IL86632A0 - Derivatives substituted at methyl-amino nitrogen - Google Patents
Derivatives substituted at methyl-amino nitrogenInfo
- Publication number
- IL86632A0 IL86632A0 IL86632A IL8663288A IL86632A0 IL 86632 A0 IL86632 A0 IL 86632A0 IL 86632 A IL86632 A IL 86632A IL 8663288 A IL8663288 A IL 8663288A IL 86632 A0 IL86632 A0 IL 86632A0
- Authority
- IL
- Israel
- Prior art keywords
- methyl
- amino nitrogen
- derivatives substituted
- formula
- stau
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Abstract
N-Substituted derivatives of staurosporin of the formula [Stau]-N(CH3)-R (I> in which [Stau] represents the radical of the sub-formula <IMAGE> in which R represents a hydrocarbyl R<0> or an acyl Ac, which preferably have at most 30 C atoms, and salts of compounds of the formula I having salt-forming properties, are distinguished as selective inhibitors of protein kinase C. They are prepared by conventional alkylation or acylation of staurosporin.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH224487 | 1987-06-15 | ||
CH144088 | 1988-04-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
IL86632A0 true IL86632A0 (en) | 1988-11-30 |
Family
ID=25687663
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL86632A IL86632A0 (en) | 1987-06-15 | 1988-06-06 | Derivatives substituted at methyl-amino nitrogen |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0296110B1 (en) |
JP (1) | JP2708047B2 (en) |
KR (1) | KR970001529B1 (en) |
AT (1) | ATE134375T1 (en) |
AU (1) | AU617324B2 (en) |
CA (1) | CA1337763C (en) |
DE (1) | DE3855015D1 (en) |
DK (1) | DK175507B1 (en) |
ES (1) | ES2083956T3 (en) |
FI (1) | FI89362C (en) |
GR (1) | GR3019064T3 (en) |
HK (1) | HK1003788A1 (en) |
HU (1) | HU201329B (en) |
IE (1) | IE70523B1 (en) |
IL (1) | IL86632A0 (en) |
MY (1) | MY104316A (en) |
NO (1) | NO170634C (en) |
NZ (1) | NZ225018A (en) |
PT (1) | PT87719B (en) |
YU (1) | YU115488A (en) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62220196A (en) * | 1986-03-20 | 1987-09-28 | Kyowa Hakko Kogyo Co Ltd | Ucn-01 and production thereof |
WO1989007105A1 (en) * | 1988-02-04 | 1989-08-10 | Kyowa Hakko Kogyo Co., Ltd. | Staurosporin derivatives |
SK278989B6 (en) * | 1988-02-10 | 1998-05-06 | F. Hoffmann-La Roche Ag | Substituted pyrroles, their use for producing a drug, and the drug on their base |
USRE36736E (en) * | 1989-02-06 | 2000-06-13 | Hoffman-La Roche Inc. | Substituted pyrroles |
DE3924538A1 (en) * | 1989-07-25 | 1991-01-31 | Goedecke Ag | INDOLOCARBAZOL AND THEIR USE |
US5618809A (en) * | 1989-12-14 | 1997-04-08 | Schering Corporation | Indolocarbazoles from saccharothrix aerocolonigenes copiosa subsp. nov SCC 1951 ATCC 53856 |
US5292747A (en) * | 1990-08-07 | 1994-03-08 | Hoffman-La Roche Inc. | Substituted pyrroles |
AU2866992A (en) * | 1991-10-10 | 1993-05-03 | Schering Corporation | 4'-(n-substituted-n-oxide)staurosporine derivatives |
EP0541486A1 (en) * | 1991-11-07 | 1993-05-12 | Ciba-Geigy Ag | Polycyclic conjugates |
WO1993018771A1 (en) * | 1992-03-24 | 1993-09-30 | Asahi Kasei Kogyo Kabushiki Kaisha | PLATELET AGGLUTINATION INHIBITOR CONTAINING STAUROSPORINE η-LACTAM DERIVATIVE |
US5621101A (en) * | 1992-07-24 | 1997-04-15 | Cephalon, Inc. | Protein kinase inhibitors for treatment of neurological disorders |
US5621100A (en) * | 1992-07-24 | 1997-04-15 | Cephalon, Inc. | K-252a derivatives for treatment of neurological disorders |
US5756494A (en) * | 1992-07-24 | 1998-05-26 | Cephalon, Inc. | Protein kinase inhibitors for treatment of neurological disorders |
