HRP20080018T3 - Derivati 5-amino-2,4,7-triokso-3,4,7,8-tetrahidro-2h-pirido'2,3-d! pirimidina i slični spojevi za liječenje raka - Google Patents
Derivati 5-amino-2,4,7-triokso-3,4,7,8-tetrahidro-2h-pirido'2,3-d! pirimidina i slični spojevi za liječenje rakaInfo
- Publication number
- HRP20080018T3 HRP20080018T3 HR20080018T HRP20080018T HRP20080018T3 HR P20080018 T3 HRP20080018 T3 HR P20080018T3 HR 20080018 T HR20080018 T HR 20080018T HR P20080018 T HRP20080018 T HR P20080018T HR P20080018 T3 HRP20080018 T3 HR P20080018T3
- Authority
- HR
- Croatia
- Prior art keywords
- group
- atom
- alkyl group
- different
- alkyl
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- FKJJWLKXDSASLR-UHFFFAOYSA-N 5-amino-1,8-dihydropyrido[2,3-d]pyrimidine-2,4,7-trione Chemical class N1C(=O)NC(=O)C2=C1NC(=O)C=C2N FKJJWLKXDSASLR-UHFFFAOYSA-N 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 10
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 9
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 7
- 125000001424 substituent group Chemical group 0.000 abstract 6
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 4
- 150000001721 carbon Chemical group 0.000 abstract 4
- 229910052799 carbon Inorganic materials 0.000 abstract 4
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000005842 heteroatom Chemical group 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 229920006395 saturated elastomer Polymers 0.000 abstract 3
- 125000004434 sulfur atom Chemical group 0.000 abstract 3
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Addiction (AREA)
- Molecular Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- AIDS & HIV (AREA)
- Neurology (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Transplantation (AREA)
Abstract
Upotreba spoja prikazanog slijedećom formulom [I]ili njegove farmaceutski prihvatljive soli, hidrata ili solvata kao aktivnog sastojka u proizvodnjifarmaceutskog agensa za liječenje tumora: gdjeX1 i X2 su isti ili različiti i svaki je ugljikov atom ili dušikov atom, skupina je R1, R2 i R6 su istiili različiti i svaki jeC1-6 alkilna grupa, C2-6 alkenilna grupa, pri čemu su C1-6 alkilna grupa i C2-6 alkenilna grupa prema izboru supstituirane s 1 do 3 supstituenta odabrana iz slijedeće grupe A,iligdje m je 0 ili cijeli broj od 1 do 4, prsten Cy je C3-12 grupa ugljikovog prstena ili heterociklička grupa, gdje je heterociklička grupa zasićeniili nezasićeni prsten koji ima, osim ugljikovog atoma, 1 do 4 hetero atoma odabrana između atoma kisika, atoma dušika ili atoma sumpora, i C3-12 grupa ugljikovog prstena i heterociklička grupa su po izboru supstituirane s 1 do 5 supstituenata odabrana iz slijedeće grupe B, R3, R4 i R5 su isti ili različiti i svaki jeatom vodika, hidroksilna grupa,C1-6 alkilna grupa, C2-6 alkenilna grupa, pri čemu su C1-6 alkilna grupa i C2-6 alkenilna grupa prema izboru supstituirane s 1 do 3 supstituenta odabrana iz slijedeće grupe A, C3-12 grupa ugljikovog prstena iliheterociklička grupa, gdje je heterociklička grupa zasićeni ili nezasićeni prsten koji ima, osim ugljikovog atoma, 1 do 4 hetero atoma odabrana između atoma kisika, atoma dušika ili atoma sumpora, i C3-12 grupa ugljikovog prstena i heterociklička grupa su po izboru supstituirane s 1 do 5 supstituenata odabrana iz slijedeće grupe B, R2 i R3 su po izboru povezani da tvore C1-4 alkilensku grupu, ili R4 i R5 su po izboru povezani da tvore C1-4 alkilensku grupu, gdje je grupa A grupa koja se sastoji od1) halogenog atoma, 2) nitro grupe, 3) cijano grupe, 4) C1-4 alkilne grupe, 5) -ORA1 gdje je RA1 atom vodika ili C1-4 alkilna grupa, 6) -SRA2 gdje je RA2 atom vodika ili C1-4 alkilna grupa, 7) -NRA3RA4 gdje su RA3 i RA4 isti ili različiti i svaki je atom vodika ili C1-4 alkilna grupa, 8) -COORA5 gdje je RA5 atom vodika ili C1-4 alkilnagrupa, 9) -NRA6CORA7 gdje je RA6 atom vodika ili C1-4 alkilna grupa, RA7 je C1-4 alkilna grupa, C3-12 grupa ugljikovog prstena ili heterociklička grupa, 10) -NRA8COORA9 gdje su RA8 i RA9 isti ili različiti i svaki je atom vodika ili C1-4 alkilna grupa, 11) C3-12 grupa ugljikovog prstena i12) heterociklička grupa, gdje je heterociklička grupa zasićeni ili nezasićeni prsten koji ima, osim ugljikovog atoma, 1 do 4 hetero atoma odabrana između atomakisika, atoma dušika ili atoma sumpora, svaka od C1-4 alkilne grupe iz gore navedenog 4), RA1, RA2,RA3, RA4, RA5, RA6, RA7, RA8 i RA9 su po izboru supstituirani s istih ili različitih 1 do 3 supstituenata odabranih iz slijedeće grupe C, isvaka od C3-12 grupa ugljikovog prstena iz gore navednog 11)i RA7, i heterociklička grupa iz 12) i RA7 su po izboru supstituirane s istih ili različitih 1 do 5supstituenata odabranih iz slijedeće grupe C, grupa B je grupa koja se sastoji od1) halogenog atoma, 2) nitro g
