EA200701257A1 - Пирролопиразолы в качестве сильнодействующих ингибиторов киназы - Google Patents

Пирролопиразолы в качестве сильнодействующих ингибиторов киназы

Info

Publication number
EA200701257A1
EA200701257A1 EA200701257A EA200701257A EA200701257A1 EA 200701257 A1 EA200701257 A1 EA 200701257A1 EA 200701257 A EA200701257 A EA 200701257A EA 200701257 A EA200701257 A EA 200701257A EA 200701257 A1 EA200701257 A1 EA 200701257A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyrrophorasoles
strongly
kinase inhibitors
acting
compounds
Prior art date
Application number
EA200701257A
Other languages
English (en)
Other versions
EA011815B1 (ru
Inventor
Джамал Бузида
Лимин Дун
Чуансин Го
Юйфын Хун
Хайтао Ли
Джозеф Тимоти Мараковиц
Аньлэ Ян
Цзюньху Чжан
Original Assignee
Пфайзер Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Инк. filed Critical Пфайзер Инк.
Publication of EA200701257A1 publication Critical patent/EA200701257A1/ru
Publication of EA011815B1 publication Critical patent/EA011815B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Предложены соединения пирролпиразола формулы (I), композиции, содержащие эти соединения, и способы их применения. Предпочтительные соединения формулы I обладают активностью ингибиторов протеинкиназы, в том числе активностью ингибиторов PAK4.
EA200701257A 2005-01-10 2005-12-28 Пирролопиразолы в качестве сильнодействующих ингибиторов киназы EA011815B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US64290005P 2005-01-10 2005-01-10
US73377005P 2005-11-04 2005-11-04
PCT/IB2005/003975 WO2006072831A1 (en) 2005-01-10 2005-12-28 Pyrrolopyrazoles, potent kinase inhibitors

Publications (2)

Publication Number Publication Date
EA200701257A1 true EA200701257A1 (ru) 2007-12-28
EA011815B1 EA011815B1 (ru) 2009-06-30

Family

ID=36463340

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200701257A EA011815B1 (ru) 2005-01-10 2005-12-28 Пирролопиразолы в качестве сильнодействующих ингибиторов киназы

Country Status (30)

Country Link
US (2) US8067591B2 (ru)
EP (1) EP1838718B1 (ru)
JP (1) JP4250195B2 (ru)
KR (1) KR100919343B1 (ru)
CN (1) CN101115760B (ru)
AP (1) AP2007004061A0 (ru)
AT (1) ATE512972T1 (ru)
AU (1) AU2005323797B2 (ru)
BR (1) BRPI0518509A2 (ru)
CA (1) CA2593428C (ru)
CU (1) CU23778B7 (ru)
CY (1) CY1111752T1 (ru)
DK (1) DK1838718T3 (ru)
EA (1) EA011815B1 (ru)
ES (1) ES2365245T3 (ru)
GE (1) GEP20094785B (ru)
HK (1) HK1114380A1 (ru)
HR (1) HRP20110485T1 (ru)
IL (1) IL184275A0 (ru)
MA (1) MA29141B1 (ru)
MX (1) MX2007008385A (ru)
NO (1) NO20073859L (ru)
NZ (1) NZ556273A (ru)
PL (1) PL1838718T3 (ru)
PT (1) PT1838718E (ru)
RS (1) RS51891B (ru)
SI (1) SI1838718T1 (ru)
TN (1) TNSN07254A1 (ru)
WO (1) WO2006072831A1 (ru)
ZA (1) ZA200705628B (ru)