US5461146A (en) * | 1992-07-24 | 1995-10-24 | Cephalon, Inc. | Selected protein kinase inhibitors for the treatment of neurological disorders |
US5674867A (en) * | 1992-09-21 | 1997-10-07 | Kyowa Hakko Kogyo Co., Ltd. | Indolocarbazole derivatives and therapeutic method for stimulating megakaicyocyte production |
US5981568A (en) | 1993-01-28 | 1999-11-09 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
EP2298310A3 (en) | 1993-01-28 | 2011-04-06 | Boston Scientific Limited | Therapeutic inhibitors of vascular smooth muscle cells |
PH30300A (en) * | 1993-05-07 | 1997-01-20 | Ciba Geigy Ag | Polycyclic compounds and processes for the preparation thereof |
JPH09503381A (en) * | 1993-07-09 | 1997-04-08 | ジ・インスティテュート・オブ・キャンサー・リサーチ | Protein tyrosine kinase and its ligand |
GB9325395D0 (en) * | 1993-12-11 | 1994-02-16 | Ciba Geigy Ag | Compositions |
EP0711556A1 (en) * | 1994-11-09 | 1996-05-15 | Ciba-Geigy Ag | Intravenous solutions containing staurosporine derivatives |
UA67725C2 (en) | 1996-06-03 | 2004-07-15 | Cephalon Inc | K-252a derivatives and a method for improvement of functioning and cell survival enhancement |
US6875865B1 (en) | 1996-06-03 | 2005-04-05 | Cephalon, Inc. | Selected derivatives of K-252a |
AU721942B2 (en) | 1996-06-25 | 2000-07-20 | Cephalon, Inc. | Use of K-252A derivative for the treatment of peripheral or central nerve disorders, and cytokine overproduction |
WO1998043618A2 (en) | 1997-03-31 | 1998-10-08 | Neorx Corporation | Use of cytoskeletal inhibitors for the prevention of restenosis |
CN1172673C (en) * | 1998-11-23 | 2004-10-27 | 诺瓦提斯公司 | Use of staurosporine derivatives for treating ocular neovascular diseases |
CA2994779C (en) | 2001-02-19 | 2020-08-25 | Novartis Ag | Use of 40-o-(2-hydroxyethyl)-rapamycin for inhibiting growth of a solid tumour of the brain other than lymphatic cancer |
BR0209647A (en) | 2001-05-16 | 2004-07-27 | Novartis Ag | A combination comprising n- {5- [4- (4-methyl-piperazine-methyl) -benzoylamido] -2-methyl-phenyl} -4- (3-pyridyl) -2-pyrimidine-amine and a chemotherapeutic agent |
PT1441737E (en) | 2001-10-30 | 2006-12-29 | Dana Farber Cancer Inst Inc | Staurosporine derivatives as inhibitors of flt3 receptor tyrosine kinase activity |
US6887864B2 (en) | 2002-03-12 | 2005-05-03 | Hoffmann-La Roche Inc. | Azepane derivatives |
GB0206215D0 (en) | 2002-03-15 | 2002-05-01 | Novartis Ag | Organic compounds |
PL372103A1 (en) | 2002-05-16 | 2005-07-11 | Novartis Ag | Use of edg receptor binding agents in cancer |
CA2492989C (en) * | 2002-07-23 | 2012-11-20 | Novartis Ag | Ophthalmic ointment composition comprising a drug, an ointment base and a solubilizing/dispersing agent |
MY150088A (en) | 2003-05-19 | 2013-11-29 | Irm Llc | Immunosuppressant compounds and compositions |
CL2004001120A1 (en) | 2003-05-19 | 2005-04-15 | Irm Llc | COMPOUNDS DERIVED FROM AMINA REPLACED WITH HETEROCICLES, IMMUNOSUPPRESSORS; PHARMACEUTICAL COMPOSITION; AND USE TO TREAT DISEASES MEDIATED BY LYMPHOCYTE INTERACTIONS, SUCH AS AUTOIMMUNE, INFLAMMATORY, INFECTIOUS, CANCER DISEASES. |
US20040246627A1 (en) * | 2003-06-06 | 2004-12-09 | Durrum Thomas M. | Disc drive pivot bearing assembly |
AU2004262927B2 (en) | 2003-08-08 | 2008-05-22 | Novartis Ag | Combinations comprising staurosporines |
TW200538433A (en) | 2004-02-24 | 2005-12-01 | Irm Llc | Immunosuppressant compounds and compositiions |
