PE20060479A1 - Compuestos heteroaril-aril-ureas como inhibidores de la quinasa - Google Patents

Compuestos heteroaril-aril-ureas como inhibidores de la quinasa

Info

Publication number
PE20060479A1
PE20060479A1 PE2005000736A PE2005000736A PE20060479A1 PE 20060479 A1 PE20060479 A1 PE 20060479A1 PE 2005000736 A PE2005000736 A PE 2005000736A PE 2005000736 A PE2005000736 A PE 2005000736A PE 20060479 A1 PE20060479 A1 PE 20060479A1
Authority
PE
Peru
Prior art keywords
methyl
phenyl
heteroaryl
aryl
compounds
Prior art date
Application number
PE2005000736A
Other languages
English (en)
Inventor
Yi Liu
Nathanael Schiander Gray
Bing Li
Tetsuo Uno
Werner Breitenstein
Giorgio Caravatti
Vito Guagnano
Carsten Spanka
Joseph Schoepfer
Paul W Manley
Marc Lang
Pascal Furet
Guido Bold
Soldermann Carole Pissot
Qiang Ding
Taebo Sim
Guobao Zhang
Original Assignee
Irm Llc
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34855683&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20060479(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Irm Llc, Novartis Ag filed Critical Irm Llc
Publication of PE20060479A1 publication Critical patent/PE20060479A1/es

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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61P35/00—Antineoplastic agents
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE HETEROARIL-ARIL-UREAS DE FORMULA (I), EN DONDE n ES DE 0 A 5; X, Y y Z SON INDEPENDIENTEMENTE N O C-R5, Y AL MENOS DOS DE ESTOS SON N; Y X1 ES O; R1, R2, R3 Y R4 SI ESTAN PRESENTES SE SELECCIONAN DE a) UNA FRACCION INORGANICA TAL COMO H, CLORO, HIDROXILO, CIANO, AZO, NITRO Y b) LA FRACCION ORGANICA ESTA OPCIONALMENTE SUSTITUIDA Y UNIDA POR UN ENLAZADOR -L1-, TAL COMO H, ALIFATICO INFERIOR, UN CICLICO, ENTRE OTROS; -L1- TIENE DE 1 A 5 ATOMOS EN LA CADENA DE C, N, O Y S, SELECCIONADO DE ALQUILO(C1-C4) OPCIONALMENTE TERMINADO POR O, C(O), NRa, ENTRE OTROS. SON PREFERIDOS: 3-(2,6-DICLORO-3,5-DIMETOXI-FENIL)-1-METIL-1-{6-[4-(4-METIL-PIPERAZIN-1-IL)-FENIL-AMINO]-PIRIMIDIN-4-IL}-UREA, N-[4-METIL-3-(3-METIL-3-{6-[(TETRAHIDRO-FURAN-2-ILMETIL)-AMINO]-PIRIMIDIN-4-IL}-UREIDO)FENIL]-3-TRIFLUORO-METILBENZAMIDA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS SON INHIBIDORES DE LA ACTIVIDAD DE LA QUINASA DE PROTEINA, POR LO QUE SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES PROLIFERATIVAS
PE2005000736A 2004-06-24 2005-06-24 Compuestos heteroaril-aril-ureas como inhibidores de la quinasa PE20060479A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58242504P 2004-06-24 2004-06-24
GBGB0512324.5A GB0512324D0 (en) 2005-06-16 2005-06-16 Organic compounds

Publications (1)

Publication Number Publication Date
PE20060479A1 true PE20060479A1 (es) 2006-07-14

Family

ID=34855683

Family Applications (3)

Application Number Title Priority Date Filing Date
PE2012002442A PE20130239A1 (es) 2004-06-24 2005-06-24 Compuestos heteroaril-aril-ureas como inhibidores de la quinasa
PE2005000736A PE20060479A1 (es) 2004-06-24 2005-06-24 Compuestos heteroaril-aril-ureas como inhibidores de la quinasa
PE2011001630A PE20120252A1 (es) 2004-06-24 2005-06-24 Compuestos heteroaril-aril-ureas como inhibidores de la quinasa

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PE2012002442A PE20130239A1 (es) 2004-06-24 2005-06-24 Compuestos heteroaril-aril-ureas como inhibidores de la quinasa

Family Applications After (1)

Application Number Title Priority Date Filing Date
PE2011001630A PE20120252A1 (es) 2004-06-24 2005-06-24 Compuestos heteroaril-aril-ureas como inhibidores de la quinasa

Country Status (31)

Country Link
US (3) US8552002B2 (es)
EP (3) EP1761505B1 (es)
JP (1) JP4944776B2 (es)
KR (1) KR101238591B1 (es)
CN (3) CN101035769A (es)
AR (1) AR050343A1 (es)
AT (1) ATE520671T1 (es)
AU (2) AU2005256491C1 (es)
BR (1) BRPI0512588B1 (es)
CA (1) CA2570873C (es)
DK (1) DK1761505T3 (es)
EC (1) ECSP067076A (es)
ES (1) ES2432646T3 (es)
GB (1) GB0512324D0 (es)
HK (1) HK1104286A1 (es)
HR (1) HRP20110822T1 (es)
IL (1) IL179743A0 (es)
MA (1) MA28695B1 (es)
MX (1) MXPA06014746A (es)
MY (1) MY144655A (es)
NO (1) NO338287B1 (es)
NZ (1) NZ551438A (es)
PE (3) PE20130239A1 (es)
PL (1) PL1761505T3 (es)
PT (1) PT1761505E (es)
RU (1) RU2430093C2 (es)
SG (1) SG153875A1 (es)
SI (1) SI1761505T1 (es)
TN (1) TNSN06411A1 (es)
TW (1) TWI361187B (es)
WO (1) WO2006000420A1 (es)

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