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US8114871B2 (en) * 2007-04-12 2012-02-14 Pfizer Inc. 3-amido-pyrrolo[3,4-C]pyrazole-5(1H,4H,6H) carbaldehyde derivatives
US8415340B2 (en) 2007-07-25 2013-04-09 Bristol-Myers Squibb Company Triazine kinase inhibitors
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EP2145891A1 (en) 2008-07-09 2010-01-20 Vetoquinol S.A. 9-substituted-5-carboxy-oxadiazino-quinolone derivatives, their preparation and their application as anti-bacterials
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RU2013126036A (ru) 2010-11-17 2014-12-27 Ф. Хоффманн-Ля Рош Аг Способ лечения опухолей
AR088218A1 (es) 2011-07-19 2014-05-21 Infinity Pharmaceuticals Inc Compuestos heterociclicos utiles como inhibidores de pi3k
WO2013113776A1 (en) 2012-02-03 2013-08-08 Basf Se Fungicidal pyrimidine compounds
WO2013113719A1 (en) 2012-02-03 2013-08-08 Basf Se Fungicidal pyrimidine compounds ii
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CN104220427A (zh) 2012-02-03 2014-12-17 巴斯夫欧洲公司 杀真菌嘧啶化合物
WO2013113773A1 (en) 2012-02-03 2013-08-08 Basf Se Fungicidal pyrimidine compounds
CN104220428A (zh) 2012-02-03 2014-12-17 巴斯夫欧洲公司 杀真菌嘧啶化合物
WO2013113778A1 (en) 2012-02-03 2013-08-08 Basf Se Fungicidal pyrimidine compounds
WO2013113781A1 (en) 2012-02-03 2013-08-08 Basf Se Fungicidal pyrimidine compounds i
WO2013113787A1 (en) 2012-02-03 2013-08-08 Basf Se Fungicidal pyrimidine compounds
WO2013135671A1 (en) 2012-03-13 2013-09-19 Basf Se Fungicidal pyrimidine compounds
WO2013135672A1 (en) 2012-03-13 2013-09-19 Basf Se Fungicidal pyrimidine compounds
MX2014010953A (es) * 2012-03-16 2014-10-13 Hoffmann La Roche Metodos para tratamiento de melanoma con inhibidores pak1.
JP6186440B2 (ja) 2012-09-19 2017-08-23 ノバルティス アーゲー キナーゼ阻害剤としてのジヒドロピロリジノピリミジン
BR112015007821B1 (pt) * 2012-10-15 2022-02-15 Pfizer Ireland Pharmaceuticals Processo para a preparação de voriconazol e análogos do mesmo
US20160221964A1 (en) 2013-09-16 2016-08-04 Basf Se Fungicidal pyrimidine compounds
WO2015036059A1 (en) 2013-09-16 2015-03-19 Basf Se Fungicidal pyrimidine compounds
CN104926735A (zh) * 2015-06-16 2015-09-23 上海合全药物研发有限公司 4-氯-5-氟-2-甲基嘧啶的工业化制备方法
SG11201804901WA (en) 2015-12-22 2018-07-30 SHY Therapeutics LLC Compounds for the treatment of cancer and inflammatory disease
WO2017144546A1 (en) 2016-02-23 2017-08-31 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of nasopharyngeal carcinoma
WO2018098361A1 (en) 2016-11-22 2018-05-31 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 12 (cdk12) and uses thereof
EA201992780A1 (ru) 2017-06-21 2020-06-02 ШАЙ ТЕРАПЬЮТИКС ЭлЭлСи Соединения, которые взаимодействуют с суперсемейством ras, для лечения рака, воспалительных заболеваний, ras-опатий и фиброзного заболевания
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WO2021198511A1 (en) 2020-04-03 2021-10-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for treatment of sars-cov-2 infection
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10894798B2 (en) 2015-06-15 2021-01-19 Ube Industries, Ltd. Substituted dihydropyrrolopyrazole derivative
RU2765718C1 (ru) * 2015-06-15 2022-02-02 Убе Индастриз, Лтд. Замещенное производное дигидропирролопиразола

Also Published As

Publication number Publication date
CN101115760A (zh) 2008-01-30
US8530652B2 (en) 2013-09-10
NO20073859L (no) 2007-10-03
PT1838718E (pt) 2011-08-17
EP1838718A1 (en) 2007-10-03
RS51891B (en) 2012-02-29
MX2007008385A (es) 2007-08-21
ATE512972T1 (de) 2011-07-15
TNSN07254A1 (en) 2008-12-31
NZ556273A (en) 2010-01-29
AU2005323797A1 (en) 2006-07-13
CU20070160A7 (es) 2009-03-16
CA2593428A1 (en) 2006-07-13
SI1838718T1 (sl) 2011-08-31
US8067591B2 (en) 2011-11-29
ZA200705628B (en) 2008-11-26
BRPI0518509A2 (pt) 2008-11-25
DK1838718T3 (da) 2011-07-25
HRP20110485T1 (hr) 2011-07-31
EP1838718B1 (en) 2011-06-15
IL184275A0 (en) 2007-10-31
HK1114380A1 (en) 2008-10-31
CN101115760B (zh) 2010-11-03
EA011815B1 (ru) 2009-06-30
AU2005323797B2 (en) 2009-07-09
CU23778B7 (es) 2012-02-15
CA2593428C (en) 2012-04-17
ES2365245T3 (es) 2011-09-27
KR100919343B1 (ko) 2009-09-25
PL1838718T3 (pl) 2011-10-31
GEP20094785B (en) 2009-09-25
US20100222342A1 (en) 2010-09-02
US20120264751A1 (en) 2012-10-18
AP2007004061A0 (en) 2007-08-31
CY1111752T1 (el) 2015-10-07
MA29141B1 (fr) 2008-01-02
JP4250195B2 (ja) 2009-04-08
KR20070096007A (ko) 2007-10-01
JP2008526826A (ja) 2008-07-24
WO2006072831A1 (en) 2006-07-13

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU