SI2488033T1 - Kombinacija, ki vsebuje inhibitor MEK in inhibitor B-RAF - Google Patents

Kombinacija, ki vsebuje inhibitor MEK in inhibitor B-RAF

Info

Publication number
SI2488033T1
SI2488033T1 SI201031933T SI201031933T SI2488033T1 SI 2488033 T1 SI2488033 T1 SI 2488033T1 SI 201031933 T SI201031933 T SI 201031933T SI 201031933 T SI201031933 T SI 201031933T SI 2488033 T1 SI2488033 T1 SI 2488033T1
Authority
SI
Slovenia
Prior art keywords
inhibitor
combination
raf
mek
mek inhibitor
Prior art date
Application number
SI201031933T
Other languages
English (en)
Inventor
Melissa Dumble
Rakesh Kumar
Sylvie Laquerre
Peter Lebowitz
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43876568&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI2488033(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of SI2488033T1 publication Critical patent/SI2488033T1/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
SI201031933T 2009-10-16 2010-10-15 Kombinacija, ki vsebuje inhibitor MEK in inhibitor B-RAF SI2488033T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25221309P 2009-10-16 2009-10-16
EP10824148.0A EP2488033B1 (en) 2009-10-16 2010-10-15 Combination comprising an MEK inhibitor and a B-raf inhibitor
PCT/US2010/052808 WO2011047238A1 (en) 2009-10-16 2010-10-15 Combination

Publications (1)

Publication Number Publication Date
SI2488033T1 true SI2488033T1 (sl) 2019-10-30

Family

ID=43876568

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201031933T SI2488033T1 (sl) 2009-10-16 2010-10-15 Kombinacija, ki vsebuje inhibitor MEK in inhibitor B-RAF

Country Status (33)

