JP2012520478A - 自動合焦方法および自動合焦装置 - Google Patents
自動合焦方法および自動合焦装置 Download PDFInfo
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/24—Base structure
- G02B21/241—Devices for focusing
- G02B21/245—Devices for focusing using auxiliary sources, detectors
- G02B21/247—Differential detectors
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/06—Means for illuminating specimens
- G02B21/08—Condensers
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/18—Arrangements with more than one light path, e.g. for comparing two specimens
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
- G02B21/365—Control or image processing arrangements for digital or video microscopes
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B7/00—Mountings, adjusting means, or light-tight connections, for optical elements
- G02B7/02—Mountings, adjusting means, or light-tight connections, for optical elements for lenses
- G02B7/04—Mountings, adjusting means, or light-tight connections, for optical elements for lenses with mechanism for focusing or varying magnification
- G02B7/09—Mountings, adjusting means, or light-tight connections, for optical elements for lenses with mechanism for focusing or varying magnification adapted for automatic focusing or varying magnification
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- Automatic Focus Adjustment (AREA)
Abstract
【解決手段】
【選択図】図1
Description
・試料の位置または基準点からの試料の距離が測定され、試料から反射された光は、パターン、強度などについて干渉計を使用して調べられる。
・試料の画像は、コントラスト、解像度、自動相関、または位相コントラストについて調べられる。
2 顕微鏡
6 試料
8 画像検出器
10 制御手段
12 光源
14 光生成器
16 光学機器
18 ダイヤフラム
20 光軸
22 光学系
24 光学要素
26 対物レンズ
28 手段
30 ビームスプリッタ
32 ビームスプリッタ
34 顕微鏡収納容器
36 光学要素
38 アクチュエータ
40 光学機器
42 光学機器
44 検出器
46 アパーチャ
48 光経路
50 光経路
52 測定光焦点
54 距離
56 焦点
58 標本スライド
60 試料材料
62 カバースリップ
64 境界面
66 境界面
68 境界面
70 目標焦点面
72 検出器要素
74 検出器要素
76 信号
78 信号
80 位置
82 差分信号
84 ゼロクロシング
86 目標位置
88 方向
90 距離
92 焦点
94 ミラー
96 距離
98 距離
100 ミラー
102 顕微鏡
104 標本台
106 試料
108 光源
110 矢印
112 光学系
114 ミラー
116 対物レンズ
118 アクチュエータ
120 顕微鏡収納容器
122 光軸
124 光学要素
126 カメラ
128 検出器
130 濾光器
132 検出器要素
134 フィルタエリア
136 アクチュエータ
138 矢印
140 制御手段
142 アクチュエータ
144 アクチュエータ
146 検出器
148 検出器領域
150 検出器領域
152 検出器領域
154 ミラー
156 ミラー
158 フィルタエリア
160 フィルタエリア
162 フィルタエリア
164 試料容器
166 対象物
168 対象物
170 濾光器
172 エッジ
174 カットオフフィルタ
176 カットオフフィルタ
178 透過ウィンドウ
A 吸収
E 感度
λ 波長
Δλ 波長範囲
A 振幅
g 限界値
t 時間
z 光軸方向
Claims (15)
- 光源(12)からの光が試料(6)中の測定光焦点(52)において合焦され、そこから反射され、前記反射された光は2つの光経路(48、50)において光学系(22)を通して、少なくとも2つの検出器要素(72、74)上に導かれる自動合焦方法であって、
前記測定光焦点(52)は、光を異なる程度に反射する複数の層を有する前記試料(6)の複数層にわたって移動し、
前記検出器要素(72、74)は、受光する2つの光経路の放射特性のプロファイルがお互いに異なるように設けられており、
焦点位置は、前記検出器要素(72、74)により示される2つの光経路の放射特性のプロファイルに基づいて設定されることを特徴とする自動合焦方法。 - 前記反射された光は、前記光学系(22)の光軸(20)中心から外れて配置されている、少なくとも1つのアパーチャ(46)を通して前記検出器要素(72、74)に導かれることを特徴とする請求項1に記載の方法。
- 前記測定光焦点(52)から反射された、前記光経路(48、50)両者からの光は、等しい範囲で前記検出器要素(72、74)に当たることを特徴とする請求項1または請求項2に記載の方法。
- 前記測定光焦点(52)の上方または下方から反射された光は、異なる範囲で前記検出器要素(72、74)に当たることを特徴とする請求項1から請求項3のうちのいずれか1項に記載の方法。
- 異なる境界面層(64、66)から反射された前記光の選択は、異なる光路長に従って光学手段により行われることを特徴とする請求項1から請求項4のいずれか1項に記載の方法。
