MX2023004518A - Compuestos espiro heterocíclicos y métodos de uso. - Google Patents
Compuestos espiro heterocíclicos y métodos de uso.Info
- Publication number
- MX2023004518A MX2023004518A MX2023004518A MX2023004518A MX2023004518A MX 2023004518 A MX2023004518 A MX 2023004518A MX 2023004518 A MX2023004518 A MX 2023004518A MX 2023004518 A MX2023004518 A MX 2023004518A MX 2023004518 A MX2023004518 A MX 2023004518A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- spiro compounds
- heterocyclic spiro
- compounds
- heterocyclic
- Prior art date
Links
- -1 Heterocyclic spiro compounds Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 abstract 1
- 102100030708 GTPase KRas Human genes 0.000 abstract 1
- 101000584612 Homo sapiens GTPase KRas Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 abstract 1
- 208000020816 lung neoplasm Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 102200006538 rs121913530 Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Abstract
La presente divulgación proporciona compuestos de Fórmula I que tienen actividad como inhibidores de la proteína mutante KRAS G12C. (ver fórmula) Esta divulgación también proporciona composiciones farmacéuticas que comprenden los compuestos, usos y métodos para tratar determinados trastornos, tales como el cáncer, que incluyen, pero sin limitación, cáncer de pulmón, cáncer de páncreas y cáncer colorrectal.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2020122197 | 2020-10-20 | ||
PCT/CN2021/124598 WO2022083569A1 (en) | 2020-10-20 | 2021-10-19 | Heterocyclic spiro compounds and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2023004518A true MX2023004518A (es) | 2023-06-19 |
Family
ID=81291543
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2023004518A MX2023004518A (es) | 2020-10-20 | 2021-10-19 | Compuestos espiro heterocíclicos y métodos de uso. |
Country Status (10)
Country | Link |
---|---|
US (1) | US20240059703A1 (es) |
EP (1) | EP4232444A1 (es) |
JP (1) | JP2023545545A (es) |
AR (1) | AR123848A1 (es) |
AU (1) | AU2021363262A1 (es) |
CA (1) | CA3198809A1 (es) |
MX (1) | MX2023004518A (es) |
TW (1) | TW202233629A (es) |
UY (1) | UY39477A (es) |
WO (1) | WO2022083569A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20230107642A1 (en) | 2020-12-18 | 2023-04-06 | Erasca, Inc. | Tricyclic pyridones and pyrimidones |
CR20230570A (es) | 2021-05-05 | 2024-01-22 | Revolution Medicines Inc | Inhibidores de ras |
WO2022235870A1 (en) | 2021-05-05 | 2022-11-10 | Revolution Medicines, Inc. | Ras inhibitors for the treatment of cancer |
WO2022266206A1 (en) | 2021-06-16 | 2022-12-22 | Erasca, Inc. | Kras inhibitor conjugates |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201004200D0 (en) * | 2010-03-15 | 2010-04-28 | Univ Basel | Spirocyclic compounds and their use as therapeutic agents and diagnostic probes |
GB201504565D0 (en) * | 2015-03-18 | 2015-05-06 | Takeda Pharmaceutical | Novel compounds |
CN107814792B (zh) * | 2016-09-14 | 2021-08-10 | 中国科学院上海药物研究所 | 一类喹唑啉衍生物、其组合物及用途 |
US20210317127A1 (en) * | 2018-08-01 | 2021-10-14 | Araxes Pharma Llc | Heterocyclic spiro compounds and methods of use thereof for the treatment of cancer |
JP2022505835A (ja) * | 2018-10-24 | 2022-01-14 | アラクセス ファーマ エルエルシー | 腫瘍転移を阻害するためのg12c変異体krasタンパク質の阻害剤としての2-(2-アクリロイル-2,6-ジアザスピロ[3.4]オクタン-6-イル)-6-(1h-インダゾール-4-イル)-ベンゾニトリル誘導体および関連化合物 |
-
2021
- 2021-10-19 US US18/032,548 patent/US20240059703A1/en active Pending
- 2021-10-19 AU AU2021363262A patent/AU2021363262A1/en active Pending
- 2021-10-19 MX MX2023004518A patent/MX2023004518A/es unknown
- 2021-10-19 CA CA3198809A patent/CA3198809A1/en active Pending
- 2021-10-19 UY UY0001039477A patent/UY39477A/es unknown
- 2021-10-19 EP EP21881985.2A patent/EP4232444A1/en active Pending
- 2021-10-19 AR ARP210102881A patent/AR123848A1/es unknown
- 2021-10-19 WO PCT/CN2021/124598 patent/WO2022083569A1/en active Application Filing
- 2021-10-19 JP JP2023523247A patent/JP2023545545A/ja active Pending
- 2021-10-19 TW TW110138700A patent/TW202233629A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
UY39477A (es) | 2022-05-31 |
AR123848A1 (es) | 2023-01-18 |
CA3198809A1 (en) | 2022-04-28 |
AU2021363262A1 (en) | 2023-06-08 |
EP4232444A1 (en) | 2023-08-30 |
US20240059703A1 (en) | 2024-02-22 |
TW202233629A (zh) | 2022-09-01 |
JP2023545545A (ja) | 2023-10-30 |
WO2022083569A1 (en) | 2022-04-28 |
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