Country Link
US (3) US8703781B2 (sl)
EP (3) EP2488033B1 (sl)
JP (1) JP5718929B2 (sl)
KR (1) KR101729116B1 (sl)
CN (1) CN102655753B (sl)
AU (1) AU2010306653B2 (sl)
BR (1) BR112012008854B8 (sl)
CA (1) CA2775803C (sl)
CL (1) CL2012000964A1 (sl)
CO (1) CO6531498A2 (sl)
CR (1) CR20120155A (sl)
CY (1) CY1122013T1 (sl)
DK (2) DK2488033T3 (sl)
DO (1) DOP2012000091A (sl)
EA (1) EA020589B1 (sl)
ES (2) ES2930157T3 (sl)
HR (2) HRP20221304T1 (sl)
HU (2) HUE060206T2 (sl)
IL (1) IL219073A (sl)
LT (2) LT3560498T (sl)
MA (1) MA33746B1 (sl)
ME (1) ME03497B (sl)
MX (1) MX2012004413A (sl)
MY (1) MY174759A (sl)
NZ (1) NZ598913A (sl)
PE (1) PE20121093A1 (sl)
PL (2) PL3560498T3 (sl)
PT (2) PT2488033T (sl)
RS (2) RS59181B1 (sl)
SI (1) SI2488033T1 (sl)
UA (1) UA105064C2 (sl)
WO (1) WO2011047238A1 (sl)
ZA (1) ZA201202612B (sl)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9029408B2 (en) 2008-06-16 2015-05-12 Gtx, Inc. Compounds for treatment of cancer
US9447049B2 (en) 2010-03-01 2016-09-20 University Of Tennessee Research Foundation Compounds for treatment of cancer
PT3289876T (pt) 2008-06-16 2022-10-28 Univ Tennessee Res Found Compostos para o tratamento do câncer
US11084811B2 (en) 2010-03-01 2021-08-10 Oncternal Therapeutics, Inc. Compounds for treatment of cancer
ES2714875T3 (es) 2010-03-09 2019-05-30 Dana Farber Cancer Inst Inc Métodos de diagnóstico y tratamiento del cáncer en pacientes que presentan o desarrollan resistencia a una primera terapia del cáncer
US20130217710A1 (en) * 2010-11-05 2013-08-22 Glaxosmithkline Intellectual Property (No.2) Limited Methods for treating cancer
TWI505828B (zh) * 2010-12-20 2015-11-01 葛蘭素史克智慧財產（第二）有限公司 新穎醫藥組成物
EP2791172B1 (en) 2011-12-16 2017-07-19 Synthon Biopharmaceuticals B.V. Compounds and methods for treating inflammatory diseases
WO2013096430A1 (en) * 2011-12-22 2013-06-27 Glaxosmithkline Llc Method of treating cancer with magea3 immunotherapeutic with braf inhibitor and/or mek inhibitor
CN104428001A (zh) * 2012-03-30 2015-03-18 武田药品工业有限公司 Raf抑制剂和mek抑制剂在黑素瘤治疗中的投与
AU2013313050A1 (en) * 2012-09-04 2015-03-26 Novartis Ag Method of adjuvant cancer treatment
BR112015009134A2 (pt) * 2012-10-25 2017-07-04 Glaxosmithkline Llc combinação
EA028246B1 (ru) * 2012-11-30 2017-10-31 ГЛЭКСОСМИТКЛАЙН ЭлЭлСи Фармацевтическая композиция
CN103965170A (zh) * 2013-01-24 2014-08-06 通化济达医药有限公司 苯磺酰胺吡唑激酶抑制剂
CA2904338C (en) * 2013-03-05 2022-07-05 University Of Tennessee Research Foundation Use of imidazole derivatives in combination with a braf inhibitor or mek inhibitor in the treatment of cancer
EP3003316B1 (en) * 2013-05-31 2020-07-22 Merck Sharp & Dohme Corp. Combination therapies for cancer
KR20160013049A (ko) * 2013-06-03 2016-02-03 노파르티스 아게 항-pd-l1 항체 및 mek 억제제 및/또는 braf 억제제의 조합물
CN104540822B (zh) * 2013-07-08 2016-08-31 杭州普晒医药科技有限公司 达拉菲尼甲磺酸盐的晶型及其制备方法
WO2015059677A1 (en) * 2013-10-26 2015-04-30 Glaxosmithkline Intellectual Property (No.2) Limited Methods of treating cancer
CN103588767B (zh) * 2013-11-20 2016-01-20 苏州明锐医药科技有限公司 达拉菲尼的制备方法
KR20160088884A (ko) * 2013-12-12 2016-07-26 노파르티스 아게 암의 치료를 위한 트라메티닙, 파니투무맙 및 다브라페닙의 조합물
EP3524694B1 (en) 2013-12-28 2020-07-15 Guardant Health, Inc. Methods and systems for detecting genetic variants
WO2015105822A1 (en) * 2014-01-07 2015-07-16 Glaxosmithkline Llc Cancer treatment method
JP6718823B2 (ja) 2014-05-06 2020-07-08 ジーティーエックス・インコーポレイテッド 癌の処置のための化合物
KR101629184B1 (ko) 2014-12-10 2016-06-13 현대오트론 주식회사 Autosar 플랫폼에서의 eeprom 처리속도 향상을 위한 주기함수 호출 방법
US20190008859A1 (en) 2015-08-21 2019-01-10 Acerta Pharma B.V. Therapeutic Combinations of a MEK Inhibitor and a BTK Inhibitor
AU2017354019A1 (en) * 2016-11-03 2019-05-23 The Regents Of The University Of Michigan Small molecule dual inhibitors of EGFR/PI3K and uses thereof
EP3867409A1 (en) 2018-10-16 2021-08-25 Novartis AG Tumor mutation burden alone or in combination with immune markers as biomarkers for predicting response to targeted therapy
CA3129665A1 (en) 2019-03-21 2020-09-24 Onxeo A dbait molecule in combination with kinase inhibitor for the treatment of cancer
EP4003332A4 (en) * 2019-07-26 2023-05-10 Ascentage Pharma (Suzhou) Co., Ltd. PHARMACEUTICAL COMPOSITION OF MDM2 INHIBITOR AND ITS USE FOR PREVENTING AND/OR TREATING A DISEASE
KR20220098759A (ko) 2019-11-08 2022-07-12 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 키나제 억제제에 대해 내성을 획득한 암의 치료 방법
WO2021118924A2 (en) 2019-12-12 2021-06-17 Ting Therapeutics Llc Compositions and methods for the prevention and treatment of hearing loss
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
US12014835B2 (en) 2020-02-19 2024-06-18 Vanderbilt University Methods for evaluating therapeutic benefit of combination therapies
US20230084515A1 (en) * 2020-02-19 2023-03-16 Vanderbilt University Therapeutic methods and compositions for treating cancer using braf and/or mek inhibitor combination therapy
WO2022195551A1 (en) 2021-03-18 2022-09-22 Novartis Ag Biomarkers for cancer and methods of use thereof
AU2022381730A1 (en) * 2021-11-02 2024-05-02 Verastem, Inc. Methods of treating abnormal cell growth
WO2023105286A1 (en) 2021-12-06 2023-06-15 My Personal Therapeutics Ltd A combination treatment for cancer
US11873296B2 (en) 2022-06-07 2024-01-16 Verastem, Inc. Solid forms of a dual RAF/MEK inhibitor