- 異なる境界面層(64、66)から反射された前記光の選択は、前記検出器要素(72、74)に向かう異なる方向に従って光学手段により行われることを特徴とする請求項1から請求項5のいずれか1項に記載の方法。
- 前記光経路(48、50)は、光が遮断されたエリアによりお互いに分離されることを特徴とする請求項1から請求項6のいずれか1項に記載の方法。
- 前記光経路(48、50)における前記光は異なるスペクトル特性を有し、前記光経路(48、50)は、前記スペクトル特性に従って前記検出器要素(72、74)の前で分離されることを特徴とする請求項1から請求項7のいずれか1項に記載の方法。
- 前記プロファイルは連続して検出されることを特徴とする請求項1から請求項8のいずれか1項に記載の方法。
- 前記光学系(22)の焦点は、前記検出器要素(72、74)の信号(76、78)がお互いに対して一定の比であり、特に等しい強さであるように調整されることを特徴とする請求項1から請求項9のいずれか1項に記載の方法。
- 前記測定光焦点(52)は、光を反射する前記境界面層(66)上で調整され、その後、前記試料(6)は、前記光学系(22)の前記光軸(20)に直交して移動され、前記検出器要素(72、74)の前記信号(76、78)は、前記反射する境界面層(66)上で前記測定光焦点(52)の調整に関する妥当性がその後にチェックされることを特徴とする請求項1から請求項10のいずれか1項に記載の方法。
- 前記反射された光は、形状に関して前記光源(12)の前記形状に対応する、少なくとも1つのアパーチャ(46)を通して導かれることを特徴とする請求項1から請求項11のいずれか1項に記載の方法。
- 前記光源(12)は、前記試料(6)中に投影される光パターンを有し、前記光パターンのいくつかのパターン点から反射された光は、光経路(48、50)によりそれぞれ分離して検出されることを特徴とする請求項1から請求項12のいずれか1項に記載の方法。
- 反射する境界面層(66)の傾斜は、前記いくつかのパターン点のいくつかの目標位置から検出されることを特徴とする請求項13に記載の方法。
- 光を試料(6)中の測定光焦点(52)において合焦し、そこから反射された光を、少なくとも2つの検出器要素(72、74)上に導く光学系(22)を備える自動合焦装置(2)であって、
アクチュエータ(38)と、前記アクチュエータ(38)を介して、前記光学系(22)の要素(36)を前記試料(6)に対して、前記測定光焦点(52)が光を異なる程度に反射する前記試料(6)の複数層において移動されるように移動させる制御手段(10)を具備し、
前記検出器要素(72、74)は、前記検出器要素(72、74)により示される放射特性のプロファイルが異なるように配置され、前記制御手段(10)は、前記測定光焦点(52)のいくつかの位置において、前記プロファイル(72、74)を評価するために設けられることを特徴とする自動合焦装置(2)。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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DE200910012292 DE102009012292A1 (de) | 2009-03-11 | 2009-03-11 | Verfahren und Vorrichtung zum Aufnehmen eines Bilds eines Gegenstands |
DE102009012293.1 | 2009-03-11 | ||
DE102009012293A DE102009012293A1 (de) | 2009-03-11 | 2009-03-11 | Autofokusverfahren und Autofokuseinrichtung |
DE102009012292.3 | 2009-03-11 | ||
PCT/IB2010/000518 WO2010103389A1 (de) | 2009-03-11 | 2010-03-11 | Autofokusverfahren und autofokuseinrichtung |
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JP2012520478A true JP2012520478A (ja) | 2012-09-06 |
JP5739351B2 JP5739351B2 (ja) | 2015-06-24 |
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US (2) | US9310598B2 (ja) |
EP (1) | EP2406679B1 (ja) |
JP (1) | JP5739351B2 (ja) |
CN (1) | CN102405431B (ja) |
AU (1) | AU2010222633B2 (ja) |
BR (1) | BRPI1011689B1 (ja) |
CA (1) | CA2755164C (ja) |
DK (1) | DK2406679T3 (ja) |
ES (1) | ES2617664T3 (ja) |
WO (1) | WO2010103389A1 (ja) |
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CN102405431B (zh) | 2015-09-16 |
CA2755164A1 (en) | 2010-09-16 |
EP2406679A1 (de) | 2012-01-18 |
EP2406679B1 (de) | 2017-01-25 |
AU2010222633A1 (en) | 2011-10-06 |
BRPI1011689B1 (pt) | 2019-12-17 |
US9310598B2 (en) | 2016-04-12 |
JP5739351B2 (ja) | 2015-06-24 |
ES2617664T3 (es) | 2017-06-19 |
WO2010103389A1 (de) | 2010-09-16 |
BRPI1011689A2 (pt) | 2016-03-22 |
US20160216504A1 (en) | 2016-07-28 |
US20120038979A1 (en) | 2012-02-16 |
CN102405431A (zh) | 2012-04-04 |
AU2010222633B2 (en) | 2015-05-14 |
DK2406679T3 (da) | 2017-04-18 |
US10495867B2 (en) | 2019-12-03 |
CA2755164C (en) | 2014-02-25 |
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