MX2018006225A - Composicion farmaceutica para el tratamiento o prevencion de esteatohepatitis no alcoholica (nash). - Google Patents
Composicion farmaceutica para el tratamiento o prevencion de esteatohepatitis no alcoholica (nash).Info
- Publication number
- MX2018006225A MX2018006225A MX2018006225A MX2018006225A MX2018006225A MX 2018006225 A MX2018006225 A MX 2018006225A MX 2018006225 A MX2018006225 A MX 2018006225A MX 2018006225 A MX2018006225 A MX 2018006225A MX 2018006225 A MX2018006225 A MX 2018006225A
- Authority
- MX
- Mexico
- Prior art keywords
- nash
- prophylaxis
- treatment
- indicates
- pharmaceutical composition
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
Abstract
La presente invención proporciona el uso farmacéutico de antagonistas LPA1, por ejemplo, compuestos de tiofeno halogenado- a que tienen una estructura específica o sales farmacológicamente aceptables de los mismos, como fármacos para el tratamiento y/o prevención de NASH; una composición farmacéutica para el tratamiento y/o prevención de NASH incluye, como un ingrediente activo, un antagonista LPA1, por ejemplo, un compuesto representado por la fórmula general (I): (ver Fórmula) [en donde R1 es un átomo de hidrógeno o un grupo metoxi; R2 es un átomo de hidrógeno o un grupo alquilo de C1-C6; X es un átomo de halógeno; y A es un grupo seleccionado del grupo que consiste en los grupos: (ver Fórmula) o una sal farmacológicamente aceptable de los mismos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2015227468 | 2015-11-20 | ||
JP2016111944 | 2016-06-03 | ||
PCT/JP2016/084227 WO2017086430A1 (ja) | 2015-11-20 | 2016-11-18 | Nashの治療又は予防のための医薬組成物 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018006225A true MX2018006225A (es) | 2018-11-09 |
Family
ID=58717447
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018006225A MX2018006225A (es) | 2015-11-20 | 2016-11-18 | Composicion farmaceutica para el tratamiento o prevencion de esteatohepatitis no alcoholica (nash). |
Country Status (11)
Country | Link |
---|---|
US (1) | US20180360803A1 (es) |
EP (1) | EP3378491A4 (es) |
JP (1) | JPWO2017086430A1 (es) |
KR (1) | KR20180082564A (es) |
CN (1) | CN108348610A (es) |
AU (1) | AU2016355863A1 (es) |
BR (1) | BR112018010107A8 (es) |
CA (1) | CA3005811A1 (es) |
MX (1) | MX2018006225A (es) |
RU (1) | RU2018122224A (es) |
WO (1) | WO2017086430A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2953472C (en) * | 2014-06-27 | 2022-08-02 | Ube Industries, Ltd. | Halogen-substituted heterocyclic compound salt |
WO2019041340A1 (en) | 2017-09-04 | 2019-03-07 | Eli Lilly And Company | LYSOPHOSPHATIDE ACID RECEPTOR 1 RECEPTOR INHIBITORS (LPAR1) |
CA3158743A1 (en) | 2019-11-15 | 2021-05-20 | Gilead Sciences, Inc. | Triazole carbamate pyridyl sulfonamides as lpa receptor antagonists and uses thereof |
AU2021282986B2 (en) | 2020-06-03 | 2024-03-07 | Gilead Sciences, Inc. | LPA receptor antagonists and uses thereof |
TW202344504A (zh) | 2020-06-03 | 2023-11-16 | 美商基利科學股份有限公司 | Lpa受體拮抗劑及其用途 |
US11939318B2 (en) | 2021-12-08 | 2024-03-26 | Gilead Sciences, Inc. | LPA receptor antagonists and uses thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2466121B (en) * | 2008-12-15 | 2010-12-08 | Amira Pharmaceuticals Inc | Antagonists of lysophosphatidic acid receptors |
CN107721940A (zh) * | 2010-12-07 | 2018-02-23 | 阿米拉制药公司 | 多环lpa1拮抗剂及其使用 |
WO2012138648A1 (en) * | 2011-04-06 | 2012-10-11 | Irm Llc | Compositions and methods for modulating lpa receptors |
AU2013366898B2 (en) * | 2012-12-28 | 2017-06-29 | Ube Corporation | Halogen-substituted heterocyclic compound |
MX2015013303A (es) * | 2013-03-15 | 2015-12-15 | Epigen Biosciences Inc | Compuestos heterociclicos utiles para el tratamiento de una enfermedad. |
CA2953472C (en) * | 2014-06-27 | 2022-08-02 | Ube Industries, Ltd. | Halogen-substituted heterocyclic compound salt |
-
2016
- 2016-11-18 RU RU2018122224A patent/RU2018122224A/ru not_active Application Discontinuation
- 2016-11-18 JP JP2017551943A patent/JPWO2017086430A1/ja not_active Withdrawn
- 2016-11-18 CN CN201680067778.1A patent/CN108348610A/zh active Pending
- 2016-11-18 MX MX2018006225A patent/MX2018006225A/es unknown
- 2016-11-18 CA CA3005811A patent/CA3005811A1/en not_active Abandoned
- 2016-11-18 BR BR112018010107A patent/BR112018010107A8/pt not_active Application Discontinuation
- 2016-11-18 WO PCT/JP2016/084227 patent/WO2017086430A1/ja active Application Filing
- 2016-11-18 EP EP16866430.8A patent/EP3378491A4/en not_active Withdrawn
- 2016-11-18 US US15/777,548 patent/US20180360803A1/en not_active Abandoned
- 2016-11-18 AU AU2016355863A patent/AU2016355863A1/en not_active Abandoned
- 2016-11-18 KR KR1020187016782A patent/KR20180082564A/ko unknown
Also Published As
Publication number | Publication date |
---|---|
JPWO2017086430A1 (ja) | 2018-09-06 |
BR112018010107A2 (pt) | 2018-11-21 |
EP3378491A1 (en) | 2018-09-26 |
AU2016355863A1 (en) | 2018-07-05 |
RU2018122224A (ru) | 2019-12-25 |
CN108348610A (zh) | 2018-07-31 |
RU2018122224A3 (es) | 2020-03-27 |
CA3005811A1 (en) | 2017-05-26 |
KR20180082564A (ko) | 2018-07-18 |
WO2017086430A1 (ja) | 2017-05-26 |
BR112018010107A8 (pt) | 2023-05-09 |
EP3378491A4 (en) | 2019-07-17 |
US20180360803A1 (en) | 2018-12-20 |
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