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5681835A (en) 1994-04-25 1997-10-28 Glaxo Wellcome Inc. Non-steroidal ligands for the estrogen receptor
GB9716557D0 (en) 1997-08-06 1997-10-08 Glaxo Group Ltd Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity
CN1543346A (zh) * 1999-11-22 2004-11-03 ʷ��˿�������ȳ�ķ���޹�˾ 新化合物
DE102004018198A1 (de) * 2004-04-15 2005-11-03 Merck Patent Gmbh Sulfonamide
US7378423B2 (en) 2004-06-11 2008-05-27 Japan Tobacco Inc. Pyrimidine compound and medical use thereof
CN101006086B (zh) 2004-06-11 2010-09-29 日本烟草产业株式会社 用于治疗癌症的5-氨基-2,4,7-三氧代-3,4,7,8-四氢-2H-吡啶并[2,3-d]嘧啶衍生物和相关化合物
WO2009018238A1 (en) 2007-07-30 2009-02-05 Ardea Biosciences, Inc. Combinations of mek inhibitors and raf kinase inhibitors and uses thereof
WO2008120004A1 (en) * 2007-04-02 2008-10-09 Astrazeneca Ab Combination of a mek- inhibitor and a b-raf inhibitor for the treatment of cancer
UA103319C2 (en) 2008-05-06 2013-10-10 Глаксосмитклайн Ллк Thiazole- and oxazole-benzene sulfonamide compounds

Also Published As

Publication number Publication date
EP3560498B1 (en) 2022-08-17
IL219073A (en) 2016-05-31
CY1122013T1 (el) 2020-10-14
PT2488033T (pt) 2019-09-10
AU2010306653A1 (en) 2012-05-10
AU2010306653B2 (en) 2013-10-24
DOP2012000091A (es) 2013-09-15
HRP20191617T1 (hr) 2019-12-13
KR101729116B1 (ko) 2017-05-02
MA33746B1 (fr) 2012-11-01
US20120196879A1 (en) 2012-08-02
CN102655753B (zh) 2015-11-25
EP2488033A1 (en) 2012-08-22
LT2488033T (lt) 2019-09-10
DK2488033T3 (da) 2019-09-02
ZA201202612B (en) 2013-09-25
US8703781B2 (en) 2014-04-22
UA105064C2 (uk) 2014-04-10
LT3560498T (lt) 2022-11-25
HUE060206T2 (hu) 2023-02-28
EP3560498A1 (en) 2019-10-30
US20140187566A1 (en) 2014-07-03
JP2013508294A (ja) 2013-03-07
WO2011047238A1 (en) 2011-04-21
PL2488033T3 (pl) 2019-12-31
PT3560498T (pt) 2022-11-03
BR112012008854A2 (pt) 2015-09-22
EP4159217A1 (en) 2023-04-05
PL3560498T3 (pl) 2022-12-12
CN102655753A (zh) 2012-09-05
US20150111904A1 (en) 2015-04-23
RS63702B1 (sr) 2022-11-30
CA2775803A1 (en) 2011-04-21
HRP20221304T1 (hr) 2022-12-23
MX2012004413A (es) 2012-05-08
KR20120104547A (ko) 2012-09-21
RS59181B1 (sr) 2019-10-31
EA201290149A1 (ru) 2012-11-30
ES2930157T3 (es) 2022-12-07
JP5718929B2 (ja) 2015-05-13
CR20120155A (es) 2012-07-05
ES2745479T3 (es) 2020-03-02
ME03497B (me) 2020-04-20
HUE046139T2 (hu) 2020-02-28
CL2012000964A1 (es) 2012-08-31
PE20121093A1 (es) 2012-09-04
EP2488033A4 (en) 2014-04-30
CA2775803C (en) 2017-11-21
EA020589B1 (ru) 2014-12-30
BR112012008854B1 (pt) 2020-12-29
BR112012008854B8 (pt) 2021-05-25
NZ598913A (en) 2013-11-29
IL219073A0 (en) 2012-06-28
MY174759A (en) 2020-05-13
US8952018B2 (en) 2015-02-10
DK3560498T3 (da) 2022-11-14
CO6531498A2 (es) 2012-09-28
EP2488033B1 (en) 2019-06-12
EP4159217B1 (en) 2024-05-22

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