EA201390421A1 - Модуляторы рецептора gpr119 и лечение связанных с ним нарушений - Google Patents

Модуляторы рецептора gpr119 и лечение связанных с ним нарушений

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Publication number
EA201390421A1
EA201390421A1 EA201390421A EA201390421A EA201390421A1 EA 201390421 A1 EA201390421 A1 EA 201390421A1 EA 201390421 A EA201390421 A EA 201390421A EA 201390421 A EA201390421 A EA 201390421A EA 201390421 A1 EA201390421 A1 EA 201390421A1
Authority
EA
Eurasian Patent Office
Prior art keywords
fluoro
fluoropropan
oxadiazol
gpr119 receptor
inhibitor
Prior art date
Application number
EA201390421A
Other languages
English (en)
Inventor
Роберт М. Джонс
Юэрг Леманн
Вэйчао Чэнь
Джеффри Эдвардс
Глен Маркес
Майкл Е. Морган
Абу Дж.М. Садекве
Сун Хи Ким
Original Assignee
Арена Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Арена Фармасьютикалз, Инк. filed Critical Арена Фармасьютикалз, Инк.
Publication of EA201390421A1 publication Critical patent/EA201390421A1/ru

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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

Изобретение относится к агонистам рецептора GPR119: 3-фтор-4-(5-фтор-6-(4-(3-(2-фторпропан-2-ил)-1,2,4-оксадиазол-5-ил)пиперидин-1-ил)пиримидин-4-иламино)-N,N-диметилбензамиду; 3-фтор-4-(5-фтор-6-(4-(3-(2-фторпропан-2-ил)-1,2,4-оксадиазол-5-ил)пиперидин-1-ил)пиримидин-4-иламино)-N-метилбензамиду; и 3-фтор-4-(5-фтор-6-(4-(3-(2-фторпропан-2-ил)-1,2,4-оксадиазол-5-ил)пиперидин-1-ил)пиримидин-4-иламино)бензамиду, и их фармацевтически приемлемым солям, сольватам и гидратам, которые могут быть пригодны в качестве единичного фармацевтического агента или в комбинации с одним или более дополнительными фармацевтическими агентами, такими как ингибитор ДПП-IV, бигуанид, ингибитор альфа-глюкозидазы, аналог инсулина, сульфонилмочевина, ингибитор SGLT2, меглитинид, тиазолидиндион или противодиабетический пептидный аналог, при лечении, например, нарушения, выбранного из связанного с GPR119-рецептором нарушения; состояния, улучшенного с помощью повышения секреции инкретина; состояния, улучшенного с помощью повышения уровня инкретина в крови; состояния, охарактеризованного с помощью низкой костной массы; неврологического нарушения; связанного с метаболизмом нарушения; сахарного диабета 2-го типа; ожирения и связанных с ним осложнений.
EA201390421A 2010-09-22 2011-09-21 Модуляторы рецептора gpr119 и лечение связанных с ним нарушений EA201390421A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38541010P 2010-09-22 2010-09-22
US201161478262P 2011-04-22 2011-04-22
PCT/US2011/052478 WO2012040279A1 (en) 2010-09-22 2011-09-21 Modulators of the gpr119 receptor and the treatment of disorders related thereto

Publications (1)

Publication Number Publication Date
EA201390421A1 true EA201390421A1 (ru) 2013-09-30

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US (2) US10894787B2 (ru)
EP (2) EP3323818A1 (ru)
JP (1) JP5941916B2 (ru)
KR (1) KR101871011B1 (ru)
CN (2) CN103221410B (ru)
AU (2) AU2011305525B2 (ru)
BR (1) BR112013008100A2 (ru)
CA (1) CA2812061A1 (ru)
CL (1) CL2013000785A1 (ru)
CO (1) CO6700841A2 (ru)
CR (1) CR20130145A (ru)
DO (1) DOP2013000061A (ru)
EA (1) EA201390421A1 (ru)
EC (1) ECSP13012704A (ru)
GT (1) GT201300075A (ru)
HK (1) HK1254745A1 (ru)
MX (1) MX2013003184A (ru)
NI (1) NI201300030A (ru)
PE (1) PE20131371A1 (ru)
SG (1) SG188548A1 (ru)
WO (1) WO2012040279A1 (ru)

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JP6463631B2 (ja) 2011-06-09 2019-02-06 ライゼン・ファーマシューティカルズ・エスアー Ｇｐｒ−１１９のモジュレータとしての新規化合物
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