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004174770 | 2004-06-11 | ||
JP2004327111 | 2004-11-10 | ||
PCT/JP2005/011082 WO2005121142A1 (en) | 2004-06-11 | 2005-06-10 | 5-amino-2,4,7-trioxo-3,4,7,8-tetrahydro-2h-pyrido’2,3-d! pyrimidine derivatives and related compounds for the treatment of cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20080018T3 true HRP20080018T3 (hr) | 2008-01-31 |
Family
ID=34970318
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20080018T HRP20080018T3 (hr) | 2004-06-11 | 2008-01-14 | Derivati 5-amino-2,4,7-triokso-3,4,7,8-tetrahidro-2h-pirido'2,3-d! pirimidina i slični spojevi za liječenje raka |
HRP20121020TT HRP20121020T1 (hr) | 2004-06-11 | 2012-12-12 | DERIVATI 5-AMINO-2,4,7-TRIOKSO-3,4,7,8-TETRAHIDRO-2H-PIRIDO[2,3-d]PIRIMIDINA I SRODNI SPOJEVI, NAMIJENJENI LIJEÄŚENJU RAKA |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20121020TT HRP20121020T1 (hr) | 2004-06-11 | 2012-12-12 | DERIVATI 5-AMINO-2,4,7-TRIOKSO-3,4,7,8-TETRAHIDRO-2H-PIRIDO[2,3-d]PIRIMIDINA I SRODNI SPOJEVI, NAMIJENJENI LIJEÄŚENJU RAKA |
Country Status (27)
Country | Link |
---|---|
EP (3) | EP1894932A1 (hr) |
JP (3) | JP4163738B2 (hr) |
KR (1) | KR100883289B1 (hr) |
CN (2) | CN101006086B (hr) |
AT (1) | ATE383360T1 (hr) |
AU (1) | AU2005252110B2 (hr) |
BR (1) | BRPI0511967B8 (hr) |
CA (2) | CA2727841A1 (hr) |
CY (3) | CY1107253T1 (hr) |
DE (1) | DE602005004286T2 (hr) |
DK (2) | DK2298768T3 (hr) |
ES (2) | ES2297723T3 (hr) |
HK (1) | HK1107084A1 (hr) |
HR (2) | HRP20080018T3 (hr) |
IL (1) | IL179671A0 (hr) |
LU (1) | LU92602I2 (hr) |
ME (1) | ME01480B (hr) |
MX (1) | MXPA06014478A (hr) |
NL (1) | NL300701I1 (hr) |
NO (2) | NO338355B1 (hr) |
NZ (1) | NZ552090A (hr) |
PL (2) | PL2298768T3 (hr) |
PT (2) | PT1761528E (hr) |
RS (2) | RS50569B (hr) |
RU (1) | RU2364596C2 (hr) |
SI (2) | SI1761528T1 (hr) |
WO (1) | WO2005121142A1 (hr) |
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US7919598B2 (en) * | 2006-06-28 | 2011-04-05 | Bristol-Myers Squibb Company | Crystal structures of SGLT2 inhibitors and processes for preparing same |
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ES2320955B1 (es) | 2007-03-02 | 2010-03-16 | Laboratorios Almirall S.A. | Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida. |
WO2008115890A2 (en) | 2007-03-19 | 2008-09-25 | Takeda Pharmaceutical Company Limited | Mapk/erk kinase inhibitors |
ES2329639B1 (es) | 2007-04-26 | 2010-09-23 | Laboratorios Almirall S.A. | Nuevos derivados de 4,8-difenilpoliazanaftaleno. |
WO2009014100A1 (ja) * | 2007-07-20 | 2009-01-29 | Chugai Seiyaku Kabushiki Kaisha | p27蛋白質誘導剤 |
JP5453290B2 (ja) * | 2007-11-12 | 2014-03-26 | 武田薬品工業株式会社 | Mapk/erkキナーゼ阻害剤 |
US20090246198A1 (en) * | 2008-03-31 | 2009-10-01 | Takeda Pharmaceutical Company Limited | Mapk/erk kinase inhibitors and methods of use thereof |
EP2108641A1 (en) | 2008-04-11 | 2009-10-14 | Laboratorios Almirall, S.A. | New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors |
EP2113503A1 (en) | 2008-04-28 | 2009-11-04 | Laboratorios Almirall, S.A. | New substituted indolin-2-one derivatives and their use as p39 mitogen-activated kinase inhibitors |
UA103319C2 (en) | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
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JP5651125B2 (ja) | 2008-12-10 | 2015-01-07 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | Mek阻害剤に対する耐性を付与するmek突然変異 |
AU2010228902A1 (en) * | 2009-03-26 | 2011-10-06 | Mapi Pharma Limited | Process for the preparation of alogliptin |
CN101619063B (zh) * | 2009-06-02 | 2011-08-10 | 华中师范大学 | 具有抗肿瘤活性的3,7,8-多取代吡啶并[4,3-d]嘧啶衍生物及制备 |
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SI2488033T1 (sl) | 2009-10-16 | 2019-10-30 | Novartis Ag | Kombinacija, ki vsebuje inhibitor MEK in inhibitor B-RAF |
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HUP0104607A3 (en) | 1998-12-15 | 2002-12-28 | Warner Lambert Co | Use of a mek inhibitor for preventing transplant rejection |
HUP0104693A3 (en) | 1998-12-16 | 2003-12-29 | Warner Lambert Co | Treatment of arthritis with mek inhibitors |
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JP2003504401A (ja) | 1999-07-16 | 2003-02-04 | ワーナー−ランバート・カンパニー | Mek阻害剤を用いる慢性疼痛の治療方法 |
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