GB0512324D0 (en) | 2005-06-16 | 2005-07-27 | Novartis Ag | Organic compounds |
CN101010082A (en) * | 2004-08-31 | 2007-08-01 | 诺瓦提斯公司 | Use of midostaurin for treating gastrointestinal stromal tumors |
JO2897B1 (en) * | 2004-11-05 | 2015-09-15 | نوفارتيس ايه جي | Organic compounds |
PT2275103E (en) | 2005-11-21 | 2014-07-24 | Novartis Ag | Mtor inhibitors in the treatment of endocrine tumors |
RU2011129230A (en) | 2008-12-18 | 2013-01-27 | Новартис Аг | NEW POLYMORPHIC FORM 1- [4- [1- (4-Cyclohexyl-3-trifluoromethylbenzyloxylimino) Ethyl] -2-Ethylbenzyl] Azetidine-3-Carboxylic Acid |
CN103204794A (en) | 2008-12-18 | 2013-07-17 | 诺瓦提斯公司 | New Salts |
UY32330A (en) | 2008-12-18 | 2010-07-30 | Novartis Ag | NEW FORM OF SALT OF ACID 1- (4- {1- [E-4-CICLOHEXIL-3-TRIFLUORO-METIL-BENCILOXI-IMINO] -ETIL} -2-ETIL-BENCIL) -AZETIDIN-3-CARBOXYLICAL, POLYMODIC FORMS , PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, PREPARATION PROCESSES AND APPLICATIONS |
EP2327706A1 (en) * | 2009-11-30 | 2011-06-01 | Novartis AG | Polymorphous forms III and IV of N-benzoyl-staurosporine |
US8846712B2 (en) | 2011-09-12 | 2014-09-30 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EP2847191B1 (en) | 2012-05-09 | 2016-06-15 | Sanofi | Substituted 6-(4-hydroxy-phenyl)-1h-pyrazolo[3,4-b]pyridine derivatives as kinase inhibitors |
WO2019215759A1 (en) * | 2018-05-09 | 2019-11-14 | Alaparthi Lakshmi Prasad | An improved process for preparation of midostaurin |
US20220395553A1 (en) | 2019-11-14 | 2022-12-15 | Cohbar, Inc. | Cxcr4 antagonist peptides |
IT202000004291A1 (en) * | 2020-03-02 | 2021-09-02 | Indena Spa | PROCESS FOR THE PURIFICATION OF CARBAZOLIC INDOLE ALKALOIDS |
CN112812129A (en) * | 2020-12-31 | 2021-05-18 | 浙江海正药业股份有限公司 | Novel crystalline form of midostaurin, process for its preparation and its use |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989007105A1 (en) * | 1988-02-04 | 1989-08-10 | Kyowa Hakko Kogyo Co., Ltd. | Staurosporin derivatives |
-
1988
- 1988-06-06 IL IL86632A patent/IL86632A0/en not_active IP Right Cessation
- 1988-06-09 AT AT88810383T patent/ATE134375T1/en not_active IP Right Cessation
- 1988-06-09 MY MYPI88000629A patent/MY104316A/en unknown
- 1988-06-09 EP EP88810383A patent/EP0296110B1/en not_active Expired - Lifetime
- 1988-06-09 ES ES88810383T patent/ES2083956T3/en not_active Expired - Lifetime
- 1988-06-09 DE DE3855015T patent/DE3855015D1/en not_active Expired - Lifetime
- 1988-06-10 AU AU17571/88A patent/AU617324B2/en not_active Expired
- 1988-06-13 CA CA000569303A patent/CA1337763C/en not_active Expired - Lifetime
- 1988-06-13 FI FI882808A patent/FI89362C/en active IP Right Grant
- 1988-06-14 PT PT87719A patent/PT87719B/en not_active IP Right Cessation
- 1988-06-14 IE IE178788A patent/IE70523B1/en not_active IP Right Cessation
- 1988-06-14 DK DK198803248A patent/DK175507B1/en not_active IP Right Cessation
- 1988-06-14 YU YU01154/88A patent/YU115488A/en unknown
- 1988-06-14 KR KR1019880007102A patent/KR970001529B1/en not_active IP Right Cessation
- 1988-06-14 NZ NZ225018A patent/NZ225018A/en unknown
- 1988-06-14 NO NO882613A patent/NO170634C/en not_active IP Right Cessation
- 1988-06-14 HU HU883048A patent/HU201329B/en unknown
- 1988-06-15 JP JP63145937A patent/JP2708047B2/en not_active Expired - Lifetime
-
1996
- 1996-02-22 GR GR960400221T patent/GR3019064T3/en unknown
-
1998
- 1998-04-04 HK HK98102862A patent/HK1003788A1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR890000494A (en) | 1989-03-15 |
YU115488A (en) | 1989-12-31 |
PT87719A (en) | 1988-07-01 |
GR3019064T3 (en) | 1996-05-31 |
DK324888A (en) | 1988-12-16 |
ES2083956T3 (en) | 1996-05-01 |
HU201329B (en) | 1990-10-28 |
DK175507B1 (en) | 2004-11-15 |
FI882808A (en) | 1988-12-16 |
ATE134375T1 (en) | 1996-03-15 |
AU617324B2 (en) | 1991-11-28 |
FI882808A0 (en) | 1988-06-13 |
JP2708047B2 (en) | 1998-02-04 |
EP0296110A2 (en) | 1988-12-21 |
EP0296110A3 (en) | 1991-02-27 |
FI89362C (en) | 1993-09-27 |
CA1337763C (en) | 1995-12-19 |
NZ225018A (en) | 1990-09-26 |
EP0296110B1 (en) | 1996-02-21 |
AU1757188A (en) | 1988-12-15 |
NO882613L (en) | 1988-12-16 |
IE881787L (en) | 1988-12-15 |
KR970001529B1 (en) | 1997-02-11 |
DE3855015D1 (en) | 1996-03-28 |
HUT47587A (en) | 1989-03-28 |
MY104316A (en) | 1994-03-31 |
IE70523B1 (en) | 1996-12-11 |
PT87719B (en) | 1992-10-30 |
JPS6434989A (en) | 1989-02-06 |
NO170634B (en) | 1992-08-03 |
FI89362B (en) | 1993-06-15 |
DK324888D0 (en) | 1988-06-14 |
NO170634C (en) | 1992-11-11 |
HK1003788A1 (en) | 1998-11-06 |
NO882613D0 (en) | 1988-06-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL86632A0 (en) | Derivatives substituted at methyl-amino nitrogen | |
HK15397A (en) | Benzodiazepine derivatives and pharmaceutical compositions containing them | |
HU9302330D0 (en) | 7-(substituted)-9-|(substituted glycyl)-amino¨-6-desmethyl-6-desoxy-tetracyclines, pharmaceutical preparatives containing them and methods for producing them | |
GR3018557T3 (en) | Hydantoin derivatives. | |
BE888778A (en) | PROCESS FOR THE PREPARATION OF AN EGG WHITE SUBSTITUTE BASED ON SOY PROTEIN | |
SE8502017D0 (en) | 1,4-DIHYDRO-4-OXONAPHTHYRIDINE DERIVATIVES AND SALTS THEREOF, PROCESS FOR PRODUCING THE SAME AND ANTIBACTERIAL AGENTS COMPRISING THE SAME | |
MA22540A1 (en) | SUBSTITUTED DIAMINOPHTHALIMIDES AND SIMILAR DERIVATIVES. | |
MA22251A1 (en) | PROCESS FOR THE PREPARATION OF PIPERIDINE DERIVATIVES SUBSTITUTED IN POSITION 3 | |
FR2626572B1 (en) | PROCESS FOR THE ALKYLATION OF ALIPHATIC HYDROCARBONS | |
GR3034888T3 (en) | Special chemiluminescent acridine derivatives and their use in luminescence immunoassays. | |
FR2627493B1 (en) | PROCESS FOR THE PREPARATION OF ISOQUINOLEIN DERIVATIVES | |
GR3003738T3 (en) | ||
FR2632521B1 (en) | NOVEL PHENOTHIAZINE DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
FR2632952B1 (en) | PROCESS FOR THE PREPARATION OF ARYLSULFONYL ISOCYANATES AND DERIVATIVES THEREOF | |
ES503895A0 (en) | PROCEDURE FOR PREPARING 3B-HIDROXIMETIL-4A-HIDROXI-8B- ALCOXI-2,9-DIOXATRICICLO (4,3,1,03,7) DEAN | |
MA23081A1 (en) | PROCESS FOR THE PREPARATION OF INDOLONE DERIVATIVES | |
FR2555578B1 (en) | PROCESS FOR THE PREPARATION OF AZETIDINONE DERIVATIVES | |
ES8505363A1 (en) | 1,4-Dihydropyridine derivatives. | |
FR2659650B1 (en) | PROCESS FOR THE PREPARATION OF N-PHENYL N '- (CYCLO) ALKYL PARAPHNYLENE DIAMINES. | |
FR2572072B1 (en) | PROCESS FOR THE PREPARATION OF INDOLE DERIVATIVES | |
FR2618781B2 (en) | PROCESS FOR THE PREPARATION OF DERIVATIVES OF 4,4-DIMETHYL TETRAHYDRO PYR-2-ONE | |
RO92697A2 (en) | PROCESS FOR THE PREPARATION OF COUMARIN DERIVATIVES | |
FR2620449B1 (en) | PROCESS FOR THE PREPARATION OF BENZODIAZEPINE-1,4 ONE-2 DERIVATIVES | |
CS18189A1 (en) | Basically substituted 2,3-dichlorodiphenylmethane derivatives of their salts | |
MX12187A (en) | PROCEDURE FOR PREPARING DERIVATIVES OF 2,4-DIHYDRO-3H-1,2,4-TRIAZOL-3-ONA |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
KB | Patent renewed | ||
KB | Patent renewed | ||
EXP | Patent expired |