WO2009014100A1 - ｐ２７蛋白質誘導剤 - Google Patents

ｐ２７蛋白質誘導剤 Download PDF

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Publication number
WO2009014100A1
WO2009014100A1 PCT/JP2008/063053 JP2008063053W WO2009014100A1 WO 2009014100 A1 WO2009014100 A1 WO 2009014100A1 JP 2008063053 W JP2008063053 W JP 2008063053W WO 2009014100 A1 WO2009014100 A1 WO 2009014100A1
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WO
WIPO (PCT)
Prior art keywords
protein inducer
oxygen atom
inducer
protein
group
Prior art date
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PCT/JP2008/063053
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English (en)
French (fr)
Inventor
Toshiyuki Sakai
Hitoshi Iikura
Ikumi Hyoudoh
Toshihiro Aoki
Noriyuki Furuichi
Masayuki Matsushita
Fumio Watanabe
Sawako Ozawa
Masahiro Sakaitani
Pil-Su Ho
Yasushi Tomii
Kenji Takanashi
Naoki Harada
Original Assignee
Chugai Seiyaku Kabushiki Kaisha
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Publication date
Application filed by Chugai Seiyaku Kabushiki Kaisha filed Critical Chugai Seiyaku Kabushiki Kaisha
Priority to JP2009524476A priority Critical patent/JP5325103B2/ja
Priority to EP08791362.0A priority patent/EP2172198B1/en
Priority to US12/669,944 priority patent/US8569378B2/en
Priority to KR1020107000227A priority patent/KR101511396B1/ko
Publication of WO2009014100A1 publication Critical patent/WO2009014100A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered

Abstract

　本発明は、下記一般式（１１）で表される化合物又はその薬学上許容しうる塩を有効成分とするｐ２７蛋白質誘導剤を提供する。 〔式中、Ｇ１、Ｇ２、Ｇ３及びＧ８は、それぞれ独立に、－Ｎ＝等から選択され、環Ｇ６は２価のアリール基等から選択され、Ａはアミノ基等から選択され、Ｇ４は酸素原子等から選択され、Ｇ５は酸素原子等から選択され、Ｇ７は－ＣＨ２－等から選択され、Ｒ２はＣ１－６アルキル基等から選択される。〕
PCT/JP2008/063053 2007-07-20 2008-07-18 ｐ２７蛋白質誘導剤 WO2009014100A1 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2009524476A JP5325103B2 (ja) 2007-07-20 2008-07-18 ｐ２７蛋白質誘導剤
EP08791362.0A EP2172198B1 (en) 2007-07-20 2008-07-18 p27 PROTEIN INDUCER
US12/669,944 US8569378B2 (en) 2007-07-20 2008-07-18 p27 protein inducer
KR1020107000227A KR101511396B1 (ko) 2007-07-20 2008-07-18 ｐ27 단백질 유도제

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007189480 2007-07-20
JP2007-189480 2007-07-20

Publications (1)

Publication Number Publication Date
WO2009014100A1 true WO2009014100A1 (ja) 2009-01-29

Family

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Family Applications (1)

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PCT/JP2008/063053 WO2009014100A1 (ja) 2007-07-20 2008-07-18 ｐ２７蛋白質誘導剤

Country Status (5)

Country Link
US (1) US8569378B2 (ja)
EP (1) EP2172198B1 (ja)
JP (1) JP5325103B2 (ja)
KR (1) KR101511396B1 (ja)
WO (1) WO2009014100A1 (ja)

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WO2012171488A1 (en) * 2011-06-17 2012-12-20 Beijing Hanmi Pharmaceutical Co., Ltd. Coumarin derivative, pharmaceutical composition and use thereof
WO2013035754A1 (ja) 2011-09-05 2013-03-14 中外製薬株式会社 クマリン誘導体の製造方法
WO2014046224A1 (ja) * 2012-09-21 2014-03-27 日本臓器製薬株式会社 クマリン誘導体
JP2015193610A (ja) * 2014-03-20 2015-11-05 日本臓器製薬株式会社 クマリン誘導体を含有する医薬
JP2016516702A (ja) * 2013-03-13 2016-06-09 ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン Ｍｅｋ／ｐｉ３ｋ二重阻害剤および該阻害剤を使用する治療方法
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WO2019096449A1 (en) 2017-11-16 2019-05-23 The Institute Of Cancer Research: Royal Cancer Hospital Coumarin derivative for therapy or prophylaxis of a cell proliferative disorder
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CN104119690B (zh) * 2014-06-27 2016-06-29 安徽大学 一种七位取代的香豆素衍生物双光子荧光染料及其制备方法
CN104059378B (zh) * 2014-06-27 2016-04-20 安徽大学 一种六位取代的香豆素衍生物双光子荧光染料及其制备方法
CN107200716B (zh) * 2016-03-17 2020-04-17 北京大学 苯并噁嗪类化合物及其制备方法与应用
EP3481822B1 (en) 2016-07-06 2022-06-22 The Regents of The University of Michigan Multifunctional inhibitors of mek/pi3k and mtor/mek/pi3k biological pathways and therapeutic methods using the same
KR102539877B1 (ko) 2016-09-12 2023-06-05 인테그랄 헬스 인코퍼레이티드 Gpr120 조정제로서 유용한 이환형 화합물
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CN108003112B (zh) * 2017-12-23 2021-03-19 宁夏蓝博思化学技术有限公司 一种杂环脲类吲哚胺-2,3-双加氧酶抑制剂中间体制备方法
US10730885B1 (en) 2019-04-30 2020-08-04 King Saud University Coumarin derivatives
CN113024384A (zh) * 2021-03-16 2021-06-25 湖南工程学院 一种2-氟-3-硝基苯甲酸中间体原料的合成方法
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