahtjevu 10, ili njegova farmaceutski prihvatljiva sol; ili pripravak prema patentnom zahtjevu 11, naznačen time, da je za uporabu u postupku poboljšavanja, poticanja i/ili povećavanja imunosnog odgovora kod pacijenta.
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